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References from Cancer-associated fibroblasts during and after therapy: disentangling state, function and persistence. Local targets link to admitted publications; unresolved targets remain external evidence.
A framework for advancing our understanding of cancer-associated fibroblasts
10.1038/s41568-019-0238-1 · 2020 · External reference
Cancer-associated fibroblasts in the single-cell era
10.1038/s43018-022-00411-z · 2022 · External reference
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
10.1016/j.ccr.2014.04.005 · 2014 · External reference
Stress-adapted cancer-associated fibroblasts as mediators of immunosuppression and therapy resistance
10.1016/j.canlet.2026.218706 · 2026 · External reference
Chemotherapy-induced inflammatory gene signature and protumorigenic phenotype in pancreatic CAFs via stress-associated MAPK
10.1158/1541-7786.mcr-15-0348 · 2016 · External reference
Anti-EGFR therapy induces EGF secretion by cancer-associated fibroblasts to confer colorectal cancer chemoresistance
2020 · External reference
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
10.1016/j.ccell.2023.05.016 · 2023 · External reference
Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway
10.1038/s41467-024-45595-3 · 2024 · External reference
Functional heterogeneity of cancer-associated fibroblasts with distinct neoadjuvant immunotherapy plus chemotherapy response in esophageal squamous cell carcinoma
10.1186/s40364-024-00656-z · 2024 · External reference
Platinum-based chemotherapy induces opposing effects on immunotherapy response-related spatial and stromal biomarkers in the bladder cancer microenvironment
10.1158/1078-0432.ccr-24-0724 · 2024 · External reference
Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy
10.1038/s41467-023-36334-1 · 2023 · External reference
Biomarker analysis from patients with metastatic PDAC treated with TGFβ antibody, NIS793, plus abraxane+gemcitabine vs. abraxane+gemcitabine alone in a phase II, open label, randomized study
10.1158/1078-0432.ccr-26-0805 · 2026 · External reference
Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)
10.3892/etm.2024.12438 · 2024 · External reference
Senescent cancer-associated fibroblasts in cancer progression: from formation to therapeutic opportunities
10.1016/j.mad.2026.112158 · 2026 · External reference
The multifaceted contributions of cancer-associated fibroblasts to drug resistance in primary and metastatic tumors
10.1016/j.drup.2025.101273 · 2025 · External reference
Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics
2023 · External reference
Lipid oxidation reprogramming in cancer-associated fibroblasts enhances CD8(+) T cell cytotoxicity and therapeutic response
10.1016/j.ccell.2026.01.012 · 2026 · External reference
Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer
10.1158/1078-0432.ccr-21-3570 · 2022 · External reference
Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma
10.1038/s41467-024-52977-0 · 2024 · External reference
Immune-featured stromal niches associate with response to neoadjuvant immunotherapy in oral squamous cell carcinoma
2025 · External reference
Targeting VEGF signaling and stromal remodeling enhances chemoimmunotherapy efficacy in esophageal cancer
10.1136/jitc-2025-014249 · 2026 · External reference
Cellular responses to neoadjuvant FOLFOX6-bevacizumab treatment in colorectal cancers analyzed by single-cell transcriptome analysis
10.1016/j.prp.2024.155681 · 2024 · External reference
PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer
10.1080/2162402x.2025.2516294 · 2025 · External reference
Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma
10.1038/s41588-025-02253-8 · 2025 · External reference
Concurrent chemoradiotherapy plus immunotherapy versus concurrent chemoradiotherapy in locally advanced cervical cancer: a randomized, single-center, phase II trial of early tumor regression and pro-inflammatory tumor microenvironment remodeling
2020 · External reference
Single-cell dissection of therapy-induced remodeling uncovers a fibroblast-driven immunosuppressive niche and targetable vulnerabilities in lethal prostate cancer
2026 · External reference
10.1038/s12276-026-01792-2 · 2026 · Admitted local publication
Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer
2025 · External reference
Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy
10.1016/j.jcms.2017.12.016 · 2018 · External reference
Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast
10.1186/1471-2407-8-364 · 2008 · External reference
Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer
10.18632/oncotarget.5924 · 2015 · External reference
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
10.1016/j.ccell.2022.01.004 · 2022 · External reference
An extracellular matrix-producing subset of cancer-associated fibroblasts drives chemoresistance in breast cancer via SRC activation and G0S2 upregulation
10.1158/0008-5472.can-25-0966 · 2026 · External reference
CD266+ myofibroblasts mediate resistance to immunochemotherapy through ECM stiffness in head and neck squamous cell carcinoma
10.1158/2326-6066.cir-25-1379 · 2026 · External reference
Cancer-associated fibroblasts are associated with neo-adjuvant treatment response in oesophageal adenocarcinoma
10.1038/s41416-025-03080-8 · 2025 · External reference
Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer
