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References from A high-confidence inventory of the proteins in the mitochondrion-related organelle of Giardia. Local targets link to admitted publications; unresolved targets remain external evidence.
The Origin and Diversification of Mitochondria
10.1016/j.cub.2017.09.015 · 2017 · External reference
Reinventing an Organelle: The Reduced Mitochondrion in Parasitic Protists
10.1016/j.pt.2018.08.008 · 2018 · External reference
Extreme mitochondrial reduction in a novel group of free-living metamonads
10.1038/s41467-024-50991-w · 2024 · External reference
Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes
10.1038/s41559-017-0092 · 2017 · External reference
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
10.1126/science.1143837 · 2007 · External reference
Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis
10.1146/annurev-biochem-013118-111540 · 2020 · External reference
A mitochondrial protein compendium elucidates complex I disease biology
10.1016/j.cell.2008.06.016 · 2008 · External reference
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations
10.1093/nar/gkaa1011 · 2021 · External reference
Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale
10.1016/j.celrep.2017.06.014 · 2017 · External reference
Giardia duodenalis: Biology and Pathogenesis
10.1128/cmr.00024-19 · 2021 · External reference
Behind the smile: cell biology and disease mechanisms of Giardia species
10.1038/nrmicro2317 · 2010 · External reference
An up-date on Giardia and giardiasis
10.1016/j.mib.2016.07.019 · 2016 · External reference
Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation
10.1038/nature01945 · 2003 · External reference
Inheritance of the reduced mitochondria of Giardia intestinalis is coupled to the flagellar maturation cycle
10.1186/s12915-021-01129-7 · 2021 · External reference
Mitochondrial dynamics in parasitic protists
10.1371/journal.ppat.1008008 · 2019 · External reference
Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum
10.1186/s12915-017-0361-y · 2017 · External reference
Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
10.1371/journal.ppat.1010773 · 2023 · External reference
Minimal cytosolic iron-sulfur cluster assembly machinery of Giardia intestinalis is partially associated with mitosomes
10.1111/mmi.13487 · 2016 · External reference
The protein import channel in the outer mitosomal membrane of Giardia intestinalis
10.1093/molbev/msp117 · 2009 · External reference
Giardia mitosomes and trichomonad hydrogenosomes share a common mode of protein targeting
10.1073/pnas.0500349102 · 2005 · External reference
Reductive evolution of the mitochondrial processing peptidases of the unicellular parasites Trichomonas vaginalis and Giardia intestinalis
10.1371/journal.ppat.1000243 · 2008 · External reference
The minimal proteome in the reduced mitochondrion of the parasitic protist Giardia intestinalis
10.1371/journal.pone.0017285 · 2011 · External reference
Probing the Biology of Giardia intestinalis Mitosomes Using In Vivo Enzymatic Tagging
10.1128/mcb.00448-15 · 2015 · External reference
An Interactome-Centered Protein Discovery Approach Reveals Novel Components Involved in Mitosome Function and Homeostasis in Giardia lamblia
10.1371/journal.ppat.1006036 · 2016 · External reference
Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition
10.1038/s41587-023-02099-7 · 2024 · External reference
A mammalian organelle map by protein correlation profiling
10.1016/j.cell.2006.03.022 · 2006 · External reference
Isolation of functional pure mitochondria by superparamagnetic microbeads
10.1016/j.ab.2009.02.040 · 2009 · External reference
Selective loss of ATP carriers in favour of SLC25A43 orthologues in metamonad mitochondria adapted to anaerobiosis
10.1098/rsob.240202 · 2025 · External reference
Novel structural components of the ventral disc and lateral crest in Giardia intestinalis
10.1371/journal.pntd.0001442 · 2011 · External reference
Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia
10.1371/journal.ppat.1012617 · 2024 · External reference
DeepLoc 2.1: multi-label membrane protein type prediction using protein language models
10.1093/nar/gkae237 · 2024 · External reference
Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix
10.1093/gbe/evv175 · 2015 · External reference
Protein import, replication, and inheritance of a vestigial mitochondrion
10.1074/jbc.m500787200 · 2005 · External reference
AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage
10.1093/nar/gkaf1226 · 2026 · External reference
Fast and accurate protein structure search with Foldseek
10.1038/s41587-023-01773-0 · 2024 · External reference
pLM-BLAST: distant homology detection based on direct comparison of sequence representations from protein language models
10.1093/bioinformatics/btad579 · 2023 · External reference
A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core
