Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from M-Ras distinct activation scenarios: A mechanistic outlook and targeting. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure of the MRAS-SHOC2-PP1C phosphatase complex
10.1038/s41586-022-05086-1 · 2022 · External reference
SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
10.1073/pnas.1720352115 · 2018 · External reference
10.1038/s41586-022-04838-3
10.1038/s41586-022-04838-3 · External reference
The small GTPase MRAS is a broken switch
10.1038/s41467-025-55967-y · 2025 · External reference
10.1016/j.jmb.2022.167695
10.1016/j.jmb.2022.167695 · External reference
10.1016/j.ajpath.2021.05.008
10.1016/j.ajpath.2021.05.008 · External reference
MRAS: a close but understudied member of the RAS family
10.1101/cshperspect.a033621 · 2018 · External reference
10.1016/j.gene.2008.10.001
10.1016/j.gene.2008.10.001 · External reference
10.1016/j.csbj.2023.10.003 · Admitted local publication
10.1002/ajmg.a.61261
10.1002/ajmg.a.61261 · External reference
10.1093/hmg/ddz108
10.1093/hmg/ddz108 · External reference
10.1016/j.gde.2009.04.001
10.1016/j.gde.2009.04.001 · External reference
10.1038/jhg.2015.114
10.1038/jhg.2015.114 · External reference
SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
10.1007/s00018-023-05052-8 · 2023 · External reference
10.1038/s41525-023-00377-6
10.1038/s41525-023-00377-6 · External reference
10.1007/s12551-023-01054-9
10.1007/s12551-023-01054-9 · External reference
Structural insights into isoform-specific RAS-PI3Kalpha interactions and the role of RAS in PI3Kalpha activation
10.1038/s41467-024-55766-x · 2025 · External reference
10.1016/s0021-9258(18)35739-9
10.1016/s0021-9258(18)35739-9 · External reference
10.1126/science.2406906
10.1126/science.2406906 · External reference
10.1038/nrm2438
10.1038/nrm2438 · External reference
10.1016/j.cell.2017.06.009
10.1016/j.cell.2017.06.009 · External reference
10.1016/j.molcel.2024.06.027
10.1016/j.molcel.2024.06.027 · External reference
10.1042/bcj20220234
10.1042/bcj20220234 · External reference
10.1074/jbc.m000981200
10.1074/jbc.m000981200 · External reference
10.1016/j.yexcr.2020.112342
10.1016/j.yexcr.2020.112342 · External reference
10.1111/febs.16800
10.1111/febs.16800 · External reference
10.1038/s41586-022-04928-2
10.1038/s41586-022-04928-2 · External reference
10.1038/s41594-022-00841-4
10.1038/s41594-022-00841-4 · External reference
10.1038/s43018-023-00575-2
10.1038/s43018-023-00575-2 · External reference
10.1074/jbc.m505503200
10.1074/jbc.m505503200 · External reference
10.1002/anie.201305434
10.1002/anie.201305434 · External reference
10.1016/j.jbc.2024.105650
10.1016/j.jbc.2024.105650 · External reference
10.1039/d3cb00114h
10.1039/d3cb00114h · External reference
10.1016/j.sbi.2023.102722
10.1016/j.sbi.2023.102722 · External reference
Crystal structure of the GDP-bound human M-RAS protein in two crystal forms
10.1107/s2053230x24007969 · 2024 · External reference
10.1002/jcc.20289
10.1002/jcc.20289 · External reference
10.1063/5.0014475
10.1063/5.0014475 · External reference
10.1038/nmeth.4067
10.1038/nmeth.4067 · External reference
A configurational temperature Nose-Hoover thermostat
10.1063/1.2013227 · 2005 · External reference
10.1063/1.467468
10.1063/1.467468 · External reference
10.1063/1.464397
10.1063/1.464397 · External reference
10.1038/349117a0
10.1038/349117a0 · External reference
Allosteric modulation of NF1 GAP: Differential distributions of catalytically competent populations in loss-of-function and gain-of-function mutants
10.1002/pro.70042 · 2025 · External reference
Revisiting 310-helices: biological relevance, mimetics and applications
