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References from The impact of the IGF-1 system of cancer cells on radiation response – An in vitro study. Local targets link to admitted publications; unresolved targets remain external evidence.
A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
1994 · External reference
Insulin-like growth factor I receptor signaling in transformation by src oncogenes
10.1128/mcb.17.7.3744 · 1997 · External reference
Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
10.1186/bcr2883 · 2011 · External reference
Inhibitory effect of small interfering RNA targeting insulin-like growth factor-I receptor in ovarian cancer OVCAR3 cells
2010 · External reference
Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
10.1158/1535-7163.mct-09-0058 · 2009 · External reference
AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells
10.1158/1535-7163.mct-08-1171 · 2009 · External reference
Overexpression of the insulin-like growth factor I receptor in human colon carcinomas
10.1002/cncr.10945 · 2002 · External reference
Overexpression of the insulin-like growth factor I receptor in human pheochromocytomas
10.1677/jme.1.01975 · 2006 · External reference
The role of the insulin-like growth factor system in adrenocortical tumourigenesis
10.1046/j.1365-2362.2000.0300s3069.x · 2000 · External reference
Radiation-induced signaling pathways that promote cancer cell survival (review)
10.3892/ijo.2014.2614 · 2014 · External reference
Protection of the genome and central protein-coding sequences by non-coding DNA against DNA damage from radiation
10.1016/j.mrrev.2015.04.001 · 2015 · External reference
Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism
10.1038/sj.onc.1210037 · 2007 · External reference
Overexpression of IGF-I receptor in HeLa cells enhances in vivo radioresponse
10.1016/j.bbrc.2007.09.070 · 2007 · External reference
Effect of the insulin-like growth factor I receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts
10.1006/excr.1997.3683 · 1997 · External reference
Roles of the insulin-like growth factor I receptor C-terminus in cellular radioresistance
10.1016/j.bbrc.2003.09.195 · 2003 · External reference
Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
1997 · External reference
IGF-1R expression in localized cervical carcinoma patients treated by radiochemotherapy
10.1016/j.ygyno.2007.04.004 · 2007 · External reference
Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance
10.1016/j.gendis.2014.10.004 · 2015 · External reference
Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma
10.1007/s10549-008-0139-6 · 2009 · External reference
Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R
10.1002/(sici)1097-0215(19980413)76:2<223::aid-ijc9>3.0.co;2-z · 1998 · External reference
Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing’s sarcoma cells
10.1002/ijc.10537 · 2002 · External reference
Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect
1998 · External reference
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor
10.1038/sj.onc.1202984 · 1999 · External reference
Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors
2001 · External reference
Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant
10.1172/jci116096 · 1992 · External reference
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)
10.1016/s0021-9258(18)53824-2 · 1993 · External reference
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
10.1128/mcb.01315-06 · 2007 · External reference
Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells
10.1186/bcr1392 · 2006 · External reference
Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas
10.1016/s0046-8177(03)00291-0 · 2003 · External reference
Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer
1993 · External reference
MVP expression is related to IGF1-R in cervical carcinoma patients treated by radiochemotherapy
10.1016/j.ygyno.2008.04.034 · 2008 · External reference
IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma
10.1016/j.oraloncology.2011.05.005 · 2011 · External reference
BCL-2, in combination with MVP and IGF-1R expression, improves prediction of clinical outcome in complete response cervical carcinoma patients treated by radiochemotherapy
10.1016/j.ygyno.2011.05.037 · 2011 · External reference
IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells
10.1002/stem.1328 · 2013 · External reference
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
10.1073/pnas.98.4.1676 · 2001 · External reference
GammaH2AX: a sensitive molecular marker of DNA damage and repair
10.1038/leu.2010.6 · 2010 · External reference
GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence
10.4161/cc.5.24.3569 · 2006 · External reference
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
10.1074/jbc.c100569200 · 2001 · External reference
Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks
10.1016/j.radonc.2012.03.009 · 2012 · External reference
Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination
10.1128/mcb.23.21.7510-7524.2003 · 2003 · External reference
Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability
10.1093/nar/gkp1063 · 2010 · External reference
Major vault protein may affect nonhomologous end-joining repair and apoptosis through Ku70/80 and bax downregulation in cervical carcinoma tumors
10.1016/j.ijrobp.2008.11.013 · 2009 · External reference
Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells
10.1002/mc.20463 · 2009 · External reference
BRCA2-dependent and independent formation of RAD51 nuclear foci
10.1038/sj.onc.1206263 · 2003 · External reference
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition
10.1002/ijc.29327 · 2015 · External reference
BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage
10.1016/j.dnarep.2012.12.007 · 2013 · External reference
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C
10.1074/jbc.m109.024646 · 2009 · External reference
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer
10.1038/sj.cgt.7700775 · 2005 · External reference
Insulin-like growth factor-I receptor signaling blockade combined with radiation
10.1158/0008-5472.can-06-2000 · 2007 · External reference
Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells
10.1158/1078-0432.ccr-09-0478 · 2009 · External reference
Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells
10.1007/s11010-009-0064-y · 2009 · External reference
Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers
10.1016/j.ijrobp.2010.10.003 · 2011 · External reference
