Research graph
References from Timeline of sex differentiation and stabilization in zebrafish: Interplay between methyl-sensitive transcription factors, prostaglandin-related genes and DNA methylation. Local targets link to admitted publications; unresolved targets remain external evidence.
Sexual determination in zebrafish
10.1007/s00018-021-04066-4 · 2021 · External reference
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish
10.1016/j.aquatox.2020.105476 · 2020 · External reference
Impacts of environmental stressors on fertility and fecundity across taxa, with implications for planetary health
10.1038/s44454-026-00032-6 · 2026 · External reference
DNA methylation of the first exon is tightly linked to transcriptional silencing
10.1371/journal.pone.0014524 · 2011 · External reference
Vertebrate sex determination: evolutionary plasticity of a fundamental switch
10.1038/nrg.2017.60 · 2017 · External reference
Gonad differentiation and puberty onset in the zebrafish: evidence for the dependence of puberty onset on body growth but not age in females
10.1002/mrd.22172 · 2013 · External reference
The role of transposable elements in sexual development
10.3389/fnbeh.2022.923732 · 2022 · External reference
PGE2 inhibits spermatogonia differentiation in zebrafish: interaction with Fsh and an androgen
10.1530/joe-19-0309 · 2020 · External reference
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
10.1186/s13059-022-02728-5 · 2022 · External reference
Epigenetic regulation of male fate commitment from an initially bipotential system
10.1016/j.mce.2018.01.009 · 2018 · External reference
Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis
10.1016/j.stem.2014.04.006 · 2014 · External reference
Two phases of gonadal sex differentiation in zebrafish with ZZ/ZW sex determination system
10.1016/j.ygcen.2024.114613 · 2024 · External reference
Prostaglandin E₂ increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression
10.1096/fj.11-203323 · 2012 · External reference
Sex determination and maintenance: the role of DMRT1 and FOXL2
10.4103/1008-682x.194420 · 2017 · External reference
DNA methylation and evolution of duplicate genes
10.1073/pnas.1321420111 · 2014 · External reference
Many putative endocrine disruptors inhibit prostaglandin synthesis
10.1289/ehp.1002635 · 2011 · External reference
Sexual dimorphic expression pattern of a splice variant of zebrafish vasa during gonadal development
10.1016/j.ydbio.2004.04.004 · 2004 · External reference
Decoding the epigenetic mechanism of mammalian sex determination
10.1016/j.yexcr.2024.114011 · 2024 · External reference
Epigenetic reprogramming in mouse and human primordial germ cells
10.1038/s12276-024-01359-z · 2024 · External reference
Polygenic sex determination system in zebrafish
10.1371/journal.pone.0034397 · 2012 · External reference
Regulation of prostaglandin synthesis in ovaries of sexually-mature zebrafish (Danio rerio)
10.1002/mrd.21072 · 2009 · External reference
Context-dependent CpG methylation directs cell-specific binding of transcription factor ZBTB38
10.1080/15592294.2022.2111135 · 2022 · External reference
DNA methylation: a historical perspective
10.1016/j.tig.2022.03.010 · 2022 · External reference
Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish
2017 · External reference
DNA methylation shapes transcription factor binding beyond canonical CpG contexts
10.1073/pnas.2520814122 · 2025 · External reference
De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine
10.1038/sj.onc.1208540 · 2005 · External reference
Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
10.1038/s41467-019-10894-7 · 2019 · External reference
Sex-specific DNA methylation and transcription of zbtb38 and effects of gene-environment interactions on its natural antisense transcript in zebrafish
10.1080/15592294.2023.2260963 · 2023 · External reference
Epigenetic regulation of sex: the role of DNA methylation and zbtb38 in zebrafish sex differentiation and heat-induced masculinization
10.1016/j.mce.2025.112636 · 2025 · External reference
The Role of DNA Methylation and ZBTB transcription factors in sex differentiation, maintenance and heat-induced masculinization in Zebrafish
