Research graph
References from Multidimensional roles of the transcription factor EB-regulated autophagy-lysosomal network in tumor drug resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
Chloroquine and chemotherapeutic compounds in experimental cancer treatment
10.3390/ijms25020945 · 2024 · External reference
TFEB controls sensitivity to chemotherapy and immuno-killing in non-small cell lung cancer
10.1186/s13046-024-03142-4 · 2024 · External reference
Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death
10.1080/15548627.2024.2440842 · 2025 · External reference
TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism
10.1038/s41419-023-05828-7 · 2023 · External reference
TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
10.1007/s10456-022-09840-x · 2022 · External reference
Multifaceted activities of transcription factor EB in cancer onset and progression
10.1002/1878-0261.12867 · 2021 · External reference
The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells
10.1038/s41467-022-32855-3 · 2022 · External reference
Differential regulation of STING expression and cisplatin sensitivity by autophagy in non-small cell lung cancer cells
10.1007/s12032-025-02786-2 · 2025 · External reference
VPS34 in autophagy, cancer, and cancer therapy
10.3390/cells15070636 · 2026 · External reference
Aggrephagy at a glance
10.1242/jcs.260888 · 2023 · External reference
Emerging roles for TFEB in the immune response and inflammation
10.1080/15548627.2017.1313943 · 2018 · External reference
Role of TFEB-autophagy lysosomal pathway in palmitic acid induced renal tubular epithelial cell injury
10.1016/j.bbrc.2024.149472 · 2024 · External reference
High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice
10.1016/j.apsb.2023.10.017 · 2024 · External reference
CLC3 regulates V-ATPase to enhance lysosomal degradation and cisplatin resistance in cervical cancer cells
10.1038/s41420-025-02876-0 · 2026 · External reference
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
10.1038/s41467-018-03225-9 · 2018 · External reference
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice
10.1039/d3fo01801f · 2023 · External reference
From the regulatory mechanism of TFEB to its therapeutic implications
10.1038/s41420-024-01850-6 · 2024 · External reference
TFEB biology and agonists at a glance
10.3390/cells10020333 · 2021 · External reference
Research progress on regulatory mechanisms of TFEB and targeting drugs
2020 · External reference
Intra-articular injection of torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
10.1302/2046-3758.56.bjr-2015-0001 · 2016 · External reference
Vectorized ULK1/2 and VPS34 inhibitors for tissue-selective autophagy inhibition in oncology
10.1021/acs.jmedchem.5c00997 · 2026 · External reference
Structural basis for phosphorylation of TFEB by mTORC1
10.1038/s41594-023-00952-6 · 2023 · External reference
AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
10.1096/fj.201900841r · 2019 · External reference
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
10.1016/j.ccr.2006.06.001 · 2006 · External reference
Lysosome as a chemical reactor
10.3390/ijms262311581 · 2025 · External reference
Mechanism and medical implications of mammalian autophagy
10.1038/s41580-018-0003-4 · 2018 · External reference
Inhibition of TFEB promotes tumor-educated dendritic cells activation to enhance antitumor immune responses
10.1016/j.molimm.2022.04.011 · 2022 · External reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · 2024 · External reference
The oncogene transcription factor EB regulates vascular functions
10.3389/fphys.2021.640061 · 2021 · External reference
TFEB controls vascular development by regulating the proliferation of endothelial cells
10.15252/embj.201798250 · 2019 · External reference
Hydroxychloroquine's diverse targets: a new frontier in precision medicine
10.3389/fimmu.2025.1655573 · 2025 · External reference
Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction
10.1161/circulationaha.124.071774 · 2026 · External reference
Lysosomal gene ATP6AP1 promotes doxorubicin resistance via up-regulating autophagic flux in breast cancer
10.1186/s12935-024-03579-9 · 2024 · External reference
Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress
