Research graph
References from Zearalenone exposure is associated with increased tumor burden and coordinated host-microbiota-metabolic alterations in colitis-associated colorectal cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Intestinal inflammation targets cancer-inducing activity of the microbiota
10.1126/science.1224820 · 2012 · External reference
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
10.1038/s41587-019-0209-9 · 2019 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
DADA2: high-resolution sample inference from Illumina amplicon data
10.1038/nmeth.3869 · 2016 · External reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
Bifidobacterium inhibits the progression of colorectal tumorigenesis in mice through fatty acid isomerization and gut microbiota modulation
10.1080/19490976.2025.2464945 · 2025 · External reference
Colorectal cancer
10.1016/s0140-6736(19)32319-0 · 2019 · External reference
Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer
2025 · External reference
PICRUSt2 for prediction of metagenome functions
10.1038/s41587-020-0548-6 · 2020 · External reference
Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer
10.7717/peerj.16159 · 2023 · External reference
Enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation
10.1002/ibd.21852 · 2012 · External reference
Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited 'FAO estimate' of 25%
10.1080/10408398.2019.1658570 · 2020 · External reference
ABC transporters in cancer: more than just drug efflux pumps
10.1038/nrc2789 · 2010 · External reference
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
10.1038/mi.2010.61 · 2011 · External reference
Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis
10.1016/j.toxlet.2011.07.015 · 2011 · External reference
Choline metabolism in malignant transformation
10.1038/nrc3162 · 2011 · External reference
Gut microbiota in inflammation and colorectal cancer: a potential toolbox for clinicians
10.1016/j.bpg.2024.101942 · 2024 · External reference
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
10.1016/j.ccr.2009.01.001 · 2009 · External reference
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
10.1038/nature11465 · 2012 · External reference
Sphingolipids and their metabolism in physiology and disease
10.1038/nrm.2017.107 · 2018 · External reference
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
10.1016/j.canlet.2020.06.021 · 2020 · External reference
Zearalenone-induced mechanical damage of intestinal barrier via the RhoA/ROCK signaling pathway in IPEC-J2 cells
10.3390/ijms232012550 · 2022 · External reference
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
10.1038/nm.2385 · 2011 · External reference
Sex differences in inflammation correlated with estrogen and estrogen receptor-β levels in azoxymethane/dextran sodium sulfate-induced colitis-associated colorectal cancer mice
10.1016/j.heliyon.2024.e28121 · 2024 · External reference
Solvent precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads
10.1021/acs.analchem.1c04200 · 2022 · External reference
The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model
10.1038/s41598-019-48974-9 · 2019 · External reference
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway
10.1042/bsr20212418 · 2022 · External reference
Bifidobacterium lactis inhibits NF-κB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice
10.1002/ibd.21262 · 2010 · External reference
A mouse model of Staphylococcus aureus small intestinal infection
10.1099/jmm.0.001163 · 2020 · External reference
Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion
10.1016/j.biopha.2023.114973 · 2023 · External reference
MUC1-C drives stemness in progression of colitis to colorectal cancer
10.1172/jci.insight.137112 · 2020 · External reference
Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro
10.1289/ehp.1104689 · 2012 · External reference
Mycotoxin: its impact on gut health and microbiota
10.3389/fcimb.2018.00060 · 2018 · External reference
Effect of zearalenone on the jejunum of weaned gilts through the Epac1/Rap1/JNK pathway
10.1093/jas/skae208 · 2024 · External reference
Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
10.1038/s41598-021-86788-w · 2021 · External reference
Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches
10.1016/j.csbj.2023.02.048 · 2023 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Intestinal PPARα protects against colon carcinogenesis via regulation of methyltransferases DNMT1 and PRMT6
10.1053/j.gastro.2019.05.057 · 2019 · External reference
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
10.1016/j.celrep.2021.109212 · 2021 · External reference
Colorectal carcinoma: a general overview and future perspectives in colorectal cancer
10.3390/ijms18010197 · 2017 · External reference
Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN
10.1136/gutjnl-2022-327736 · 2023 · External reference
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
10.1038/nprot.2007.279 · 2007 · External reference
Design of 16S rRNA gene primers for 454 pyrosequencing of the human foregut microbiome
10.3748/wjg.v16.i33.4135 · 2010 · External reference
Changes in lipids composition and metabolism in colorectal cancer: a review
10.1186/s12944-019-0977-8 · 2019 · External reference
Occurrence and toxicity of a fusarium mycotoxin, zearalenone
10.1080/10408398.2019.1655388 · 2020 · External reference
Impact of mycotoxins on the intestine: are mucus and microbiota new targets?
