Research graph
References from Advancing component-based mixture risk assessment using new approach methodologies: An environmental case study. Local targets link to admitted publications; unresolved targets remain external evidence.
Alternative oxidase of plants mitochondria is related with increased resistance of tomato mtDNA to the difenoconazole exposure
10.1016/j.plgene.2024.100475 · 2024 · External reference
Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment
10.1002/etc.34 · 2010 · External reference
Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening
10.1021/tx4001754 · 2013 · External reference
Metabolism and signaling of plant mitochondria in adaptation to environmental stresses
10.3390/ijms231911176 · 2022 · External reference
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories
2022 · External reference
An “EAR” on environmental surveillance and monitoring: a case study on the use of exposure–activity ratios (EARs) to prioritize sites, chemicals, and bioactivities of concern in Great Lakes Waters
10.1021/acs.est.7b01613 · 2017 · External reference
Mixed-chemical exposure and predicted effects potential in wadeable southeastern USA streams
10.1016/j.scitotenv.2018.11.186 · 2019 · External reference
The Oxidative Phosphorylation system of the mitochondria in plants
10.1016/j.mito.2020.04.007 · 2020 · External reference
Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network
2023 · External reference
Quantitative adverse outcome pathways and their application to predictive toxicology
10.1021/acs.est.6b06230 · 2017 · External reference
Prioritizing chemicals of ecological concern in Great Lakes tributaries using high-throughput screening data and adverse outcome pathways
10.1016/j.scitotenv.2019.05.457 · 2019 · External reference
Uptake of pesticides from water by curly waterweed Lagarosiphon major and lesser duckweed Lemna minor
10.1002/ps.1389 · 2007 · External reference
Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)
2022 · External reference
Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
2018 · External reference
Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals
10.2903/j.efsa.2019.5634 · 2019 · External reference
Unresolved reference
2021 · External reference
The advantages of linear concentration-response curves for in vitro bioassays with environmental samples
10.1002/etc.4178 · 2018 · External reference
Tracking complex mixtures of chemicals in our changing environment
10.1126/science.aay6636 · 2020 · External reference
Development of a Roadmap for Action on New Approach Methodologies in Risk Assessment
2022 · External reference
Unresolved reference
2023 · External reference
Methodology for indicator on pesticides in rivers, lakes and groundwater. Methodology for pesticides in water indicator 1 Methodology for indicator on pesticides in rivers, lakes and groundwater (Version: 8.0). UBA-DE, TC Vode
2025 · External reference
The ToxCast pipeline: updates to curve-fitting approaches and database structure
10.3389/ftox.2023.1275980 · 2023 · External reference
Unresolved reference
External reference
Construction of an In Silico Structural Profiling Tool Facilitating Mechanistically Grounded Classification of Aquatic Toxicants
10.1021/acs.est.2c03736 · 2022 · External reference
Modeling Exposure in the Tox21 in Vitro Bioassays
10.1021/acs.chemrestox.7b00023 · 2017 · External reference
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome
10.2741/2128 · 2007 · External reference
Chemical Informatics Functionality in R
2007 · External reference
Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries
10.1093/toxsci/kfaa059 · 2020 · External reference
Strategies for Transferring Mixtures of Organic Contaminants from Aquatic Environments into Bioassays
10.1021/acs.est.5b04687 · 2016 · External reference
Advancing the quantitative understanding of adverse outcome pathways: current status, methodologies, and future directions
10.1093/etojnl/vgae063 · 2025 · External reference
Bayesian Networks in Environmental Risk Assessment: A Review
10.1002/ieam.4332 · 2021 · External reference
The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death
10.1016/j.tiv.2015.02.011 · 2015 · External reference
TK-TD Model of Lemna Populations (MoLePo), Version 1 - TRACE documentation
2018 · External reference
Curated mode-of-action data and effect concentrations for chemicals relevant for the aquatic environment
10.1038/s41597-023-02904-7 · 2024 · External reference
MitoTox: a comprehensive mitochondrial toxicity database
10.1186/s12859-021-04285-3 · 2021 · External reference
Prioritizing Pesticides of Potential Concern and Identifying Potential Mixture Effects in Great Lakes Tributaries Using Passive Samplers
10.1002/etc.5491 · 2023 · External reference
Probabilistic risk assessment - the keystone for the future of toxicology
2022 · External reference
A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe
10.1007/s00204-022-03435-7 · 2023 · External reference
Mitochondria as a Target of Environmental Toxicants
10.1093/toxsci/kft102 · 2013 · External reference
