Research graph
References from Adult depression-like behavior, amygdala and olfactory cortex functions are restored by odor previously paired with shock during infant's sensitive period attachment learning. Local targets link to admitted publications; unresolved targets remain external evidence.
Do early-life events permanently alter behavioral and hormonal responses to stressors?
10.1016/s0736-5748(98)00025-2 · 1998 · External reference
Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments
10.1038/npp.2008.234 · 2009 · External reference
Ontogeny of nociception and antinociception
1995 · External reference
The interrelationships of shock and critical periods in infancy as they affect adult learning and activity
10.1016/0003-3472(63)90003-4 · 1962 · External reference
Long-term impact of early olfactory experience on later olfactory conditioning
10.1002/dev.20176 · 2006 · External reference
Species-specific defense reactions and avoidance learning
10.1037/h0028589 · 1970 · External reference
GABAergic dysfunction in mood disorders
10.1038/sj.mp.4001362 · 2003 · External reference
The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
10.1016/j.neubiorev.2005.03.022 · 2005 · External reference
Changes in the categorization of appetitive and aversive events during postnatal development of the rat
10.1002/dev.420210103 · 1988 · External reference
Safety signals from avoidance learning but not from yoked classical conditioning training pass both summation and retardation tests for inhibition
10.1016/j.beproc.2004.01.011 · 2004 · External reference
Early experience modifies the postnatal assembly of autonomic emotional motor circuits in rats
10.1523/jneurosci.2345-05.2005 · 2005 · External reference
Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat
10.1371/journal.pone.0008618 · 2010 · External reference
Reconsideration of the role of the hippocampus in learned inhibition
10.1016/s0166-4328(00)00363-6 · 2001 · External reference
Child maltreatment
10.1146/annurev.clinpsy.1.102803.144029 · 2005 · External reference
Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-humans primates
10.1016/j.neubiorev.2008.09.001 · 2009 · External reference
The ontogenesis of defensive reactions to shock in preweanling rats
10.1002/dev.420130206 · 1980 · External reference
Aggressive behavior in abused children
10.1196/annals.1301.009 · 2003 · External reference
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
10.1007/s00429-008-0189-x · 2008 · External reference
Effects of 6-hydroxydopamine-induced catecholamine depletion on shock-precipitated wall climbing of infant rat pups
10.1002/dev.420180303 · 1985 · External reference
The amygdala, fear, and memory
10.1111/j.1749-6632.2003.tb07077.x · 2003 · External reference
Infantile experience with suckling odors determines adult sexual behavior in male rats
10.1126/science.3945807 · 1986 · External reference
The development of nociceptive circuits
10.1038/nrn1701 · 2005 · External reference
Unresolved reference
External reference
Integrating neuroscience and psychological approaches in the study of early experiences
10.1196/annals.1301.024 · 2003 · External reference
Association and commissural fiber systems of the olfactory cortex of the rat. I. Systems originating in the piriform cortex and adjacent areas
10.1002/cne.901810407 · 1978 · External reference
Association and commissural fiber systems of the olfactory cortex of the rat. II. Systems originating in the olfactory peduncle
10.1002/cne.901810407 · 1978 · External reference
Feeding and behavioral activation in infant rats
10.1126/science.451591 · 1979 · External reference
The affectional system
1965 · External reference
Emergence of interoceptive and exteroceptive control of behavior in rats
10.1126/science.472715 · 1979 · External reference
Developmental origins of moral masochism: a failure-to-thrive toddler's interactions with mother
10.1016/0145-2134(87)90005-6 · 1987 · External reference
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
10.1016/s0006-3223(01)01157-x · 2001 · External reference
Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene
10.3389/neuro.08.041.2009 · 2009 · External reference
Unresolved reference
1997 · External reference
Evidence that maternal ventral skin substances promote suckling in infant rats
10.1016/0031-9384(76)90279-1 · 1976 · External reference
Towards a neurobiology of attachment
2008 · External reference
The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior
10.1038/sj.npp.1300530 · 2005 · External reference
Early life stress impairs fear conditioning in adult male and female rats
10.1016/j.brainres.2006.03.009 · 2006 · External reference
Conditioning of aversion to an odor paired with peripheral shock in the developing rat
10.1002/dev.420170505 · 1984 · External reference
Long-term behavioral and neuroendocrine adaptations to adverse early experience
