Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex. Local targets link to admitted publications; unresolved targets remain external evidence.
Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour
10.1038/s41586-022-05161-7 · 2022 · External reference
A preoptic neuronal population controls fever and appetite during sickness
10.1038/s41586-022-04793-z · 2022 · External reference
The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β
10.1016/j.neuron.2023.05.009 · 2023 · External reference
Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
10.7554/elife.83644 · 2023 · External reference
Characterizing COVID-19 and influenza illnesses in the real world via person-generated health data
2021 · External reference
Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood
10.1016/j.bbi.2009.12.009 · 2010 · External reference
Biological basis of the behavior of sick animals
10.1016/s0149-7634(88)80004-6 · 1988 · External reference
Neural circuitry engaged by prostaglandins during the sickness syndrome
10.1038/nn.3159 · 2012 · External reference
Cytokine-induced sickness behaviour: mechanisms and implications
10.1016/s0166-2236(00)02088-9 · 2002 · External reference
Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies
10.1016/j.neubiorev.2018.07.013 · 2018 · External reference
Neural origins of human sickness in interoceptive responses to inflammation
10.1016/j.biopsych.2009.03.007 · 2009 · External reference
A body–brain circuit that regulates body inflammatory responses
10.1038/s41586-024-07469-y · 2024 · External reference
c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1)
10.1016/j.bbi.2007.05.003 · 2007 · External reference
Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
10.1016/j.psyneuen.2007.03.005 · 2007 · External reference
The emerging science of interoception: sensing, integrating, interpreting, and regulating signals within the self
10.1016/j.tins.2020.10.007 · 2021 · External reference
The neurobiology of interoception and affect
10.1016/j.tics.2024.01.009 · 2024 · External reference
Thirst regulates motivated behavior through modulation of brainwide neural population dynamics
10.1126/science.aav3932 · 2019 · External reference
Neural control and modulation of thirst, sodium appetite, and hunger
10.1016/j.cell.2019.11.040 · 2020 · External reference
Homeostatic circuits selectively gate food cue responses in insular cortex
10.1038/nature22375 · 2017 · External reference
Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
10.1038/s41593-021-00850-4 · 2021 · External reference
Comparison of bacterial lipopolysaccharide-induced sickness behavior in rodents and humans: Relevance for symptoms of anxiety and depression
10.1016/j.neubiorev.2020.05.001 · 2020 · External reference
Methodology of fever research: why are polyphasic fevers often thought to be biphasic?
1998 · External reference
Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons
10.1016/j.neubiorev.2015.07.015 · 2015 · External reference
The eicosanoids and their biochemical mechanisms of action
10.1042/bj2590315 · 1989 · External reference
Prostaglandin E2 at new glance: Novel insights in functional diversity offer therapeutic chances
10.1016/j.biocel.2009.09.015 · 2010 · External reference
Prostaglandin production in brain endothelial cells during the initiation of fever
10.1080/19420889.2023.2166237 · 2023 · External reference
Brain-specific endothelial induction of prostaglandin E2 synthesis enzymes and its temporal relation to fever
10.1016/s0168-0102(02)00083-4 · 2002 · External reference
Vagotomy attenuates the effect of lipopolysaccharide on body temperature of rats in a dose-dependent manner
10.1177/09680519010070050301 · 2001 · External reference
International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of prostanoid receptors, updating 15 years of progress
10.1124/pr.110.003517 · 2011 · External reference
Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum
10.1385/jmn:27:3:303 · 2005 · External reference
Distribution of the EP3 prostaglandin E2 receptor subtype in the rat brain: Relationship to sites of interleukin-1-induced cellular responsiveness
10.1002/1096-9861(20001204)428:1<5::aid-cne2>3.0.co;2-m · 2000 · External reference
Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation
10.1046/j.1460-9568.1999.00682.x · 1999 · External reference
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
10.1038/nn1949 · 2007 · External reference
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats
10.1016/s0006-8993(01)02861-x · 2001 · External reference
Major roles of prostanoid receptors IP and EP3 in endotoxin-induced enhancement of pain perception1
10.1016/s0006-2952(01)00654-2 · 2001 · External reference
The expression of TRPV channels, prostaglandin E2 and pro-inflammatory cytokines during behavioural fever in fish
10.1016/j.bbi.2018.03.023 · 2018 · External reference
A new look on brain mechanisms of acute illness anorexia
10.1016/j.physbeh.2010.04.009 · 2010 · External reference
Effect of central and peripheral injection of prostaglandin E2 and F2α on feeding and the crop-emptying rate in chicks
10.1016/j.prostaglandins.2017.03.005 · 2017 · External reference
The emergence and influence of internal states
10.1016/j.neuron.2022.04.030 · 2022 · External reference
From inflammation to sickness and depression: when the immune system subjugates the brain
10.1038/nrn2297 · 2008 · External reference
Core features and inherent diversity of post-acute infection syndromes
10.3389/fimmu.2025.1509131 · 2025 · External reference
Thermal physiology of laboratory mice: Defining thermoneutrality
10.1016/j.jtherbio.2012.08.004 · 2012 · External reference
Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature
10.1152/ajpregu.00370.2005 · 2005 · External reference
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
10.1113/jphysiol.2003.048140 · 2003 · External reference
Animal models of sepsis
10.4161/viru.26083 · 2014 · External reference
Lipopolysaccharide-induced lethality and cytokine production in aged mice
10.1128/iai.64.3.769-774.1996 · 1996 · External reference
Preoptic EP3R neurons constitute a two-way switch for fever and torpor
10.1038/s41586-025-09056-1 · 2025 · External reference
Effects of intracerebroventricular administration of PGE1, E2 and F2alpha on electrically induced convulsions in mice
10.1016/0090-6980(78)90036-9 · 1978 · External reference
Prostaglandin fevers in rats: regulated change in body temperature or change in regulated body temperature?
