Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Double Helix: Reciprocity between juvenile play and brain development. Local targets link to admitted publications; unresolved targets remain external evidence.
Organizational and activational effects of sex steroids on brain and behavior: a reanalysis
10.1016/0018-506x(85)90042-x · 1985 · External reference
Unresolved reference
External reference
Brain sex differences and the organisation of juvenile social play behaviour
10.1111/j.1365-2826.2009.01871.x · 2009 · External reference
Fetal testosterone predicts sexually differentiated childhood behavior in girls and in boys
10.1111/j.1467-9280.2009.02279.x · 2009 · External reference
Temporal boundary of the sensitive period for hormonal organization of social play in juvenile rats
10.1016/0031-9384(81)90017-2 · 1981 · External reference
Intentional communication and social play: how and why animals negotiate and agree to play
1998 · External reference
Unresolved reference
1998 · External reference
Juvenile peer play experience and the development of the orbitofrontal and medial prefrontal cortices
10.1016/j.bbr.2009.09.029 · 2010 · External reference
Neuroimaging studies of aggressive and violent behavior: current findings and implications for criminology and criminal justice
10.1177/1524838005275089 · 2005 · External reference
Uncovering the molecular basis of positive affect using rough-and-tumble play in rats: a role for insulin-like growth factor I
10.1016/j.neuroscience.2010.03.045 · 2010 · External reference
Unresolved reference
2010 · External reference
Prenatal stress alters time characteristics and intensity of formalin-induced pain responses in juvenile rats
10.1016/s0006-8993(01)02819-0 · 2001 · External reference
Biological effects of locomotor play: getting into shape, or something more specific?
1998 · External reference
Place conditioning reveals the rewarding aspect of social interaction in juvenile rats
10.1016/0031-9384(92)90101-7 · 1992 · External reference
Unresolved reference
1962 · External reference
Adaptive significance of play: are we getting closer?
10.1016/0169-5347(88)90048-1 · 1988 · External reference
Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide
10.1016/s0031-9384(03)00120-3 · 2003 · External reference
Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats: effects of adult ovariectomy and estradiol replacement
10.1016/j.brainres.2005.08.003 · 2005 · External reference
Neural circuitry of play fighting in golden hamsters
10.1016/j.neuroscience.2008.07.048 · 2008 · External reference
Role of steroids in sex differences in morphine-induced analgesia: activational and organizational effects
10.1124/jpet.300.2.695 · 2002 · External reference
Synaptic reorganization of the medial amygdala during puberty
2010 · External reference
Steroid-dependent plasticity in the medial amygdala
10.1016/j.neuroscience.2005.06.018 · 2006 · External reference
Post-weaning social isolation of male rats reduces the volume of the medial amygdala and leads to deficits in adult sexual behavior
10.1016/s0166-4328(00)00301-6 · 2000 · External reference
Pubertal growth of the medial amygdala delayed by short photoperiods in the Siberian hamster, Phodopus sungorus
10.1016/j.yhbeh.2007.04.008 · 2007 · External reference
Morphological sex differences and laterality in the prepubertal medial amygdala
10.1002/cne.21281 · 2007 · External reference
A brain sexual dimorphism controlled by adult circulating androgens
10.1073/pnas.96.13.7538 · 1999 · External reference
Sexually dimorphic organization of synapses in the medial amygdala
2005 · External reference
Effects of prepubertal gonadectomy on a male-typical behavior and excitatory synaptic transmission in the amygdala
2008 · External reference
Sex differences in analgesic, reinforcing, discriminative, and motoric effects of opioids
10.1037/a0012931 · 2008 · External reference
