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References from Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo. Local targets link to admitted publications; unresolved targets remain external evidence.
Physiology and diseases of tissue-resident macrophages
10.1038/s41586-023-06002-x · 2023 · External reference
Macrophages in health and disease
10.1016/j.cell.2022.10.007 · 2022 · External reference
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
10.1016/j.cell.2014.11.018 · 2014 · External reference
Niche signals and transcription factors involved in tissue-resident macrophage development
10.1016/j.cellimm.2018.02.005 · 2018 · External reference
Specification of tissue-resident macrophages during organogenesis
10.1126/science.aaf4238 · 2016 · External reference
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
10.1038/nature13989 · 2015 · External reference
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
10.1016/j.immuni.2015.03.011 · 2015 · External reference
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
10.1126/science.1219179 · 2012 · External reference
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
10.1126/science.1194637 · 2010 · External reference
Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo
10.1016/j.celrep.2015.05.036 · 2015 · External reference
Haematopoietic stem cells derive directly from aortic endothelium during development
10.1038/nature08738 · 2010 · External reference
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
10.1038/nature08764 · 2010 · External reference
Blood stem cells emerge from aortic endothelium by a novel type of cell transition
10.1038/nature08761 · 2010 · External reference
Ontogeny of Tissue-Resident Macrophages
10.3389/fimmu.2015.00486 · 2015 · External reference
Deciphering human macrophage development at single-cell resolution
10.1038/s41586-020-2316-7 · 2020 · External reference
Yolk sac cell atlas reveals multiorgan functions during human early development
10.1126/science.add7564 · 2023 · External reference
Decoding human fetal liver haematopoiesis
10.1038/s41586-019-1652-y · 2019 · External reference
Mapping the developing human immune system across organs
10.1126/science.abo0510 · 2022 · External reference
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development
10.1016/j.cell.2023.08.019 · 2023 · External reference
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration
10.1016/j.immuni.2022.07.004 · 2022 · External reference
Microglia protect against age-associated brain pathologies
10.1016/j.neuron.2024.05.018 · 2024 · External reference
Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy
10.1016/j.neuron.2024.05.023 · 2024 · External reference
Microglia replacement halts the progression of microgliopathy in mice and humans
10.1126/science.adr1015 · 2025 · External reference
Robust temporal map of human in vitro myelopoiesis using single-cell genomics
10.1038/s41467-022-30557-4 · 2022 · External reference
Stem-cell-derived human microglia transplanted into mouse brain to study human disease
10.1038/s41596-020-00447-4 · 2021 · External reference
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
10.1038/s41593-024-01600-y · 2024 · External reference
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
10.1038/s41593-019-0525-x · 2019 · External reference
Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain
10.1038/s41467-022-35166-9 · 2022 · External reference
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
10.1038/s41593-019-0393-4 · 2019 · External reference
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
10.1038/s41467-019-11053-8 · 2019 · External reference
Efficient Strategies for Microglia Replacement in the Central Nervous System
10.1016/j.celrep.2020.108041 · 2020 · External reference
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders
10.1126/scitranslmed.ads6111 · 2025 · External reference
Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development
10.1016/j.neuron.2026.07.007 · 2026 · External reference
Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions
2013 · External reference
Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
2020 · External reference
Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling
10.1016/j.celrep.2023.112425 · 2023 · External reference
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
10.1016/0306-4522(90)90229-w · 1990 · External reference
A new fate mapping system reveals context-dependent random or clonal expansion of microglia
10.1038/nn.4547 · 2017 · External reference
The Lifespan and Turnover of Microglia in the Human Brain
10.1016/j.celrep.2017.07.004 · 2017 · External reference
CSF1R-related leukoencephalopathy: A major player in primary microgliopathies
10.1212/wnl.0000000000006642 · 2018 · External reference
The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective
2015 · External reference
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
10.1126/scitranslmed.3009750 · 2014 · External reference
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
10.1126/science.abp9556 · 2023 · External reference
Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
10.1016/j.neuron.2017.02.001 · 2017 · External reference
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
10.1038/s41593-025-02125-8 · 2026 · External reference
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
10.1038/s41467-018-06318-7 · 2018 · External reference
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
10.1016/j.cell.2021.12.018 · 2022 · External reference
Cells of the adult human heart
10.1038/s41586-020-2797-4 · 2020 · External reference
Spatiotemporal immune zonation of the human kidney
10.1126/science.aat5031 · 2019 · External reference
Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease
10.1038/s41586-024-07871-6 · 2024 · External reference
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
10.1016/j.immuni.2021.07.007 · 2021 · External reference
Fast gene set enrichment analysis
2021 · External reference
