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References from Single-cell study of human ovarian response to phthalate exposure reveals glial cell susceptibility and disruption of adhesion and mitochondrial pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
Exposure to phthalates and female reproductive health: a literature review
10.1016/j.reprotox.2022.02.006 · 2022 · External reference
Phthalate exposure and male reproductive outcomes: a systematic review of the human epidemiological evidence
10.1016/j.envint.2018.07.029 · 2018 · External reference
A global assessment of phthalates burden and related links to health effects
10.1016/j.envint.2016.09.013 · 2016 · External reference
Adverse effects of microplastics and nanoplastics on the reproductive system: a comprehensive review of fertility and potential harmful interactions
10.1016/j.scitotenv.2023.166258 · 2023 · External reference
Chemicals used in plastic materials: an estimate of the attributable disease burden and costs in the United States
10.1210/jendso/bvad163 · 2024 · External reference
Metabolism of phthalates in humans
10.1002/mnfr.200600243 · 2007 · External reference
A review of phthalate pharmacokinetics in human and rat: what factors drive phthalate distribution and partitioning?
10.1080/03602532.2019.1620762 · 2019 · External reference
Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia
10.1016/j.envres.2022.114447 · 2023 · External reference
Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment
10.1038/s41370-023-00579-1 · 2023 · External reference
Urinary phthalate metabolites and ovarian reserve among women seeking infertility care
10.1093/humrep/dev292 · 2016 · External reference
Urinary levels of phthalate metabolites in women associated with risk of premature ovarian failure and reproductive hormones
10.1016/j.chemosphere.2019.125206 · 2020 · External reference
Serum levels of phthalates and bisphenol-A in patients with primary ovarian insufficiency
10.1080/09513590.2018.1534951 · 2019 · External reference
Estimation of plasma levels of bisphenol-A & phthalates in fertile & infertile women by gas chromatography-mass spectrometry
10.4103/ijmr.ijmr_2077_16 · 2018 · External reference
Female exposure to phthalates and time to pregnancy: a first pregnancy planner study
2017 · External reference
Persistent organic pollutants and early menopause in U.S. women
10.1371/journal.pone.0116057 · 2015 · External reference
Serum phthalate levels and time to pregnancy in couples from Greenland, Poland and Ukraine
10.1371/journal.pone.0120070 · 2015 · External reference
Urinary phthalate monoesters concentration in couples with infertility problems
10.1016/j.toxlet.2011.11.033 · 2012 · External reference
Endocrine-disrupting chemicals: an endocrine society scientific statement
10.1210/er.2009-0002 · 2009 · External reference
Phthalates, ovarian function and fertility in adulthood
10.1016/j.beem.2021.101552 · 2021 · External reference
Bayesian benchmark dose modeling analysis and derivation of points of departure for female reproductive toxicity following exposure to di(2-ethylhexyl) phthalate (DEHP) - effects on reproductive hormones, folliculogenesis and estrous cyclicity
10.1093/toxsci/kfaf052 · 2025 · External reference
Unresolved reference
External reference
Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro
10.1016/j.tox.2024.153815 · 2024 · External reference
The adult ovary at single cell resolution: an expert review
10.1016/j.ajog.2024.05.046 · 2025 · External reference
Comparative analysis of human and mouse ovaries across age
10.1126/science.adx0659 · 2025 · External reference
Endocrine-disrupting chemicals and ovarian somatic cells: knowledge gaps in non-follicular cell toxicology
10.1093/enendo/wkag003 · 2026 · External reference
A novel approach to chemical mixture risk assessment—linking data from population-based epidemiology and experimental animal tests
10.1111/risa.13323 · 2019 · External reference
Culture of human ovarian tissue in xeno-free conditions using laminin components of the human ovarian extracellular matrix
10.1007/s10815-020-01886-4 · 2020 · External reference
Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
10.1038/s41467-020-14936-3 · 2020 · External reference
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1
10.1038/s43587-024-00607-1 · 2024 · External reference
CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics
10.1038/s41596-024-01045-4 · 2025 · External reference
Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
10.1158/2159-8290.cd-21-0316 · 2022 · External reference
NicheNet: modeling intercellular communication by linking ligands to target genes
10.1038/s41592-019-0667-5 · 2020 · External reference
Schwann cell precursors; multipotent glial cells in embryonic nerves
10.3389/fnmol.2019.00069 · 2019 · External reference
PTPRC is an immunotherapeutic predictor and serum biomarker in lung adenocarcinoma correlated with immune cell infiltration
2025 · External reference
CellProfiler 4: improvements in speed, utility and usability
10.1186/s12859-021-04344-9 · 2021 · External reference
Transcriptomics and spatial proteomics for discovery and validation of missing proteins in the human ovary
10.1021/acs.jproteome.3c00545 · 2024 · External reference
Defined culture conditions robustly maintain human stem cell pluripotency, highlighting a role for Ca2+ signaling
10.1038/s42003-025-07658-z · 2025 · External reference
Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells
10.1038/s41467-020-15326-5 · 2020 · External reference
