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References from PAK-family kinases promote cell fusion irreversibility by preventing cell-wall repair. Local targets link to admitted publications; unresolved targets remain external evidence.
Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization
10.1038/s41586-018-0407-5 · 2018 · External reference
A focus on yeast mating: From pheromone signaling to cell-cell fusion
10.1016/j.semcdb.2022.02.003 · 2023 · External reference
Mechanobiology of the cell wall - insights from tip-growing plant and fungal cells
10.1242/jcs.259208 · 2022 · External reference
High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation
10.1083/jcb.202510018 · 2026 · External reference
Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion
10.1083/jcb.202103142 · 2021 · External reference
Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion
10.1016/j.cub.2022.09.026 · 2022 · External reference
A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast
10.1083/jcb.201411124 · 2015 · External reference
A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion
10.1371/journal.pgen.1006721 · 2017 · External reference
Fission yeast cell wall biosynthesis and cell integrity signalling
10.1016/j.tcsw.2018.10.001 · 2018 · External reference
The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond
2021 · External reference
Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast
10.1016/j.devcel.2021.09.024 · 2021 · External reference
Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity
10.1242/jcs.112.20.3569 · 1999 · External reference
Rho 1 GTPase activates the (1–3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis
10.1002/j.1460-2075.1996.tb00836.x · 1996 · External reference
Cryo-EM structure of the beta-1,3-glucan synthase FKS1-Rho1 complex
2025 · External reference
Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast
10.1371/journal.pone.0088020 · 2014 · External reference
Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe
10.1074/jbc.m506467200 · 2006 · External reference
Cell fusion in yeast is negatively regulated by components of the cell wall integrity pathway
10.1091/mbc.e18-04-0236 · 2019 · External reference
Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae
10.1083/jcb.138.5.961 · 1997 · External reference
Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast
10.1073/pnas.0603403103 · 2006 · External reference
Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism
10.7554/elife.83285 · 2023 · External reference
Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast
10.1074/jbc.273.29.18481 · 1998 · External reference
Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast
10.1074/jbc.273.29.18490 · 1998 · External reference
Genetic evidence for Pak1 autoinhibition and its release by Cdc42
10.1128/mcb.19.1.602 · 1999 · External reference
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe
10.1073/pnas.92.13.6180 · 1995 · External reference
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating
10.1002/j.1460-2075.1995.tb00278.x · 1995 · External reference
Rho family GTPase signaling through type II p21-activated kinases
10.1007/s00018-022-04618-2 · 2022 · External reference
Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
10.1073/pnas.95.13.7526 · 1998 · External reference
Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis
10.1083/jcb.200806127 · 2008 · External reference
Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis
10.1083/jcb.201908017 · 2020 · External reference
Oscillatory Dynamics of Cdc42 GTPase in the Control of Polarized Growth
10.1126/science.1218377 · 2012 · External reference
Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase
10.1371/journal.pbio.3000600 · 2020 · External reference
Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast
10.7554/elife.83062 · 2023 · External reference
The Kelch repeat protein, Tea1, is a potential substrate target of the p21-activated kinase, Shk1, in the fission yeast, Schizosaccharomyces pombe
10.1074/jbc.m302609200 · 2003 · External reference
Pak1 kinase controls cell shape through ribonucleoprotein granules
10.7554/elife.67648 · 2021 · External reference
The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe
10.1074/jbc.m306819200 · 2003 · External reference
Cdc42p and Fus2p act together late in yeast cell fusion
10.1091/mbc.e11-08-0723 · 2012 · External reference
Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe
10.1371/journal.pbio.3003712 · 2026 · External reference
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo
10.1083/jcb.201204065 · 2012 · External reference
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
10.1016/s1097-2765(01)00428-2 · 2002 · External reference
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis
10.1042/bcj20180867 · 2019 · External reference
Structure, biochemistry, and biology of PAK kinases
10.1016/j.gene.2016.12.014 · 2017 · External reference
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
10.1038/367040a0 · 1994 · External reference
