Research graph
References from Discovery of H-10 as a potent and safe GABAA receptor positive allosteric modulator: A novel benzothiazine-triazole lead compound with broad-spectrum anticonvulsant activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Classification and diagnosis of epilepsy
10.1212/cont.0000000000001519 · 2025 · External reference
Seizure cycles in focal epilepsy
10.1001/jamaneurol.2020.5370 · 2021 · External reference
Antiseizure medications in poststroke seizures
10.1212/wnl.0000000000210231 · 2025 · External reference
The epidemiology of epilepsy
10.1159/000503831 · 2020 · External reference
Global, regional, and national burden of epilepsy, 1990-2021: a systematic analysis for the global burden of disease study 2021
2025 · External reference
Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the global burden of disease study 2021
10.1016/s1474-4422(24)00038-3 · 2024 · External reference
Epilepsy in adults
10.1016/s0140-6736(18)32596-0 · 2019 · External reference
Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention
10.1016/s1474-4422(16)30158-2 · 2016 · External reference
Sudden unexpected death in epilepsy
10.1097/wco.0000000000001034 · 2022 · External reference
Premature mortality and causes of death among people with epilepsy
10.1212/wnl.0000000000207212 · 2023 · External reference
Gabaergic mechanisms in epilepsy
10.1046/j.1528-1157.2001.042suppl.3008.x · 2001 · External reference
Gabaa receptor heterogeneity, function, and implications for epilepsy
10.1212/01.wnl.0000255669.83468.dd · 2007 · External reference
Gaba(a) receptor variants in epilepsy
2022 · External reference
Functional genomics of epilepsy-associated mutations in the gabaa receptor subunits reveal that one mutation impairs function and two are catastrophic
10.1074/jbc.ra118.005697 · 2019 · External reference
Molecular and clinical descriptions of patients withgabaa receptor gene variants (gabra1 ,gabrb2 ,gabrb3 ,gabrg2): a cohort study, review of literature, and genotype–phenotype correlation
10.1111/epi.17336 · 2022 · External reference
Gaba and the gabaa receptor
1997 · External reference
Gaba(a) receptors, seizures, and epilepsy
2024 · External reference
The benzodiazepine binding site of gabaa receptors
10.1016/s0165-6147(97)90675-1 · 1997 · External reference
Discovery of novel antiepileptic agents targeting the α1β2γ2 gabaa receptor
10.1021/acs.jmedchem.5c01770 · 2025 · External reference
Spectrum of gabaa receptor variants in epilepsy
10.1097/wco.0000000000000657 · 2019 · External reference
Gaba(a) receptor signalling mechanisms revealed by structural pharmacology
10.1038/s41586-018-0832-5 · 2019 · External reference
In silico prediction, molecular docking study for identification of novel nitrogen substituted benzoxazole derivative for their potential biological activity
10.1007/s42250-025-01208-0 · 2025 · External reference
Sedative and anxiolytic effects of capparis sicula duhamel: in vivo and in silico approaches with phytochemical profiling
10.3389/fphar.2024.1443173 · 2024 · External reference
Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (go-fe3o4–ti(iv)): anticonvulsant evaluation and computational studies
10.1186/s13065-022-00836-8 · 2022 · External reference
1,4-benzothiazines-a biologically attractive scaffold
2018 · External reference
New benzothiazines. 4. 1h-2,3-benzothiazin-4(3h)-one 2,2-dioxide and 2h-1,2-benzothiazin-3(4h)-one 1,1-dioxide nitrogen derivatives with central nervous system activity
10.1021/jm00268a014 · 1973 · External reference
An important potential anti-epileptic/anticonvulsant active group: a review of 1,2,4-triazole groups and their action
10.1055/a-1670-6992 · 2022 · External reference
Discovery of novel 1,2,4-triazole schiff bases hybridized with 1,4-naphthoquinones as potent stat3 inhibitors
2025 · External reference
The neuroprotection of 1,2,4‐triazole derivative by inhibiting inflammation and protecting bbb integrity in acute ischemic stroke, CNS Neurosci
2024 · External reference
Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (vgscs) as promising anticonvulsant drug candidates
10.1016/j.bioorg.2019.103355 · 2020 · External reference
Recent developments on triazole nucleus in anticonvulsant compounds: a review, J. Enzym. Inhib
