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References from Revisiting the potential of elongation factors as drug targets for pathogenic mycobacteria. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Unresolved reference
2025 · External reference
Seminars in respiratory and critical care medicine
2013 · External reference
Update on pulmonary disease due to non-tuberculous mycobacteria
10.1016/j.ijid.2016.03.006 · 2016 · External reference
Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii
10.1038/s41467-021-22760-6 · 2021 · External reference
Nontuberculous mycobacteria—overview
10.1128/microbiolspec.tnmi7-0024-2016 · 2017 · External reference
Pretomanid with bedaquiline and linezolid for drug-resistant TB: a comparison of prospective cohorts
10.5588/ijtld.21.0035 · 2021 · External reference
Bedaquiline: what might the future hold?
10.1016/s2666-5247(24)00149-6 · 2024 · External reference
Unlocking translational machinery for antitubercular drug development
10.1016/j.tibs.2023.12.008 · 2024 · External reference
Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation
10.1002/prot.26655 · 2025 · External reference
Ribosome dynamics during decoding
10.1098/rstb.2016.0182 · 2017 · External reference
Mechanism of EF-Ts-catalyzed guanine nucleotide exchange in EF-Tu: contribution of interactions mediated by helix B of EF-Tu
10.1021/bi602486c · 2007 · External reference
EF-G and EF4: translocation and back-translocation on the bacterial ribosome
10.1038/nrmicro3176 · 2014 · External reference
Mechanism for the disassembly of the post termination complex inferred from cryo-EM studies
10.1016/j.molcel.2005.05.005 · 2005 · External reference
Mechanism of trans-translation revealed by in vitro studies
10.3389/fmicb.2014.00065 · 2014 · External reference
Mechanisms of ribosome rescue in bacteria
10.1038/nrmicro3438 · 2015 · External reference
Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA
10.1128/mbio.01461-23 · 2023 · External reference
tRNA/mRNA mimicry by tmRNA and SmpB in trans‐translation
10.4061/2011/130581 · 2011 · External reference
Trans-translation exposed: understanding the structures and functions of tmRNA-SmpB
10.3389/fmicb.2014.00113 · 2014 · External reference
Trans-translation is an appealing target for the development of new antimicrobial compounds
10.3390/microorganisms10010003 · 2021 · External reference
Mechanism of elongation factor (EF)-Ts-catalyzed nucleotide exchange in EF-Tu: contribution of contacts at the guanine base
10.1074/jbc.m110888200 · 2002 · External reference
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis
10.1038/s42003-022-04019-y · 2022 · External reference
Identification of novel inhibitors of bacterial translation elongation factors
10.1128/aac.49.1.131-136.2005 · 2005 · External reference
Probing the molecular basis of cofactor affinity and conformational dynamics of Mycobacterium tuberculosis elongation factor Tu: an integrated approach employing steered molecular dynamics and umbrella sampling simulations
10.1021/acs.jpcb.1c09438 · 2022 · External reference
The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA
10.1126/science.1179700 · 2009 · External reference
Elfamycins: inhibitors of elongation factor‐Tu
10.1111/mmi.13750 · 2017 · External reference
In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu
10.1128/aac.00582-11 · 2011 · External reference
Synthesis and biological evaluation of new fragments from kirromycin antibiotic
10.7164/antibiotics.49.1249 · 1996 · External reference
Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding: crystal structure of the complex between EF-Tu· GDP and aurodox
10.1074/jbc.m100017200 · 2001 · External reference
New polyenic antibiotics active against Gram-positive and Gram-negative bacteria VII. Isolation and structure of enacyloxin IVa, a possible biosynthetic intermediate of enacyloxin IIa
10.7164/antibiotics.45.575 · 1992 · External reference
Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic Burkholderia ambifaria genomic island
10.1016/j.chembiol.2011.01.020 · 2011 · External reference
New polyenic antibiotics active against Gram-positive and-negative bacteria I. isolation and purification of antibiotics produced by Gluconobacter sp. W-315
10.7164/antibiotics.35.1141 · 1982 · External reference
Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome
10.1002/j.1460-2075.1996.tb00618.x · 1996 · External reference
Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1
10.1038/ja.2010.13 · 2010 · External reference
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu
10.1021/bi0525122 · 2006 · External reference