Unresolved reference
1872 · External reference
Model-oriented sexual behavior in surrogate-reared rhesus monkeys
10.1159/000123662 · 1974 · External reference
Aggression decreases as play emerges in infant spotted hyaenas: preparation for joining the clan
10.1006/anbe.1996.0136 · 1996 · External reference
The emergence of affiliative behavior in infant spotted hyenas (Crocuta crocuta)
10.1111/j.1749-6632.1997.tb51950.x · 1997 · External reference
Dissociable neural systems resolve conflict from emotional versus nonemotional distracters
10.1093/cercor/bhm179 · 2008 · External reference
Effects of prenatal sex hormones on gender-related behavior
10.1126/science.7209510 · 1981 · External reference
Brief periods of socialization and later behavior in the rat
10.1002/dev.420110305 · 1978 · External reference
Unresolved reference
2008 · External reference
Unresolved reference
1981 · External reference
Juvenile survival and benefits of play behaviour in brown bears, Ursus arctos
2004 · External reference
Play fighting in androgen-insensitive tfm rats: evidence that androgen receptors are necessary for the development of adult playful attack and defense
10.1002/dev.20121 · 2006 · External reference
The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor
10.1046/j.1460-9568.2003.02932.x · 2003 · External reference
Pubertal development and behavior: hormonal activation of social and motivational tendencies
10.1016/j.bandc.2009.10.007 · 2010 · External reference
Neurophysiological evidence of corollary discharge dysfunction in schizophrenia
10.1176/appi.ajp.158.12.2069 · 2001 · External reference
Rough and tumble social play in humans
2005 · External reference
Disruption of the male rat's sexual behaviour induced by social isolation
10.1016/s0003-3472(67)80010-1 · 1967 · External reference
Socially-induced brain fertilization: play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats
10.1016/s0304-3940(03)00158-7 · 2003 · External reference
Expression of c-fos gene activation during rough and tumble play in juvenile rats
10.1016/s0361-9230(01)00762-6 · 2002 · External reference
Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression
10.1016/s0278-5846(00)00150-0 · 2001 · External reference
Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior
10.1146/annurev-physiol-021909-135843 · 2010 · External reference
A common neural system mediating two different forms of social judgement
10.1017/s0033291709991395 · 2010 · External reference
Impairment of mating behavior in male rats following lesions in the preoptic-anterior hypothalamic continuum
10.1016/0006-8993(67)90076-5 · 1967 · External reference
Play in common ravens (Corvus corvax)
1988 · External reference
Limbic system mechanisms of stress regulation: hypothalamo–pituitary–adrenocortical axis
10.1016/j.pnpbp.2005.08.006 · 2005 · External reference
Neuronal circuit regulation of the hypothalamo–pituitary–adrenocortical stress axis
10.1615/critrevneurobiol.v10.i3-4.50 · 1996 · External reference
Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats
2010 · External reference
Sex steroids and human behavior: prenatal androgen exposure and sex-typical play behavior in children
10.1196/annals.1286.026 · 2003 · External reference
Psychosexual development in individuals who have female pseudohermaphroditism
10.1016/j.chc.2004.02.013 · 2004 · External reference
Isolation during the play period in infancy decreases adult social interactions in rats
10.1016/s0166-4328(98)00116-8 · 1999 · External reference
An environmental antiandrogen, vinclozolin, alters the organization of play behavior
10.1016/s0031-9384(03)00093-3 · 2003 · External reference
Action selection and refinement in subcortical loops through basal ganglia and cerebellum
10.1098/rstb.2007.2063 · 2007 · External reference
Social conflict models: can they inform us about human psychopathology?