10.1158/1535-7163.mct-25-0505 · 2026 · External reference
An immune-privileged niche mediates immunotherapy resistance in esophageal carcinoma
10.1136/jitc-2025-013959 · 2026 · External reference
POSTN(+) cancer-associated fibroblasts forming fortress-like barrier to mediate immunotherapy resistance in colorectal cancer
10.1016/j.canlet.2026.218683 · 2026 · External reference
Caspase-1-dependent pyroptosis converts αSMA(+) CAFs into collagen-III(high) iCAFs to fuel chemoresistant cancer stem cells
10.1126/sciadv.adt8697 · 2025 · External reference
Transfer of damaged mitochondria from cancer cells to cancer-associated fibroblasts promotes tyrosine kinase inhibitor tolerance in EGFR-mutant lung cancer
10.1158/0008-5472.can-25-0433 · 2026 · External reference
PAI-1-driven SFRP2(high) cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
10.1016/j.ccell.2025.02.024 · 2025 · External reference
The SDC1-ENO1 axis in cancer-associated fibroblasts generates a lactate-rich microenvironment that drives tumor radioresistance
10.1158/0008-5472.can-25-3806 · 2026 · External reference
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
10.1016/j.ccr.2012.01.007 · 2012 · External reference
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer
10.1186/s12943-020-01168-8 · 2020 · External reference
Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer
10.1038/s41467-022-33598-x · 2022 · External reference
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
10.1073/pnas.1320318110 · 2013 · External reference
NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors
10.1158/0008-5472.can-19-3158 · 2020 · External reference
Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity
10.1136/gutjnl-2020-322924 · 2022 · External reference
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
10.1038/s41586-025-09303-5 · 2025 · External reference
Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer
2025 · External reference
Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy
10.1080/2162402x.2022.2144669 · 2022 · External reference
Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression
10.1111/gtc.13177 · 2024 · External reference
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade
10.26508/lsa.202101230 · 2022 · External reference
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
10.1038/nm.2890 · 2012 · External reference
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
10.1084/jem.20131195 · 2013 · External reference
Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF1R activation
10.1158/0008-5472.can-17-0524 · 2018 · External reference
Radiation-induced extracellular vesicles from cancer-associated fibroblasts drive oesophageal squamous cell carcinoma metastasis via the miR-193a-3p/PTEN/Akt pathway
10.1002/ctm2.70483 · 2025 · External reference
Targeting the CAF-GDF15 axis attenuates AKT-mediated mitochondrial rewiring and chemoradiation resistance in esophageal adenocarcinoma
10.1186/s13046-026-03776-6 · 2026 · External reference
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
10.1136/gutjnl-2016-311954 · 2018 · External reference
Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors
10.1038/s41587-026-03152-x · 2026 · External reference
Cancer-associated fibroblasts in radiotherapy: bystanders or protagonists?
10.1186/s12964-023-01093-5 · 2023 · External reference
Cholesterol-mediated metabolic-mechanotransductive crosstalk orchestrates castration resistance in prostate cancer
2026 · External reference
Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis
10.1172/jci.insight.146334 · 2021 · External reference
Immunological signatures from irradiated cancer-associated fibroblasts
10.3389/fimmu.2024.1433237 · 2024 · External reference
Head and neck squamous cell carcinoma patient-derived cancer-associated fibroblasts undergo senescence while retaining protumorigenic properties after ex vivo irradiation
10.1016/j.ijrobp.2026.02.209 · 2026 · External reference
Bepotastine sensitizes ovarian cancer to PARP inhibitors through suppressing NF-κB-triggered SASP in cancer-associated fibroblasts
10.1158/1535-7163.mct-22-0396 · 2023 · External reference
Fibroblast inhibition by tocilizumab enabled gemcitabine/nab-paclitaxel rechallenge for pancreatic cancer
10.1111/cas.15929 · 2023 · External reference
Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer
10.1038/s41588-024-01998-y · 2025 · External reference
Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer
10.1016/j.ccell.2023.04.011 · 2023 · External reference
Spatial profiling identified senescent cancer-associated fibroblasts localized in the border region of human pancreatic ductal adenocarcinoma
10.1016/j.jcmgh.2026.101808 · 2026 · External reference
Lactate derived from cancer-associated fibroblasts promotes alternative splicing and castration resistance in prostate cancer
2026 · External reference
Ionizing radiation curtails immunosuppressive effects from cancer-associated fibroblasts on dendritic cells
10.3389/fimmu.2021.662594 · 2021 · External reference
Irradiated Tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over natural killer cells
2020 · External reference
Radiation-induced effects on TGF-β and PDGF receptor signaling in cancer-associated fibroblasts
2024 · External reference
Cancer-associated fibroblasts promote radioresistance of breast cancer cells via the HGF/c-met signaling pathway
10.1016/j.ijrobp.2022.12.029 · 2023 · External reference
