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References from Side-chain effects on solubility, chemical stability, and bioactivation of propofol ester prodrugs. Local targets link to admitted publications; unresolved targets remain external evidence.
An overview of techniques for multifold enhancement in solubility of poorly soluble drugs
10.2478/cipms-2019-0035 · 2019 · External reference
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Salt formation to improve drug solubility
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Subcutaneous Injection of drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site
10.1007/s12325-019-01101-6 · 2019 · External reference
pH‐adjustment and discomfort caused by the intradermal injection of lignocaine
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Sterile Basics: Intravenous Admixture Preparation Considerations, Part 5: pH Considerations
2020 · External reference
The prodrug approach: a successful tool for improving drug solubility
10.3390/molecules21010042 · 2015 · External reference
Recent developments in phosphorus-containing ester prodrugs and its prospectives
10.54254/3029-0821/2025.21120 · 2025 · External reference
Metabolic profiles of propofol and fospropofol: clinical and forensic interpretative aspects
10.1155/2018/6852857 · 2018 · External reference
Amino acids in the development of prodrugs
2018 · External reference
Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters
10.1016/s0928-0987(03)00161-1 · 2003 · External reference
Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas
10.1016/j.ejpb.2025.114797 · 2025 · External reference
New natural amino acid-bearing prodrugs boost pterostilbene’s oral pharmacokinetic and distribution profile
10.1016/j.ejpb.2017.02.017 · 2017 · External reference
The development of orally administrable gemcitabine prodrugs with d-enantiomer amino acids: Enhanced membrane permeability and enzymatic stability
10.1016/j.ejpb.2013.12.009 · 2014 · External reference
Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies
10.1016/j.ejpb.2015.01.001 · 2015 · External reference
Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media
10.1016/j.ejpb.2014.12.014 · 2015 · External reference
Propofol: the challenges of Formulation
10.1097/00000542-200510000-00026 · 2005 · External reference
Design and evaluation of microemulsions for improved parenteral delivery of propofol
10.1208/s12249-007-9023-7 · 2008 · External reference
Fospropofol: clinical pharmacology
10.4103/0970-9185.76656 · 2011 · External reference
An improved design of water-soluble propofol prodrugs characterized by rapid onset of action
10.1213/ane.0000000000000124 · 2014 · External reference
Design, synthesis, and activity study of water-soluble, rapid-release propofol prodrugs
10.1021/acs.jmedchem.0c00698 · 2020 · External reference
Synthesis and characterization of novel quick-release propofol prodrug via lactonization
10.1016/j.bmcl.2013.01.034 · 2013 · External reference
An improved water-soluble prodrug of propofol with high molecular utilization and rapid onset of action
10.1016/j.ejps.2018.09.024 · 2019 · External reference
Efficacy comparison of the novel water-soluble propofol prodrug HX0969w and fospropofol in mice and rats
10.1093/bja/aet218 · 2013 · External reference
Design, synthesis, and activity evaluation of water-soluble propofol derivatives as anesthetic drugs
10.1016/j.bmcl.2024.129972 · 2024 · External reference
Unresolved reference
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Unresolved reference
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Evaluation of new propofol aqueous solutions for intravenous anesthesia
10.1016/j.ijpharm.2004.02.028 · 2004 · External reference
Systematic review of the stability and compatibility of propofol injection
10.5114/ait.2021.103542 · 2021 · External reference
Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1
10.1016/j.ejps.2020.105455 · 2020 · External reference
The Baldwin rules: revised and extended
10.1002/wcms.1261 · 2016 · External reference
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase
10.1016/j.dmpk.2021.100391 · 2021 · External reference
Design and synthesis of carbamate-linked ester prodrugs selectively activated by carboxylesterase 1 with enhanced stability against intestinal hydrolysis
10.1016/j.xphs.2025.104146 · 2026 · External reference
Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase
10.1016/j.bcp.2023.115910 · 2023 · External reference
Clinical use of Fospropofol Disodium: Evaluation of Pharmacology, Safety, and Efficacy
10.2147/dddt.s516789 · 2025 · External reference
