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References from Engineering clinically actionable nanomedicine for cancer immunometabolic ecosystem reprogramming. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting metabolic reprogramming in tumor: from mechanisms to precision immunotherapies
2025 · External reference
Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy
10.1186/s12943-024-02205-6 · 2025 · External reference
What is cancer metabolism?
10.1016/j.cell.2023.01.038 · 2023 · External reference
Chemistry of advanced nanomedicines in cancer cell metabolism regulation
2020 · External reference
Cathepsin B-Responsive dendronized-hyaluronic acid nanomedicine for simultaneous cancer theranostics
2025 · External reference
Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity
10.1039/d4cs00679h · 2025 · External reference
Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective
10.1016/j.ebiom.2024.105301 · 2024 · External reference
Metabolic fuel, molecular code: how cancer rewires metabolite-driven post-translational modifications to shape tumor fate
10.1016/j.cbs.2026.100005 · 2026 · External reference
Short-chain fatty acids in the tumor microenvironment: from molecular mechanisms to cancer therapy
10.7150/thno.119304 · 2026 · External reference
Oxygen/sulfate radicals-generating CaS2O8 nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy
10.1016/j.scib.2025.03.015 · 2025 · External reference
The cancer metabolic reprogramming and immune response
10.1186/s12943-021-01316-8 · 2021 · External reference
Nanodrug delivery systems in tumor immunotherapy: from immune activation to tumor reprogramming
10.1016/j.addr.2026.115838 · 2026 · External reference
Precise subcellular organelle targeting for boosting endogenous-stimuli-mediated tumor therapy
10.1002/adma.202101572 · 2021 · External reference
Nanomaterials in tumor immunotherapy: new strategies and challenges
10.1186/s12943-023-01797-9 · 2023 · External reference
Nanomedicine-mediated modulation of tumor metabolism for enhanced immunotherapy
10.1016/j.jconrel.2025.114587 · 2026 · External reference
Metabolic crosstalk among cancer-associated fibroblasts, adipocytes and immune cells as an immunosuppressive tumor microenvironment driver
10.1038/s12276-026-01650-1 · 2026 · External reference
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine
10.1038/s41467-024-54963-y · 2024 · External reference
Disulfidptosis nanoinducer interrupts tumor metabolic privilege to boost sustained immunotherapy
10.1021/acsnano.5c08432 · 2025 · External reference
Sonodynamic activated nanoparticles with Glut1 inhibitor and cystine-containing polymer stimulate disulfidptosis for improved immunotherapy in bladder cancer
10.1016/j.biomaterials.2025.123178 · 2025 · External reference
Nano-energy interference: a novel strategy for blunting tumor adaptation and metastasis
2024 · External reference
NIR-II imaging-guided precise photodynamic therapy for augmenting tumor-starvation therapy by glucose metabolism reprogramming interference
10.1016/j.scib.2024.02.008 · 2024 · External reference
Dual-targeted novel temozolomide nanocapsules encapsulating siPKM2 inhibit aerobic glycolysis to sensitize glioblastoma to chemotherapy
10.1002/adma.202400502 · 2024 · External reference
Peptide-appended nanosonosensitizers targeting tumor glycolysis for synergistic sonodynamic-immunometabolic therapy of spinal-metastasized tumors
10.1002/adma.202304246 · 2023 · External reference
Cell membrane inspired nano-shell enabling long-acting glucose oxidase for melanoma starvation therapy via microneedles-based percutaneous delivery
10.7150/thno.60758 · 2021 · External reference
Multienzyme-like reactivity cooperatively impairs glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways in triple-negative breast cancer for sensitized ferroptosis therapy
10.1021/acsnano.1c08664 · 2022 · External reference
A robust Au@Cu(2-x)S nanoreactor assembled by silk fibroin for enhanced intratumoral glucose depletion and redox dyshomeostasis
10.1016/j.biomaterials.2022.121970 · 2023 · External reference
Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma
10.1186/s12951-025-03646-x · 2025 · External reference
Bifunctional cascading nanozymes based on carbon dots promotes photodynamic therapy by regulating hypoxia and glycolysis
10.1021/acsnano.3c03169 · 2023 · External reference
DNA-free guanosine-based polymer nanoreactors with multienzyme activities for ferroptosis-apoptosis combined antitumor therapy
10.1021/acsnano.4c11275 · 2024 · External reference
Glucose-fueled gated nanomotors: enhancing in vivo anticancer efficacy via deep drug penetration into tumors
10.1021/acsnano.5c03799 · 2025 · External reference
Correction: acidic and hypoxic tumor microenvironment regulation by CaO(2)-loaded polydopamine nanoparticles
10.1186/s12951-023-01934-y · 2023 · External reference
Reactive oxygen species responsive nanomotors for gene edited metabolic disruption and immunotherapy
10.1038/s41467-025-59590-9 · 2025 · External reference
Tumor-selective nano-dispatcher enforced cancer immunotherapeutic effects via regulating lactate metabolism and activating toll-like receptors
2025 · External reference
Reduction-responsive RNAi nanoplatform to reprogram tumor lipid metabolism and repolarize macrophage for combination pancreatic cancer therapy
10.1016/j.biomaterials.2021.121264 · 2022 · External reference
Dendritic cell-based in situ nanovaccine for reprogramming lipid metabolism to boost tumor immunotherapy
10.1021/acsnano.3c06784 · 2023 · External reference