10.1080/10937404.2017.1326071 · 2017 · External reference
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
10.1038/ncomms14128 · 2017 · External reference
Understanding dysbiosis and resilience in the human gut microbiome: biomarkers, interventions, and challenges
10.3389/fmicb.2025.1559521 · 2025 · External reference
Estrogen receptor-β protects against colitis-associated neoplasia in mice
10.1002/ijc.27578 · 2012 · External reference
The inflammatory pathogenesis of colorectal cancer
10.1038/s41577-021-00534-x · 2021 · External reference
Murine model for colitis-associated cancer of the colon
10.1007/978-1-4939-3661-8_14 · 2016 · External reference
Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression
10.1016/j.toxlet.2014.10.022 · 2015 · External reference
The gut microbial metabolite formate exacerbates colorectal cancer progression
10.1038/s42255-022-00558-0 · 2022 · External reference
Role of glutathione in cancer progression and chemoresistance
10.1155/2013/972913 · 2013 · External reference
Quantitative microbiome profiling links gut community variation to microbial load
10.1038/nature24460 · 2017 · External reference
Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer
10.1038/s41419-020-02959-z · 2020 · External reference
Eicosanoids and cancer
10.1038/nrc2809 · 2010 · External reference
Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth
10.1073/pnas.1324233111 · 2014 · External reference
Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice
10.1007/s00253-020-10621-z · 2020 · External reference
The microbial landscape of colorectal cancer
10.1038/s41579-023-00973-4 · 2024 · External reference
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
10.1038/s41575-019-0209-8 · 2019 · External reference
Molecular pathogenesis of colitis-associated colorectal cancer: immunity, genetics, and intestinal microecology
10.1093/ibd/izad081 · 2023 · External reference
Zearalenone and its masked forms in cereals and cereal-derived products: a review of the characteristics, incidence, and fate in food processing
10.3390/jof8090976 · 2022 · External reference
Manipulation of the gut microbiota reveals role in colon tumorigenesis
10.1128/msphere.00001-15 · 2016 · External reference
Integrated network toxicology and transcriptomics reveal NF-κB signaling as a key mediator of TDCPP-induced inflammatory responses in human microglia
10.1016/j.envint.2026.110373 · 2026 · External reference
Zearalenone promotes cell proliferation or causes cell death?
10.3390/toxins10050184 · 2018 · External reference
Bifidobacterium lactis inhibits NF-κB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice
10.1002/ibd.21262 · ExternalCitation · doi-reference
Enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation
10.1002/ibd.21852 · ExternalCitation · doi-reference
Estrogen receptor-β protects against colitis-associated neoplasia in mice
10.1002/ijc.27578 · ExternalCitation · doi-reference
Murine model for colitis-associated cancer of the colon
10.1007/978-1-4939-3661-8_14 · ExternalCitation · doi-reference
Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice
10.1007/s00253-020-10621-z · ExternalCitation · doi-reference
Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion
10.1016/j.biopha.2023.114973 · ExternalCitation · doi-reference
Gut microbiota in inflammation and colorectal cancer: a potential toolbox for clinicians
10.1016/j.bpg.2024.101942 · ExternalCitation · doi-reference
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
10.1016/j.canlet.2020.06.021 · ExternalCitation · doi-reference
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
10.1016/j.ccr.2009.01.001 · ExternalCitation · doi-reference
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
10.1016/j.celrep.2021.109212 · ExternalCitation · doi-reference
Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches
10.1016/j.csbj.2023.02.048 · ExternalCitation · doi-reference
Integrated network toxicology and transcriptomics reveal NF-κB signaling as a key mediator of TDCPP-induced inflammatory responses in human microglia
10.1016/j.envint.2026.110373 · ExternalCitation · doi-reference
Sex differences in inflammation correlated with estrogen and estrogen receptor-β levels in azoxymethane/dextran sodium sulfate-induced colitis-associated colorectal cancer mice
10.1016/j.heliyon.2024.e28121 · ExternalCitation · doi-reference
Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis
10.1016/j.toxlet.2011.07.015 · ExternalCitation · doi-reference
Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression
10.1016/j.toxlet.2014.10.022 · ExternalCitation · doi-reference
Colorectal cancer
10.1016/s0140-6736(19)32319-0 · ExternalCitation · doi-reference
Solvent precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads
10.1021/acs.analchem.1c04200 · ExternalCitation · doi-reference
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
10.1038/mi.2010.61 · ExternalCitation · doi-reference
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
10.1038/nature11465 · ExternalCitation · doi-reference
Quantitative microbiome profiling links gut community variation to microbial load
10.1038/nature24460 · ExternalCitation · doi-reference
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
10.1038/ncomms14128 · ExternalCitation · doi-reference
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
10.1038/nm.2385 · ExternalCitation · doi-reference
