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References from Network pharmacology of cellular targets in major depressive disorder and differential mechanisms of fluoxetine, ketamine and esketamine. Local targets link to admitted publications; unresolved targets remain external evidence.
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Microglia-Derived Interleukin-6 triggers astrocyte apoptosis in the hippocampus and mediates depression-like behavior
2025 · External reference
Functions of p38 MAP Kinases in the Central Nervous System
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An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals
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Opiates as antidepressants
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Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women
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Unresolved reference
External reference
Antidepressant effects of ketamine in depressed patients
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Fluoxetine Regulates Neurogenesis In Vitro Through Modulation of GSK-3 / -Catenin Signaling
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Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions
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Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents
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Analysis of potential mechanism of Herbal Formula Taohong Siwu Decoction against vascular dementia based on network pharmacology and molecular docking
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Molecular mechanisms of Schisandra chinensis in treating depression-neuropathic pain comorbidity by network pharmacology and molecular docking analysis
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Centrality Analysis Methods for Biological Networks and Their Application to Gene Regulatory Networks
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Mechanisms of the Inhibition of Nuclear Factor-κB by Morphine in Neuronal Cells
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Inflammatory cytokines and nuclear factor-kappa B activation in adolescents with bipolar and major depressive disorders
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Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study
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Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients
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Fluoxetine Increases GABAA Receptor Activity through a Novel Modulatory Site
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Ketamine Inhibits Lipopolysaccharide-Induced Astrocytes Activation by Suppressing TLR4/NF-?B Pathway
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Ketamine inhibits LPS-mediated BV2 microglial inflammation via NMDA receptor blockage
10.1111/fcp.12508 · 2020 · External reference
Antidepressant mechanisms of ketamine’s action: NF-κB in the spotlight
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Ketamine exerts antidepressant effects and reduces IL-1β and IL-6 levels in rat prefrontal cortex and hippocampus
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Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
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Fluoxetine reverses the behavioral despair induced by neurogenic stress in mice: role of N-methyl-D-aspartate and opioid receptors
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Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats
2025 · External reference
Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents
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