1989 · External reference
The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2
10.1210/en.2008-0806 · 2009 · External reference
Fever is mediated by conversion of endocannabinoid 2-arachidonoylglycerol to prostaglandin E2
10.1371/journal.pone.0133663 · 2015 · External reference
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
10.1038/nn1137 · 2003 · External reference
Anorexia of infection as a mechanism of host defense
10.1093/ajcn/32.3.593 · 1979 · External reference
Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation
10.1016/s0306-9877(98)90022-6 · 1998 · External reference
Moderate cortical cooling eliminates thalamocortical silent states during slow oscillation
10.1523/jneurosci.1359-15.2015 · 2015 · External reference
Thermal constraints on in vivo optogenetic manipulations
10.1038/s41593-019-0422-3 · 2019 · External reference
Brain temperature affects quantitative features of hippocampal sharp wave ripples
10.1152/jn.00047.2022 · 2022 · External reference
Brain temperature as proxy for brain state and oscillatory activity in the mouse
10.1038/s41598-025-21175-3 · 2025 · External reference
A synaptic temperature sensor for body cooling
10.1016/j.neuron.2021.10.001 · 2021 · External reference
Gender specific differences in the immune response to infection
10.1007/s00005-011-0124-3 · 2011 · External reference
Sex differences in the response to influenza virus infection: Modulation by stress
10.1016/j.yhbeh.2010.12.002 · 2011 · External reference
Age and sex differences in immune response following LPS treatment in mice
10.1016/j.bbi.2016.08.002 · 2016 · External reference
Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms
10.1016/j.bbi.2015.08.013 · 2016 · External reference
Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records
10.1186/s13293-022-00451-1 · 2022 · External reference
Sex- and age-specific differences in core body temperature of C57Bl/6 mice
10.1007/s11357-010-9164-6 · 2011 · External reference
Estimation of current and future physiological states in insular cortex
10.1016/j.neuron.2019.12.027 · 2020 · External reference
Brain-body physiology: Local, reflex, and central communication
10.1016/j.cell.2024.08.050 · 2024 · External reference
Neural circuits of interoception
10.1016/j.tins.2020.09.011 · 2021 · External reference
The central autonomic network: functional organization, dysfunction, and perspective
10.1016/s0025-6196(12)62272-1 · 1993 · External reference
Stimulus-transcription coupling in neurons: role of cellular immediate-early genes
10.1016/0166-2236(89)90096-9 · 1989 · External reference
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging
10.1016/j.cell.2014.10.010 · 2014 · External reference
Mapping of brain activity by automated volume analysis of immediate early genes
10.1016/j.cell.2016.05.007 · 2016 · External reference
Genetic reporters of neuronal activity: c-Fos and G-CaMP6
10.1016/bs.mie.2018.01.023 · 2018 · External reference
Central mechanisms for thermoregulation
10.1146/annurev-physiol-020518-114546 · 2019 · External reference
The paraventricular nucleus of the hypothalamus: development, function, and human diseases
10.1210/en.2018-00453 · 2018 · External reference
Relationship of EP(1–4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses
10.1002/1096-9861(20001204)428:1<20::aid-cne3>3.0.co;2-x · 2000 · External reference
The coding of cutaneous temperature in the spinal cord
10.1038/nn.4350 · 2016 · External reference
Parabrachial complex: a hub for pain and aversion
10.1523/jneurosci.1162-19.2019 · 2019 · External reference
Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography
10.1016/0006-8993(92)90720-t · 1992 · External reference
New perspectives on central amygdala function
10.1016/j.conb.2018.02.009 · 2018 · External reference
Effects of indomethacin and prostaglandin injections on plasma prolactin and growth hormone levels in rats
10.1210/endo-102-2-531 · 1978 · External reference
Prostaglandin transporter OATP2A1/SLCO2A1 is essential for body temperature regulation during fever
10.1523/jneurosci.3276-17.2018 · 2018 · External reference
A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo
10.1016/j.neuron.2026.01.030 · 2026 · External reference
Contributions of the amygdala to emotion processing: from animal models to human behavior
10.1016/j.neuron.2005.09.025 · 2005 · External reference
Coding of facial expressions of pain in the laboratory mouse
10.1038/nmeth.1455 · 2010 · External reference
The consistency of facial expressions of pain: a comparison across modalities
10.1016/0304-3959(92)90213-u · 1992 · External reference
The free-energy principle: a unified brain theory?
