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References from Single-cell transcriptomic analysis reveals endothelial mitochondrial dysfunction and synaptic impairment underlying arsenic-induced hippocampal neurotoxicity in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development
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A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity
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The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery
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Methylseleninic acid elevating the Nrf2-GPX4 axis relieves endothelial dysfunction and ferroptosis induced by arsenic exposure
2025 · External reference
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Arsenic-induced neurotoxicity by dysfunctioning cholinergic and dopaminergic system in brain of developing rats
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Control of excitatory and inhibitory synapse formation by neuroligins
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Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro
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Epigenetically modulated MTCH2 and regulated ATP5 in the liver of obese mice subjected to strength training
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Single-cell transcriptomic analysis defines heterogeneity and transcriptional dynamics in the adult neural stem cell lineage
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Arsenic-induced mice model of Parkinson's disease: revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain
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Bromelain restores glutamatergic homeostasis via regulation of NR2A, GLT-1, EAAC1, and xCT in arsenic-induced cerebral cortex and hippocampal neurotoxicity
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PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
10.1038/s41467-021-23116-w · 2021 · External reference
Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism
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Early low-level arsenic exposure impacts post-synaptic hippocampal function in juvenile mice
10.3390/toxics9090206 · 2021 · External reference
Regulation of hippocampal synaptic plasticity by the tyrosine kinase receptor, REK7/EphA5, and its ligand, AL-1/Ephrin-A5
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Chronic exposure to inorganic arsenic and fluoride induces redox imbalance, inhibits the transsulfuration pathway, and alters glutamate receptor expression in the brain, resulting in memory impairment in adult male mouse offspring
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Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFβ1-mediated tumor progression
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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
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Disease-associated astrocytes in Alzheimer's disease and aging
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Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer's disease
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Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model
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Mitochondrial dysfunction associated with TANGO2 deficiency
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AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing
10.1038/s41593-017-0056-2 · 2018 · External reference
Down-regulation of neuregulin2 (NRG2) following spinal cord injury in C57BL/6 mice: its implications in therapeutic potential
2025 · External reference
Neuronal cholesterol deficiency mediated by astrocytic SREBP2 downregulation leads to postoperative cognitive dysfunction through impairment of hippocampal synaptic plasticity and excitatory synaptic transmission
10.1002/advs.202519874 · 2026 · External reference
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease
10.1038/s41467-020-19473-7 · 2020 · External reference
A role for the juxtamembrane domain of beta-dystroglycan in agrin-induced acetylcholine receptor clustering
10.1523/jneurosci.23-02-00392.2003 · 2003 · External reference
Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes
10.1073/pnas.1920433117 · 2020 · External reference
Oligodendrocyte-derived laminin-γ1 regulates the blood-brain barrier and CNS myelination in mice
10.1016/j.celrep.2024.114123 · 2024 · External reference
GluA4 facilitates cerebellar expansion coding and enables associative memory formation
10.7554/elife.65152 · 2021 · External reference
Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory
10.1038/s41380-022-01579-7 · 2022 · External reference
Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson's disease-like neurodegeneration by causing energy metabolism disorders in mice
10.1016/j.jhazmat.2022.128459 · 2022 · External reference
Assessment of relationship on excess arsenic intake from drinking water and cognitive impairment in adults and elders in arsenicosis areas
10.1016/j.ijheh.2016.12.004 · 2017 · External reference
Single-cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury
10.1016/j.stem.2015.07.002 · 2015 · External reference
Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model
10.1038/s41467-022-34679-7 · 2022 · External reference
Abcb1 is involved in the efflux of trivalent inorganic arsenic from brain microvascular endothelial cells
10.1016/j.ecoenv.2024.117515 · 2025 · External reference
Gas chromatography-mass spectrometry based metabolomics profile of hippocampus and cerebellum in mice after chronic arsenic exposure
10.1002/tox.22662 · 2019 · External reference
Cortical synaptic reorganization under chronic arsenic exposure
10.1007/s12640-021-00409-y · 2021 · External reference
Public health. Worldwide occurrences of arsenic in ground water
10.1126/science.1072375 · 2002 · External reference
The ecology of arsenic
10.1126/science.1081903 · 2003 · External reference
Global threat of arsenic in groundwater
10.1126/science.aba1510 · 2020 · External reference
Groundwater arsenic contamination throughout China
10.1126/science.1237484 · 2013 · External reference
Association between arsenic exposure and behavior among first-graders from Torreón, Mexico
10.1016/j.envres.2011.03.003 · 2011 · External reference
TANGO2 binds crystallin alpha B and its loss causes desminopathy
10.1038/s41467-025-60563-1 · 2025 · External reference
Very long chain sphingolipids govern brain myelination by regulating oligodendrocyte differentiation and membrane microdomain integrity
10.1186/s12967-026-07881-0 · 2026 · External reference
Molecular mechanism of arsenic-induced neurotoxicity including neuronal dysfunctions
10.3390/ijms221810077 · 2021 · External reference
Pericyte hypoxia-inducible factor-1 (HIF-1) drives blood-brain barrier disruption and impacts acute ischemic stroke outcome
10.1007/s10456-021-09796-4 · 2021 · External reference
Overexpression of hypoxia-inducible factor-1α exacerbates endothelial barrier dysfunction induced by hypoxia
10.1159/000354488 · 2013 · External reference
Neurotransmitter metabolism in arsenic exposure-induced cognitive impairment: emerging insights and predictive implications
10.1021/acs.est.4c06269 · 2024 · External reference
Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway
10.1289/ehp.0901510 · 2010 · External reference
Arsenic-induced IGF-1 signaling impairment and neurite shortening: the protective roles of IGF-1 through the PI3K/Akt axis
10.1002/tox.23995 · 2024 · External reference
Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
10.1084/jem.20201290 · 2021 · External reference
Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders
10.1038/mp.2017.22 · 2018 · External reference
Arsenic exposure induces neuro-immune toxicity in the cerebral cortex and the hippocampus via neuroglia and NLRP3 inflammasome activation in C57BL/6 mice
10.1007/s12011-023-04012-4 · 2024 · External reference
Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
10.1126/science.aaa1934 · 2015 · External reference
Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain
10.1016/j.toxlet.2018.06.1065 · 2018 · External reference
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease
10.1038/s41591-019-0695-9 · 2020 · External reference