2018 · External reference
Synaptic correlates of benzodiazepine tolerance
10.1038/s41380-026-03512-8 · 2026 · External reference
Gabakines - advances in the discovery, development, and commercialization of positive allosteric modulators of gaba(a) receptors
10.1016/j.pharmthera.2021.108035 · 2022 · External reference
Benzodiazepine dependence: clinical and molecular aspects, preventive strategies and therapeutic approaches
10.3390/ijms27031430 · 2026 · External reference
Nonsedating anxiolytics
10.1016/j.pbb.2024.173895 · 2024 · External reference
Respiratory depression in rats induced by alcohol and barbiturate and rescue by ampakine cx717
2012 · External reference
Studies on annelated [1,4]benzothiazines and [1,5]benzothiazepines, v. Synthesis and biological activity of n-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine
10.1002/ardp.19923250909 · 1992 · External reference
Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles
10.2174/157340610793358855 · 2010 · External reference
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of gabaa1 and gabaa4 receptors with potent antiepileptic activity
10.1016/j.bioorg.2021.105565 · 2022 · External reference
Animal models of drug-resistant epilepsy as tools for deciphering the cellular and molecular mechanisms of pharmacoresistance and discovering more effective treatments
10.3390/cells12091233 · 2023 · External reference
Development of an antiseizure drug screening platform for Dravet syndrome at the ninds contract site for the epilepsy therapy screening program
10.1111/epi.16925 · 2021 · External reference
The national institute of neurological disorders and stroke (ninds) epilepsy therapy screening program (etsp)
10.1007/s11064-017-2275-z · 2017 · External reference
Pentylenetetrazole: a review
10.1016/j.neuint.2024.105841 · 2024 · External reference
A convulsant, 3-mercaptopropionic acid, decreases the level of gaba and gad in rat pancreatic islets and brain
10.1007/bf01931099 · 1995 · External reference
Unresolved reference
2016 · External reference
The point mutation gamma 2f77i changes the potency and efficacy of benzodiazepine site ligands in different gabaa receptor subtypes
10.1016/j.ejphar.2010.03.015 · 2010 · External reference
Identification of triazolopyridines as selective α5-gaba(a) receptor negative allosteric modulators by a hybridization approach
10.1021/acschemneuro.2c00608 · 2023 · External reference
Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals
10.1016/s0022-3565(25)13216-3 · 1990 · External reference
Trimmed spearman-karber method for estimating median lethal concentrations in toxicity bioassays
1978 · External reference
Pentylenetetrazol (ptz) kindling model of epilepsy
2012 · External reference
Seizure cycles in focal epilepsy
10.1001/jamaneurol.2020.5370 · ExternalCitation · doi-reference
Studies on annelated [1,4]benzothiazines and [1,5]benzothiazepines, v. Synthesis and biological activity of n-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine
10.1002/ardp.19923250909 · ExternalCitation · doi-reference
A convulsant, 3-mercaptopropionic acid, decreases the level of gaba and gad in rat pancreatic islets and brain
10.1007/bf01931099 · ExternalCitation · doi-reference
The national institute of neurological disorders and stroke (ninds) epilepsy therapy screening program (etsp)
10.1007/s11064-017-2275-z · ExternalCitation · doi-reference
In silico prediction, molecular docking study for identification of novel nitrogen substituted benzoxazole derivative for their potential biological activity
10.1007/s42250-025-01208-0 · ExternalCitation · doi-reference
Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (vgscs) as promising anticonvulsant drug candidates
10.1016/j.bioorg.2019.103355 · ExternalCitation · doi-reference
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of gabaa1 and gabaa4 receptors with potent antiepileptic activity
10.1016/j.bioorg.2021.105565 · ExternalCitation · doi-reference
The point mutation gamma 2f77i changes the potency and efficacy of benzodiazepine site ligands in different gabaa receptor subtypes
10.1016/j.ejphar.2010.03.015 · ExternalCitation · doi-reference
Pentylenetetrazole: a review
10.1016/j.neuint.2024.105841 · ExternalCitation · doi-reference
Nonsedating anxiolytics