Ionizing radiation normalizes the features of active breast cancer stromal fibroblasts and suppresses their paracrine pro-carcinogenic effects
10.1016/j.tranon.2023.101780 · 2023 · External reference
Secretion rates and protein composition of extracellular vesicles released by cancer-associated fibroblasts after radiation
10.1093/jrr/rrab018 · 2021 · External reference
The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy
10.1186/s12943-022-01666-x · 2022 · External reference
Cancer-associated fibroblast classification in single-cell and spatial proteomics data
10.1038/s41467-023-39762-1 · 2023 · External reference
A comprehensive benchmarking with practical guidelines for cellular deconvolution of spatial transcriptomics
10.1038/s41467-023-37168-7 · 2023 · External reference
scCODA is a Bayesian model for compositional single-cell data analysis
10.1038/s41467-021-27150-6 · 2021 · External reference
Differential abundance testing on single-cell data using k-nearest neighbor graphs
10.1038/s41587-021-01033-z · 2022 · External reference
Bioelectronics of The cellular cytoskeleton: monitoring cytoskeletal conductance variation for sensing drug resistance
10.1021/acssensors.8b01142 · 2019 · External reference
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data
10.1038/s41467-022-30755-0 · 2022 · External reference
Comparative analysis of cell-cell communication at single-cell resolution
10.1038/s41587-023-01782-z · 2024 · External reference
Best practices for single-cell analysis across modalities
10.1038/s41576-023-00586-w · 2023 · External reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
2003 · External reference
Mesenchymal-like tumor cells and myofibroblastic cancer-associated fibroblasts are associated with progression and immunotherapy response of clear cell renal cell carcinoma
10.1158/0008-5472.can-22-3034 · 2023 · External reference
Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structures
2025 · External reference
FMO2(+) cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma
10.1136/jitc-2025-011648 · 2025 · External reference
Perioperative tislelizumab for early-stage hepatocellular carcinoma: A phase II trial with integrated tumour microenvironment profiling and predictive modeling
10.1016/j.drup.2026.101440 · 2026 · External reference
The pre-treatment tumor microenvironment immune status determines Bacillus Calmette-Guerin immunotherapy response in early-stage bladder cancer
2026 · External reference
PET/CT imaging of activated cancer-associated fibroblasts predict response to PD-1 blockade in gastric cancer patients
2021 · External reference
Comparison of baseline (68)Ga-FAPI and (18)F-FDG PET/CT for prediction of response and clinical outcome in patients with unresectable hepatocellular carcinoma treated with PD-1 inhibitor and lenvatinib
10.2967/jnumed.123.265712 · 2023 · External reference
Predicting pathologic complete response in locally advanced rectal cancer with [(68)Ga]Ga-FAPI-04 PET, [(18)F]FDG PET, and contrast-enhanced MRI: lesion-to-lesion comparison with pathology
10.2967/jnumed.124.267581 · 2024 · External reference
IL-17-induced HIF1α drives resistance to anti-PD-L1 via fibroblast-mediated immune exclusion
10.1084/jem.20210693 · 2022 · External reference
Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits
10.1038/s41467-026-74073-1 · 2026 · External reference
Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer
10.1038/s41467-025-66485-2 · 2025 · External reference
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
10.1016/j.cell.2014.08.007 · 2014 · External reference
Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics
10.1038/s41388-022-02288-9 · 2022 · External reference
Stromal fibroblasts mediate anti-PD-1 resistance via MMP-9 and dictate TGFβ inhibitor sequencing in melanoma
10.1158/2326-6066.cir-18-0086 · 2018 · External reference
ATM regulates differentiation of myofibroblastic cancer-associated fibroblasts and can be targeted to overcome immunotherapy resistance
10.1158/0008-5472.can-22-0435 · 2022 · External reference
CD10(+)GPR77(+) Cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness
10.1016/j.cell.2018.01.009 · 2018 · External reference
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer
10.1186/s13046-025-03487-4 · 2025 · External reference
Depletion of adipose stroma-like cancer-associated fibroblasts potentiates pancreatic cancer immunotherapy
10.1158/2767-9764.crc-24-0298 · 2025 · External reference
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
10.1084/jem.20122344 · 2013 · External reference
Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial
10.1038/s41591-026-04380-z · 2026 · External reference
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
10.1073/pnas.2013644117 · 2020 · External reference
Bintrafusp alfa versus pembrolizumab in patients with treatment-naive, programmed death-ligand 1-high advanced NSCLC: a randomized, open-label, phase 3 trial
10.1016/j.jtho.2023.08.018 · 2023 · External reference
Randomized phase III trial of pegvorhyaluronidase alfa with nab-paclitaxel plus gemcitabine for patients with hyaluronan-high metastatic pancreatic adenocarcinoma
10.1200/jco.20.00590 · 2020 · External reference
Efficacy of losartan plus modified FOLFIRINOX versus modified FOLFIRINOX in advanced pancreatic cancers: a randomized clinical trial (AFPAC Study)
10.1002/cncr.35945 · 2025 · External reference
