Research graph
References from Bisdemethoxycurcumin attenuates myocardial fibrosis in heart failure with preserved ejection fraction by targeting TGFBR1 and oxidative stress. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1093/cvr/cvac013
10.1093/cvr/cvac013 · External reference
Heart failure with preserved ejection fraction: a stepchild no more!
10.1093/eurheartj/ehab601 · 2021 · External reference
10.1038/s41569-020-00480-6
10.1038/s41569-020-00480-6 · External reference
Empagliflozin in heart failure with a preserved ejection fraction
10.1056/nejmoa2107038 · 2021 · External reference
Fluorescence-based high throughput screening technologies for natural chloride ion channel blockers
10.1021/acs.chemrestox.8b00205 · 2018 · External reference
Bisdemethoxycurcumin inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat diet-fed C57BL/6 mice
10.1021/acs.jafc.5b05577 · 2016 · External reference
Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes
10.1016/j.jphs.2017.12.013 · 2018 · External reference
Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes
10.1016/j.foodchem.2012.06.110 · 2012 · External reference
Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice
10.3390/ijms23137395 · 2022 · External reference
Bisdemethoxycurcumin protection of Cardiomyocyte mainly depends on Nrf2/HO-1 activation mediated by the PI3K/AKT pathway
10.1021/acs.chemrestox.9b00222 · 2019 · External reference
Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology
10.1016/j.phymed.2022.154538 · 2023 · External reference
10.1038/s41586-019-1100-z
10.1038/s41586-019-1100-z · External reference
Heart failure with preserved ejection fraction: mechanisms and treatment strategies
10.1146/annurev-med-042220-022745 · 2022 · External reference
Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking
10.1016/j.compbiomed.2022.105454 · 2022 · External reference
10.1007/s00395-024-01074-w
10.1007/s00395-024-01074-w · External reference
10.1016/j.freeradbiomed.2021.01.022
10.1016/j.freeradbiomed.2021.01.022 · External reference
10.1093/nar/gkq300
10.1093/nar/gkq300 · External reference
DrugBank 5.0: a major update to the DrugBank database for 2018
10.1093/nar/gkx1037 · 2018 · External reference
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
2020 · External reference
10.1093/database/baq020
10.1093/database/baq020 · External reference
10.1002/1873-3468.14242
10.1002/1873-3468.14242 · External reference
10.1063/5.0014475
10.1063/5.0014475 · External reference
Molecular dynamics recipes for genome research
10.1093/bib/bbx006 · 2018 · External reference
Fibrotic Signaling in Cardiac Fibroblasts and Vascular Smooth Muscle Cells: The Dual Roles of Fibrosis in HFpEF and CAD
10.3390/cells11101657 · 2022 · External reference
10.1038/nrneph.2016.48
10.1038/nrneph.2016.48 · External reference
10.1111/bph.13344
10.1111/bph.13344 · External reference
Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways
10.1016/j.phymed.2022.154277 · 2022 · External reference
Suppression of TGF-β1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid
10.1007/s00403-010-1075-y · 2010 · External reference
Insulin-Like Growth Factor 1 Attenuates the Pro-Inflammatory Phenotype of Neutrophils in Myocardial Infarction
10.3389/fimmu.2022.908023 · 2022 · External reference
Insulin-Like Growth Factor 1 receptor deficiency alleviates Angiotensin II-induced cardiac fibrosis through the protein Kinase B/extracellular signal-regulated Kinase/Nuclear factor-κB pathway
10.1161/jaha.123.029631 · 2023 · External reference
10.1016/j.cell.2022.06.010
10.1016/j.cell.2022.06.010 · External reference
Dysfunctional and Dysregulated Nitric Oxide Synthases in Cardiovascular Disease: Mechanisms and Therapeutic Potential
2023 · External reference
Modelling the complexity of heart failure with preserved ejection fraction
10.1093/cvr/cvy095 · 2018 · External reference
Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanism
10.1210/en.2008-0708 · 2009 · External reference
Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injury
10.1152/ajpheart.00479.2005 · 2005 · External reference
ESR1 in myocardial infarction
10.1016/j.cca.2011.10.028 · 2012 · External reference
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
10.1038/sj.bjp.0707659 · 2008 · External reference
10.1186/s12933-020-01177-3
10.1186/s12933-020-01177-3 · External reference
Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt
2011 · External reference
