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References from In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed. Local targets link to admitted publications; unresolved targets remain external evidence.
Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases
10.1038/sj.emboj.7601545 · 2007 · External reference
The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis
1993 · External reference
Stem cell factor and hematopoiesis
10.1182/blood.v90.4.1345 · 1997 · External reference
Expression and function of c-kit in hemopoietic progenitor cells
10.1084/jem.174.1.63 · 1991 · External reference
Structural and functional properties of platelet-derived growth factor and stem cell factor receptors
10.1101/cshperspect.a009100 · 2013 · External reference
Coexpression of stem cell factor and its receptor c-Kit in human malignant glioma cell lines
10.1007/bf00296360 · 1995 · External reference
Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors
10.1038/onc.2010.494 · 2011 · External reference
Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells
10.1016/j.ijrobp.2011.03.033 · 2011 · External reference
Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/beta-arrestin-1 dependent manner in NSCLC
10.18632/oncotarget.2395 · 2014 · External reference
KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro
10.1002/jcp.22431 · 2011 · External reference
The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells
10.1186/1476-4598-5-46 · 2006 · External reference
Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway
10.1007/s10620-007-9759-7 · 2007 · External reference
SCF, regulated by HIF-1alpha, promotes pancreatic ductal adenocarcinoma cell progression
10.1371/journal.pone.0121338 · 2015 · External reference
Possible prognostic and therapeutic significance of c-Kit expression, mast cell count and microvessel density in renal cell carcinoma
10.3390/ijms150713060 · 2014 · External reference
Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection
10.1093/carcin/bgu162 · 2014 · External reference
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
10.1016/s0022-3565(24)38879-2 · 2000 · External reference
Imatinib-induced long-term remission in a relapsed RCSD1-ABL1-positive acute lymphoblastic leukemia
10.3324/haematol.2015.139568 · 2016 · External reference
Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in china
2016 · External reference
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
10.1056/nejmoa020461 · 2002 · External reference
Radiotherapy for GIST progressing during or after tyrosine kinase inhibitor therapy: a prospective study
10.1016/j.radonc.2015.07.025 · 2015 · External reference
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571
10.1038/sj.onc.1203698 · 2000 · External reference
Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells
2001 · External reference
Resistance to c-Kit inhibitors in melanoma: insights for future therapies
10.18632/oncoscience.51 · 2014 · External reference
Imatinib: a breakthrough of targeted therapy in cancer
2014 · External reference
Therapeutic targeting of c-KIT in cancer
10.1517/13543784.2013.740010 · 2013 · External reference
Effects of stem cell factor on the growth and radiation survival of tumor cells
1995 · External reference
Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect
10.1182/blood.v100.4.1294.h81602001294_1294_1301 · 2002 · External reference
The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor slug
10.1038/sj.onc.1206467 · 2003 · External reference
Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor
10.1016/j.bcmd.2004.11.006 · 2005 · External reference
Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec)
10.1007/s00066-006-1445-8 · 2006 · External reference
Influence of imatinib mesylate on radiosensitivity of astrocytoma cells
2009 · External reference
Imatinib radiosensitizes bladder cancer by targeting homologous recombination
10.1158/0008-5472.can-12-1170 · 2013 · External reference
Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation
10.1016/j.radonc.2016.04.036 · 2016 · External reference
Clonogenic assay of cells in vitro
10.1038/nprot.2006.339 · 2006 · External reference
Three-dimensional cell growth confers radioresistance by chromatin density modification
10.1158/0008-5472.can-09-3848 · 2010 · External reference
The small molecule inhibitor QLT0267 Radiosensitizes squamous cell carcinoma cells of the head and neck
10.1371/journal.pone.0006434 · 2009 · External reference
[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs
10.1016/j.bcp.2007.05.028 · 2007 · External reference
Expression of the c-Kit receptor and its ligand SCF in non-small-cell lung carcinomas
10.1002/(sici)1097-0215(19980119)75:2<171::aid-ijc1>3.0.co;2-r · 1998 · External reference
Bone-induced c-kit expression in prostate cancer: a driver of intraosseous tumor growth
10.1002/ijc.28948 · 2015 · External reference
Stem cell factor receptor/c-Kit: from basic science to clinical implications
10.1152/physrev.00046.2011 · 2012 · External reference
Radioprotection of mice by recombinant rat stem cell factor
10.1073/pnas.89.20.9464 · 1992 · External reference
The effect of imatinib mesylate on the proliferation, invasive ability, and radiosensitivity of retinoblastoma cell lines
10.1038/eye.2012.231 · 2013 · External reference
In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells
10.1186/1471-2407-10-412 · 2010 · External reference
Combined antiproliferative activity of imatinib mesylate (STI-571) with radiation or cisplatin in vitro
2007 · External reference
C-kit expression is rate-limiting for stem cell factor-mediated disease progression in adenoid cystic carcinoma of the salivary glands
10.1016/j.tranon.2014.07.006 · 2014 · External reference
Histological specificity of alterations and expression of KIT and KITLG in non-small cell lung carcinoma
10.1002/gcc.22103 · 2013 · External reference