10.1083/jcb.202403104 · 2025 · External reference
Dual targeting of glutamine metabolism and lysosomal function in eliminating drug-tolerant KRAS-mutant cancer cells
10.1038/s42003-026-10374-x · 2026 · External reference
Dysregulated TFEB–autophagy-lysosome pathway links acute COVID-19 immunopathology to long COVID sequelae
10.3389/fimmu.2025.1708364 · 2025 · External reference
GADD45α is a direct target of TFEB and contributes to tacrolimus-induced chronic nephrotoxicity
10.1172/jci.insight.183560 · 2025 · External reference
Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators
10.3390/cells11152262 · 2022 · External reference
Sphk2 suppresses ferroptosis in ischemic hearts by promoting HSP90AA1-mediated TFEB nuclear translocation, lysosome biogenesis and lysosome-autophagy pathway-dependent lipid-ROS clearance
10.1016/j.metabol.2025.156428 · 2026 · External reference
Balancing nutrient and energy demand and supply via autophagy
10.1016/j.cub.2022.04.071 · 2022 · External reference
NoxO1 promotes endosome formation and reduces intracellular vesicle processing
10.1016/j.redox.2025.103973 · 2026 · External reference
Targeting autophagy for acetaminophen-induced liver injury: an update
10.3390/livers4030027 · 2024 · External reference
TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1
10.1126/sciadv.aea9302 · 2026 · External reference
The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage
10.7554/elife.40856 · 2018 · External reference
Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding atp-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration
10.1016/j.drup.2024.101100 · 2024 · External reference
Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein
10.1371/journal.pone.0120819 · 2015 · External reference
Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
2016 · External reference
Failure of lysosomal acidification and endomembrane network in neurodegeneration
10.1038/s12276-025-01579-x · 2025 · External reference
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
10.1080/15548627.2020.1797280 · 2021 · External reference
Effects of autophagy inhibition by SAR405 , a selective VPS34 inhibitor, on pleural mesothelioma cells. Thorac
2026 · External reference
Acetylation of transcription factor TFEB: impact for nuclear translocation, gene activation and synthesis of lysosomal enzymes. Doctoral dissertation
2023 · External reference
Lysosomal Ca2+ release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons
10.1038/s41598-024-75802-6 · 2024 · External reference
Cholesterol metabolism: a strategy for overcoming drug resistance in tumors
10.1016/j.bcp.2025.116974 · 2025 · External reference
Drug resistance in cancer: molecular mechanisms and emerging treatment strategies
10.1186/s43556-025-00352-w · 2025 · External reference
TFEB: a emerging regulator in lipid homeostasis for atherosclerosis
2021 · External reference
Oxidative stress and reprogramming of lipid metabolism in cancers
10.3390/antiox14020201 · 2025 · External reference
PINK1-Mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells
10.1158/0008-5472.can-22-2370 · 2023 · External reference
Empagliflozin alleviates iron accumulation and ferroptosis to mitigate bleomycin-induced pulmonary fibrosis through TFEB-mediated regulation of ACSL4 and GPX4
10.1016/j.ejphar.2025.178375 · 2026 · External reference
Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB‐mediated lysosomal function
10.1111/jcmm.16593 · 2021 · External reference
The novel TFEB agonist desloratadine ameliorates hepatic steatosis by activating the autophagy-lysosome pathway
10.3389/fphar.2024.1449178 · 2024 · External reference
TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice
10.1016/j.jbc.2024.107929 · 2024 · External reference
A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB
2023 · External reference
The lipid basis of cell death and autophagy
10.1080/15548627.2023.2259732 · 2024 · External reference
Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy
10.18632/aging.102951 · 2020 · External reference
Gemcitabine promotes autophagy and lysosomal function through ERK- and TFEB-dependent mechanisms
10.1038/s41420-023-01342-z · 2023 · External reference
The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