10.1002/mrd.70112 · 2026 · External reference
Transgenerational epigenetic sex determination: Environment experienced by female fish affects offspring sex ratio
10.1016/j.envpol.2021.116864 · 2021 · External reference
Juvenile ovary to testis transition in zebrafish involves inhibition of ptges
10.1095/biolreprod.114.119016 · 2014 · External reference
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation
10.1186/s12920-020-0657-6 · 2020 · External reference
Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads
10.1186/s13072-017-0168-7 · 2017 · External reference
The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development
10.1242/dev.025569 · 2009 · External reference
Zebrafish sex differentiation and gonad development: A review on the impact of environmental factors
10.1016/j.aquatox.2017.08.005 · 2017 · External reference
Sequence-specific recognition of methylated DNA by human zinc-finger proteins
10.1093/nar/gkq280 · 2010 · External reference
Retention of paternal DNA methylome in the developing zebrafish germline
10.1038/s41467-019-10895-6 · 2019 · External reference
Sox9-related signaling controls zebrafish juvenile ovary-testis transformation
10.1038/cddis.2013.456 · 2013 · External reference
Prostaglandins in teleost ovulation: a review of the roles with a view to comparison with prostaglandins in mammalian ovulation
10.1016/j.mce.2017.09.019 · 2018 · External reference
Induction of female-to-male sex change in adult zebrafish by aromatase inhibitor treatment
10.1038/srep03400 · 2013 · External reference
Exposure of zebrafish to elevated temperature induces sex ratio shifts and alterations in the testicular epigenome of unexposed offspring
10.1016/j.envres.2020.109601 · 2020 · External reference
Sox9 induces testis development in XX transgenic mice
10.1038/90046 · 2001 · External reference
The timing and extent of 'juvenile ovary' phase are highly variable during zebrafish testis differentiation
10.1111/j.1095-8649.2007.01363.x · 2007 · External reference
Dissection of Larval Zebrafish Gonadal Tissue
2017 · External reference
The Role of DNA methylation reprogramming during sex determination and transition in zebrafish
10.1016/j.gpb.2020.10.004 · 2021 · External reference
Sex determination without sex chromosomes
10.1098/rstb.2020.0109 · 2021 · External reference
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation
10.1038/emboj.2008.85 · 2008 · External reference
Dmrt1 is necessary for male sexual development in zebrafish
10.1016/j.ydbio.2016.12.008 · 2017 · External reference
Demographic and genetic consequences of disturbed sex determination
10.1098/rstb.2016.0326 · 2017 · External reference
SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development
10.1074/jbc.m609578200 · 2007 · External reference
Wild sex in zebrafish: loss of the natural sex determinant in domesticated strains
10.1534/genetics.114.169284 · 2014 · External reference
Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo
10.7150/thno.35766 · 2019 · External reference
Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis
10.1038/s42003-025-07719-3 · 2025 · External reference
Prostaglandin E2 promotes intestinal tumor growth via DNA methylation
10.1038/nm.2608 · 2012 · External reference
A hormone that lost its receptor: anti-müllerian hormone (AMH) in zebrafish gonad development and sex determination
10.1534/genetics.119.302365 · 2019 · External reference
Sequential, divergent, and cooperative requirements of Foxl2a and Foxl2b in ovary development and maintenance of zebrafish
10.1534/genetics.116.199133 · 2017 · External reference
A landscape of differentiated biological processes involved in the initiation of sex differentiation in zebrafish
2022 · External reference
Disruption of Zar1 leads to arrested oogenesis by regulating polyadenylation via Cpeb1 in tilapia (Oreochromis niloticus)
2024 · External reference
Functional characterization of a novel zinc finger and BTB domain-containing gene reveals its essential role in male sex differentiation in channel catfish (Ictalurus punctatus)
10.1016/j.aquaculture.2025.743603 · 2026 · External reference