10.37349/eds.2024.00034 · 2024 · External reference
10.1056/nejmoa2103695
10.1056/nejmoa2103695 · External reference
10.1056/nejmoa2204619
10.1056/nejmoa2204619 · External reference
10.1016/j.jbc.2025.110331
10.1016/j.jbc.2025.110331 · External reference
10.1016/j.cell.2024.08.017
10.1016/j.cell.2024.08.017 · External reference
10.1016/j.csbj.2024.05.038
10.1016/j.csbj.2024.05.038 · External reference
10.1158/2159-8290.cd-24-0840
10.1158/2159-8290.cd-24-0840 · External reference
10.1016/j.csbj.2023.10.013 · Admitted local publication
10.1021/acs.jmedchem.1c01688
10.1021/acs.jmedchem.1c01688 · External reference
10.1002/anie.201910124
10.1002/anie.201910124 · External reference
10.1038/s41586-024-07205-6
10.1038/s41586-024-07205-6 · External reference
10.1126/science.adg9652
10.1126/science.adg9652 · External reference
10.1021/acs.jmedchem.4c02313
10.1021/acs.jmedchem.4c02313 · External reference
Targeting the SHOC2-RAS interaction in RAS-mutant cancers
10.1038/s41586-025-08931-1 · 2025 · External reference
The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants
10.1101/cshperspect.a031427 · 2018 · External reference
10.1016/j.febslet.2012.04.058
10.1016/j.febslet.2012.04.058 · External reference
10.1016/j.str.2018.03.018
10.1016/j.str.2018.03.018 · External reference
Exploring binding and allosteric energy landscapes for the KRAS interactions with effector proteins using Markov state modeling of conformational ensembles and allosteric network modeling
10.1002/pro.70228 · 2025 · External reference
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state
10.1038/s41467-024-51445-z · 2024 · External reference
10.1074/jbc.m110.125161
10.1074/jbc.m110.125161 · External reference
Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations
10.1080/14756366.2023.2195995 · 2023 · External reference
Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects
10.1073/pnas.83.4.952 · 1986 · External reference
Isolation of ras GTP-binding mutants using an in situ colony-binding assay
10.1073/pnas.83.13.4607 · 1986 · External reference
Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides
1996 · External reference
10.1128/mcb.19.9.6297
10.1128/mcb.19.9.6297 · External reference
10.1074/jbc.270.17.10002
10.1074/jbc.270.17.10002 · External reference
10.7554/elife.27810
10.7554/elife.27810 · External reference
10.7554/elife.76595
10.7554/elife.76595 · External reference
10.1038/s41586-023-06954-0
10.1038/s41586-023-06954-0 · External reference
10.1111/febs.15450
10.1111/febs.15450 · External reference
10.1016/j.semcancer.2018.03.005
10.1016/j.semcancer.2018.03.005 · External reference
10.1016/0092-8674(89)90985-9
10.1016/0092-8674(89)90985-9 · External reference
10.1016/j.trecan.2020.02.002
10.1016/j.trecan.2020.02.002 · External reference
10.1128/mcb.20.16.6074-6083.2000
10.1128/mcb.20.16.6074-6083.2000 · External reference
10.1016/j.bpj.2020.12.007
10.1016/j.bpj.2020.12.007 · External reference
10.1074/jbc.m000076200
10.1074/jbc.m000076200 · External reference
10.1074/jbc.271.33.19794
10.1074/jbc.271.33.19794 · External reference
10.1128/mcb.21.16.5287-5298.2001
10.1128/mcb.21.16.5287-5298.2001 · External reference
10.1016/s0014-5793(03)01351-6
10.1016/s0014-5793(03)01351-6 · External reference
10.1016/s0021-9258(18)54000-x
10.1016/s0021-9258(18)54000-x · External reference
10.1042/bj20050104
10.1042/bj20050104 · External reference
10.1038/28548
10.1038/28548 · External reference
10.1126/sciadv.abm2059
10.1126/sciadv.abm2059 · External reference
10.1039/d5sc04657b
10.1039/d5sc04657b · External reference
10.1128/mcb.24.11.4943-4954.2004
10.1128/mcb.24.11.4943-4954.2004 · External reference
