Research graph
References from Serotonin biology as a basis for explaining psychedelic drug action. Local targets link to admitted publications; unresolved targets remain external evidence.
Single-dose psilocybin treatment for major depressive disorder: A randomized clinical trial
10.1001/jama.2023.14530 · 2023 · External reference
Single-dose psilocybin for a treatment-resistant episode of major depression
10.1056/nejmoa2206443 · 2022 · External reference
Single treatment with MM120 (lysergide) in generalized anxiety disorder: A randomized clinical trial
10.1001/jama.2025.13481 · 2025 · External reference
Serotonin
10.1016/j.cub.2023.09.068 · 2023 · External reference
The neural basis of psychedelic action
10.1038/s41593-022-01177-4 · 2022 · External reference
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics
10.1016/j.neuron.2025.06.012 · 2025 · External reference
5-Hydroxytryptamine receptors in GtoPdb v.2025.3
2025 · External reference
The ABCs of psychedelics: a preclinical roadmap for drug discovery
10.1016/j.tips.2025.07.017 · 2025 · External reference
Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels
10.1038/s41386-019-0324-9 · 2019 · External reference
An exploration of the relationships between the effects of psilocybin on behavior, 5-HT2A receptor occupancy, and neuroplastic effects in mice
10.1177/02698811251395386 · 2026 · External reference
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
10.1523/jneurosci.1869-10.2010 · 2010 · External reference
Innovations present in the primate interneuron repertoire
10.1038/s41586-020-2781-z · 2020 · External reference
Transcriptomic diversity of cell types across the adult human brain
10.1126/science.add7046 · 2023 · External reference
5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons
10.1523/jneurosci.22-17-07389.2002 · 2002 · External reference
Serotonin nerve terminals in adult rat neocortex
10.1016/0006-8993(75)90158-4 · 1975 · External reference
Pharmacokinetics and pharmacodynamics of oral psilocybin administration in healthy participants
10.1002/cpt.2821 · 2023 · External reference
N,N-dimethyltryptamine and the pineal gland: Separating fact from myth
10.1177/0269881117736919 · 2018 · External reference
Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo
10.1038/s41592-024-02188-8 · 2024 · External reference
Directed evolution of a selective and sensitive serotonin sensor via machine learning
10.1016/j.cell.2020.11.040 · 2020 · External reference
Serotonergic neurons signal reward and punishment on multiple timescales
10.7554/elife.06346 · 2015 · External reference
Embracing diversity in the 5-HT neuronal system
10.1038/s41583-019-0151-3 · 2019 · External reference
Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems
10.1016/j.cell.2018.07.043 · 2018 · External reference
Growth retardation and altered autonomic control in mice lacking brain serotonin
10.1073/pnas.0810793106 · 2009 · External reference
Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus
10.1523/jneurosci.0021-08.2008 · 2008 · External reference
Coding of task reward value in the dorsal raphe nucleus
10.1523/jneurosci.0015-10.2010 · 2010 · External reference
A prospective code for value in the serotonin system
10.1038/s41586-025-08731-7 · 2025 · External reference
Cognitive inflexibility after prefrontal serotonin depletion
10.1126/science.1094987 · 2004 · External reference
Serotonin neurons modulate learning rate through uncertainty
10.1016/j.cub.2021.12.006 · 2022 · External reference
Activity patterns of serotonin neurons underlying cognitive flexibility
10.7554/elife.20552 · 2017 · External reference
Reversal learning enhanced by lysergic acid diethylamide (LSD): concomitant rise in brain 5-hydroxytryptamine levels
10.1111/j.1476-5381.1974.tb08611.x · 1974 · External reference
Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans
10.1017/s0033291722002963 · 2023 · External reference
Acute serotonin 2A receptor activation impairs behavioral flexibility in mice
10.1016/j.bbr.2020.112861 · 2020 · External reference
Acute psilocybin enhances cognitive flexibility in rats
10.1038/s41386-023-01545-z · 2023 · External reference
Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats
10.1038/s41398-024-03103-7 · 2024 · External reference
Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((+/-)-DOI) on cognitive flexibility
10.1038/s41380-024-02439-2 · 2024 · External reference
Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration
10.61373/pp025r.0002 · 2025 · External reference
