Research graph
References from Eugenol attenuates ferroptosis, mitochondrial damage, and inflammation in cardiac hypertrophy via the 14-3-3γ/AMPKα2 pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
The role of the 14-3-3 protein family in health, disease, and drug development
10.1016/j.drudis.2015.09.012 · 2016 · External reference
Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling
10.1161/circulationaha.121.055732 · 2021 · External reference
The Dual Antioxidant/Prooxidant Effect of Eugenol and Its Action in Cancer Development and Treatment
10.3390/nu9121367 · 2017 · External reference
Thymoquinone ameliorates pressure overload-induced cardiac hypertrophy by activating the AMPK signalling pathway
10.1111/jcmm.17138 · 2022 · External reference
Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure
10.1016/j.bbrc.2019.06.015 · 2019 · External reference
Interrelations between oxidative stress and calcineurin in the attenuation of cardiac apoptosis by eugenol
10.1007/s11010-006-2386-3 · 2006 · External reference
Targeting cardiovascular risk factors with eugenol: an anti-inflammatory perspective
10.1007/s10787-023-01392-w · 2024 · External reference
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
10.1038/s41569-022-00735-4 · 2023 · External reference
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
10.1161/circresaha.120.316509 · 2020 · External reference
Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy
10.1016/j.redox.2021.102185 · 2021 · External reference
AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η
10.1016/j.biopha.2024.116542 · 2024 · External reference
Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η
2024 · External reference
Ferroptosis: mechanisms, biology, and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
AMPK activators: mechanisms of action and physiological activities
10.1038/emm.2016.16 · 2016 · External reference
Iron overload cardiomyopathy in clinical practice
10.1161/circulationaha.111.050773 · 2011 · External reference
The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks
10.7150/ijbs.83348 · 2023 · External reference
PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner
10.1016/j.redox.2024.103158 · 2024 · External reference
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway
2023 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway
10.1016/j.cellsig.2023.110974 · 2024 · External reference
Antimicrobial activity of eugenol and essential oils containing eugenol: A mechanistic viewpoint
10.1080/1040841x.2017.1295225 · 2017 · External reference
Worsening of chronic heart failure: definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology
10.1002/ejhf.2874 · 2023 · External reference
14-3-3 proteins--an update
10.1038/sj.cr.7290291 · 2005 · External reference
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
10.1038/s41392-024-01816-1 · 2024 · External reference
Puerarin activates adaptive autophagy and protects the myocardium against doxorubicin-induced cardiotoxicity via the 14-3-3γ/PKCε pathway
10.1016/j.biopha.2022.113403 · 2022 · External reference
Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?
10.3390/ijms23010030 · 2021 · External reference
Eugenol: a natural compound with versatile pharmacological actions
2010 · External reference
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
10.1161/circulationaha.121.053575 · 2021 · External reference
Global burden of heart failure: a comprehensive and updated review of epidemiology
10.1093/cvr/cvac013 · 2023 · External reference
Heart failure drug titration, discontinuation, mortality, and heart failure hospitalization risk: a multinational observational study (US, UK, and Sweden)
10.1002/ejhf.2271 · 2021 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses
2016 · External reference
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets
10.1093/nar/gkaa1074 · 2021 · External reference
Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure
10.1073/pnas.2203628119 · 2022 · External reference
Contemporary biophysical approaches for studying 14-3-3 protein-protein interactions
10.3389/fmolb.2022.1043673 · 2022 · External reference
Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress
10.1080/13880209.2022.2157021 · 2023 · External reference
Biological Properties and Prospects for the Application of Eugenol: A Review
10.3390/ijms22073671 · 2021 · External reference
Treating oxidative stress in heart failure: past, present, and future
10.1002/ejhf.1320 · 2019 · External reference
Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation
10.1016/j.redox.2024.103079 · 2024 · External reference
Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting the NF-κB pathway in vitro and in vivo
10.1016/j.ejmech.2023.115669 · 2023 · External reference
Puerarin attenuates isoproterenol-induced myocardial hypertrophy via inhibition of the Wnt/β-catenin signaling pathway
10.3892/mmr.2022.12822 · 2022 · External reference
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
10.1093/nar/gkq537 · 2010 · External reference
Renalase improves pressure overload-induced heart failure in rats by regulating extracellular signal-regulated protein kinase 1/2 signaling
10.1038/s41440-020-00599-6 · 2021 · External reference
NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling
10.1016/j.lfs.2023.121873 · 2023 · External reference
Salidroside pretreatment alleviates ferroptosis induced by myocardial ischemia/reperfusion through mitochondrial superoxide-dependent AMPKα2 activation
10.1016/j.phymed.2024.155365 · 2024 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3
10.1161/circresaha.119.315861 · 2020 · External reference
FNDC5/Irisin inhibits pathological cardiac hypertrophy
10.1042/cs20190016 · 2019 · External reference
Ferroptosis in cardiac hypertrophy and heart failure
10.1016/j.biopha.2023.115765 · 2023 · External reference
The molecular mechanisms of ferroptosis and its role in cardiovascular disease
10.1016/j.biopha.2021.112423 · 2022 · External reference
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis, and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling
10.1016/j.freeradbiomed.2022.01.020 · 2022 · External reference
Mitochondrial dysfunction in the pathophysiology of heart failure
10.1172/jci120849 · 2018 · External reference
FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations
10.1093/nar/gkac935 · 2023 · External reference
DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics
10.1161/circulationaha.121.055727 · 2022 · External reference