The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast
10.1091/mbc.e08-07-0673 · 2009 · External reference
Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe
10.1093/emboj/16.6.1318 · 1997 · External reference
Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p
10.1242/jcs.01530 · 2004 · External reference
Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast
10.1091/mbc.e05-10-0933 · 2006 · External reference
Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast
10.1111/j.1365-2443.2005.00908.x · 2005 · External reference
Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe
10.1046/j.1365-2958.1998.01009.x · 1998 · External reference
cps1+, a Schizosaccharomyces pombe gene homolog of Saccharomyces cerevisiae FKS genes whose mutation confers hypersensitivity to cyclosporin A and papulacandin B
10.1128/jb.179.24.7653-7662.1997 · 1997 · External reference
Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast
10.1534/genetics.113.154807 · 2013 · External reference
Forces that shape fission yeast cells
10.1091/mbc.e16-09-0671 · 2017 · External reference
Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner
10.1242/jcs.261160 · 2023 · External reference
Proteasomal degradation resolves competition between cell polarization and cellular wound healing
10.1016/j.cell.2012.05.030 · 2012 · External reference
Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating
10.1038/s41467-026-70631-9 · 2026 · External reference
Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control
10.1002/j.1460-2075.1993.tb05848.x · 1993 · External reference
The novel fission yeast (1,3)beta-D-glucan synthase catalytic subunit Bgs4p is essential during both cytokinesis and polarized growth
10.1242/jcs.01585 · 2005 · External reference
Isolation and characterization of Schizosaccharomyces pombe mutants defective in cell wall (1–3)beta-D-glucan
10.1128/jb.173.11.3456-3462.1991 · 1991 · External reference
Cell wall analysis
10.1016/j.ymeth.2003.11.020 · 2004 · External reference
Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle
10.1083/jcb.131.6.1529 · 1995 · External reference
Differential activities of three families of specific beta(1,3)glucan synthase inhibitors in wild-type and resistant strains of fission yeast
10.1074/jbc.m110.174300 · 2011 · External reference
Three-Dimensional Remodeling of SARS-CoV2-Infected Cells Revealed by Cryogenic Soft X-ray Tomography
10.1021/acsnano.3c07265 · 2023 · External reference
Mechanosensation Promotes Local Cell Wall Repair
2026 · External reference
Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival
10.1016/j.devcel.2018.03.022 · 2018 · External reference
Regulation of the Cell Wall Integrity pathway at the contact site between mating partners in yeast
10.1083/jcb.202508068 · 2026 · External reference
Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion
10.1101/gad.286922.116 · 2016 · External reference
Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating
10.1016/j.cub.2016.02.064 · 2016 · External reference
Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating
10.1083/jcb.201708195 · 2018 · External reference
The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway
10.1007/s002940100210 · 2001 · External reference
Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast
10.1016/j.cub.2012.06.042 · 2012 · External reference
Two S. pombe septation phases differ in ingression rate, septum structure, and response to F-actin loss
10.1083/jcb.201808163 · 2019 · External reference
A toolbox of stable integration vectors in the fission yeast Schizosaccharomyces pombe
10.1242/jcs.240754 · 2020 · External reference
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe
10.1002/(sici)1097-0061(199807)14:10<943::aid-yea292>3.0.co;2-y · 1998 · External reference
Computer visualization of three-dimensional image data using IMOD
10.1006/jsbi.1996.0013 · 1996 · External reference
Algebraic reconstruction techniques (ART) for three-dimensional electron microscopy and x-ray photography
10.1016/0022-5193(70)90109-8 · 1970 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
Membrane recognition by phospholipid-binding domains
10.1038/nrm2328 · 2008 · External reference
Microscopy of Fission Yeast Sexual Lifecycle
2016 · External reference
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast
10.1371/journal.pbio.3002963 · 2024 · External reference
MISTRAL: a transmission soft X-ray microscopy beamline for cryo nano-tomography of biological samples and magnetic domains imaging
10.1107/s1600577515008632 · 2015 · External reference
A soft X-ray beamline for transmission X-ray microscopy at ALBA
10.1107/s0909049509019396 · 2009 · External reference
Structural Changes In Cells Imaged by Soft X-ray Cryo-Tomography During Hepatitis C Virus Infection
10.1021/acsnano.6b01374 · 2016 · External reference
Characterization of transfer function, resolution and depth of field of a soft X-ray microscope applied to tomography enhancement by Wiener deconvolution
10.1364/boe.7.005092 · 2016 · External reference