Serotonin and dopamine: unifying affective, activational, and decision functions
10.1038/npp.2010.121 · 2011 · External reference
Activation of dorsal raphe serotonin neurons underlies waiting for delayed rewards
10.1523/jneurosci.3714-10.2011 · 2011 · External reference
Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task
10.1016/s0028-3908(99)00159-8 · 2000 · External reference
Acute LSD effects on response inhibition neural networks
10.1017/s0033291717002914 · 2018 · External reference
Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe
10.1126/science.161.3842.706 · 1968 · External reference
Monoaminergic neuromodulation of sensory processing
10.3389/fncir.2018.00051 · 2018 · External reference
Effects of stimulating the dorsal raphe nucleus of the rat on neuronal activity in the dorsal lateral geniculate nucleus
10.1016/0006-8993(89)90002-4 · 1989 · External reference
Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation
10.1016/0014-4886(80)90060-6 · 1980 · External reference
Brainstem serotonin neurons selectively gate retinal information flow to thalamus
10.1016/j.neuron.2022.12.006 · 2023 · External reference
Modulation of retinotectal transmission by presynaptic 5-HT1B receptors in the superior colliculus of the adult hamster
10.1152/jn.1994.72.1.3 · 1994 · External reference
Some effects of lysergic acid diethylamide and bufotenine on electrical activity in the cat's visual system
10.1152/ajplegacy.1955.182.3.594 · 1955 · External reference
Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis
10.1016/0006-8993(90)91422-d · 1990 · External reference
Serotonin decreases the gain of visual responses in awake macaque V1
10.1523/jneurosci.1339-17.2017 · 2017 · External reference
Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input
10.7554/elife.53552 · 2020 · External reference
Electrophysiological studies of d-lysergic acid diethylamide in the visual system
10.1016/0149-7634(82)90032-x · 1982 · External reference
A hallucinogenic serotonin-2A receptor agonist reduces visual response gain and alters temporal dynamics in mouse V1
10.1016/j.celrep.2019.02.104 · 2019 · External reference
Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: an immunohistochemical study
10.1073/pnas.79.7.2401 · 1982 · External reference
Comprehensive topographical map of the serotonergic fibers in the male mouse brain
10.1002/cne.25027 · 2021 · External reference
Serotonergic hallucinogen-induced visual perceptual alterations
10.1007/7854_2016_461 · 2018 · External reference
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
10.1097/00001756-199812010-00024 · 1998 · External reference
The fabric of meaning and subjective effects in LSD-induced states depend on serotonin 2A receptor activation
10.1016/j.cub.2016.12.030 · 2017 · External reference
Cross-species evidence for psilocin-induced visual distortions: Apparent motion is perceived by both humans and rats
2025 · External reference
Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
10.1002/(sici)1098-2396(199709)27:1<79::aid-syn8>3.0.co;2-a · 1997 · External reference
Psilocybin's lasting action requires pyramidal cell types and 5-HT(2A) receptors
10.1038/s41586-025-08813-6 · 2025 · External reference
Single-nucleus transcriptomics reveals time-dependent and cell-type-specific effects of psilocybin on gene expression
2025 · External reference
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
10.1016/j.cell.2021.04.021 · 2021 · External reference
Activation of specific interneurons improves V1 feature selectivity and visual perception
10.1038/nature11312 · 2012 · External reference
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
10.1016/j.cell.2025.11.009 · 2026 · External reference
5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
10.1073/pnas.95.2.735 · 1998 · External reference
Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells
10.1016/s0028-3908(97)00051-8 · 1997 · External reference
Layer 6b controls brain state via apical dendrites and the higher-order thalamocortical system
10.1016/j.neuron.2023.11.021 · 2024 · External reference
What visual illusions teach us about schizophrenia
10.3389/fnint.2014.00063 · 2014 · External reference
Hallucinations and strong priors
10.1016/j.tics.2018.12.001 · 2019 · External reference
Delusions and the role of beliefs in perceptual inference
10.1523/jneurosci.1778-13.2013 · 2013 · External reference
Enhanced predictive signalling in schizophrenia
10.1002/hbm.23480 · 2017 · External reference
Hallucinations and acetylcholine: Signal or noise?