10.1126/scisignal.2004754 · 2014 · External reference
Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
10.1083/jcb.201209135 · 2013 · External reference
Defective lysosome reformation during autophagy causes skeletal muscle disease
10.1172/jci135124 · 2021 · External reference
Transcriptional activation of lysosomal exocytosis promotes cellular clearance
10.1016/j.devcel.2011.07.016 · 2011 · External reference
Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron
10.1038/s41598-025-89127-5 · 2025 · External reference
Autophagic flux measurement: cargo degradation versus generation of degradation products
10.1016/j.ceb.2025.102463 · 2025 · External reference
Autophagy in human diseases
10.1056/nejmra2022774 · 2020 · External reference
Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration
10.1016/j.biopha.2022.113328 · 2022 · External reference
TFEB-mediated transcriptional regulation of autophagy induces autosis during ischemia/reperfusion in the heart
10.3390/cells11020258 · 2022 · External reference
Mechanisms governing autophagosome biogenesis
10.1038/s41580-020-0241-0 · 2020 · External reference
Autophagic lysosome reformation in health and disease
10.1080/15548627.2022.2128019 · 2023 · External reference
TFEB at a glance
10.1242/jcs.146365 · 2016 · External reference
MiT/TFE transcription factors are activated during mitophagy downstream of parkin and Atg5
10.1083/jcb.201501002 · 2015 · External reference
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
10.1038/s41580-024-00757-5 · 2024 · External reference
PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
10.1016/j.celrep.2023.112519 · 2023 · External reference
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3
10.1080/15548627.2021.1898748 · 2021 · External reference
Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress
10.1038/s41467-022-28874-9 · 2022 · External reference
Transcription factor EB inhibition in response to genotoxic stress promotes apoptosis of glioblastoma cells
10.1016/j.neuint.2025.106087 · 2025 · External reference
Transition metals activate TFEB in overexpressing cells
10.1042/bj20140645 · 2015 · External reference
The lysosome as a regulatory hub
10.1146/annurev-cellbio-111315-125125 · 2016 · External reference
TFEB regulates ATP7B expression to promote platinum chemoresistance in human ovarian cancer cells
10.3390/cells11020219 · 2022 · External reference
Oxidative stress: harms and benefits for human health
10.1155/2017/8416763 · 2017 · External reference
TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression
10.1016/j.devcel.2024.12.005 · 2025 · External reference
Turning tumor acidosis into a therapeutic advantage with nanomedicine
10.1021/acsnanomed.5c00021 · 2026 · External reference
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
10.1038/s41598-018-28265-5 · 2018 · External reference
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
10.1126/scisignal.2002790 · 2012 · External reference
LC3-positive structures are prominent in autophagy-deficient cells
10.1038/s41598-019-46657-z · 2019 · External reference
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
10.1080/15548627.2018.1535292 · 2019 · External reference
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities
10.1038/s41568-024-00737-z · 2024 · External reference
Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
10.1038/s41568-023-00612-3 · 2023 · External reference
MTOR inhibitors in targeting autophagy and autophagy-associated signaling for cancer cell death and therapy
2025 · External reference
Feeding activates FGF15‐SHP‐TFEB‐mediated lipophagy in the gut
10.15252/embj.2021109997 · 2022 · External reference
Epidrug screening identifies type I PRMT inhibitors as modulators of lysosomal exocytosis and drug sensitivity in cancers
10.1038/s41419-025-07900-w · 2025 · External reference
TFEB links autophagy to lysosomal biogenesis
10.1126/science.1204592 · 2011 · External reference
Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation
10.1042/bcj20200676 · 2021 · External reference
Exosomal circRHCG promotes breast cancer metastasis via facilitating M2 polarization through TFEB ubiquitination and degradation
10.1038/s41698-024-00507-y · 2024 · External reference