10.1016/s0079-6123(08)62132-9 · 2000 · External reference
Developmental determinants of sensitivity and resistance to stress
10.1016/j.psyneuen.2005.03.013 · 2005 · External reference
The distribution of axon collaterals from the olfactory bulb and the nucleus of the horizontal limb of the diagonal band to the olfactory cortex, demonstrated by double retrograde labeling techniques
10.1002/cne.902090304 · 1982 · External reference
The topographic organization of associational fibers of the olfactory system in the rat, including centrifugal fibers to the olfactory bulb
10.1002/cne.902160305 · 1983 · External reference
Causation of sexual preference in the house mouse. The behavior of mice reared by parents whose odor was artificially altered
1965 · External reference
Early olfactory experience and later social behavior in the rat preference, sexual responsiveness, and care of young
10.1080/00221325.1965.10532774 · 1965 · External reference
Usefulness of antidepressants for improving the neuropathic pain-like state and pain-induced anxiety through actions at different brain sites
10.1038/sj.npp.1301590 · 2008 · External reference
Cortical pathways to the mammalian amygdala
10.1016/s0301-0082(98)00003-3 · 1998 · External reference
Early life influences on life-long patterns of behavior and health
10.1002/mrdd.10074 · 2003 · External reference
Understanding the potency of stressful early life experiences on brain and body function
10.1016/j.metabol.2008.07.006 · 2008 · External reference
Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression
10.1176/appi.ajp.2007.06111917 · 2008 · External reference
Early olfactory experience, novelty, and choice of sexual partner by male rats
10.1016/s0031-9384(96)00249-1 · 1996 · External reference
Enduring neurobehavioral effects of early life trauma mediated through learning and corticosterone suppression
10.3389/neuro.08.022.2009 · 2009 · External reference
Maternal presence serves as a switch between learning fear and attraction in infancy
10.1038/nn1733 · 2006 · External reference
Dual circuitry for odor–shock conditioning during infancy: corticosterone switches between fear and attraction via amygdala
10.1523/jneurosci.0499-06.2006 · 2006 · External reference
Entorhinal cortex stimulation modulates amygdala and piriform cortex responses to olfactory bulb inputs in the rat
10.1016/j.neuroscience.2005.10.024 · 2006 · External reference
Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety
10.1016/j.biopsych.2006.08.035 · 2007 · External reference
Pyramidal cells of the rat basolateral amygdala: synaptology and innervation by parvalbumin-immunoreactive interneurons
10.1002/cne.20832 · 2006 · External reference
Neurobiological consequences of childhood trauma
2004 · External reference
Neurobiology of depression
10.1016/s0896-6273(02)00653-0 · 2002 · External reference
Preclinical models: status of basic research in depression
10.1016/s0006-3223(02)01405-1 · 2002 · External reference
Brain development under stress: hypotheses of glucocorticoid actions revisited
10.1016/j.neubiorev.2009.07.006 · 2010 · External reference
Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala
10.1073/pnas.0913384107 · 2010 · External reference
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress
10.1007/bf02244188 · 1991 · External reference
Experience-dependent affective learning and risk for psychopathology in children
10.1196/annals.1301.011 · 2003 · External reference
An animal model of a behavioral intervention for depression
10.1016/j.neuron.2008.07.041 · 2008 · External reference
Depression: a new animal model sensitive to antidepressant treatments
10.1038/266730a0 · 1977 · External reference
An autoradiographic study of complementary laminar patterns of termination of afferent fibers to the olfactory cortex
10.1002/cne.901500105 · 1973 · External reference
Layer-specific immunocytochemical localization of GABABR1a and GABABR1b receptors in the rat piriform cortex
10.1046/j.1460-9568.2000.01060.x · 2000 · External reference
Early life stress: long-term physiological impact in rodents and primates
2002 · External reference
Long-term effects of early-life environmental manipulations in rodents and primates: potential animal models in depression research
10.1016/j.neubiorev.2005.03.011 · 2005 · External reference
Developing a neurobehavioral animal model of infant attachment to an abusive caregiver
10.1016/j.biopsych.2009.12.019 · 2010 · External reference
Towards a general theory of infantile attachment: a comparative review of aspects of the social bond
10.1017/s0140525x00075816 · 1978 · External reference
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
10.1038/nn1944 · 2007 · External reference
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat
10.1038/sj.npp.1301253 · 2007 · External reference
Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse
10.1016/j.neuron.2005.02.017 · 2005 · External reference
Memory of early maltreatment: neonatal behavioral and neural correlates of maternal maltreatment within the context of classical conditioning
10.1016/j.biopsych.2005.01.032 · 2005 · External reference
Gene-environment interplay and psychopathology: multiple varieties but real effects
10.1111/j.1469-7610.2005.01557.x · 2006 · External reference
The amygdaloid complex: anatomy and physiology
10.1152/physrev.00002.2003 · 2003 · External reference
The ontogeny of fear in animals
1979 · External reference
Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models
10.1017/s0954579401003029 · 2001 · External reference
Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat
10.1016/0304-3940(96)12750-6 · 1996 · External reference
From fear to safety and back: reversal of fear in the human brain
10.1523/jneurosci.2265-08.2008 · 2008 · External reference
Failure to escape traumatic shock
10.1037/h0024514 · 1967 · External reference
Rearing with artificially scented mothers attenuates conditioned odor aversion in adulthood but not its amygdala dependency
10.1016/j.bbr.2008.11.003 · 2009 · External reference
Enduring effects of infant memories: infant odor–shock conditioning attenuates amygdala activity and adult fear conditioning
10.1016/j.biopsych.2007.04.025 · 2007 · External reference
Long-term effects of infant learning on adult conditioned odor aversion are determined by the last preweaning experience
10.1002/dev.20378 · 2009 · External reference
Neonatal odor–shock conditioning alters the neural network involved in odor fear learning at adulthood
10.1101/lm.998508 · 2008 · External reference
Effects of preweaning exposure to novel maternal odors on maternal responsiveness and selectivity in adulthood
10.1002/dev.10064 · 2002 · External reference
Potentiation and inhibition of ultrasonic vocalization of rat pups: regulation by social cues
10.1002/(sici)1098-2302(199704)30:3<195::aid-dev2>3.0.co;2-k · 1997 · External reference
Amygdala core nuclei volumes are decreased in recurrent major depression
10.1097/00001756-199806220-00021 · 1998 · External reference
A neuropharmacologically relevant animal model of depression
10.1016/0028-3908(79)90087-x · 1979 · External reference
Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pups
10.1016/j.yhbeh.2007.06.004 · 2007 · External reference
Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect
10.1016/j.neuroscience.2007.09.017 · 2007 · External reference
Inhibition of infant glucocorticoid stress response: specific role of maternal cues
10.1002/dev.420230504 · 1990 · External reference
Habituation of the forelimb-withdrawal response in neonatal rats
10.1037/0097-7403.4.2.104 · 1978 · External reference
Unresolved attachment, PTSD, and dissociation in women with childhood abuse histories
10.1037/0022-006x.74.2.219 · 2006 · External reference
Olfactory-guided orientation in neonatal rats is enhanced by a conditioned change in behavioral state
10.1002/dev.420190612 · 1986 · External reference
Good memories of bad events in infancy
10.1038/35024156 · 2000 · External reference
Early olfactory learning induces an enhanced olfactory bulb response in young rats
10.1016/0165-3806(86)90256-7 · 1986 · External reference
Neural correlates of conditioned odor avoidance in infant rats
10.1037/0735-7044.105.2.307 · 1991 · External reference
Modified behavioral and olfactory bulb responses to maternal odors in preweanling rats
10.1016/0165-3806(90)90013-o · 1990 · External reference
What is the amygdala?
10.1016/s0166-2236(98)01265-x · 1998 · External reference
The neurobiological consequences of early stress and childhood maltreatment
10.1016/s0149-7634(03)00007-1 · 2003 · External reference
First suckling response of the newborn albino rat: the roles of olfaction and amniotic fluid
10.1126/science.918660 · 1977 · External reference
Characterization of synaptically mediated fast and slow inhibitory processes in piriform cortex in an in vitro slice preparation
10.1152/jn.1988.59.5.1352 · 1988 · External reference
Long-term colonic hypersensitivity in adult rats induced by neonatal unpredictable vs predictable shock
10.1111/j.1365-2982.2007.00955.x · 2007 · External reference
Defining ages limits of the sensitive period for attachment learning in rat pups
10.1002/dev.20448 · 2010 · External reference
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
10.1016/j.euroneuro.2007.01.001 · 2007 · External reference
Mother lowers glucocorticoid levels of preweanling rats after acute threat
10.1196/annals.1301.038 · 2003 · External reference
Functional neuroimaging studies of the amygdala in depression
10.1053/scnp.2002.35219 · 2002 · External reference
Attachment relationships experiences and childhood psychopathology
10.1196/annals.1301.003 · 2003 · External reference
