Research graph
References from Prenatal PM2.5 exposure disrupts cortical excitatory/inhibitory balance in male offspring by suppressing Lhx8-regulated cholinergic homeostasis and cell adhesion. Local targets link to admitted publications; unresolved targets remain external evidence.
Neural cell adhesion molecule regulates cell contact-mediated changes in choline acetyltransferase activity of embryonic chick sympathetic neurons
10.1083/jcb.106.2.479 · 1988 · External reference
Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes
10.1038/s41598-019-40670-y · 2019 · External reference
Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
10.1210/en.2011-1699 · 2012 · External reference
Identification and localization of multiple classic cadherins in developing rat limbic system
10.1016/s0306-4522(02)00375-5 · 2002 · External reference
Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice
10.1016/j.neuro.2017.10.007 · 2018 · External reference
Acetylcholine, GABA and neuronal networks: a working hypothesis for compensations in the dystrophic brain
10.1016/j.brainresbull.2014.10.004 · 2015 · External reference
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders
2020 · External reference
Cell adhesion molecules: signalling functions at the synapse
10.1038/nrn2075 · 2007 · External reference
Gene network analysis identifies dysregulated pathways in an autism spectrum disorder caused by mutations in Transcription Factor 4
10.1038/s41598-025-89334-0 · 2025 · External reference
Modulation of synaptic transmission and plasticity by cell adhesion and repulsion molecules
10.1017/s1740925x09990111 · 2008 · External reference
Particulate matter exposure and attention-deficit/hyperactivity disorder in children: a systematic review of epidemiological studies
2019 · External reference
Cadherin combinations recruit dendrites of distinct retinal neurons to a shared interneuronal scaffold
10.1016/j.neuron.2018.08.019 · 2018 · External reference
Autism spectrum disorder and air pollution: a systematic review and meta-analysis
2021 · External reference
Risk of exposure to air pollution among British children with and without intellectual disabilities
10.1111/jir.12561 · 2019 · External reference
Role of CD36 in central nervous system diseases
10.4103/1673-5374.380821 · 2024 · External reference
Longitudinal association between air pollution exposure at school and cognitive development in school children over a period of 3.5 years
10.1016/j.envres.2017.08.031 · 2017 · External reference
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease
2023 · External reference
Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development
10.1242/dev.125.11.2063 · 1998 · External reference
Prenatal PM(2.5) exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis
10.1186/s12989-023-00520-2 · 2023 · External reference
Transcriptome sequencing analysis reveals a potential role of lncRNA NONMMUT058932.2 and NONMMUT029203.2 in abnormal myelin development of male offspring following prenatal PM(2.5) exposure
2023 · External reference
Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor
10.1074/jbc.m705110200 · 2008 · External reference
Gender differences in fetal growth of newborns exposed prenatally to airborne fine particulate matter
10.1016/j.envres.2009.01.009 · 2009 · External reference
The Lancet Commission on pollution and health
10.1016/s0140-6736(17)32345-0 · 2018 · External reference
Neural transcription factors: from embryos to neural stem cells
10.14348/molcells.2014.0227 · 2014 · External reference
Conditional loss of Hoxa5 function early after birth impacts on expression of genes with synaptic function
10.3389/fnmol.2017.00369 · 2017 · External reference
L3/Lhx8 is involved in the determination of cholinergic or GABAergic cell fate
10.1111/j.1471-4159.2005.03261.x · 2005 · External reference
L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells
10.1038/sj.cdd.4402106 · 2007 · External reference
To stick or not to stick: the multiple roles of cell adhesion molecules in neural circuit assembly
2022 · External reference
The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons
10.1111/j.0953-816x.2004.03415.x · 2004 · External reference
Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
10.1016/j.neuron.2015.07.033 · 2015 · External reference
Neurodevelopmental disorders: from genetics to functional pathways
10.1016/j.tins.2020.05.004 · 2020 · External reference
Prenatal exposure to air pollution during the early and middle stages of pregnancy is associated with adverse neurodevelopmental outcomes at ages 1–3 years
10.1186/s12940-024-01132-9 · 2024 · External reference
Passage of exogeneous fine particles from the lung into the brain in humans and animals
2022 · External reference
Potential cytotoxicity of PM2.5-bound PAHs and toxic metals collected from areas with different traffic densities on human lung epithelial cells (A549)
10.1007/s40201-021-00724-8 · 2021 · External reference
Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABA(A) receptors
10.1523/jneurosci.4476-11.2011 · 2011 · External reference
Model of autism: increased ratio of excitation/inhibition in key neural systems
10.1034/j.1601-183x.2003.00037.x · 2003 · External reference
Loss of CNTNAP2 alters human cortical excitatory neuron differentiation and neural network development
10.1016/j.biopsych.2023.03.014 · 2023 · External reference
Synaptic neurexin complexes: a molecular code for the logic of neural circuits
10.1016/j.cell.2017.10.024 · 2017 · External reference
Neural cell adhesion molecule ablation in mice causes hippocampal dysplasia and loss of septal cholinergic neurons
10.1002/cne.22636 · 2011 · External reference
GABA(A) receptors, gephyrin and homeostatic synaptic plasticity
10.1113/jphysiol.2009.178517 · 2010 · External reference
Common genetic variants on 5p14.1 associate with autism spectrum disorders
10.1038/nature07999 · 2009 · External reference
Neighborhood environmental exposures and incidence of attention deficit/hyperactivity disorder: a population-based cohort study
2022 · External reference
Presynaptic nicotinic alpha7 and non-alpha7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action
2011 · External reference
Maternal exposure to atmospheric PM(2.5) and fetal brain development: associations with BAI1 methylation and thyroid hormones
2022 · External reference
CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment
10.1038/s41467-024-49684-1 · 2024 · External reference
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
10.1073/pnas.1537759100 · 2003 · External reference
Lhx6 and Lhx8: cell fate regulators and beyond
10.1096/fj.14-267500 · 2015 · External reference
Lhx8 mediated Wnt and TGFbeta pathways in tooth development and regeneration
10.1016/j.biomaterials.2015.06.004 · 2015 · External reference
