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References from Berbamine alleviates chronic inflammatory pain via microglial inhibition and oxidative stress reduction in the anterior cingulate cortex. Local targets link to admitted publications; unresolved targets remain external evidence.
The pathophysiological role of microglia in dynamic surveillance, phagocytosis and structural remodeling of the developing CNS
10.3389/fnmol.2017.00191 · 2017 · External reference
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
10.1152/physrev.00044.2005 · 2007 · External reference
Viral methyltransferase inhibitors: berbamine, venetoclax, and ponatinib as efficacious antivirals against chikungunya virus
10.1016/j.abb.2024.110111 · 2024 · External reference
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
10.1038/nrn2038 · 2007 · External reference
Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
10.1016/j.neuron.2018.11.009 · 2018 · External reference
NMDA receptors and synaptic plasticity in the anterior cingulate cortex
10.1016/j.neuropharm.2021.108749 · 2021 · External reference
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease
10.1080/17425255.2023.2223959 · 2023 · External reference
Chronic pain: an update on burden, best practices, and new advances
10.1016/s0140-6736(21)00393-7 · 2021 · External reference
Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway
10.1186/s12974-022-02474-2 · 2022 · External reference
Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production
10.3389/fimmu.2023.1239592 · 2023 · External reference
Curcumin restrains oxidative stress of after intracerebral hemorrhage in rat by activating the Nrf2/HO-1 pathway
10.3389/fphar.2022.889226 · 2022 · External reference
Neuroprotective effect of natural compounds in paclitaxel-induced chronic inflammatory pain
10.3390/molecules27154926 · 2022 · External reference
Investigation of natural compounds for therapeutic potential in streptozotocin-induced diabetic neuroinflammation and neuropathic pain
10.3389/fphar.2022.1019033 · 2022 · External reference
Molecular regulation mechanisms and interactions between reactive oxygen species and mitophagy
10.1089/dna.2018.4348 · 2019 · External reference
Inflammation in pathogenesis of chronic pain: foe and friend
10.1177/17448069231178176 · 2023 · External reference
Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression
10.1111/j.1476-5381.2010.01105.x · 2011 · External reference
Linking oxidative stress to inflammation: Toll-like receptors
10.1016/j.freeradbiomed.2010.01.006 · 2010 · External reference
Mechanisms underlying inflammation in neurodegeneration
10.1016/j.cell.2010.02.016 · 2010 · External reference
Anti-hypercholesterolemic effect of berbamine isolated from rhizoma coptidis in hypercholesterolemic zebrafish induced by high-cholesterol diet
2018 · External reference
Multimodal glioma immunotherapy combining TLR9-targeted STAT3 antisense oligodeoxynucleotides with PD1 immune checkpoint blockade
10.1093/neuonc/noaf099 · 2025 · External reference
Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain
10.1016/j.brs.2024.07.020 · 2024 · External reference
Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach
10.1038/s12276-025-01409-0 · 2025 · External reference
Berbamine and thymoquinone exert protective effects against immune-mediated liver injury via NF-kappaB dependent pathway
10.3389/fvets.2022.960981 · 2022 · External reference
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA
10.1111/j.1398-9995.2011.02557.x · 2011 · External reference
Mitochondrial membrane permeabilization in cell death
10.1152/physrev.00013.2006 · 2007 · External reference
Microglia-neuronal communication mediated by P2X4R-BDNF-TrkB promotes synaptic plasticity and anterior cingulate cortex hyperactivity in muscle pain chronicity
10.1016/j.bja.2025.04.048 · 2025 · External reference
Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells
10.1038/aps.2009.167 · 2009 · External reference
Effect of berbamine on T-cell mediated immunity and the prevention of rejection on skin transplants in mice
10.1016/s0378-8741(97)00117-7 · 1998 · External reference
Role of nrf2 in oxidative stress and toxicity
10.1146/annurev-pharmtox-011112-140320 · 2013 · External reference
Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species
10.1016/j.redox.2015.02.001 · 2015 · External reference
