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References from Anti-angiogenic and anti-metastatic effects of PEDF overexpression in anaplastic thyroid cancer cells: A preliminary in vitro study. Local targets link to admitted publications; unresolved targets remain external evidence.
Trends in incidence, metastasis, and mortality from thyroid cancer in the USA from 1975 to 2019: a population-based study of age, period, and cohort effects
10.1016/s2213-8587(24)00310-3 · 2025 · External reference
Anaplastic thyroid carcinoma: an update
10.3390/cancers14041061 · 2022 · External reference
Mechanisms of angiogenesis in tumour
2024 · External reference
Targeting the tumour vasculature: from vessel destruction to promotion
10.1038/s41568-024-00736-0 · 2024 · External reference
The roles and role-players in thyroid cancer angiogenesis
10.1507/endocrj.ej18-0537 · 2019 · External reference
Tumor angiogenesis and anti-angiogenic therapy
10.1097/cm9.0000000000003231 · 2024 · External reference
NFκB-Mediated mechanisms drive PEDF expression and function in pre- and post-menopausal oestrogen levels in breast cancer
10.3390/ijms232415641 · 2022 · External reference
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
10.1038/s41392-023-01460-1 · 2023 · External reference
Pigment epithelium-derived factor (PEDF), a serpin with potent anti-angiogenic and neurite outgrowth-promoting properties
10.1515/bc.2002.188 · 2002 · External reference
PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor
10.1038/s41419-021-03583-1 · 2021 · External reference
The role of PEDF, VEGF, and Ki-67 in tissue invasion and tumor angiogenesis of medullary thyroid carcinoma
10.32552/2023.actamedica.974 · 2023 · External reference
Overexpression of pigment epithelium-derived factor in breast cancer cell-derived exosomes induces M1 polarization in macrophages
10.1016/j.imlet.2022.05.005 · 2022 · External reference
VEGF in signaling and disease: beyond discovery and development
10.1016/j.cell.2019.01.021 · 2019 · External reference
Angiogenesis-inhibitors for metastatic thyroid cancer
2010 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling
10.1186/s12906-019-2739-6 · 2019 · External reference
2021 American thyroid association guidelines for management of patients with anaplastic thyroid cancer
10.1089/thy.2020.0944 · 2021 · External reference
Update on current diagnosis and management of anaplastic thyroid carcinoma
10.5306/wjco.v14.i12.570 · 2023 · External reference
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential
10.1038/nrc3484 · 2013 · External reference
Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a
10.1515/hmbci-2020-0050 · 2021 · External reference
Evaluation of miRNAs expression in medullary thyroid carcinoma tissue samples: miR-34a and miR-144 as promising overexpressed markers in MTC
10.1016/j.humpath.2018.05.019 · 2018 · External reference
An investigation on the expression of miRNAs including miR-144 and miR-34a in plasma samples of RET-positive and RET-negative medullar thyroid carcinoma patients
10.1002/jcp.29055 · 2020 · External reference
PEDF-induced alteration of metabolism leading to insulin resistance
10.1016/j.mce.2014.11.006 · 2015 · External reference
PEDF inhibits non‑small cell lung cancer proliferation by suppressing autophagy through downregulation of AMPK‑ULK1 signaling
10.3892/or.2022.8434 · 2022 · External reference
Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors
10.1007/s00432-024-05714-5 · 2024 · External reference
Prognostic and therapeutic role of angiogenic microenvironment in thyroid cancer
10.3390/cancers13112775 · 2021 · External reference
PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells
10.1016/j.exer.2021.108828 · 2021 · External reference
Pigment epithelium‑derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α‑VEGF signaling pathway
10.3892/ol.2016.5316 · 2016 · External reference
The novel oncogenic factor TET3 combines with AHR to promote thyroid cancer lymphangiogenesis via the HIF-1α/VEGF signaling pathway
10.1186/s12935-023-03021-6 · 2023 · External reference
Characterization of PEDF: a multi-functional serpin family protein
10.1002/jcb.22072 · 2009 · External reference
Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2
10.4161/cbt.6.3.3757 · 2007 · External reference
Inhibitory effects of pigment epithelium-derived factor on epithelial-mesenchymal transition, migration and invasion of breast cancer
2017 · External reference
The contrary intracellular and extracellular functions of PEDF in HCC development
10.1038/s41419-019-1976-4 · 2019 · External reference
Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo
10.1016/s0002-9440(10)63210-5 · 2004 · External reference
Pigment epithelium-derived factor (PEDF) inhibits survival and proliferation of VEGF-exposed multiple myeloma cells through its anti-oxidative properties
10.1016/j.bbrc.2013.01.057 · 2013 · External reference
Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells
10.1016/j.lfs.2005.05.048 · 2005 · External reference
Evaluation of protein pigment epithelium-derived factor (PEDF) and microvessel density (MVD) as prognostic indicators in breast cancer
10.1007/s00432-010-0830-y · 2010 · External reference
New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer
10.1016/j.ctrv.2016.03.004 · 2016 · External reference
Neoadjuvant BRAF- and immune-directed therapy for anaplastic thyroid carcinoma
10.1089/thy.2018.0060 · 2018 · External reference
Lenvatinib as a novel treatment for anaplastic thyroid cancer: a retrospective study
2018 · External reference
Development and safety of PI3K inhibitors in cancer
10.1007/s00204-023-03440-4 · 2023 · External reference
Anti-inflammatory properties of pigment epithelium-derived factor
10.1177/1721727x221138857 · 2022 · External reference
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies
10.1158/1078-0432.ccr-18-2953 · 2019 · External reference
Molecular diagnostics and predictors in thyroid cancer
10.1089/thy.2009.0240 · 2009 · External reference