10.1016/j.yhbeh.2006.06.022 · 2006 · External reference
Play as a reinforcer for maze-learning in juvenile rats
10.1016/s0003-3472(81)80173-x · 1981 · External reference
The nuclear receptor corepressor has organizational effects within the developing amygdala on juvenile social play and anxiety-like behavior
10.1210/en.2009-0594 · 2010 · External reference
Social competence is reduced in socially deprived rhesus monkeys (Macaca mulatta)
10.1037/0735-7036.122.1.62 · 2008 · External reference
The time course of brain activations during response inhibition: evidence from event-related potentials in a go-no go task
10.1097/00001756-199803090-00037 · 1998 · External reference
Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior
10.1073/pnas.1005003107 · 2010 · External reference
Reversal of sex differences in morphine analgesia elicited from the ventrolateral periaqueductal gray in rats by neonatal hormone manipulations
10.1016/s0006-8993(01)03350-9 · 2002 · External reference
Unresolved reference
1999 · External reference
Mecp2 organizes juvenile social behavior in a sex-specific manner
10.1523/jneurosci.1345-08.2008 · 2008 · External reference
Sex difference in mecp2 expression during a critical period of rat brain development
10.4161/epi.2.3.4841 · 2007 · External reference
Unresolved reference
1978 · External reference
Brief report: a double-blind study of naltrexone in infantile autism
10.1007/bf01058158 · 1992 · External reference
Effect of prepuberal medial preoptic area lesions on male rat sexual behavior
10.1016/0031-9384(80)90097-9 · 1980 · External reference
A critique of Konrad Lorenz's theory of instinctive behavior
10.1086/399858 · 1953 · External reference
Naltrexone open trial with a 5-year-old-boy. A social rebound reaction
1992 · External reference
The neural correlates of perceiving one's own movements
10.1016/j.neuroimage.2003.07.033 · 2003 · External reference
Sexually dimorphic behavior in group-housed rhesus monkeys (Macaca mulatta)
10.3758/bf03327332 · 1988 · External reference
The cortico-medial amygdala in the central nervous system organization of agonistic behavior
10.1016/0006-8993(85)90597-9 · 1985 · External reference
Testosterone aromatization in rat brain is modulated by social environment
10.1016/0031-9384(78)90230-5 · 1978 · External reference
Unresolved reference
1998 · External reference
Steroid hormone action in the brain: cross-talk between signalling pathways
10.1111/j.1365-2826.2009.01844.x · 2009 · External reference
Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor
10.1016/j.jsbmb.2008.12.014 · 2009 · External reference
Reframing sexual differentiation of the brain
10.1038/nn.2834 · 2011 · External reference
Projections of the medial and lateral prefrontal cortices to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat
10.1016/0306-4522(95)00417-3 · 1996 · External reference
Cortical afferents to the extended amygdala
10.1111/j.1749-6632.1999.tb09275.x · 1999 · External reference
Sex dependent effects of amygdaloid lesions on the social play of prepubertal rats
10.1016/0031-9384(81)90175-x · 1981 · External reference
Sex-dependent effects of amygdaloid lesions on the social play of prepubertal rats
10.1016/0031-9384(81)90175-x · 1981 · External reference
A descriptive study of social development in the rat (Rattus Norvegicus)
10.1016/s0003-3472(81)80149-2 · 1981 · External reference
Neonatal androgens influence the social play of prepubescent rats
10.1016/0018-506x(81)90028-3 · 1981 · External reference
Serum 5α-androstane-3α 17β-diol androsterone, and testosterone concentrations in the male rat. Influence of age and gonadotropin concentration
10.1210/endo-100-4-1027 · 1977 · External reference
The medial extended amygdala in male reproductive behavior. A node in the mammalian social behavior network
10.1111/j.1749-6632.1999.tb09271.x · 1999 · External reference
Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats
10.1016/0028-3908(89)90038-5 · 1989 · External reference
Endocrine and energetic mediation of play behavior in free-living Belding's ground squirrels
10.1006/hbeh.1999.1538 · 1999 · External reference
Play behavior and motor development in juvenile Belding's ground squirrels (Spermophilus beldingi)
10.1007/s00265-004-0765-x · 2004 · External reference
An autoradiographic map of (3H)diprenorphine binding in rat brain: effects of social interaction
10.1016/0361-9230(81)90038-1 · 1981 · External reference
Endogenous opioids and social behavior
10.1016/0149-7634(80)90036-6 · 1980 · External reference
Sex differences in the play behavior of immature spotted hyenas, Crocuta crocuta
