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References from Design, synthesis, and evaluation of fluorescent probes targeting DNA polymerase theta (Polθ) for inhibitor screening and cellular imaging. Local targets link to admitted publications; unresolved targets remain external evidence.
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells
10.1093/nar/gkg814 · 2003 · External reference
Molecular cloning of drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes
10.1128/mcb.16.10.5764 · 1996 · External reference
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
10.1038/nsmb.3494 · 2017 · External reference
Template and primer requirements for DNA Pol θ-mediated end joining
10.1073/pnas.1807329115 · 2018 · External reference
Structural basis of DNA polymerase θ mediated DNA end joining
10.1093/nar/gkac1201 · 2023 · External reference
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
10.1038/s41467-019-12272-9 · 2019 · External reference
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts
10.1016/j.jmb.2010.10.041 · 2011 · External reference
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
10.1038/nsmb.2993 · 2015 · External reference
DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability
10.1016/j.gde.2020.02.017 · 2020 · External reference
Targeting the DNA repair enzyme polymerase θ in cancer therapy
10.1016/j.trecan.2020.09.007 · 2021 · External reference
Beyond PARP-POLθ as an anticancer target
10.1126/science.aar5149 · 2018 · External reference
Synthetic lethality targeting Polθ
10.3390/genes13061101 · 2022 · External reference
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
10.1038/nature14184 · 2015 · External reference
Genome protection by DNA polymerase θ
10.1146/annurev-genet-072920-041046 · 2022 · External reference
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
10.1038/s41467-024-46593-1 · 2024 · External reference
Identification of RP-6685, an orally bioavailable compound that inhibits the DNA polymerase activity of Polθ
10.1021/acs.jmedchem.2c00998 · 2022 · External reference
The discovery of RP-2119: a potent, selective, and orally bioavailable Polθ ATPase inhibitor
10.1021/acs.jmedchem.5c02103 · 2025 · External reference
A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations
10.1038/s41467-022-34627-5 · 2022 · External reference
Fluorescent and theranostic probes for imaging nicotinamide phosphoribosyl transferase (NAMPT)
10.1016/j.ejmech.2022.115080 · 2023 · External reference
Discovery of nonpeptide, environmentally sensitive fluorescent probes for imaging p53-MDM2 interactions in living cell lines and tissue slice
10.1021/acs.analchem.9b04551 · 2020 · External reference
Signaling recognition events with fluorescent sensors and switches
10.1021/cr960386p · 1997 · External reference
Protein labeling with fluorescent probes
10.1016/s0091-679x(01)63013-9 · 2001 · External reference
Development of near-infrared fluorescent probes for use in alzheimer's disease diagnosis
10.1021/acs.bioconjchem.9b00695 · 2020 · External reference
Development and characterization of a fluorescent probe for GLS1 and the application for high-throughput screening of allosteric inhibitors
10.1021/acs.jmedchem.9b01035 · 2019 · External reference
Environment-sensitive fluorophores with benzothiadiazole and benzoselenadiazole structures as candidate components of a fluorescent polymeric thermometer
10.1002/chem.201200597 · 2012 · External reference
A structural remedy toward bright dipolar fluorophores in aqueous media
10.1039/c5sc01076d · 2015 · External reference
Lipidated ras and rab peptides and proteins—synthesis, structure, and function
10.1002/anie.200600855 · 2006 · External reference
Discovery of RORγ allosteric fluorescent probes and their application: fluorescence polarization, screening, and bioimaging
10.1021/acs.jmedchem.4c00058 · 2024 · External reference
Polarization of the fluorescence of macromolecules. I. Theory and experimental method
10.1042/bj0510145 · 1952 · External reference
A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
10.1039/d0cc06353c · 2020 · External reference
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
10.1038/s41467-021-23463-8 · 2021 · External reference
Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models
10.1158/1078-0432.ccr-22-2977 · 2023 · External reference