10.1038/nrn2787 · 2010 · External reference
Computational models of interoception and body regulation
10.1016/j.tins.2020.09.012 · 2021 · External reference
Interoceptive predictions in the brain
10.1038/nrn3950 · 2015 · External reference
Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states
10.1016/j.neuron.2021.08.036 · 2021 · External reference
A whole-brain connectivity map of mouse insular cortex
10.7554/elife.55585 · 2020 · External reference
Fully integrated silicon probes for high-density recording of neural activity
10.1038/nature24636 · 2017 · External reference
Unresolved reference
2001 · External reference
Neural manifolds for the control of movement
10.1016/j.neuron.2017.05.025 · 2017 · External reference
Large-scale neural recordings call for new insights to link brain and behavior
10.1038/s41593-021-00980-9 · 2022 · External reference
Brain–body states embody complex temporal dynamics
10.1016/j.tics.2024.05.003 · 2024 · External reference
Dimensionality reduction in neuroscience
10.1016/j.cub.2016.05.029 · 2016 · External reference
Stereotyped goal-directed manifold dynamics in the insular cortex
10.1016/j.celrep.2024.114027 · 2024 · External reference
Learnable latent embeddings for joint behavioural and neural analysis
10.1038/s41586-023-06031-6 · 2023 · External reference
Why is everyone talking about brain state?
10.1016/j.tins.2023.04.001 · 2023 · External reference
Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammation
10.1016/j.bbi.2015.12.018 · 2016 · External reference
Quantitative magnetization transfer imaging as a biomarker for effects of systemic inflammation on the brain
10.1016/j.biopsych.2014.09.023 · 2015 · External reference
The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice
2020 · External reference
Distinct neural representations of hunger and thirst in neonatal mice before the emergence of food- and water-seeking behaviors
2025 · External reference
TRPV3 channel activity helps cortical neurons stay active during fever
2025 · External reference
The cellular coding of temperature in the mammalian cortex
10.1038/s41586-023-05705-5 · 2023 · External reference
Neocortical circuits in pain and pain relief
10.1038/s41583-021-00468-2 · 2021 · External reference
Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit
10.1038/s41593-024-01864-4 · 2025 · External reference
Insular cortex neurons encode and retrieve specific immune responses
10.1016/j.cell.2021.10.013 · 2021 · External reference
Activation of ACTH release is mediated by the same molecule as the final mediator, PGE2, of febrile response in rats
10.1016/0006-8993(89)91492-3 · 1989 · External reference
Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats
1995 · External reference
Central administration of prostaglandin E2 suppresses in vitro cellular immune responses
1995 · External reference
Microinjection of prostaglandin E2 and muscimol into the preoptic area in conscious rats: Comparison of effects on plasma adrenocorticotrophic hormone (ACTH), body temperature, locomotor activity, and cardiovascular function
10.1016/j.neulet.2005.12.032 · 2006 · External reference
Microglial activation and neuroinflammation in acute and chronic cognitive deficits in sepsis
10.1016/j.neuropharm.2024.110285 · 2025 · External reference
The effect of prostaglandin E2 on the body temperature of restrained rats
10.1016/0031-9384(91)90528-v · 1991 · External reference
Lipopolysaccharide-induced hypothermia and hypotension are associated with inflammatory signaling that is triggered outside the brain
10.1016/j.bbi.2012.11.015 · 2013 · External reference
Noisy neuronal populations effectively encode sound localization in the dorsal inferior colliculus of awake mice
10.7554/elife.97598.4 · 2024 · External reference
EP3R-expressing glutamatergic preoptic neurons mediate inflammatory fever
10.1523/jneurosci.2887-19.2020 · 2020 · External reference
A tool for analyzing electrode tracks from slice histology
2018 · External reference
Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling and cloud-native open-source tools
10.1038/s41592-024-02319-1 · 2024 · External reference
SuperAnimal pretrained pose estimation models for behavioral analysis
10.1038/s41467-024-48792-2 · 2024 · External reference
Unresolved reference
2025 · External reference
DeepEthogram: a machine learning pipeline for supervised behavior classification from raw pixels
10.7554/elife.63377 · 2021 · External reference
Facemap: a framework for modeling neural activity based on orofacial tracking
10.1038/s41593-023-01490-6 · 2024 · External reference
Spike sorting with Kilosort4
10.1038/s41592-024-02232-7 · 2024 · External reference
Mapping the fine-scale organization and plasticity of the brain vasculature
10.1016/j.cell.2020.01.028 · 2020 · External reference