Research graph
References from Substituted methyl acridone-carboxylate derivatives as CD1/CD2 dual-targeting HDAC6 inhibitors to ameliorate the pathological phenotype of Alzheimer's disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Alzheimer's disease
10.1136/bmj.b158 · 2009 · External reference
Pathogenesis of Alzheimer's disease
10.3390/ijms24010107 · 2022 · External reference
Alzheimer's disease: from immunotherapy to immunoprevention
10.1016/j.cell.2023.08.021 · 2023 · External reference
HDAC6 in diseases of cognition and of neurons
10.3390/cells10010012 · 2020 · External reference
Inhibition of histone deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer'S disease: a review (2010-2020)
10.1016/j.ejmech.2021.113874 · 2021 · External reference
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer'S disease models via HDAC6 inhibition
10.1016/j.phymed.2021.153887 · 2022 · External reference
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
10.1016/s1097-2765(02)00450-1 · 2002 · External reference
An acetylation site in the middle domain of Hsp90 regulates chaperone function
10.1016/j.molcel.2006.12.008 · 2007 · External reference
Characterization of the two catalytic domains in histone deacetylase 6
10.1016/j.bbrc.2005.12.144 · 2006 · External reference
Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastoma
10.1021/acs.jmedchem.1c01585 · 2022 · External reference
HDAC6 as privileged target in drug discovery: a perspective
10.1016/j.phrs.2020.105274 · 2021 · External reference
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
10.1021/ja102758v · 2010 · External reference
Small molecules targeting HDAC6 for cancer treatment: current progress and novel strategies
10.1016/j.biopha.2024.117218 · 2024 · External reference
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
10.1038/nchembio.2134 · 2016 · External reference
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease
10.1093/brain/awag089 · 2026 · External reference
Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy
10.1080/14756366.2023.2206581 · 2023 · External reference
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
10.1038/ncomms15368 · 2017 · External reference
Synthesis and anticancer research of n‐(2-aminophenyl)benzamide acridine derivatives as dual topoisomerase I and isoform-selective HDAC inhibitors
10.1002/slct.202001880 · 2020 · External reference
Synthesis and evaluation of novel N-arylamide-quinoline derivatives as HDAC isoform-selective inhibitors: in vitro and in vivo anticancer efficacy and pharmacokinetic studies
10.1016/j.bioorg.2026.109877 · 2026 · External reference
Target identification using drug affinity responsive target stability (DARTS)
10.1073/pnas.0910040106 · 2009 · External reference
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation
10.1093/emboj/cdf682 · 2002 · External reference
Therapeutic potential of dual HDAC6/SIRT2 inhibition in Alzheimer's disease
10.1016/j.ejmech.2025.117733 · 2025 · External reference
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
10.1016/j.ebiom.2020.102919 · 2020 · External reference
The role of HDAC6 in Alzheimer's disease
10.3233/jad-2012-120727 · 2013 · External reference
NF-κB in immunobiology
10.1038/cr.2011.13 · 2011 · External reference
Recent development of selective inhibitors targeting the HDAC6 as anti-cancer drugs: structure, function and design
10.1016/j.bioorg.2023.106622 · 2023 · External reference
Analysing protein complexes in plant science: insights and limitation with AlphaFold 3
10.1186/s40529-025-00462-2 · 2025 · External reference
PRODIGY: a web server for predicting the binding affinity of protein-protein complexes
10.1093/bioinformatics/btw514 · 2016 · External reference
Zinc cofactor in human histone deacetylase 8: requirement for function and opportunity for drug discovery
10.1016/j.ijbiomac.2025.149851 · 2026 · External reference
MCPB.py: a python based metal center parameter builder
10.1021/acs.jcim.5b00674 · 2016 · External reference
iClick-Mediated Au(I) functionalization of polystyrene: lighting up polystyrene with phosphorescence
10.1021/acsapm.4c03897 · 2025 · External reference
Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation
10.1021/ar8000475 · 2008 · External reference
Fascaplysin derivatives are potent multitarget agents against Alzheimer's disease: in vitro and in vivo evidence
10.1021/acschemneuro.9b00503 · 2019 · External reference
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
10.1126/scitranslmed.aba7394 · 2021 · External reference
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease
10.1093/brain/awz364 · 2020 · External reference
The Y-maze for assessment of spatial working and reference memory in mice
10.1007/978-1-4939-8994-2_10 · 2019 · External reference
Retinoic acid receptor is a novel therapeutic target for postoperative cognitive dysfunction
10.3390/pharmaceutics15092311 · 2023 · External reference
