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References from Cell-line dependent effects of hypoxia prior to irradiation in squamous cell carcinoma lines. Local targets link to admitted publications; unresolved targets remain external evidence.
Assessing tumor oxygenation for predicting outcome in radiation oncology: a review of studies correlating tumor hypoxic status and outcome in the preclinical and clinical settings
10.3389/fonc.2017.00010 · 2017 · External reference
The impact of hypoxia and its modification of the outcome of radiotherapy
2016 · External reference
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
10.1016/j.radonc.2005.06.038 · 2005 · External reference
Predicting recurrence after radiotherapy in head and neck cancer
10.1016/j.semradonc.2011.12.002 · 2012 · External reference
Hypoxia and predicting radiation response
10.1016/j.semradonc.2015.05.004 · 2015 · External reference
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
10.1259/0007-1285-26-312-638 · 1953 · External reference
Relationship between cellular radiosensitivity and non-repaired double-strand breaks studied for different growth states, dose rates and plating conditions in a normal human fibroblast line
10.1080/09553000050028922 · 2000 · External reference
The DNA damage response: ten years after
10.1016/j.molcel.2007.11.015 · 2007 · External reference
Genome maintenance mechanisms for preventing cancer
10.1038/35077232 · 2001 · External reference
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
10.1016/j.molcel.2008.05.017 · 2008 · External reference
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations
10.1667/rr3308.2 · 2013 · External reference
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
10.1093/nar/gkn550 · 2008 · External reference
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
10.1074/jbc.273.10.5858 · 1998 · External reference
Crosstalk between histone modifications during the DNA damage response
10.1016/j.tcb.2009.03.001 · 2009 · External reference
Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody
10.1667/0033-7587(2002)158[0486:qdoiid]2.0.co;2 · 2002 · External reference
Gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
10.1016/j.molcel.2005.10.003 · 2005 · External reference
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication
10.1016/j.molcel.2008.05.016 · 2008 · External reference
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery
10.1038/nature04384 · 2006 · External reference
GammaH2AX and cancer
10.1038/nrc2523 · 2008 · External reference
Use of the gamma-H2AX assay to monitor DNA damage and repair in translational cancer research
10.1016/j.canlet.2011.12.025 · 2012 · External reference
Retention of gammaH2AX foci as an indication of lethal DNA damage
10.1016/j.radonc.2011.05.055 · 2011 · External reference
Residual gammaH2AX foci as an indication of lethal DNA lesions
10.1186/1471-2407-10-4 · 2010 · External reference
Tumor hypoxia as a driving force in genetic instability
10.1186/2041-9414-4-5 · 2013 · External reference
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
10.1038/nrc2344 · 2008 · External reference
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
10.1158/0008-5472.can-07-5472 · 2008 · External reference
The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
10.1186/2045-3701-2-30 · 2012 · External reference
SWI/SNF regulates the cellular response to hypoxia
10.1074/jbc.m808491200 · 2009 · External reference
ATM activation and signaling under hypoxic conditions
10.1128/mcb.01301-08 · 2009 · External reference
Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
10.1158/0008-5472.can-04-1520 · 2004 · External reference
Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis
10.7603/s40681-016-0001-9 · 2016 · External reference
Chromatin as an oxygen sensor and active player in the hypoxia response
10.1016/j.cellsig.2011.08.019 · 2012 · External reference
Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A
10.1128/mcb.06643-11 · 2012 · External reference
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
10.1038/ncomms6203 · 2014 · External reference
Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours
10.1016/j.radonc.2011.07.001 · 2011 · External reference
Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection
10.1177/002215540205000207 · 2002 · External reference
Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining
10.3109/09553000903242149 · 2009 · External reference
Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation
10.1016/j.radonc.2010.04.020 · 2010 · External reference
The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair
10.1016/j.radonc.2008.10.019 · 2009 · External reference
Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma
10.1016/j.radonc.2012.10.020 · 2013 · External reference
Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS
10.1016/j.radonc.2004.11.008 · 2005 · External reference
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells
10.1091/mbc.e05-01-0065 · 2005 · External reference
Phosphorylation of histone H2AX as a measure of radiosensitivity
10.1016/j.ijrobp.2003.09.028 · 2004 · External reference
Unresolved reference
2012 · External reference
Molecular aspects of tumour hypoxia
10.1016/j.molonc.2008.03.006 · 2008 · External reference
Increased radiosensitivity with chronic hypoxia in four human tumor cell lines
10.1016/s0360-3016(02)02963-2 · 2002 · External reference
Checking in on hypoxia/reoxygenation
10.4161/cc.5.12.2811 · 2006 · External reference
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner
10.1158/0008-5472.can-05-1160 · 2005 · External reference
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs
10.1158/0008-5472.can-05-2119 · 2005 · External reference
Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability
10.1242/jcs.092262 · 2012 · External reference
Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status
10.1016/j.ijrobp.2005.09.031 · 2006 · External reference
Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells
10.1038/emm.2004.32 · 2004 · External reference
MTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1alpha
10.1016/j.molcel.2010.10.030 · 2010 · External reference
ATM activation in hypoxia – causes and consequences
10.4161/mco.29903 · 2014 · External reference
