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References from Tirzepatide attenuates cardiac microvascular injury and ferroptosis-related lipid peroxidation in diabetic mice: endothelial responses in the context of partial PRKN silencing. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial quality control mechanisms as molecular targets in diabetic heart
10.1016/j.metabol.2022.155313 · 2022 · External reference
The effect of unhealthy lifestyle on the pathogenesis of sick sinus syndrome: a life-guiding review
2024 · External reference
Targeting mitochondria by lipid-selenium conjugate drug results in malate/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression
10.7150/ijbs.102424 · 2024 · External reference
Potential candidates of natural antioxidants from herbs for treating lung disorders: focus on redox balance and natural products
10.1002/ptr.70008 · 2025 · External reference
CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis
10.1016/j.phrs.2022.106086 · 2022 · External reference
Dihydromyricetin attenuates diabetic cardiomyopathy by inhibiting oxidative stress, inflammation and necroptosis via sirtuin 3 activation
10.3390/antiox12010200 · 2023 · External reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · 2017 · External reference
GLP-1-based therapies for diabetes, obesity and beyond
10.1038/s41573-025-01183-8 · 2025 · External reference
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
10.1038/s41569-022-00735-4 · 2023 · External reference
Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes
10.1056/nejmoa2107519 · 2021 · External reference
Liraglutide attenuates doxorubicin-induced cardiomyocyte ferroptosis via DHHC7-mediated STAT3 palmitoylation
10.1016/j.lfs.2025.123912 · 2025 · External reference
Glycemia reduction in type 2 diabetes—microvascular and cardiovascular outcomes
10.1056/nejmoa2200436 · 2022 · External reference
Heart failure in diabetes
10.1016/j.metabol.2021.154910 · 2021 · External reference
Tirzepatide once weekly for the treatment of obesity
10.1056/nejmoa2206038 · 2022 · External reference
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
10.1038/s41392-023-01400-z · 2023 · External reference
Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomics
10.1186/s12944-024-02416-2 · 2025 · External reference
Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression
10.1186/s13062-023-00363-z · 2023 · External reference
Hyperglycemia-induced DNA damage response activates DNA-PK complex to promote endothelial ferroptosis in type 2 diabetic cardiomyopathy
10.7150/thno.109514 · 2025 · External reference
Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis
10.1038/s41467-024-48970-2 · 2024 · External reference
Insulin resistance and coronary microvascular dysfunction: a complex interplay
10.1186/s12933-025-03068-x · 2026 · External reference
Prevalence of coronary microvascular disease and coronary vasospasm in patients with nonobstructive coronary artery disease: systematic review and meta-analysis
10.1161/jaha.121.023207 · 2022 · External reference
The role of PINK1–Parkin in mitochondrial quality control
10.1038/s41556-024-01513-9 · 2024 · External reference
Unresolved reference
2011 · External reference
Tirzepatide for heart failure with preserved ejection fraction and obesity
10.1056/nejmoa2410027 · 2025 · External reference
Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality
10.3389/fphar.2024.1422686 · 2024 · External reference
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
10.1007/s10456-024-09938-4 · 2024 · External reference
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
10.1038/s41392-024-01816-1 · 2024 · External reference
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia–reperfusion model
10.1016/j.jgr.2025.04.006 · 2025 · External reference
Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury
10.1016/j.phymed.2025.156982 · 2025 · External reference
Long-chain acyl-CoA synthetase-1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells
10.1152/ajpendo.00117.2020 · 2020 · External reference
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
10.1172/jci146353 · 2021 · External reference
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue
10.1016/j.molmet.2022.101550 · 2022 · External reference
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis
10.1038/s41556-025-01668-z · 2025 · External reference
Increasing fatty acid oxidation prevents high-fat diet–induced cardiomyopathy through regulating Parkin-mediated mitophagy
10.1161/circulationaha.119.043319 · 2020 · External reference
Ferrostatin-1 alleviates tissue and cell damage in diabetic retinopathy by improving the antioxidant capacity of the Xc--GPX4 system
10.1038/s41420-022-01141-y · 2022 · External reference
A novel ligustrazine-based nanodelivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5-DUSP1 axis for mitochondrial repair
10.1186/s12951-025-03667-6 · 2025 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide
10.1186/s12933-024-02319-7 · 2024 · External reference
Semaglutide administration protects cardiomyocytes in db/db mice via energetic improvement and mitochondrial quality control
10.1038/s41401-024-01448-9 · 2025 · External reference
Mitophagy for cardioprotection
10.1007/s00395-023-01009-x · 2023 · External reference
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
10.1038/s41569-023-00849-3 · 2023 · External reference
DNA-PKcs-driven YAP1 phosphorylation and nuclear translocation: a key regulator of ferroptosis in hyperglycemia-induced cardiac dysfunction in type 1 diabetes
2025 · External reference
Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-dependent mitophagy
10.7150/ijbs.95853 · 2024 · External reference
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance
10.1186/s12951-025-03420-z · 2025 · External reference
Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice
2023 · External reference
Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy
10.1186/s13287-022-03099-1 · 2022 · External reference
Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases
10.1186/s12933-025-02614-x · 2025 · External reference
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
10.1172/jci.insight.140532 · 2020 · External reference
Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies
10.1016/j.biocel.2024.106650 · 2024 · External reference
Metabolic coordination structures contribute to diabetic myocardial dysfunction
10.1161/circresaha.124.326044 · 2025 · External reference
Organelle dynamics of endothelial mitochondria in diabetic angiopathy
10.1016/j.ejphar.2021.173865 · 2021 · External reference
Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart
10.1002/jcp.31149 · 2024 · External reference
Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
10.1016/j.jpha.2024.101034 · 2024 · External reference
AP39 inhibits ferroptosis by inhibiting mitochondrial autophagy through the PINK1/parkin pathway to improve myocardial fibrosis with myocardial infarction
10.1016/j.biopha.2023.115195 · 2023 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Astragaloside VI attenuates mechanical stress-induced cardiac remodeling through piezo1-VDAC1 dependent endoplasmic reticulum unfolded protein response
10.1016/j.phymed.2025.157288 · 2025 · External reference
Curcumin attenuates ferroptosis-induced myocardial injury in diabetic cardiomyopathy through the Nrf2 pathway
2022 · External reference
Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway
10.4239/wjd.v16.i12.112423 · 2025 · External reference