10.1017/s0140525x0425018x · 2005 · External reference
Fast modulation of visual perception by basal forebrain cholinergic neurons
10.1038/nn.3552 · 2013 · External reference
The discovery of serotonin and its role in neuroscience
10.1038/sj.npp.1395355 · 1999 · External reference
How LSD originated
10.1080/02791072.1979.10472092 · 1979 · External reference
Neurobiology of migraine
10.1038/nrn1102 · 2003 · External reference
Migraine and the trigeminovascular system-40 years and counting
10.1016/s1474-4422(19)30185-1 · 2019 · External reference
Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion
10.1016/0028-3908(91)90165-8 · 1991 · External reference
Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels
10.1016/s0014-2999(00)00712-3 · 2000 · External reference
5-HT1F receptor agonists in acute migraine treatment: a hypothesis
10.1046/j.1468-2982.2003.00525.x · 2003 · External reference
Resistant and refractory migraine - two different entities with different comorbidities? Results from the REFINE study
10.1186/s10194-024-01910-3 · 2024 · External reference
Prophylactic treatment of migraine by means of lysergic acid derivatives
1963 · External reference
Exploratory controlled study of the migraine-suppressing effects of psilocybin
10.1007/s13311-020-00962-y · 2021 · External reference
Comparing single- and repeat-dose psilocybin with active placebo for migraine prevention in an exploratory randomized controlled clinical trial
10.1111/head.70024 · 2026 · External reference
Response of cluster headache to psilocybin and LSD
10.1212/01.wnl.0000219761.05466.43 · 2006 · External reference
Unresolved reference
2024 · External reference
Exploratory investigation of a patient-informed low-dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double-blind, placebo-controlled trial
10.1111/head.14420 · 2022 · External reference
CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity
10.1111/head.14656 · 2024 · External reference
The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: an open, non-randomized case series
10.1177/0333102410363490 · 2010 · External reference
Effects of electrical stimulation of the dorsal raphe nucleus on local cerebral blood flow in the rat
10.1038/jcbfm.1989.41 · 1989 · External reference
A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine
10.1038/s41467-018-08256-w · 2019 · External reference
Effects of dorsal raphe nucleus stimulation on cerebral blood flow and flow-metabolism coupling in the conscious rat
10.1016/0306-4522(93)90508-d · 1993 · External reference
Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow
10.1016/j.neuroimage.2017.07.020 · 2017 · External reference
Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences
10.1038/s41598-023-44153-z · 2023 · External reference
Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans
10.1177/0271678x251323364 · 2025 · External reference
Psychedelic 5-HT(2A) receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
10.1038/s41593-025-02069-z · 2025 · External reference
Psilocybin prolongs the neurovascular coupling response in mouse visual cortex
2025 · External reference
The antidepressant fluoxetine restores plasticity in the adult visual cortex
10.1126/science.1150516 · 2008 · External reference
Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation
10.1038/s41467-024-48489-6 · 2024 · External reference
Shared and distinct brain regions targeted for immediate early gene expression by ketamine and psilocybin
10.1021/acschemneuro.2c00637 · 2023 · External reference
Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape
10.1038/s41467-022-33578-1 · 2022 · External reference
A mathematical theory of visual hallucination patterns
10.1007/bf00336965 · 1979 · External reference
The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms
2025 · External reference