Superoxide and inflammation: a mechanism for the anti-inflammatory activity of superoxide dismutase
1980 · External reference
Long-term adverse effects of paracetamol - a review
10.1111/bcp.13656 · 2018 · External reference
Role of microglia in mechanical allodynia in the anterior cingulate cortex
10.1016/j.jphs.2017.05.010 · 2017 · External reference
Pharmacological and therapeutic potential of berbamine: a potent alkaloid from genus berberis
2024 · External reference
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
10.1172/jci25437 · 2005 · External reference
Microglial M1/M2 polarization and metabolic states
10.1111/bph.13139 · 2016 · External reference
Nrf2: a dark horse in Alzheimer's disease treatment
10.1016/j.arr.2020.101206 · 2020 · External reference
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
10.1016/j.redox.2017.01.006 · 2017 · External reference
Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation
10.1016/j.biopha.2024.117309 · 2024 · External reference
Santacruzamate A alleviates pain and pain-related adverse emotions through the inhibition of microglial activation in the anterior cingulate cortex
10.1021/acsptsci.3c00282 · 2024 · External reference
Berbamine reduces chloroquine-induced itch in mice through inhibition of MrgprX1
10.3390/ijms232214321 · 2022 · External reference
Ginkgo biloba attenuates complete Freund's adjuvant-induced inflammatory pain by suppressing the NF-kappaB-CXCL1/CXCR2 signaling cascade in the rat spinal cord
10.1080/13510002.2024.2447778 · 2025 · External reference
Ameliorating effect of berbamine on hepatic key enzymes of carbohydrate metabolism in high-fat diet and streptozotocin induced type 2 diabetic rats
10.1016/j.biopha.2018.04.066 · 2018 · External reference
First-in-human prediction of chronic pain state using intracranial neural biomarkers
10.1038/s41593-023-01338-z · 2023 · External reference
Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
10.1126/science.abe3040 · 2021 · External reference
Opioid receptors
10.1146/annurev-med-062613-093100 · 2016 · External reference
Ganoderma Microsporum immunomodulatory protein alleviates inflammaging and oxidative stress in diabetes-associated periodontitis via Nrf2 signaling activation: an in vitro study
10.3390/antiox13070817 · 2024 · External reference
Berbamine ameliorates DSS-induced colitis by inhibiting peptidyl-arginine deiminase 4-dependent neutrophil extracellular traps formation
10.1016/j.ejphar.2024.176634 · 2024 · External reference
Neuroinflammation, oxidative stress and their interplay in neuropathic pain: focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies
10.1016/j.phrs.2020.105280 · 2020 · External reference
Localization of Mu and delta opioid receptors to anterior cingulate afferents and projection neurons and input/output model of Mu regulation
10.1006/exnr.1995.1069 · 1995 · External reference
Nitrate/nitrite as critical mediators to limit oxidative injury and inflammation
10.1089/ars.2015.6256 · 2015 · External reference
Risk factors for opioid-use disorder and overdose
10.1213/ane.0000000000002496 · 2017 · External reference
Central sensitization: implications for the diagnosis and treatment of pain
10.1016/j.pain.2010.09.030 · 2011 · External reference
Icariin inhibits osteoblast ferroptosis via Nrf2/HO-1 signaling and enhances healing of osteoporotic fractures
10.1016/j.ejphar.2023.176244 · 2024 · External reference
Electroacupuncture stimulation alleviates CFA-induced inflammatory pain via suppressing P2X3 expression
10.3390/ijms20133248 · 2019 · External reference
Cerebral cortex modulation of pain
10.1038/aps.2008.14 · 2009 · External reference
Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCepsilon in rat dorsal root ganglion neurons
10.1186/s12974-021-02155-6 · 2021 · External reference
Pharmacological profiling of a berbamine derivative for lymphoma treatment
10.1182/bloodadvances.2023010873 · 2024 · External reference
Epigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis
10.1016/j.scitotenv.2023.164619 · 2023 · External reference
The TLR4/NF-kappaB/NLRP3 and Nrf2/HO-1 pathways mediate the neuroprotective effects of alkaloids extracted from Uncaria rhynchophylla in Parkinson's disease
10.1016/j.jep.2024.118391 · 2024 · External reference
Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression
10.1016/j.intimp.2023.110009 · 2023 · External reference
Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy
