References

Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial

10.1016/s0140-6736(11)61095-7 · 2011 · External reference

PI3K: downstream AKTion blocks apoptosis

10.1016/s0092-8674(00)81883-8 · 1997 · External reference

Cellular survival: a play in three Akts

10.1101/gad.13.22.2905 · 1999 · External reference

Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells

10.1038/sj.onc.1205500 · 2002 · External reference

The Ras radiation resistance pathway

2001 · External reference

The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer

10.1038/sj.bjc.6604938 · 2009 · External reference

Radiosensitization of prostate cancer cells by the dual PI3K/mTOR inhibitor BEZ235 under normoxic and hypoxic conditions

10.1016/j.radonc.2012.11.014 · 2013 · External reference

Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

10.1158/1078-0432.ccr-07-0161 · 2007 · External reference

HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

10.1111/j.1349-7006.2005.00063.x · 2005 · External reference

HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo

10.1158/0008-5472.can-05-1220 · 2005 · External reference

The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response

10.1593/neo.07124 · 2007 · External reference

Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir

10.1158/0008-5472.can-06-3398 · 2007 · External reference

Radiosensitization of EGFR/HER2 positive pancreatic cancer is mediated by inhibition of Akt independent of Ras mutational status

10.1158/1078-0432.ccr-09-1324 · 2010 · External reference

Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer

10.1200/jco.2007.15.2355 · 2008 · External reference

Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer

10.1016/j.radonc.2013.03.023 · 2013 · External reference

Clinical trial of oral nelfinavir before and during radiation therapy for advanced rectal cancer

10.1158/1078-0432.ccr-15-1489 · 2016 · External reference

A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy (CT-RT) for unresectable stage IIIA/IIIB NSCLC: a report of toxicities and clinical response

10.1097/jto.0b013e3182435aa6 · 2012 · External reference

Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer

10.1111/j.1742-4658.2012.08619.x · 2012 · External reference

Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells

10.1371/journal.pone.0103109 · 2014 · External reference

Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells

2002 · External reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

10.1126/science.275.5308.1943 · 1997 · External reference

Nelfinavir down-regulates hypoxia-inducible factor 1α and VEGF expression and increases tumor oxygenation: implications for radiotherapy

10.1158/0008-5472.can-06-1239 · 2006 · External reference

Synthesis, and in vitro and in vivo evaluation of a diphenylchlorin sensitizer for photodynamic therapy

10.1016/s1011-1344(03)00020-4 · 2003 · External reference

PKA knockdown enhances cell killing in response to radiation and androgen deprivation

10.1002/ijc.25634 · 2011 · External reference

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

10.1172/jci1269 · 1998 · External reference

Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts

10.1016/j.ijrobp.2011.02.015 · 2011 · External reference

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines

10.1038/sj.bjc.6603435 · 2006 · External reference

Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5Gy of γ-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity

10.1080/09553000600632261 · 2006 · External reference

Androgen receptor signaling regulates DNA repair in prostate cancers

10.1158/2159-8290.cd-13-0172 · 2013 · External reference

Association of BCL-2 with membrane hyperpolarization and radioresistance

10.1002/(sici)1097-4652(199607)168:1<114::aid-jcp14>3.0.co;2-7 · 1996 · External reference

Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions

10.1111/j.1349-7006.2008.00970.x · 2008 · External reference

HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2

2004 · External reference

Overexpression of STAT3 potentiates growth, survival, and radioresistance of non-small-cell lung cancer (NSCLC) cells

10.1016/j.jss.2010.03.053 · 2011 · External reference

Downregulation of ERK2 is essential for the inhibition of radiation-induced cell death in HSP25 overexpressed L929 cells

10.1038/sj.cdd.4400979 · 2002 · External reference

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir

10.1093/jnci/djs396 · 2012 · External reference

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

10.1196/annals.1391.012 · 2007 · External reference

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

10.1128/mcb.16.10.5221 · 1996 · External reference

Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells

10.1186/bcr2602 · 2010 · External reference

Inhibin beta E is upregulated by drug-induced endoplasmic reticulum stress as a transcriptional target gene of ATF4

10.1016/j.taap.2012.08.011 · 2012 · External reference

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine

10.1016/j.molonc.2014.11.005 · 2015 · External reference