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References from Multidimensional molecular profiling reveals decidual and circulating NK cell dynamics in early and late pregnancy. Local targets link to admitted publications; unresolved targets remain external evidence.
Fetomaternal immune tolerance: crucial mechanisms of tolerance for successful pregnancy in humans
10.1080/08820139.2021.1909061 · 2022 · External reference
Normal human pregnancy results in maternal immune activation in the periphery and at the uteroplacental interface
10.1371/journal.pone.0096723 · 2014 · External reference
Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells
10.1172/jci.insight.171806 · 2023 · External reference
Regulatory T cells mediate maternal tolerance to the fetus
10.1038/ni1037 · 2004 · External reference
High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third-trimester pregnancy
10.1002/cti2.70096 · 2026 · External reference
Cutting edge: IL-10-producing regulatory B cells in early human pregnancy
10.1111/aji.12157 · 2013 · External reference
Characterizing the pregnancy immune phenotype: results of the viral immunity and pregnancy (VIP) study
10.1007/s10875-011-9627-2 · 2012 · External reference
Characterization of B cells in healthy pregnant women from late pregnancy to post-partum: a prospective observational study
10.1186/s12884-016-0927-7 · 2016 · External reference
B cell development undergoes profound modifications and adaptations during pregnancy in mice
10.1095/biolreprod.114.122366 · 2014 · External reference
Suppression of B lymphopoiesis during normal pregnancy
10.1084/jem.178.5.1507 · 1993 · External reference
Pregnancy-related steroids are potential negative regulators of B lymphopoiesis
10.1073/pnas.91.12.5382 · 1994 · External reference
Activated γδ T cells with higher CD107a expression and inflammatory potential during early pregnancy in patients with recurrent spontaneous abortion
10.3389/fimmu.2021.724662 · 2021 · External reference
The role of γ/δ T-Cell receptor-positive cells in pregnancy: part II
10.1111/j.1600-0897.1999.tb00470.x · 1999 · External reference
The role of γδ-T cells during human pregnancy
2017 · External reference
γδ-T cell with high toxic potential was associated with recurrent miscarriage
2023 · External reference
NKG2D as a cell surface marker on γδ-T cells for predicting pregnancy outcomes in patients with unexplained repeated implantation failure
2021 · External reference
Human decidual gamma/delta T cells possess unique effector and TCR repertoire profiles during pregnancy
10.1016/j.cellimm.2022.104634 · 2022 · External reference
Gamma/delta T cells in the course of healthy human pregnancy: cytotoxic potential and the tendency of CD8 expression make CD56+ γδT cells a unique lymphocyte subset
10.3389/fimmu.2020.596489 · 2021 · External reference
The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy
10.1016/j.clim.2011.07.008 · 2011 · External reference
Dominant IL-10 and TGF-β mRNA expression in γδT cells of human early pregnancy decidua suggests immunoregulatory potential
10.1034/j.1600-0897.2002.01131.x · 2002 · External reference
Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
10.1172/jci43998 · 2010 · External reference
Spiral artery blood flow during pregnancy: a systematic review and meta-analysis
10.1186/s12884-020-03150-0 · 2020 · External reference
Immune cells at the fetomaternal interface: how the microenvironment modulates immune cells to foster fetal development
10.4049/jimmunol.1800058 · 2018 · External reference
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
10.1084/jem.20041214 · 2004 · External reference
Single-cell reconstruction of the early maternal–fetal interface in humans
10.1038/s41586-018-0698-6 · 2018 · External reference
Trophoblast cell influence on peripheral blood natural killer cell proliferation and phenotype in non-pregnant women and women in early pregnancy
10.1016/j.imbio.2020.151910 · 2020 · External reference
Cytokine profile of natural killer cells in early human pregnancy
10.1111/j.1600-0897.2005.00279.x · 2005 · External reference
Peripheral blood NK cell cytotoxicities are negatively correlated with CD8+ T cells in fertile women but not in women with a history of recurrent pregnancy loss
10.1111/j.1600-0897.2012.01133.x · 2012 · External reference
Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations
10.1172/jci.insight.167157 · 2023 · External reference
Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts
10.1016/j.immuni.2023.06.005 · 2023 · External reference
Limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
Cellsnp-lite: an efficient tool for genotyping single cells
10.1093/bioinformatics/btab358 · 2021 · External reference
Vireo: bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference
10.1186/s13059-019-1865-2 · 2019 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
Detection and removal of barcode swapping in single-cell RNA-seq data
10.1038/s41467-018-05083-x · 2018 · External reference
Normalizing and denoising protein expression data from droplet-based single cell profiling
10.1038/s41467-022-29356-8 · 2022 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Unresolved reference
2019 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
Differential expression analysis of multifactor RNA-seq experiments with respect to biological variation
10.1093/nar/gks042 · 2012 · External reference
clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
2021 · External reference
Unresolved reference
2023 · External reference
Cross-tissue immune cell analysis reveals tissue-specific features in humans
10.1126/science.abl5197 · 2022 · External reference
Automatic cell-type harmonization and integration across Human Cell Atlas datasets
10.1016/j.cell.2023.11.026 · 2023 · External reference