10.1016/j.pbb.2024.173895 · ExternalCitation · doi-reference
Gabakines - advances in the discovery, development, and commercialization of positive allosteric modulators of gaba(a) receptors
10.1016/j.pharmthera.2021.108035 · ExternalCitation · doi-reference
Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals
10.1016/s0022-3565(25)13216-3 · ExternalCitation · doi-reference
Epilepsy in adults
10.1016/s0140-6736(18)32596-0 · ExternalCitation · doi-reference
The benzodiazepine binding site of gabaa receptors
10.1016/s0165-6147(97)90675-1 · ExternalCitation · doi-reference
Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention
10.1016/s1474-4422(16)30158-2 · ExternalCitation · doi-reference
Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the global burden of disease study 2021
10.1016/s1474-4422(24)00038-3 · ExternalCitation · doi-reference
Discovery of novel antiepileptic agents targeting the α1β2γ2 gabaa receptor
10.1021/acs.jmedchem.5c01770 · ExternalCitation · doi-reference
Identification of triazolopyridines as selective α5-gaba(a) receptor negative allosteric modulators by a hybridization approach
10.1021/acschemneuro.2c00608 · ExternalCitation · doi-reference
New benzothiazines. 4. 1h-2,3-benzothiazin-4(3h)-one 2,2-dioxide and 2h-1,2-benzothiazin-3(4h)-one 1,1-dioxide nitrogen derivatives with central nervous system activity
10.1021/jm00268a014 · ExternalCitation · doi-reference
Synaptic correlates of benzodiazepine tolerance
10.1038/s41380-026-03512-8 · ExternalCitation · doi-reference
Gaba(a) receptor signalling mechanisms revealed by structural pharmacology
10.1038/s41586-018-0832-5 · ExternalCitation · doi-reference
Gabaergic mechanisms in epilepsy
10.1046/j.1528-1157.2001.042suppl.3008.x · ExternalCitation · doi-reference
An important potential anti-epileptic/anticonvulsant active group: a review of 1,2,4-triazole groups and their action
10.1055/a-1670-6992 · ExternalCitation · doi-reference
Functional genomics of epilepsy-associated mutations in the gabaa receptor subunits reveal that one mutation impairs function and two are catastrophic
10.1074/jbc.ra118.005697 · ExternalCitation · doi-reference
Spectrum of gabaa receptor variants in epilepsy
10.1097/wco.0000000000000657 · ExternalCitation · doi-reference
Sudden unexpected death in epilepsy
10.1097/wco.0000000000001034 · ExternalCitation · doi-reference
Development of an antiseizure drug screening platform for Dravet syndrome at the ninds contract site for the epilepsy therapy screening program
10.1111/epi.16925 · ExternalCitation · doi-reference
Molecular and clinical descriptions of patients withgabaa receptor gene variants (gabra1 ,gabrb2 ,gabrb3 ,gabrg2): a cohort study, review of literature, and genotype–phenotype correlation
10.1111/epi.17336 · ExternalCitation · doi-reference
The epidemiology of epilepsy
10.1159/000503831 · ExternalCitation · doi-reference
Efficient synthesis of 1,3-naphtoxazine derivatives using reusable magnetic catalyst (go-fe3o4–ti(iv)): anticonvulsant evaluation and computational studies
10.1186/s13065-022-00836-8 · ExternalCitation · doi-reference
Gabaa receptor heterogeneity, function, and implications for epilepsy
10.1212/01.wnl.0000255669.83468.dd · ExternalCitation · doi-reference
Classification and diagnosis of epilepsy
10.1212/cont.0000000000001519 · ExternalCitation · doi-reference
Premature mortality and causes of death among people with epilepsy
10.1212/wnl.0000000000207212 · ExternalCitation · doi-reference
Antiseizure medications in poststroke seizures
10.1212/wnl.0000000000210231 · ExternalCitation · doi-reference
Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles
10.2174/157340610793358855 · ExternalCitation · doi-reference
Sedative and anxiolytic effects of capparis sicula duhamel: in vivo and in silico approaches with phytochemical profiling
10.3389/fphar.2024.1443173 · ExternalCitation · doi-reference
Animal models of drug-resistant epilepsy as tools for deciphering the cellular and molecular mechanisms of pharmacoresistance and discovering more effective treatments
10.3390/cells12091233 · ExternalCitation · doi-reference
Benzodiazepine dependence: clinical and molecular aspects, preventive strategies and therapeutic approaches
10.3390/ijms27031430 · ExternalCitation · doi-reference