10.1016/j.jmb.2017.12.007 · 2018 · External reference
MIB2: metal ion-binding site prediction and modeling server
10.1093/bioinformatics/btac534 · 2022 · External reference
The lure of a LYR: The logistics of iron sulfur cluster delivery
10.1016/j.cmet.2014.02.011 · 2014 · External reference
Exploring the protein universe with distant similarity detection methods
10.1002/pro.70397 · 2026 · External reference
Comparative analysis of mitochondrial proteomes across the tree of life
2026 · External reference
A Eukaryote without a Mitochondrial Organelle
10.1016/j.cub.2016.03.053 · 2016 · External reference
Characterization of the SUF FeS cluster synthesis machinery in the amitochondriate eukaryote Monocercomonoides exilis
10.1016/j.cub.2024.07.018 · 2024 · External reference
Why metronidazole is active against both bacteria and parasites
10.1128/aac.43.7.1533 · 1999 · External reference
Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms
10.1093/jac/dkx351 · 2018 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
The Mtm1p carrier and pyridoxal 5′-phosphate cofactor trafficking in yeast mitochondria
10.1016/j.abb.2015.01.021 · 2015 · External reference
The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2
10.1038/sj.emboj.7601064 · 2006 · External reference
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS
2022 · External reference
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells
10.1038/s41586-021-04025-w · 2021 · External reference
Giardia intestinalis incorporates heme into cytosolic cytochrome b(5)
10.1128/ec.00200-13 · 2014 · External reference
The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
10.1186/s12915-023-01765-1 · 2023 · External reference
In situ architecture of the ER-mitochondria encounter structure
10.1038/s41586-023-06050-3 · 2023 · External reference
Mitosomes in Entamoeba histolytica contain a sulfate activation pathway
10.1073/pnas.0907106106 · 2009 · External reference
Assessing the function of the alternative electron transport chain in the Cryptosporidium parvum mitosome
10.1128/mbio.01120-25 · 2025 · External reference
The mitochondrion-like organelle of Trimastix pyriformis contains the complete glycine cleavage system
10.1371/journal.pone.0055417 · 2013 · External reference
A Mitosome With Distinct Metabolism in the Uncultured Protist Parasite Paramikrocytos canceri (Rhizaria, Ascetosporea)
10.1093/gbe/evad022 · 2023 · External reference
Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines
10.3389/fmicb.2017.00398 · 2017 · External reference
Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics
10.3389/fmicb.2022.834008 · 2022 · External reference
Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates
10.2147/idr.s177997 · 2019 · External reference
Iron-sensing is governed by mitochondrial, not by cytosolic iron-sulfur cluster biogenesis in Aspergillus fumigatus
10.1039/c8mt00263k · 2018 · External reference
Iron Regulatory Mechanisms in Saccharomyces cerevisiae
10.3389/fmicb.2020.582830 · 2020 · External reference
Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family
10.1073/pnas.1632471100 · 2003 · External reference
Iron-sulfur cluster biogenesis and trafficking in mitochondria
10.1074/jbc.r117.787101 · 2017 · External reference
Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease
10.1016/j.abb.2015.11.031 · 2016 · External reference
Insights into the iron-ome and manganese-ome of Δmtm1 Saccharomyces cerevisiae mitochondria
10.1039/c3mt00041a · 2013 · External reference
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis
10.1016/j.cmet.2009.06.012 · 2009 · External reference
Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile
10.1016/0035-9203(83)90120-7 · 1983 · External reference
Rapid tagging and integration of genes in Giardia intestinalis
10.1128/ec.00190-10 · 2011 · External reference
GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis
10.1093/nar/gkn631 · 2009 · External reference
A chromosome-scale reference genome for Giardia intestinalis WB
10.1038/s41597-020-0377-y · 2020 · External reference
HMMER web server: 2015 update
10.1093/nar/gkv397 · 2015 · External reference
Pfam: The protein families database in 2021
10.1093/nar/gkaa913 · 2021 · External reference
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
10.1006/jmbi.2000.4315 · 2001 · External reference
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
10.1093/nar/25.17.3389 · 1997 · External reference
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
10.1093/nar/gkv1003 · 2016 · External reference
The Protein Data Bank
10.1093/nar/28.1.235 · 2000 · External reference
OrthoFinder: phylogenetic orthology inference for comparative genomics
10.1186/s13059-019-1832-y · 2019 · External reference
Purification of mitochondria from yeast cells
2009 · External reference
Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells
10.1016/j.ab.2004.03.049 · 2004 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