DADA2: high-resolution sample inference from Illumina amplicon data
10.1038/nmeth.3869 · ExternalCitation · doi-reference
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
10.1038/nprot.2007.279 · ExternalCitation · doi-reference
ABC transporters in cancer: more than just drug efflux pumps
10.1038/nrc2789 · ExternalCitation · doi-reference
Eicosanoids and cancer
10.1038/nrc2809 · ExternalCitation · doi-reference
Choline metabolism in malignant transformation
10.1038/nrc3162 · ExternalCitation · doi-reference
Sphingolipids and their metabolism in physiology and disease
10.1038/nrm.2017.107 · ExternalCitation · doi-reference
Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer
10.1038/s41419-020-02959-z · ExternalCitation · doi-reference
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
10.1038/s41575-019-0209-8 · ExternalCitation · doi-reference
The inflammatory pathogenesis of colorectal cancer
10.1038/s41577-021-00534-x · ExternalCitation · doi-reference
The microbial landscape of colorectal cancer
10.1038/s41579-023-00973-4 · ExternalCitation · doi-reference
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
10.1038/s41587-019-0201-4 · ExternalCitation · doi-reference
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
10.1038/s41587-019-0209-9 · ExternalCitation · doi-reference
PICRUSt2 for prediction of metagenome functions
10.1038/s41587-020-0548-6 · ExternalCitation · doi-reference
The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model
10.1038/s41598-019-48974-9 · ExternalCitation · doi-reference
Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
10.1038/s41598-021-86788-w · ExternalCitation · doi-reference
The gut microbial metabolite formate exacerbates colorectal cancer progression
10.1038/s42255-022-00558-0 · ExternalCitation · doi-reference
Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway
10.1042/bsr20212418 · ExternalCitation · doi-reference
Intestinal PPARα protects against colon carcinogenesis via regulation of methyltransferases DNMT1 and PRMT6
10.1053/j.gastro.2019.05.057 · ExternalCitation · doi-reference
Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth
10.1073/pnas.1324233111 · ExternalCitation · doi-reference
Occurrence and toxicity of a fusarium mycotoxin, zearalenone
10.1080/10408398.2019.1655388 · ExternalCitation · doi-reference
Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited 'FAO estimate' of 25%
10.1080/10408398.2019.1658570 · ExternalCitation · doi-reference
Impact of mycotoxins on the intestine: are mucus and microbiota new targets?
10.1080/10937404.2017.1326071 · ExternalCitation · doi-reference
Bifidobacterium inhibits the progression of colorectal tumorigenesis in mice through fatty acid isomerization and gut microbiota modulation
10.1080/19490976.2025.2464945 · ExternalCitation · doi-reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · ExternalCitation · doi-reference
Molecular pathogenesis of colitis-associated colorectal cancer: immunity, genetics, and intestinal microecology
10.1093/ibd/izad081 · ExternalCitation · doi-reference
Effect of zearalenone on the jejunum of weaned gilts through the Epac1/Rap1/JNK pathway
10.1093/jas/skae208 · ExternalCitation · doi-reference
A mouse model of Staphylococcus aureus small intestinal infection
10.1099/jmm.0.001163 · ExternalCitation · doi-reference
Intestinal inflammation targets cancer-inducing activity of the microbiota
10.1126/science.1224820 · ExternalCitation · doi-reference
Manipulation of the gut microbiota reveals role in colon tumorigenesis
10.1128/msphere.00001-15 · ExternalCitation · doi-reference
Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN
10.1136/gutjnl-2022-327736 · ExternalCitation · doi-reference
Role of glutathione in cancer progression and chemoresistance
10.1155/2013/972913 · ExternalCitation · doi-reference
MUC1-C drives stemness in progression of colitis to colorectal cancer
10.1172/jci.insight.137112 · ExternalCitation · doi-reference
Changes in lipids composition and metabolism in colorectal cancer: a review
10.1186/s12944-019-0977-8 · ExternalCitation · doi-reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · ExternalCitation · doi-reference
Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro
10.1289/ehp.1104689 · ExternalCitation · doi-reference
Mycotoxin: its impact on gut health and microbiota
10.3389/fcimb.2018.00060 · ExternalCitation · doi-reference
Understanding dysbiosis and resilience in the human gut microbiome: biomarkers, interventions, and challenges
10.3389/fmicb.2025.1559521 · ExternalCitation · doi-reference
Colorectal carcinoma: a general overview and future perspectives in colorectal cancer
10.3390/ijms18010197 · ExternalCitation · doi-reference
Zearalenone-induced mechanical damage of intestinal barrier via the RhoA/ROCK signaling pathway in IPEC-J2 cells
10.3390/ijms232012550 · ExternalCitation · doi-reference
Zearalenone and its masked forms in cereals and cereal-derived products: a review of the characteristics, incidence, and fate in food processing
10.3390/jof8090976 · ExternalCitation · doi-reference
Zearalenone promotes cell proliferation or causes cell death?
10.3390/toxins10050184 · ExternalCitation · doi-reference
Design of 16S rRNA gene primers for 454 pyrosequencing of the human foregut microbiome
10.3748/wjg.v16.i33.4135 · ExternalCitation · doi-reference
Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer
10.7717/peerj.16159 · ExternalCitation · doi-reference
