Research graph
References from 1,2-DCE exposure induces autophagosome accumulation and neuronal death via the ROS-JNK/c-Fos/c-Jun/FoxO1/FoxO3a axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Mitochondrial response and resilience to anthropogenic chemicals during embryonic development
10.1016/j.cbpc.2020.108759 · 2020 · External reference
Neuropsychological effects of ethylene dichloride exposure
10.1016/s0161-813x(03)00027-5 · 2003 · External reference
JNK Pathway in CNS Pathologies
10.3390/ijms22083883 · 2021 · External reference
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma
10.1016/j.freeradbiomed.2024.04.242 · 2024 · External reference
Lanthanum chloride induces autophagy in rat hippocampus through ROS-mediated JNK and AKT/mTOR signaling pathways
10.1039/c8mt00295a · 2019 · External reference
1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo
10.1016/j.toxlet.2020.01.004 · 2020 · External reference
Disturbance of glutamate metabolism and inhibition of CaM-CaMKII-CREB signaling pathway in the hippocampus of mice induced by 1,2-dichloroethane exposure
10.1016/j.envpol.2022.119813 · 2022 · External reference
Clinical research progress on acute 1,2-dichloroethane poisoning
2015 · External reference
Neuroprotective role of chloroquine via modulation of autophagy and neuroinflammation in MPTP-induced Parkinson's disease
10.1007/s10787-023-01141-z · 2023 · External reference
Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology
10.3390/biom10020320 · 2020 · External reference
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)
10.1080/15548627.2020.1797280 · 2021 · External reference
Autophagy in major human diseases
10.15252/embj.2021108863 · 2021 · External reference
1,2-Dichloroethane induces apoptosis in the cerebral cortexes of NIH Swiss mice through microRNA-182-5p targeting phospholipase D1 via a mitochondria-dependent pathway
10.1016/j.taap.2021.115728 · 2021 · External reference
Autophagy flux in bladder cancer: Cell death crosstalk, drug and nanotherapeutics
10.1016/j.canlet.2024.216867 · 2024 · External reference
Autophagy: regulator of cell death
10.1038/s41419-023-06154-8 · 2023 · External reference
Decoding Parkinson's disease: the interplay of cell death pathways, oxidative stress, and therapeutic innovations
10.1016/j.redox.2025.103787 · 2025 · External reference
Mitochondrial dysfunction in neurodegenerative diseases: mechanisms and corresponding therapeutic strategies
10.3390/biomedicines13020327 · 2025 · External reference
Mitochondrial toxicity
10.1093/toxsci/kfy008 · 2018 · External reference
Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases
10.1038/s41580-024-00757-5 · 2024 · External reference
Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis
2016 · External reference
Calcium and mitochondria in the regulation of cell death
10.1016/j.bbrc.2015.01.137 · 2015 · External reference
mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells
10.1002/tox.22216 · 2017 · External reference
Hallmarks of environmental insults
10.1016/j.cell.2021.01.043 · 2021 · External reference
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
10.1158/0008-5472.can-09-3537 · 2010 · External reference
ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence
10.1080/15548627.2024.2353548 · 2024 · External reference
1,2-Dichloroethane causes anxiety and cognitive dysfunction in mice by disturbing GABA metabolism and inhibiting the cAMP-PKA-CREB signaling pathway
10.1016/j.ecoenv.2024.116464 · 2024 · External reference
Synaptic architecture of a memory engram in the mouse hippocampus
10.1126/science.ado8316 · 2025 · External reference
Tumor necrosis factor signaling
10.1038/sj.cdd.4401189 · 2003 · External reference
ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
10.1007/s00204-023-03476-6 · 2023 · External reference
Health status investigation of workers exposed to dichloroethane in a Chemical enterprise
2010 · External reference
Effects of subacute exposure to 1,2-dichloroethane on mouse behavior and the related mechanisms
10.1177/0960327112470270 · 2013 · External reference
Roles of aquaporins and matrix metalloproteinases in mouse brain edema formation induced by subacute exposure to 1,2-dichloroethane
10.1016/j.ntt.2014.06.005 · 2014 · External reference
Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation
10.1016/j.fct.2021.112550 · 2021 · External reference
Ubiquitin, autophagy and neurodegenerative diseases
10.3390/cells9092022 · 2020 · External reference
Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity
10.1007/s43188-023-00197-x · 2023 · External reference
Unresolved reference
2016 · External reference
Hsp90 inhibition attenuates the 1, 2-Dichloroethane-induced cognitive impairment by blocking NLRP3 inflammasome activation in mice
2025 · External reference
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
2017 · External reference
The effect of 1,2-dichloroethane on the learning and memory of NIH mice
2018 · External reference
JNK Activation contributes to oxidative stress-induced parthanatos in glioma cells via increase of intracellular ROS production
10.1007/s12035-016-9926-y · 2017 · External reference
MicroRNA-29b-3p aggravates 1,2-dichloroethane-induced brain edema by targeting aquaporin 4 in Sprague-Dawley rats and CD-1 mice
10.1016/j.toxlet.2019.11.011 · 2020 · External reference
1,2-Dichloroethane induces cortex demyelination by depressing myelin basic protein via inhibiting aquaporin 4 in mice
10.1016/j.ecoenv.2022.113180 · 2022 · External reference
Cadmium induces apoptosis of mouse spermatocytes through JNK activation and disruption of autophagic flux
10.1016/j.ecoenv.2023.115505 · 2023 · External reference
MAPK/JNK signalling: a potential autophagy regulation pathway
10.1042/bsr20140141 · 2015 · External reference