Novel exosomal circEGFR facilitates triple negative breast cancer autophagy via promoting TFEB nuclear trafficking and modulating miR-224-5p/ATG13/ULK1 feedback loop
10.1038/s41388-024-02950-4 · 2024 · External reference
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
10.1080/15548627.2016.1179404 · 2016 · External reference
Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
10.1016/j.celrep.2024.114409 · 2024 · External reference
TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance
2025 · External reference
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
10.1038/s41418-022-01028-6 · 2022 · External reference
Multiomics identifies a cholesterol–TFEB–PLD3–TLR9 axis driving immunosuppressive tumor-associated macrophage polarization in esophageal squamous cell carcinoma
10.1073/pnas.2520427123 · 2026 · External reference
Emerging targets in lipid metabolism for cancer therapy
10.1016/j.tips.2024.04.007 · 2024 · External reference
RAF1 kinase contributes to autophagic lysosome reformation
10.1016/j.celrep.2025.115490 · 2025 · External reference
Lysosomal biology and function: modern view of cellular debris bin
10.3390/cells9051131 · 2020 · External reference
Lysosomal exocytosis: from cell protection to protumoral functions
10.1016/j.canlet.2024.217024 · 2024 · External reference
Lys-ing the resistance: targeting lysosomes to overcome chemoresistance in ovarian cancer
10.1007/s11912-026-01742-1 · 2026 · External reference
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
10.1038/s41593-023-01494-2 · 2024 · External reference
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
10.1038/s41467-017-02332-3 · 2017 · External reference
TFEB promotes ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma
10.7150/thno.106469 · 2025 · External reference
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity
10.1038/s41586-026-10193-4 · 2026 · External reference
A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
10.1038/s41401-023-01078-7 · 2023 · External reference
STING-driven activation of TFEB/TFE3 establishes a negative feedback loop to control immune homeostasis
10.1016/j.cellsig.2025.112322 · 2026 · External reference
Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson's disease
2026 · External reference
Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway
10.1083/jcb.202112024 · 2022 · External reference
Low-dose simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB
10.1007/s13402-026-01164-y · 2026 · External reference
Lysosome regulation of microglia in Alzheimer's disease via TFEB–vacuolar ATPase
10.1038/s41593-023-01495-1 · 2024 · External reference
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux
10.1016/j.cellsig.2025.111834 · 2025 · External reference
Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy
10.1186/s12944-024-02024-0 · 2024 · External reference
Gal3‐CaN‐Smurf1 complex sequestrates FLCN‐FNIPs to facilitate TFEB activation in response to endomembrane damage
10.1002/advs.202413241 · 2025 · External reference
Induction of lysosome biogenesis is a novel function of the CGAS-STING1 pathway
10.1080/15548627.2025.2456064 · 2025 · External reference
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
10.1016/j.immuni.2024.11.017 · 2025 · External reference
Lysosome biogenesis: regulation and functions
10.1083/jcb.202102001 · 2021 · External reference
Novel insight into functions of transcription factor EB (TFEB) in Alzheimer's disease and Parkinson's disease
10.14336/ad.2022.0927 · 2023 · External reference
Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation
10.1016/j.bbrc.2010.03.155 · 2010 · External reference
Role and research progress of transcription factor EB in inflammatory diseases through regulation of the autophagy-lysosome pathway
2025 · External reference
Termination of autophagy and reformation of lysosomes regulated by mTOR
10.1038/nature09076 · 2010 · External reference
TFEB-nuclear translocation promotes BNIP3-mediated mitophagy and alleviates oxidative stress and ferroptosis in acute pancreatitis
10.1016/j.freeradbiomed.2025.11.045 · 2026 · External reference
3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury
10.7150/thno.78370 · 2023 · External reference
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
2016 · External reference