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data
10.1038/s41467-022-30755-0 · 2022 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
High-dimensional single-cell analysis of human natural killer cell heterogeneity
10.1038/s41590-024-01883-0 · 2024 · External reference
Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection
10.1073/pnas.1110900108 · 2011 · External reference
The CD6 scavenger receptor is differentially expressed on a CD56 natural killer cell subpopulation and contributes to natural killer-derived cytokine and chemokine secretion
10.1159/000322720 · 2011 · External reference
Human cytomegalovirus non-primary infection during pregnancy: antibody response, risk factors and newborn outcome
10.1016/j.cmi.2021.09.013 · 2022 · External reference
Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing
10.1126/scitranslmed.adh8335 · 2024 · External reference
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
10.1074/jbc.m208586200 · 2002 · External reference
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
10.1016/s0092-8674(00)80047-1 · 1999 · External reference
IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
10.1093/intimm/12.2.151 · 2000 · External reference
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production
10.4049/jimmunol.161.7.3400 · 1998 · External reference
Human cytomegalovirus antigen presentation by HLA-DR+ NKG2C+ adaptive NK cells specifically activates polyfunctional effector memory CD4+ T lymphocytes
10.3389/fimmu.2019.00687 · 2019 · External reference
Trained memory of human uterine NK cells enhances their function in subsequent pregnancies
10.1016/j.immuni.2018.03.030 · 2018 · External reference
Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells
10.1073/pnas.1110584108 · 2011 · External reference
High expression of CD38 and MHC class II on CD8(+) T cells during severe influenza disease reflects bystander activation and trogocytosis
10.1002/cti2.1336 · 2021 · External reference
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
10.1016/j.xcrm.2021.100208 · 2021 · External reference
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
10.1016/s0092-8674(00)80438-9 · 1997 · External reference
Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow
10.1084/jem.188.8.1413 · 1998 · External reference
Fractalkine-mediated endothelial cell injury by NK Cells1
10.4049/jimmunol.164.8.4055 · 2000 · External reference
Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation
10.1016/j.ebiom.2023.104811 · 2023 · External reference
Coexpression of fractalkine and its receptor in normal human endometrium and in endometrium from users of progestin-only contraception supports a role for fractalkine in leukocyte recruitment and endometrial remodeling
10.1210/jc.2003-031379 · 2004 · External reference
The dual role of CCR5 in the course of influenza infection: exploring treatment opportunities
10.3389/fimmu.2021.826621 · 2022 · External reference
Comparison of lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza
10.3389/fimmu.2022.834862 · 2022 · External reference
Natural killer cell recruitment to the lung during influenza A virus infection is dependent on CXCR3, CCR5, and virus exposure dose
10.3389/fimmu.2018.00781 · 2018 · External reference
CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein
10.1371/journal.pone.0029092 · 2011 · External reference
CD36 associates with CD9 and integrins on human blood platelets
10.1182/blood.v97.6.1689 · 2001 · External reference
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy
10.1126/sciimmunol.abb7800 · 2021 · External reference
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates
10.3389/fimmu.2022.861251 · 2022 · External reference
Platelet aggregation in normal pregnancy
10.1016/j.cca.2022.09.016 · 2022 · External reference
Platelet aggregation in healthy women during normal pregnancy - a longitudinal study
10.1080/09537104.2018.1492106 · 2019 · External reference
Suppressors of cytokine signalling (SOCS) in the immune system
10.1038/nri818 · 2002 · External reference
SOCS proteins, cytokine signalling and immune regulation
10.1038/nri2093 · 2007 · External reference
Suppression of cytokine signaling: the SOCS perspective
10.1016/j.cytogfr.2013.03.005 · 2013 · External reference
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
10.1016/s0092-8674(00)80048-3 · 1999 · External reference
The SOCS-1 story
10.1016/s0301-472x(99)00120-4 · 1999 · External reference
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
10.1038/ni1287 · 2006 · External reference
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy
10.1084/jem.20190185 · 2019 · External reference
Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop Preeclampsia
10.1002/art.39029 · 2015 · External reference
Local administration of regulatory T cells promotes tissue healing
10.1038/s41467-024-51353-2 · 2024 · External reference
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair
10.1016/j.immuni.2015.01.020 · 2015 · External reference
An IGF1-expressing endometrial stromal cell population is associated with human decidualization
10.1186/s12915-022-01483-0 · 2022 · External reference
Dynamic changes in uterine NK cell subset frequency and function over the menstrual cycle and pregnancy
10.3389/fimmu.2022.880438 · 2022 · External reference
Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age
10.1016/j.jcv.2011.07.005 · 2011 · External reference
New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection
10.1002/rmv.544 · 2007 · External reference
Prevention of congenital cytomegalovirus complications by maternal and neonatal treatments: a systematic review
10.1002/rmv.1814 · 2014 · External reference
The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation
10.1086/497606 · 2005 · External reference