New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
10.1002/etc.5584 · 2023 · External reference
Robust risk assessments require probabilistic approaches
10.1002/ieam.4660 · 2022 · External reference
Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling
10.1002/ieam.4348 · 2021 · External reference
Pesticides in European rivers, lakes and groundwaters – Data assessment. ETC/ICM Tech Rep 1/2020 Eur Top Cent Inland
2020 · External reference
Plant mitochondria – past, present and future
10.1111/tpj.15495 · 2021 · External reference
Unresolved reference
External reference
vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity
10.1016/j.taap.2023.116600 · 2023 · External reference
Unresolved reference
2006 · External reference
Pesticide Prioritization by Potential Biological Effects in Tributaries of the Laurentian Great Lakes
10.1002/etc.5522 · 2023 · External reference
The ECOTOXicology Knowledgebase: A Curated Database of Ecologically Relevant Toxicity Tests to Support Environmental Research and Risk Assessment
10.1002/etc.5324 · 2022 · External reference
Navigating through the minefield of read-across tools: A review of in silico tools for grouping
10.1016/j.comtox.2017.05.003 · 2017 · External reference
Towards systematic read-across using Generalised Read-Across (GenRA)
10.1016/j.comtox.2022.100258 · 2023 · External reference
Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment
10.1002/etc.4505 · 2019 · External reference
Species sensitivity distributions for use in environmental protection, assessment, and management of aquatic ecosystems for 12 386 chemicals
10.1002/etc.4373 · 2019 · External reference
Potential mitochondrial toxicants: Tox21 screen identifies structures of interest
10.1289/ehp.123-a23 · 2015 · External reference
Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening
2021 · External reference
Unresolved reference
External reference
The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology
10.1021/acs.chemrestox.0c00264 · 2021 · External reference
Analytical Quality Evaluation of the Tox21 Compound Library
10.1021/acs.chemrestox.4c00330 · 2025 · External reference
Quantitative analysis of mitochondrial membrane potential heterogeneity in unsynchronized and synchronized cancer cells
2021 · External reference
Alternative oxidase and plant stress tolerance
10.1080/15592324.2016.1256530 · 2016 · External reference
Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species
10.1021/acs.est.0c06551 · 2021 · External reference
Mechanistic TK/TD-model simulating the effect of growth inhibitors on Lemna populations
10.1016/j.ecolmodel.2013.01.017 · 2013 · External reference
Environmental surveillance and monitoring—The next frontiers for high-throughput toxicology
10.1002/etc.3309 · 2016 · External reference
AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation
10.1002/etc.5197 · 2021 · External reference
Quantitative adverse outcome pathway (qAOP) models for toxicity prediction
10.1007/s00204-020-02774-7 · 2020 · External reference
Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
10.1016/j.yrtph.2014.09.009 · 2014 · External reference
Measuring mitochondrial membrane potential
10.1038/s44318-025-00632-9 · 2025 · External reference
Unresolved reference
External reference
ToxCast Assay Description Documentation
2019 · External reference
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
10.1289/ehp.98106775 · 1998 · External reference
Differential sensitivities of plant and animal mitochondria to the herbicide paraquat
10.1002/jbt.10010 · 2001 · External reference
Comparative effects of the herbicide dinitro-o-cresol on mitochondrial bioenergetics
10.1002/(sici)1096-9063(199809)54:1<43::aid-ps778>3.0.co;2-3 · 1998 · External reference
Case Study in 21st-Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo
10.1002/etc.5504 · 2023 · External reference
Case Study in 21st Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Short-Term In Vivo Responses in Adult Female Fish
10.1002/etc.4968 · 2021 · External reference
Derivation and application of relative potency estimates based on in vitro bioassay results
10.1002/etc.5620191131 · 2000 · External reference
High-throughput screening and environmental risk assessment: State of the science and emerging applications
10.1002/etc.4315 · 2019 · External reference
Mitochondrial targets of drug toxicity
10.1146/annurev.pharmtox.40.1.353 · 2000 · External reference
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
10.1186/s13321-017-0247-6 · 2017 · External reference
Sourcing data on chemical properties and hazard data from the US-EPA CompTox Chemicals Dashboard: A practical guide for human risk assessment
10.1016/j.envint.2021.106566 · 2021 · External reference
Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies
10.1289/ehp2589 · 2018 · External reference
Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor
10.1016/j.aquatox.2018.02.005 · 2018 · External reference
Application of three approaches for quantitative AOP development to renal toxicity
10.1016/j.comtox.2019.02.001 · 2019 · External reference