10.1016/0018-506x(90)90018-s · 1990 · External reference
Sex differences in play fighting revisited: traditional and nontraditional mechanisms of sexual differentiation in rats
10.1023/a:1014070916047 · 2002 · External reference
Structure–function interface in the analysis of play
1998 · External reference
Unresolved reference
2009 · External reference
Adrenarche in the rat
10.1677/joe.1.06972 · 2006 · External reference
Attack priming in female Syrian golden hamsters is associated with a c-fos-coupled process within the corticomedial amygdala
10.1016/0306-4522(96)00236-9 · 1996 · External reference
Adult plasticity in hormone-sensitive motoneuron morphology: methological/behavioral confounds
10.1006/hbeh.2000.1620 · 2000 · External reference
Pubertal and seasonal plasticity in the amygdala
10.1016/s0006-8993(00)03111-5 · 2001 · External reference
Brain changes in response to experience
10.1038/scientificamerican0272-22 · 1972 · External reference
Neuropharmacology of brain-stimulation-evoked aggression
10.1016/s0149-7634(98)00040-2 · 1999 · External reference
Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain
10.1146/annurev.neuro.25.112701.142745 · 2002 · External reference
In search of the neurobiological substrates for social playfulness in mammalian brains
10.1016/j.neubiorev.2011.03.006 · 2011 · External reference
The postpubertal change in the playful defense of male rats depends upon neonatal exposure to gonadal hormones
10.1016/s0031-9384(97)00397-1 · 1998 · External reference
The adolescent brain and age-related behavioral manifestations
10.1016/s0149-7634(00)00014-2 · 2000 · External reference
Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo
10.1002/glia.1097 · 2001 · External reference
Play fighting in juvenile rats and the development of agonistic behavior in male and female rats
10.1002/1098-2337(1983)9:3<217::aid-ab2480090303>3.0.co;2-4 · 1983 · External reference
Self assessment in juvenile play
1998 · External reference
Social play soliciting by male and female juvenile rats: effects of neonatal androgenization and sex of cagemates
10.1037/0735-7044.100.2.275 · 1986 · External reference
Effects of neonatal intracerebral implantation of sex steroids on sexual behavior, social play behavior and gonadotropin secretion
10.1055/s-0029-1210699 · 1987 · External reference
Pain reactivity and plasma β-endorphin in children and adolescents with autistic disorder
10.1371/journal.pone.0005289 · 2009 · External reference
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats
10.1016/j.brainres.2005.11.005 · 2006 · External reference
Toward a comprehensive neurobiology of IGF-I
10.1002/dneu.20778 · 2010 · External reference
The pleasures of play: pharmacological insights into social reward mechanisms
10.1016/j.tips.2010.06.008 · 2010 · External reference
Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats
10.1124/jpet.108.141069 · 2009 · External reference
Unresolved reference
1985 · External reference
Medial preoptic lesions and male sexual behavior: age and environmental interactions
1978 · External reference
Control of synapse number by glia
10.1126/science.291.5504.657 · 2001 · External reference
Play is indispensable for an adequate development of coping with social challenges in the rat
10.1002/(sici)1098-2302(199903)34:2<129::aid-dev6>3.0.co;2-l · 1999 · External reference
Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: behavioural and autoradiographic studies
10.1046/j.1460-9568.1999.00717.x · 1999 · External reference
Effects of morphine on different aspects of social play in juvenile rats
10.1007/bf02245191 · 1995 · External reference
Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats
10.1016/0014-2999(95)00040-r · 1995 · External reference
Social isolation and social interaction alter regional brain opioid receptor binding in rats
10.1016/0924-977x(95)00010-m · 1995 · External reference
Male–female differences in the risk of progression from first use to dependence upon cannabis, cocaine, and alcohol
10.1016/j.drugalcdep.2006.06.003 · 2007 · External reference
Prenatal stress feminizes juvenile play patterns in male rats
10.1016/0031-9384(91)90552-y · 1991 · External reference
The biology of the opioid growth factor receptor (OGFr)
10.1016/s0165-0173(01)00160-6 · 2002 · External reference
Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects
10.1111/j.1460-9568.2006.04621.x · 2006 · External reference
mu-opioid receptor-mediated antinociceptive responses differ in men and women
10.1523/jneurosci.22-12-05100.2002 · 2002 · External reference