Schwann cell precursors from human pluripotent stem cells as a potential therapeutic target for Myelin repair
10.1016/j.stemcr.2017.04.011 · 2017 · External reference
In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
10.1038/s41467-024-51185-0 · 2024 · External reference
Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1
10.1038/s12276-023-01023-y · 2023 · External reference
The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles†
10.1093/biolre/ioad178 · 2024 · External reference
Resveratrol supports and alpha-naphthoflavone disrupts growth of human ovarian follicles in an in vitro tissue culture model
10.1016/j.taap.2017.11.009 · 2018 · External reference
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology
10.1038/s41392-025-02500-8 · 2026 · External reference
Associations between phthalate metabolites and cytokines in the follicular fluid of women undergoing in vitro fertilization
10.1016/j.ecoenv.2023.115616 · 2023 · External reference
Follicular fluid concentrations of phthalate metabolites are associated with altered intrafollicular reproductive hormones in women undergoing in vitro fertilization
10.1016/j.fertnstert.2019.01.021 · 2019 · External reference
Phthalates and bisphenol do not accumulate in human follicular fluid
10.1007/s10815-012-9775-1 · 2012 · External reference
Phthalates are detected in the follicular fluid of adolescents and oocyte donors with associated changes in the cumulus cell transcriptome
2025 · External reference
Unresolved reference
2008 · External reference
Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro
10.1016/j.envint.2024.108710 · 2024 · External reference
Measurement of mitochondrial membrane potential and proton leak
2010 · External reference
Assessing mitochondrial dysfunction in cells
10.1042/bj20110162 · 2011 · External reference
Epidemiologically relevant phthalate mixture and mono(2-ethyl-5-hydroxyhexyl) phthalate exposure alter cell energy metabolism in primary mouse granulosa cells
10.1016/j.reprotox.2025.108938 · 2025 · External reference
Single-cell transcriptomic profiling to evaluate the effects of Di(2-ethylhexyl)phthalate exposure on early meiosis of female mouse germ cells
10.1016/j.chemosphere.2022.135698 · 2022 · External reference
Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly
10.7150/thno.55006 · 2021 · External reference
Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate
10.1093/toxsci/kfae064 · 2024 · External reference
Single-cell RNA-seq reveals that granulosa cells are a target of phthalate toxicity in the ovary
2025 · External reference
Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data
10.1186/s13073-021-01001-x · 2021 · External reference
Unique challenges and best practices for single cell transcriptomic analysis in toxicology
2024 · External reference
Unusual suspects: glial cells in fertility regulation and their suspected role in polycystic ovary syndrome
10.1111/jne.13136 · 2022 · External reference
From cohorts to molecules: adverse impacts of endocrine disrupting mixtures
10.1126/science.abe8244 · 2022 · External reference
Phthalates and polycystic ovary syndrome – systematic literature review
10.1016/j.reprotox.2023.108473 · 2023 · External reference
Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids
10.1016/j.envint.2024.108960 · 2024 · External reference
Environmental exposure to selected non-persistent endocrine disrupting chemicals and polycystic ovary syndrome: a systematic review
10.13075/ijomeh.1896.02551 · 2025 · External reference
The structure and regulation of vinculin
10.1016/j.tcb.2006.07.004 · 2006 · External reference
Epidemiologically relevant phthalates affect human endometrial cells in vitro through cell specific gene expression changes related to the cytoskeleton and mitochondria
10.1016/j.reprotox.2024.108660 · 2024 · External reference
Phthalate monoesters affect membrane fluidity and cell-cell contacts in endometrial stromal adherent cell lines and spheroids
10.1016/j.reprotox.2024.108733 · 2024 · External reference
Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling
10.1016/j.bbamem.2013.07.018 · 2014 · External reference
Capturing ovarian dynamics through spatial profiling of the mechano-microenvironment
10.1016/j.semcdb.2025.103642 · 2025 · External reference
Regulation of mitochondrial function by the Actin Cytoskeleton
10.3389/fcell.2021.795838 · 2021 · External reference
Links of cytoskeletal integrity with disease and aging
10.3390/cells11182896 · 2022 · External reference
Suppression of ribosomal pausing by eIF5A is necessary to maintain the fidelity of start codon selection
10.1016/j.celrep.2019.10.129 · 2019 · External reference
Protein translation paradox: implications in translational regulation of aging
10.3389/fcell.2023.1129281 · 2023 · External reference
Ovarian aging: energy metabolism of oocytes
10.1186/s13048-024-01427-y · 2024 · External reference
Role of eIF5A in mitochondrial function
10.3390/ijms23031284 · 2022 · External reference
Bisphenol A and bisphenol AF co-exposure induced apoptosis of human ovarian granulosa cells via mitochondrial dysfunction
10.1016/j.fct.2024.114894 · 2024 · External reference
Impact of DEHP on mitochondria-associated endoplasmic reticulum membranes and reproductive toxicity in ovary
10.1016/j.ecoenv.2024.116679 · 2024 · External reference
Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities
10.1016/j.envres.2021.111904 · 2022 · External reference
An effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and board
10.1016/j.fct.2017.05.061 · 2017 · External reference