10.1038/cddis.2017.7 · 2017 · External reference
Cortical excitation and chronic pain
10.1016/j.tins.2008.01.003 · 2008 · External reference
Localization of Mu and delta opioid receptors to anterior cingulate afferents and projection neurons and input/output model of Mu regulation
10.1006/exnr.1995.1069 · ExternalCitation · doi-reference
Viral methyltransferase inhibitors: berbamine, venetoclax, and ponatinib as efficacious antivirals against chikungunya virus
10.1016/j.abb.2024.110111 · ExternalCitation · doi-reference
Nrf2: a dark horse in Alzheimer's disease treatment
10.1016/j.arr.2020.101206 · ExternalCitation · doi-reference
Ameliorating effect of berbamine on hepatic key enzymes of carbohydrate metabolism in high-fat diet and streptozotocin induced type 2 diabetic rats
10.1016/j.biopha.2018.04.066 · ExternalCitation · doi-reference
Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation
10.1016/j.biopha.2024.117309 · ExternalCitation · doi-reference
Microglia-neuronal communication mediated by P2X4R-BDNF-TrkB promotes synaptic plasticity and anterior cingulate cortex hyperactivity in muscle pain chronicity
10.1016/j.bja.2025.04.048 · ExternalCitation · doi-reference
Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain
10.1016/j.brs.2024.07.020 · ExternalCitation · doi-reference
Mechanisms underlying inflammation in neurodegeneration
10.1016/j.cell.2010.02.016 · ExternalCitation · doi-reference
Icariin inhibits osteoblast ferroptosis via Nrf2/HO-1 signaling and enhances healing of osteoporotic fractures
10.1016/j.ejphar.2023.176244 · ExternalCitation · doi-reference
Berbamine ameliorates DSS-induced colitis by inhibiting peptidyl-arginine deiminase 4-dependent neutrophil extracellular traps formation
10.1016/j.ejphar.2024.176634 · ExternalCitation · doi-reference
Linking oxidative stress to inflammation: Toll-like receptors
10.1016/j.freeradbiomed.2010.01.006 · ExternalCitation · doi-reference
Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression
10.1016/j.intimp.2023.110009 · ExternalCitation · doi-reference
The TLR4/NF-kappaB/NLRP3 and Nrf2/HO-1 pathways mediate the neuroprotective effects of alkaloids extracted from Uncaria rhynchophylla in Parkinson's disease
10.1016/j.jep.2024.118391 · ExternalCitation · doi-reference
Role of microglia in mechanical allodynia in the anterior cingulate cortex
10.1016/j.jphs.2017.05.010 · ExternalCitation · doi-reference
Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
10.1016/j.neuron.2018.11.009 · ExternalCitation · doi-reference
NMDA receptors and synaptic plasticity in the anterior cingulate cortex
10.1016/j.neuropharm.2021.108749 · ExternalCitation · doi-reference
Central sensitization: implications for the diagnosis and treatment of pain
10.1016/j.pain.2010.09.030 · ExternalCitation · doi-reference
Neuroinflammation, oxidative stress and their interplay in neuropathic pain: focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies
10.1016/j.phrs.2020.105280 · ExternalCitation · doi-reference
Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species
10.1016/j.redox.2015.02.001 · ExternalCitation · doi-reference
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
10.1016/j.redox.2017.01.006 · ExternalCitation · doi-reference
Epigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis
10.1016/j.scitotenv.2023.164619 · ExternalCitation · doi-reference
Cortical excitation and chronic pain
10.1016/j.tins.2008.01.003 · ExternalCitation · doi-reference
Chronic pain: an update on burden, best practices, and new advances
10.1016/s0140-6736(21)00393-7 · ExternalCitation · doi-reference
Effect of berbamine on T-cell mediated immunity and the prevention of rejection on skin transplants in mice
10.1016/s0378-8741(97)00117-7 · ExternalCitation · doi-reference
Santacruzamate A alleviates pain and pain-related adverse emotions through the inhibition of microglial activation in the anterior cingulate cortex
10.1021/acsptsci.3c00282 · ExternalCitation · doi-reference
Cerebral cortex modulation of pain
10.1038/aps.2008.14 · ExternalCitation · doi-reference
Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells
10.1038/aps.2009.167 · ExternalCitation · doi-reference
Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy
10.1038/cddis.2017.7 · ExternalCitation · doi-reference
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
10.1038/nrn2038 · ExternalCitation · doi-reference
Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach
10.1038/s12276-025-01409-0 · ExternalCitation · doi-reference
First-in-human prediction of chronic pain state using intracranial neural biomarkers
10.1038/s41593-023-01338-z · ExternalCitation · doi-reference
Ginkgo biloba attenuates complete Freund's adjuvant-induced inflammatory pain by suppressing the NF-kappaB-CXCL1/CXCR2 signaling cascade in the rat spinal cord
10.1080/13510002.2024.2447778 · ExternalCitation · doi-reference
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease
10.1080/17425255.2023.2223959 · ExternalCitation · doi-reference
Nitrate/nitrite as critical mediators to limit oxidative injury and inflammation
10.1089/ars.2015.6256 · ExternalCitation · doi-reference
Molecular regulation mechanisms and interactions between reactive oxygen species and mitophagy
10.1089/dna.2018.4348 · ExternalCitation · doi-reference
Multimodal glioma immunotherapy combining TLR9-targeted STAT3 antisense oligodeoxynucleotides with PD1 immune checkpoint blockade
10.1093/neuonc/noaf099 · ExternalCitation · doi-reference
Long-term adverse effects of paracetamol - a review
10.1111/bcp.13656 · ExternalCitation · doi-reference
Microglial M1/M2 polarization and metabolic states
10.1111/bph.13139 · ExternalCitation · doi-reference
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA
10.1111/j.1398-9995.2011.02557.x · ExternalCitation · doi-reference
Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression
10.1111/j.1476-5381.2010.01105.x · ExternalCitation · doi-reference
Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
10.1126/science.abe3040 · ExternalCitation · doi-reference
Opioid receptors
10.1146/annurev-med-062613-093100 · ExternalCitation · doi-reference
Role of nrf2 in oxidative stress and toxicity
10.1146/annurev-pharmtox-011112-140320 · ExternalCitation · doi-reference
Mitochondrial membrane permeabilization in cell death
10.1152/physrev.00013.2006 · ExternalCitation · doi-reference
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
10.1152/physrev.00044.2005 · ExternalCitation · doi-reference
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
10.1172/jci25437 · ExternalCitation · doi-reference
Inflammation in pathogenesis of chronic pain: foe and friend
10.1177/17448069231178176 · ExternalCitation · doi-reference
Pharmacological profiling of a berbamine derivative for lymphoma treatment
10.1182/bloodadvances.2023010873 · ExternalCitation · doi-reference
Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCepsilon in rat dorsal root ganglion neurons
10.1186/s12974-021-02155-6 · ExternalCitation · doi-reference
Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway
10.1186/s12974-022-02474-2 · ExternalCitation · doi-reference
Risk factors for opioid-use disorder and overdose
10.1213/ane.0000000000002496 · ExternalCitation · doi-reference
Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production
10.3389/fimmu.2023.1239592 · ExternalCitation · doi-reference
The pathophysiological role of microglia in dynamic surveillance, phagocytosis and structural remodeling of the developing CNS
10.3389/fnmol.2017.00191 · ExternalCitation · doi-reference
Investigation of natural compounds for therapeutic potential in streptozotocin-induced diabetic neuroinflammation and neuropathic pain
10.3389/fphar.2022.1019033 · ExternalCitation · doi-reference
Curcumin restrains oxidative stress of after intracerebral hemorrhage in rat by activating the Nrf2/HO-1 pathway
10.3389/fphar.2022.889226 · ExternalCitation · doi-reference
Berbamine and thymoquinone exert protective effects against immune-mediated liver injury via NF-kappaB dependent pathway
10.3389/fvets.2022.960981 · ExternalCitation · doi-reference
Ganoderma Microsporum immunomodulatory protein alleviates inflammaging and oxidative stress in diabetes-associated periodontitis via Nrf2 signaling activation: an in vitro study
10.3390/antiox13070817 · ExternalCitation · doi-reference
Electroacupuncture stimulation alleviates CFA-induced inflammatory pain via suppressing P2X3 expression
10.3390/ijms20133248 · ExternalCitation · doi-reference
Berbamine reduces chloroquine-induced itch in mice through inhibition of MrgprX1
10.3390/ijms232214321 · ExternalCitation · doi-reference
Neuroprotective effect of natural compounds in paclitaxel-induced chronic inflammatory pain
10.3390/molecules27154926 · ExternalCitation · doi-reference