Lysosome calcium in ROS regulation of autophagy
10.1080/15548627.2016.1212787 · 2016 · External reference
Machinery, regulation and pathophysiological implications of autophagosome maturation
10.1038/s41580-021-00392-4 · 2021 · External reference
Autophagosome maturation: an epic journey from the ER to lysosomes
10.1083/jcb.201810099 · 2019 · External reference
Neddylation activated TRIM25 desensitizes triple-negative breast cancer to paclitaxel via TFEB-mediated autophagy
10.1186/s13046-024-03085-w · 2024 · External reference
Lysosomes as mediators of drug resistance in cancer
10.1016/j.drup.2015.11.004 · 2016 · External reference
Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
10.1038/s41419-018-1227-0 · 2018 · External reference
SLC7A11 is an unconventional h+ transporter in lysosomes
10.1016/j.cell.2025.04.004 · 2025 · External reference
Identification of KHS-101 as a transcription factor EB activator to promote α-synuclein degradation
10.3390/ijms27020905 · 2026 · External reference
Unraveling the mysterious veil of ULK1: from non-canonical functions to therapeutic applications
10.1016/j.ijbiomac.2025.145177 · 2025 · External reference
Acidic tumor microenvironments and emerging therapeutic strategies for cancer therapy
10.3349/ymj.2024.0210 · 2025 · External reference
Multifaceted activities of transcription factor EB in cancer onset and progression
10.1002/1878-0261.12867 · ExternalCitation · doi-reference
Gal3‐CaN‐Smurf1 complex sequestrates FLCN‐FNIPs to facilitate TFEB activation in response to endomembrane damage
10.1002/advs.202413241 · ExternalCitation · doi-reference
TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
10.1007/s10456-022-09840-x · ExternalCitation · doi-reference
Lys-ing the resistance: targeting lysosomes to overcome chemoresistance in ovarian cancer
10.1007/s11912-026-01742-1 · ExternalCitation · doi-reference
Differential regulation of STING expression and cisplatin sensitivity by autophagy in non-small cell lung cancer cells
10.1007/s12032-025-02786-2 · ExternalCitation · doi-reference
Low-dose simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB
10.1007/s13402-026-01164-y · ExternalCitation · doi-reference
High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice
10.1016/j.apsb.2023.10.017 · ExternalCitation · doi-reference
Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation
10.1016/j.bbrc.2010.03.155 · ExternalCitation · doi-reference
Role of TFEB-autophagy lysosomal pathway in palmitic acid induced renal tubular epithelial cell injury
10.1016/j.bbrc.2024.149472 · ExternalCitation · doi-reference
Cholesterol metabolism: a strategy for overcoming drug resistance in tumors
10.1016/j.bcp.2025.116974 · ExternalCitation · doi-reference
Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration
10.1016/j.biopha.2022.113328 · ExternalCitation · doi-reference
Lysosomal exocytosis: from cell protection to protumoral functions
10.1016/j.canlet.2024.217024 · ExternalCitation · doi-reference
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
10.1016/j.ccr.2006.06.001 · ExternalCitation · doi-reference
Autophagic flux measurement: cargo degradation versus generation of degradation products
10.1016/j.ceb.2025.102463 · ExternalCitation · doi-reference
SLC7A11 is an unconventional h+ transporter in lysosomes
10.1016/j.cell.2025.04.004 · ExternalCitation · doi-reference
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux
10.1016/j.cellsig.2025.111834 · ExternalCitation · doi-reference
STING-driven activation of TFEB/TFE3 establishes a negative feedback loop to control immune homeostasis
10.1016/j.cellsig.2025.112322 · ExternalCitation · doi-reference
PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
10.1016/j.celrep.2023.112519 · ExternalCitation · doi-reference
Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
10.1016/j.celrep.2024.114409 · ExternalCitation · doi-reference
RAF1 kinase contributes to autophagic lysosome reformation
10.1016/j.celrep.2025.115490 · ExternalCitation · doi-reference
Balancing nutrient and energy demand and supply via autophagy
10.1016/j.cub.2022.04.071 · ExternalCitation · doi-reference
Transcriptional activation of lysosomal exocytosis promotes cellular clearance