Changes in GE2270 antibiotic production in Planobispora rosea through modulation of methylation metabolism
10.1099/mic.0.26157-0 · 2003 · External reference
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis I. Isolation and characterization
10.7164/antibiotics.44.693 · 1991 · External reference
In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A)
10.1128/aac.37.4.741 · 1993 · External reference
Overall survival with osimertinib in untreated, EGFR-mutated advanced NSCLC
10.1056/nejmoa1913662 · 2020 · External reference
Overall survival with osimertinib in resected EGFR-mutated NSCLC
10.1056/nejmoa2304594 · 2023 · External reference
Inhibitors of ribosome rescue arrest growth of Francisella tularensis at all stages of intracellular replication
10.1128/aac.03089-15 · 2016 · External reference
Tetrazole-based trans-translation inhibitors kill bacillus anthracis spores to protect host cells
10.1128/aac.01199-17 · 2017 · External reference
trans-translation inhibitors that kill Mycobacterium tuberculosis and pathogenic non-tuberculous mycobacteria also disrupt metal homeostasis
10.1099/mic.0.001716 · 2026 · External reference
Ribosome rescue inhibitors kill actively growing and nonreplicating persister Mycobacterium tuberculosis cells
10.1021/acsinfecdis.7b00028 · 2017 · External reference
Crystal structure of Mycobacterium tuberculosis elongation factor G1
10.3389/fmolb.2021.667638 · 2021 · External reference
Fusidic acid: a new antibiotic
10.1038/193987a0 · 1962 · External reference
Fucidin: a new orally active antibiotic
10.1016/s0140-6736(62)91968-2 · 1962 · External reference
Fusidic acid in vitro activity
10.1016/s0924-8579(98)00073-9 · 1999 · External reference
Fusidic acid targets elongation factor G in several stages of translocation on the bacterial ribosome
10.1074/jbc.m114.611608 · 2015 · External reference
The postantibiotic effect of fusidic acid against gram-positive bacteria
10.1093/jac/40.3.433 · 1997 · External reference
A central interdomain protein joint in elongation factor G regulates antibiotic sensitivity, GTP hydrolysis, and ribosome translocation
10.1074/jbc.m110.214056 · 2011 · External reference
Antimicrobial and antibiofilm effects of bithionol against Mycobacterium abscessus
10.3390/antibiotics13060529 · 2024 · External reference
Susceptibility of mycobacteria to fusidic acid
10.1007/bf01968066 · 1990 · External reference
Fusidic acid-based drug combinations exhibit enhanced activity against Mycobacterium tuberculosis
2023 · External reference
Argyrins, immunosuppressive cyclic peptides from myxobacteria. Part 1. production, isolation, physico‐chemical and biological properties
10.1002/chin.200248192 · 2002 · External reference
Identification of elongation factor G as the conserved cellular target of argyrin B
10.1371/journal.pone.0042657 · 2012 · External reference
The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation
10.1073/pnas.2114214119 · 2022 · External reference
Determinants of antibacterial spectrum and resistance potential of the elongation factor G inhibitor argyrin B in key Gram-negative pathogens
10.1128/aac.02400-16 · 2017 · External reference
Computer-aided drug design approaches for the identification of potent inhibitors targeting elongation factor G of Mycobacterium tuberculosis
10.1016/j.jmgm.2025.108954 · 2025 · External reference
Identification of novel bacterial plasminogen‐binding proteins in the human pathogen Mycobacterium tuberculosis
10.1002/pmic.200600876 · 2007 · External reference
Immune evasion of the human pathogen P. aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein
10.4049/jimmunol.179.5.2979 · 2007 · External reference
Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in M. pneumoniae
10.1046/j.1365-2958.2002.03207.x · 2002 · External reference
Association of Acinetobacter baumannii EF‐Tu with cell surface, outer membrane vesicles, and fibronectin
10.1100/2012/128705 · 2012 · External reference
Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin
10.1038/ncomms5730 · 2014 · External reference
Extraintestinal pathogenic Escherichia coli utilizes the surface-expressed elongation factor Tu to bind and acquire iron from holo-transferrin
10.1080/21505594.2022.2066274 · 2022 · External reference
Extraintestinal pathogenic Escherichia coli utilizes surface-located elongation factor G to acquire iron from holo-transferrin
10.1128/spectrum.01662-21 · 2022 · External reference
Bacterial translation elongation factor EF-Tu interacts and colocalizes with actin-like MreB protein
10.1073/pnas.0911979107 · 2010 · External reference
Antibiotic susceptibility of mammalian mitochondrial translation
10.1016/j.febslet.2005.09.103 · 2005 · External reference
