Research graph
References from SIRT1/PGC-1α-regulated mitochondrial biogenesis is involved in T-2 toxin-induced chondrocyte injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage
10.1016/j.jbc.2021.101224 · 2021 · External reference
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
10.1038/nature07813 · 2009 · External reference
Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy
10.1016/j.ecoenv.2024.116503 · 2024 · External reference
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
10.1016/j.devcel.2008.02.004 · 2008 · External reference
Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells
2025 · External reference
Recent development of mitochondrial metabolism and dysfunction in osteoarthritis
2025 · External reference
T-2 Toxin-the most toxic trichothecene mycotoxin: metabolism, toxicity, and decontamination strategies
10.3390/molecules26226868 · 2021 · External reference
Immune response of large yellow croaker Larimichthys crocea towards a recombinant vaccine candidate targeting the parasitic ciliate Cryptocaryon irritans
2023 · External reference
Prevalence of T-2 Toxin in the Food and Beverages of Residents Living in a Kashin-Beck-Disease Area of Qamdo, Tibet
10.3390/nu16101449 · 2024 · External reference
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
10.1016/j.cell.2006.11.013 · 2006 · External reference
The effects of T-2 toxin on the prevalence and development of Kashin-Beck disease in China: a meta-analysis and systematic review
10.1039/c5tx00377f · 2016 · External reference
T-2 toxin exacerbates chondrocyte extracellular matrix degradation potentially through YAP/NLRP3/GSDMD-mediated pyroptosis
2026 · External reference
The TFAM-OGG1 axis mediates T-2 toxin-induced chondrocyte mitochondrial dysfunction and cartilage degeneration
10.1016/j.fct.2026.116161 · 2026 · External reference
The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease
10.1080/15384101.2020.1807665 · 2020 · External reference
Mitochondrial biogenesis in neurodegeneration
10.1002/jnr.24042 · 2017 · External reference
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway
10.1186/s13018-022-03306-y · 2022 · External reference
Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism
10.1016/j.phrs.2024.107141 · 2024 · External reference
Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?
10.2174/138945010791011956 · 2010 · External reference
The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
10.3390/biomedicines10071477 · 2022 · External reference
The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis
10.1371/journal.pone.0108394 · 2014 · External reference
LncRNA XIST inhibits mitophagy and increases mitochondrial dysfunction by promoting BNIP3 promoter methylation to facilitate the progression of KBD
10.1016/j.molimm.2025.03.016 · 2025 · External reference
Hesperetin Attenuates T-2 Toxin-Induced Chondrocyte Injury by Inhibiting the p38 MAPK Signaling Pathway
10.3390/nu16183107 · 2024 · External reference
Betulinic acid ameliorates the T-2 toxin-triggered intestinal impairment in mice by inhibiting inflammation and mucosal barrier dysfunction through the NF-κB signaling pathway
10.3390/toxins12120794 · 2020 · External reference
The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update
10.1023/a:1022945107762 · 2003 · External reference
KL: Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: a possible link between hyperhomocysteinemia and osteoarthritis
10.1016/j.redox.2018.01.010 · 2018 · External reference
Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage
10.1111/jcmm.13858 · 2018 · External reference
Resveratrol protects mitochondrial quantity by activating SIRT1/PGC-1α expression during ovarian hypoxia
10.1002/rmb2.12323 · 2020 · External reference
Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
10.1007/s00204-010-0579-8 · 2010 · External reference
The role and intervention of mitochondrial metabolism in osteoarthritis
10.1007/s11010-023-04818-9 · 2024 · External reference
The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets
10.1186/s13075-022-02983-8 · 2022 · External reference
T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province
10.1007/s12011-012-9469-7 · 2012 · External reference
PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
2023 · External reference
Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α
10.1002/art.39182 · 2015 · External reference
Resveratrol improved mitochondrial biogenesis by activating SIRT1/PGC-1α signal pathway in SAP
2024 · External reference
T-2 toxin-induced oxidative stress leads to imbalance of mitochondrial fission and fusion to activate cellular apoptosis in the human liver 7702 cell line
10.3390/toxins12010043 · 2020 · External reference
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease
10.1016/j.ecoenv.2024.117148 · 2024 · External reference
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway
10.1016/j.jhazmat.2023.133090 · 2024 · External reference
Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc(-)/GSH/GPX4 axis
10.1016/j.ecoenv.2024.117569 · 2025 · External reference
T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification
2024 · External reference
Reduced expression of α2 integrin is involved in T-2 toxin-induced matrix degradation in C28/I2 cells and cartilages from rats administrated with T-2 toxin
10.1016/j.toxicon.2020.10.016 · 2020 · External reference
Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation
2026 · External reference
T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway
10.1177/09603271221075555 · 2022 · External reference
SIRT1 regulates mitochondrial damage in N2a cells treated with the prion protein fragment 106-126 via PGC-1α-TFAM-mediated mitochondrial biogenesis
10.3390/ijms25179707 · 2024 · External reference
Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α
10.1002/art.39182 · ExternalCitation · doi-reference
Mitochondrial biogenesis in neurodegeneration
10.1002/jnr.24042 · ExternalCitation · doi-reference
Resveratrol protects mitochondrial quantity by activating SIRT1/PGC-1α expression during ovarian hypoxia
10.1002/rmb2.12323 · ExternalCitation · doi-reference
Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
10.1007/s00204-010-0579-8 · ExternalCitation · doi-reference
The role and intervention of mitochondrial metabolism in osteoarthritis
10.1007/s11010-023-04818-9 · ExternalCitation · doi-reference
T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province
10.1007/s12011-012-9469-7 · ExternalCitation · doi-reference
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
10.1016/j.cell.2006.11.013 · ExternalCitation · doi-reference
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
10.1016/j.devcel.2008.02.004 · ExternalCitation · doi-reference
Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy
10.1016/j.ecoenv.2024.116503 · ExternalCitation · doi-reference
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease
10.1016/j.ecoenv.2024.117148 · ExternalCitation · doi-reference
Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc(-)/GSH/GPX4 axis
10.1016/j.ecoenv.2024.117569 · ExternalCitation · doi-reference
The TFAM-OGG1 axis mediates T-2 toxin-induced chondrocyte mitochondrial dysfunction and cartilage degeneration
10.1016/j.fct.2026.116161 · ExternalCitation · doi-reference
Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage
10.1016/j.jbc.2021.101224 · ExternalCitation · doi-reference
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway
10.1016/j.jhazmat.2023.133090 · ExternalCitation · doi-reference
LncRNA XIST inhibits mitophagy and increases mitochondrial dysfunction by promoting BNIP3 promoter methylation to facilitate the progression of KBD
10.1016/j.molimm.2025.03.016 · ExternalCitation · doi-reference
Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism
10.1016/j.phrs.2024.107141 · ExternalCitation · doi-reference
KL: Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: a possible link between hyperhomocysteinemia and osteoarthritis
10.1016/j.redox.2018.01.010 · ExternalCitation · doi-reference
Reduced expression of α2 integrin is involved in T-2 toxin-induced matrix degradation in C28/I2 cells and cartilages from rats administrated with T-2 toxin
10.1016/j.toxicon.2020.10.016 · ExternalCitation · doi-reference
The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update
10.1023/a:1022945107762 · ExternalCitation · doi-reference
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
10.1038/nature07813 · ExternalCitation · doi-reference
The effects of T-2 toxin on the prevalence and development of Kashin-Beck disease in China: a meta-analysis and systematic review
10.1039/c5tx00377f · ExternalCitation · doi-reference
The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease
10.1080/15384101.2020.1807665 · ExternalCitation · doi-reference
Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage
10.1111/jcmm.13858 · ExternalCitation · doi-reference
T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway
10.1177/09603271221075555 · ExternalCitation · doi-reference
Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway
10.1186/s13018-022-03306-y · ExternalCitation · doi-reference
The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets
10.1186/s13075-022-02983-8 · ExternalCitation · doi-reference
The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis
10.1371/journal.pone.0108394 · ExternalCitation · doi-reference
Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?
10.2174/138945010791011956 · ExternalCitation · doi-reference
The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
10.3390/biomedicines10071477 · ExternalCitation · doi-reference
SIRT1 regulates mitochondrial damage in N2a cells treated with the prion protein fragment 106-126 via PGC-1α-TFAM-mediated mitochondrial biogenesis
10.3390/ijms25179707 · ExternalCitation · doi-reference
T-2 Toxin-the most toxic trichothecene mycotoxin: metabolism, toxicity, and decontamination strategies
10.3390/molecules26226868 · ExternalCitation · doi-reference
Prevalence of T-2 Toxin in the Food and Beverages of Residents Living in a Kashin-Beck-Disease Area of Qamdo, Tibet
10.3390/nu16101449 · ExternalCitation · doi-reference
Hesperetin Attenuates T-2 Toxin-Induced Chondrocyte Injury by Inhibiting the p38 MAPK Signaling Pathway
10.3390/nu16183107 · ExternalCitation · doi-reference
T-2 toxin-induced oxidative stress leads to imbalance of mitochondrial fission and fusion to activate cellular apoptosis in the human liver 7702 cell line
10.3390/toxins12010043 · ExternalCitation · doi-reference
Betulinic acid ameliorates the T-2 toxin-triggered intestinal impairment in mice by inhibiting inflammation and mucosal barrier dysfunction through the NF-κB signaling pathway
10.3390/toxins12120794 · ExternalCitation · doi-reference