Fatty acid synthase (FASN) siRNA-Encapsulated-Her-2 targeted fab'-immunoliposomes for gene silencing in breast cancer cells
10.2147/ijn.s256022 · 2020 · External reference
Composite hydrogel for spatiotemporal lipid intervention of tumor milieu
10.1002/adma.202211579 · 2023 · External reference
Multi-enzyme Co-Expressed nanomedicine for anti-metastasis tumor therapy by Up-Regulating cellular oxidative stress and depleting cholesterol
10.1002/adma.202307752 · 2024 · External reference
Reprogramming dysfunctional dendritic cells by a versatile metabolism nano-intervenor for enhancing cancer combinatorial immunotherapy
10.1016/j.nantod.2022.101618 · 2022 · External reference
Blocking cholesterol metabolism with tumor-penetrable nanovesicles to improve photodynamic cancer immunotherapy
10.1002/smtd.202200898 · 2023 · External reference
Endoplasmic reticulum-targeted biomimetic nanoparticles potentiate the immunotherapy of triple-negative breast cancer by improving immunogenicity and eliminating immune resistance
10.1021/acsnano.5c19913 · 2026 · External reference
Supramolecular nanoplatforms with activable ultrasound and magnetic resonance imaging for cancer diagnosis and therapy
10.1002/smll.202412566 · 2025 · External reference
Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion
10.1039/d2tb02194c · 2022 · External reference
An immunotherapeutic hydrogel booster inhibits tumor recurrence and promotes wound healing for postoperative management of melanoma
2024 · External reference
Tumor-targeted glutamine metabolism blocker synergizes with TiO(2)-Au janus nanoparticles for enhanced sono-metabolic antitumor therapy
10.1002/adma.202418800 · 2025 · External reference
Biomimetic liposome amplifying mitochondrial damage to potential cancer radio-immunotherapy
10.1016/j.colsurfb.2024.114091 · 2024 · External reference
Mn-coordination driven glutamine and cancer stemness dual-tailored nano-herb for high-efficiency activation of dendritic cells
10.1016/j.biomaterials.2025.123399 · 2025 · External reference
CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling
10.1186/s12951-023-01979-z · 2023 · External reference
Arginine-loaded nano-calcium-phosphate-stabilized lipiodol pickering emulsions potentiates transarterial embolization-immunotherapy
10.4028/b-xdtcg5 · 2025 · External reference
Dynamic tagging to drive arginine nano-assembly to metabolically potentiate immune checkpoint blockade therapy
10.1016/j.biomaterials.2022.121938 · 2023 · External reference
Arginine supplementation targeting tumor-killing immune cells reconstructs the tumor microenvironment and enhances the antitumor immune response
10.1021/acsnano.2c05408 · 2022 · External reference
Supramolecular artificial Nano-AUTACs enable tumor-specific metabolism protein degradation for synergistic immunotherapy
10.1126/sciadv.adn8079 · 2024 · External reference
Design of a targeted dual drug delivery system for boosting the efficacy of photoimmunotherapy against melanoma proliferation and metastasis
10.1016/j.jare.2024.05.017 · 2025 · External reference
Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual disruption of pyrimidine synthesis and redox homeostasis in pancreatic ductal adenocarcinoma
10.1016/j.biomaterials.2025.123630 · 2026 · External reference
Oncolytic hydrogel enhances immune checkpoint blockade by generating in situ vaccine, remodeling tumor physical and metabolic barriers
10.1021/acsnano.5c09729 · 2025 · External reference
Dynamic adjust of non-radiative and radiative attenuation of AIE molecules reinforces NIR-II imaging mediated photothermal therapy and immunotherapy
2022 · External reference
Combining High-Z sensitized radiotherapy with CD73 blockade to boost tumor immunotherapy
10.1021/acsnano.2c11403 · 2023 · External reference
Targeting the negative feedback of adenosine-A2AR metabolic pathway by a tailored nanoinhibitor for photothermal immunotherapy
2022 · External reference
Surface d-Band modulation via biodirected mineralization enables nanoenzymes to inhibit radiation-induced T-Cell exhaustion and potentiate immunoradiotherapy
10.1021/acsnano.5c09444 · 2025 · External reference
Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy
10.1038/s41467-022-31044-6 · 2022 · External reference
Metabolic modulation of the tumor microenvironment leads to multiple checkpoint inhibition and immune cell infiltration
10.1021/acsnano.9b10037 · 2020 · External reference
Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice
10.1038/s41467-023-41016-z · 2023 · External reference
Prodrug-based combinational nanomedicine remodels lipid metabolism for reinforced ferroptosis and immune activation
10.1016/j.apsb.2025.03.016 · 2025 · External reference
Multifunctional copper-phenolic nanopills achieve comprehensive polyamines depletion to provoke enhanced pyroptosis and cuproptosis for cancer immunotherapy
10.1002/adma.202409066 · 2024 · External reference
Bionic copper-piceatannol for polyamine depletion-synergized radioimmunotherapy
10.1021/acsami.6c05874 · 2026 · External reference
Lysosome-targeted degradation of leucine-rich alpha-2 glycoprotein 1 enables chemosensitization to 5-fluorouracil in colorectal cancer
10.1016/j.jconrel.2026.114962 · 2026 · External reference
Integrating metabolic modulation and nanomedicine for cancer immunotherapy
2025 · External reference
Tumor-microenvironment-responsive nanomedicine for enhanced cancer immunotherapy
2022 · External reference
Nanomedicine in cancer therapy
10.1038/s41392-023-01536-y · 2023 · External reference
Smart nanoparticles for cancer therapy
10.1038/s41392-023-01642-x · 2023 · External reference