10.1016/j.devcel.2011.07.016 · ExternalCitation · doi-reference
TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression
10.1016/j.devcel.2024.12.005 · ExternalCitation · doi-reference
Lysosomes as mediators of drug resistance in cancer
10.1016/j.drup.2015.11.004 · ExternalCitation · doi-reference
Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding atp-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration
10.1016/j.drup.2024.101100 · ExternalCitation · doi-reference
Empagliflozin alleviates iron accumulation and ferroptosis to mitigate bleomycin-induced pulmonary fibrosis through TFEB-mediated regulation of ACSL4 and GPX4
10.1016/j.ejphar.2025.178375 · ExternalCitation · doi-reference
TFEB-nuclear translocation promotes BNIP3-mediated mitophagy and alleviates oxidative stress and ferroptosis in acute pancreatitis
10.1016/j.freeradbiomed.2025.11.045 · ExternalCitation · doi-reference
Unraveling the mysterious veil of ULK1: from non-canonical functions to therapeutic applications
10.1016/j.ijbiomac.2025.145177 · ExternalCitation · doi-reference
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
10.1016/j.immuni.2024.11.017 · ExternalCitation · doi-reference
TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice
10.1016/j.jbc.2024.107929 · ExternalCitation · doi-reference
Sphk2 suppresses ferroptosis in ischemic hearts by promoting HSP90AA1-mediated TFEB nuclear translocation, lysosome biogenesis and lysosome-autophagy pathway-dependent lipid-ROS clearance
10.1016/j.metabol.2025.156428 · ExternalCitation · doi-reference
Inhibition of TFEB promotes tumor-educated dendritic cells activation to enhance antitumor immune responses
10.1016/j.molimm.2022.04.011 · ExternalCitation · doi-reference
Transcription factor EB inhibition in response to genotoxic stress promotes apoptosis of glioblastoma cells
10.1016/j.neuint.2025.106087 · ExternalCitation · doi-reference
NoxO1 promotes endosome formation and reduces intracellular vesicle processing
10.1016/j.redox.2025.103973 · ExternalCitation · doi-reference
Emerging targets in lipid metabolism for cancer therapy
10.1016/j.tips.2024.04.007 · ExternalCitation · doi-reference
Vectorized ULK1/2 and VPS34 inhibitors for tissue-selective autophagy inhibition in oncology
10.1021/acs.jmedchem.5c00997 · ExternalCitation · doi-reference
Turning tumor acidosis into a therapeutic advantage with nanomedicine
10.1021/acsnanomed.5c00021 · ExternalCitation · doi-reference
Termination of autophagy and reformation of lysosomes regulated by mTOR
10.1038/nature09076 · ExternalCitation · doi-reference
Failure of lysosomal acidification and endomembrane network in neurodegeneration
10.1038/s12276-025-01579-x · ExternalCitation · doi-reference
Novel exosomal circEGFR facilitates triple negative breast cancer autophagy via promoting TFEB nuclear trafficking and modulating miR-224-5p/ATG13/ULK1 feedback loop
10.1038/s41388-024-02950-4 · ExternalCitation · doi-reference
A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
10.1038/s41401-023-01078-7 · ExternalCitation · doi-reference
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
10.1038/s41418-022-01028-6 · ExternalCitation · doi-reference
Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
10.1038/s41419-018-1227-0 · ExternalCitation · doi-reference
TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism
10.1038/s41419-023-05828-7 · ExternalCitation · doi-reference
Epidrug screening identifies type I PRMT inhibitors as modulators of lysosomal exocytosis and drug sensitivity in cancers
10.1038/s41419-025-07900-w · ExternalCitation · doi-reference
Gemcitabine promotes autophagy and lysosomal function through ERK- and TFEB-dependent mechanisms
10.1038/s41420-023-01342-z · ExternalCitation · doi-reference
From the regulatory mechanism of TFEB to its therapeutic implications
10.1038/s41420-024-01850-6 · ExternalCitation · doi-reference
CLC3 regulates V-ATPase to enhance lysosomal degradation and cisplatin resistance in cervical cancer cells
10.1038/s41420-025-02876-0 · ExternalCitation · doi-reference
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
10.1038/s41467-017-02332-3 · ExternalCitation · doi-reference
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
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