Synthesis and anticancer research of n‐(2-aminophenyl)benzamide acridine derivatives as dual topoisomerase I and isoform-selective HDAC inhibitors
10.1002/slct.202001880 · ExternalCitation · doi-reference
The Y-maze for assessment of spatial working and reference memory in mice
10.1007/978-1-4939-8994-2_10 · ExternalCitation · doi-reference
Characterization of the two catalytic domains in histone deacetylase 6
10.1016/j.bbrc.2005.12.144 · ExternalCitation · doi-reference
Recent development of selective inhibitors targeting the HDAC6 as anti-cancer drugs: structure, function and design
10.1016/j.bioorg.2023.106622 · ExternalCitation · doi-reference
Synthesis and evaluation of novel N-arylamide-quinoline derivatives as HDAC isoform-selective inhibitors: in vitro and in vivo anticancer efficacy and pharmacokinetic studies
10.1016/j.bioorg.2026.109877 · ExternalCitation · doi-reference
Small molecules targeting HDAC6 for cancer treatment: current progress and novel strategies
10.1016/j.biopha.2024.117218 · ExternalCitation · doi-reference
Alzheimer's disease: from immunotherapy to immunoprevention
10.1016/j.cell.2023.08.021 · ExternalCitation · doi-reference
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
10.1016/j.ebiom.2020.102919 · ExternalCitation · doi-reference
Inhibition of histone deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer'S disease: a review (2010-2020)
10.1016/j.ejmech.2021.113874 · ExternalCitation · doi-reference
Therapeutic potential of dual HDAC6/SIRT2 inhibition in Alzheimer's disease
10.1016/j.ejmech.2025.117733 · ExternalCitation · doi-reference
Zinc cofactor in human histone deacetylase 8: requirement for function and opportunity for drug discovery
10.1016/j.ijbiomac.2025.149851 · ExternalCitation · doi-reference
An acetylation site in the middle domain of Hsp90 regulates chaperone function
10.1016/j.molcel.2006.12.008 · ExternalCitation · doi-reference
HDAC6 as privileged target in drug discovery: a perspective
10.1016/j.phrs.2020.105274 · ExternalCitation · doi-reference
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer'S disease models via HDAC6 inhibition
10.1016/j.phymed.2021.153887 · ExternalCitation · doi-reference
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
10.1016/s1097-2765(02)00450-1 · ExternalCitation · doi-reference
MCPB.py: a python based metal center parameter builder
10.1021/acs.jcim.5b00674 · ExternalCitation · doi-reference
Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastoma
10.1021/acs.jmedchem.1c01585 · ExternalCitation · doi-reference
iClick-Mediated Au(I) functionalization of polystyrene: lighting up polystyrene with phosphorescence
10.1021/acsapm.4c03897 · ExternalCitation · doi-reference
Fascaplysin derivatives are potent multitarget agents against Alzheimer's disease: in vitro and in vivo evidence
10.1021/acschemneuro.9b00503 · ExternalCitation · doi-reference
Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation
10.1021/ar8000475 · ExternalCitation · doi-reference
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
10.1021/ja102758v · ExternalCitation · doi-reference
NF-κB in immunobiology
10.1038/cr.2011.13 · ExternalCitation · doi-reference
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
10.1038/nchembio.2134 · ExternalCitation · doi-reference
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
10.1038/ncomms15368 · ExternalCitation · doi-reference
Target identification using drug affinity responsive target stability (DARTS)
10.1073/pnas.0910040106 · ExternalCitation · doi-reference
Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy
10.1080/14756366.2023.2206581 · ExternalCitation · doi-reference
PRODIGY: a web server for predicting the binding affinity of protein-protein complexes
10.1093/bioinformatics/btw514 · ExternalCitation · doi-reference
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease
10.1093/brain/awag089 · ExternalCitation · doi-reference
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease
10.1093/brain/awz364 · ExternalCitation · doi-reference
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation
10.1093/emboj/cdf682 · ExternalCitation · doi-reference
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
10.1126/scitranslmed.aba7394 · ExternalCitation · doi-reference
Alzheimer's disease
10.1136/bmj.b158 · ExternalCitation · doi-reference
Analysing protein complexes in plant science: insights and limitation with AlphaFold 3
10.1186/s40529-025-00462-2 · ExternalCitation · doi-reference
The role of HDAC6 in Alzheimer's disease
10.3233/jad-2012-120727 · ExternalCitation · doi-reference
HDAC6 in diseases of cognition and of neurons
10.3390/cells10010012 · ExternalCitation · doi-reference
Pathogenesis of Alzheimer's disease
10.3390/ijms24010107 · ExternalCitation · doi-reference
Retinoic acid receptor is a novel therapeutic target for postoperative cognitive dysfunction
10.3390/pharmaceutics15092311 · ExternalCitation · doi-reference
