Research graph
References from PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours. Local targets link to admitted publications; unresolved targets remain external evidence.
Radiotherapy demand and activity in England 2006–2020
10.1016/j.clon.2013.05.005 · 2013 · External reference
Human papillomavirus-negative pharyngeal cancer
10.1200/jco.2015.60.7804 · 2015 · External reference
Selective targeting of the G2/M cell cycle checkpoint to improve the therapeutic index of radiotherapy
10.1016/j.clon.2014.01.009 · 2014 · External reference
Radiosensitization by the ATR inhibitor AZD6738 through generation of acentric micronuclei
10.1158/1535-7163.mct-16-0239 · 2017 · External reference
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
10.4161/cbt.21093 · 2012 · External reference
Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
10.1038/bjc.2012.265 · 2012 · External reference
Targeted radiosensitization by the Chk1 inhibitor SAR-020106
10.1016/j.ijrobp.2012.08.006 · 2013 · External reference
Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776
10.1158/1078-0432.ccr-12-3748 · 2013 · External reference
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
10.1158/0008-5472.can-09-3573 · 2010 · External reference
Abstract 2348: discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients
10.1158/1538-7445.am2013-2348 · 2013 · External reference
Causes and consequences of replication stress
10.1038/ncb2897 · 2014 · External reference
Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers
10.1038/bjc.2011.240 · 2011 · External reference
Clinical development of new drug-radiotherapy combinations
10.1038/nrclinonc.2016.79 · 2016 · External reference
Molecular pathways: targeting ATR in cancer therapy
10.1158/1078-0432.ccr-15-0479 · 2015 · External reference
