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References from Nitrogen-functionalized 2-deoxy sp2-iminoglycolipids: Stereoselective synthesis and biological evaluation. Local targets link to admitted publications; unresolved targets remain external evidence.
Exploring carbohydrates for therapeutics: a review on future directions
2021 · External reference
U.S. FDA approved drugs from 2015−June 2020: a perspective
10.1021/acs.jmedchem.0c01786 · 2021 · External reference
Glycomimetics and glycoconjugates in drug discovery
10.3390/ph17030323 · 2024 · External reference
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
10.1039/c6cc01564f · 2016 · External reference
N-Alkylated iminosugar based ligands: synthesis and inhibition of human lysosomal β-glucocerebrosidase
10.3390/molecules25204618 · 2020 · External reference
sp2-Iminosugar azobenzene O-glycosides: Light-sensitive glycosidase inhibitors with unprecedented tunability and switching factors
10.1016/j.bioorg.2024.107555 · 2024 · External reference
sp2-Iminosugars as chemical mimics for glycodrug design
2020 · External reference
Exploring a novel anti-inflammatory therapy for diabetic retinopathy based on glyco-zeolitic-imidazolate frameworks
10.3390/pharmaceutics17060791 · 2025 · External reference
Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives
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The antileishmanial drug miltefosine (Impavido®) causes oxidation of DNA bases, apoptosis, and necrosis in mammalian cells
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Dysfunctional adaptive immunity during parasitic infections
10.2174/1573395509666131126230832 · 2013 · External reference
Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
10.1016/j.ejmech.2023.115390 · 2023 · External reference
Exploring the influence of the glycone space on the therapeutic potential of sp2-iminoglycolipids
10.1016/j.ejmech.2025.118337 · 2026 · External reference
sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo
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Function and inhibition of P38 MAP kinase signaling: targeting multiple inflammation diseases
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Diversity and versatility of p38 kinase signalling in health and disease
10.1038/s41580-020-00322-w · 2021 · External reference
Recent insights in multi-target drugs in pharmacology and medicinal chemistry
2025 · External reference
Toward dual-target glycomimetics against two bacterial lectins to fight Pseudomonas aeruginosa−burkholderia cenocepacia infections: a biophysical study
10.1021/acs.jmedchem.5c00405 · 2025 · External reference
Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes
10.1016/j.bioorg.2019.03.053 · 2019 · External reference
An orally available halothiazole glycomimetic as a cancer-targeting dual Galectin-1 and Galectin-3 inhibitor
10.1021/acs.jmedchem.5c03703 · 2026 · External reference
Selenoureido-N-alkyl-3,4,5-trihydroxypiperidines: probing their dual-target role in Gaucher disease
10.1016/j.bmc.2025.118453 · 2026 · External reference
Evidence of α-synuclein/glucocerebrosidase dual targeting by iminosugar derivatives
10.1021/acschemneuro.4c00618 · 2025 · External reference
Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases
10.1039/b712690p · 2008 · External reference
Recent advances in chemical synthesis of amino sugars
10.3390/molecules28124724 · 2023 · External reference
Synthesis of antimitotic thioglycosides: in vitro and in vivo evaluation of their anticancer activity
10.1021/jm200961q · 2011 · External reference
Synthesis, biological evaluation, and computational studies of phenolic N-acetylglucosamine glycosides as α-glucosidase inhibitors
10.3390/md24020084 · 2026 · External reference
Tn Antigen mimics based on sp2-iminosugars with affinity for an anti-MUC1 antibody
10.1021/acs.orglett.6b01899 · 2016 · External reference
Über die Verseifung acetylierter Zucker und verwandter Substanzen
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Staudinger ligation and reactions – from bioorthogonal labeling to next-generation biopharmaceuticals
10.1002/ijch.202200057 · 2023 · External reference
Malaria and leishmaniasis: updates on co-infection
10.3389/fimmu.2023.1122411 · 2023 · External reference
Leishmaniasis vaccine development: a review of current candidates and cross-species protection potential
10.3390/parasitologia6020016 · 2026 · External reference
A review of leishmaniasis: current knowledge and future directions
10.1007/s40475-021-00232-7 · 2021 · External reference
Increased ROS generation causes apoptosis-like death: mechanistic insights into the anti-leishmania activity of a potent ruthenium(II) complex
10.1016/j.jinorgbio.2019.03.005 · 2019 · External reference
Diabetic retinopathy (DR): mechanisms, current therapies, and emerging strategies
10.3390/cells14050376 · 2025 · External reference
Which treatment modality offers the best outcomes for diabetic retinopathy? A systematic review and network meta-analysis
10.1016/j.diabres.2025.112379 · 2025 · External reference
Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression
2023 · External reference
Dexamethasone in COVID-19 treatment: analyzing monotherapy and combination therapy approaches
2024 · External reference
Role of inflammasomes in neuroimmune and neurodegenerative diseases: a systematic review
10.1155/2018/1549549 · 2018 · External reference
Activation and regulation of the inflammasomes
10.1038/nri3452 · 2013 · External reference
Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group
2000 · External reference
Pharmacologic induction of heme oxygenase-1 plays a protective role in diabetic retinopathy in rats
10.1167/iovs.11-9241 · 2012 · External reference
LPS induction of gene expression in human monocytes
10.1016/s0898-6568(00)00149-2 · 2001 · External reference
Anti-inflammatory (M2) response is induced by a sp2-iminosugar glycolipid sulfoxide in diabetic retinopathy
10.3389/fimmu.2021.632132 · 2021 · External reference
Arylphthalide delays diabetic retinopathy via immunomodulating the early inflammatory response in an animal model of type 1 diabetes mellitus
10.3390/ijms25158440 · 2024 · External reference
Fitness of Leishmania donovani parasites resistant to drug combinations
10.1371/journal.pntd.0003704 · 2015 · External reference
Heme synthesis through the life cycle of the heme auxotrophic parasite Leishmania major
10.1096/fj.201901274rr · 2019 · External reference
A yeast-based high-throughput screen identifies inhibitors of trypanosomatid HRG heme transporters with potent leishmanicidal and trypanocidal activity
10.1016/j.ijantimicag.2024.107092 · 2024 · External reference
Heme limitation induces LHR2, an essential gene for Leishmania pathogenesis
10.1371/journal.ppat.1013993 · 2026 · External reference