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References from Dual blockade of PI3K and MEK in combination with radiation in head and neck cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Human papillomavirus and survival of patients with oropharyngeal cancer
10.1056/nejmoa0912217 · 2010 · External reference
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
10.1056/nejmoa053422 · 2006 · External reference
Interaction of radiation therapy with molecular targeted agents
10.1200/jco.2014.55.1366 · 2014 · External reference
Comprehensive genomic characterization of squamous cell carcinoma of the head and neck in the Cancer Genome Atlas
2013 · External reference
EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy
10.1517/14728222.2011.541440 · 2011 · External reference
Targeted therapy in head and neck cancer: an update on current clinical developments in epidermal growth factor receptor-targeted therapy and immunotherapies
10.1007/s40265-017-0734-0 · 2017 · External reference
Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma
10.1517/14728222.2015.1012157 · 2015 · External reference
MEK inhibitor PD-0325901 overcomes resistance to PI3K/mTOR inhibitor PF-5212384 and potentiates antitumor effects in human head and neck squamous cell carcinoma
10.1158/1078-0432.ccr-14-3377 · 2015 · External reference
RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma
10.1158/1078-0432.ccr-13-2721 · 2014 · External reference
Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature
10.18632/oncotarget.3768 · 2015 · External reference
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
10.1158/2159-8290.cd-13-0103 · 2013 · External reference
Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines
10.1002/ijc.10398 · 2002 · External reference
Treatment effect of buparlisib, cetuximab and irradiation in wild-type or PI3KCA-mutated head and neck cancer cell lines
10.1007/s10637-015-0210-1 · 2015 · External reference
Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial
10.1016/s1470-2045(17)30180-8 · 2017 · External reference
A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor
10.1038/bjc.2017.10 · 2017 · External reference
A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors
10.1007/s00280-016-3019-5 · 2016 · External reference
Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial
10.1016/s1470-2045(17)30376-5 · 2017 · External reference
Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer
10.1016/j.ejca.2017.02.030 · 2017 · External reference
A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel
10.1007/s10637-017-0445-0 · 2017 · External reference
Antitumor activity of the dual PI3K/MTOR inhibitor, PF-04691502, in combination with radiation in head and neck cancer
10.1016/j.radonc.2017.08.001 · 2017 · External reference
Antitumor activity of the dual PI3K/MTOR inhibitor, PF-04691502, in combination with radiation in head and neck cancer
10.1016/j.radonc.2017.08.001 · 2017 · External reference
Mechanism of MEK inhibition determines efficacy in mutant KRAS - versus BRAF-driven cancers
10.1038/nature12441 · 2013 · External reference
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
10.1016/j.tibs.2011.03.006 · 2011 · External reference
NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
10.1186/1748-717x-7-48 · 2012 · External reference
Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer
10.18632/oncotarget.22850 · 2017 · External reference
Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity
10.1158/0008-5472.can-08-0757 · 2008 · External reference
Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer
10.18632/oncotarget.9670 · 2016 · External reference
Targeting the PI3K/AKT/mTOR signaling pathway as an effectively radiosensitizing strategy for treating human oral squamous cell carcinoma in vitro and in vivo
10.18632/oncotarget.19817 · 2017 · External reference
MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways
10.1080/15384101.2015.1104437 · 2015 · External reference
Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization
10.1186/s13014-015-0514-5 · 2015 · External reference
Radiosensitization of glioblastoma cell lines by the dual PI3K and mTOR inhibitor NVP-BEZ235 depends on drug-irradiation schedule
10.1593/tlo.12364 · 2013 · External reference
Stress and radiation-induced activation of multiple intracellular signaling pathways
10.1667/0033-7587(2003)159[0283:sariao]2.0.co;2 · 2003 · External reference
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
10.1038/sj.onc.1205500 · 2002 · External reference
10.1091/mbc.10.8.2493
10.1091/mbc.10.8.2493 · 1999 · External reference
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
10.1038/sj.onc.1201275 · 1997 · External reference
Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells
10.2307/3579199 · 1996 · External reference
A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma
10.1158/1535-7163.mct-13-1090 · 2014 · External reference
Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies
10.1001/jamaoto.2015.0471 · 2015 · External reference
Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovarian clear cell carcinoma
10.1080/15384047.2014.1002362 · 2015 · External reference
Hallway gossip between Ras and PI3K pathways
10.1182/blood-2014-03-559039 · 2014 · External reference
Cooperative activation of PI3K by Ras and Rho family small GTPases
10.1016/j.molcel.2012.05.007 · 2012 · External reference
Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
10.1042/bst20110609 · 2012 · External reference
RAS interaction with PI3K: more than just another effector pathway
10.1177/1947601911408079 · 2011 · External reference
Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair
10.1073/pnas.0914242107 · 2010 · External reference
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition
10.1158/2159-8290.cd-11-0348 · 2012 · External reference
Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors
10.1186/s12885-017-3639-0 · 2017 · External reference
Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests
10.18632/oncotarget.9161 · 2016 · External reference
Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation
10.1016/j.radonc.2007.04.020 · 2007 · External reference
Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature
10.1158/0008-5472.can-11-2263 · 2012 · External reference
The effects of pulsed radiation therapy on tumor oxygenation in 2 murine models of head and neck squamous cell carcinoma
10.1016/j.ijrobp.2015.04.002 · 2015 · External reference
