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References from Engineering nanocarriers for PROTAC delivery: liposomes, cyclodextrin aggregates, and albumin-based nanoparticles for ACBI2 and ACBI3. Local targets link to admitted publications; unresolved targets remain external evidence.
Degraders on demand: engineering smart nanocarriers for PROTAC delivery
10.1021/acs.molpharmaceut.5c01070 · 2026 · External reference
Liposomal formulation of the CDK9 PROTAC THAL-SNS-032 enhances the antitumor activity in breast cancer cell lines
10.1016/j.biopha.2025.118352 · 2025 · External reference
Solution conformations shed light on PROTAC cell permeability
10.1021/acsmedchemlett.0c00556 · 2021 · External reference
PROTAC targeted protein degraders: the past is prologue
10.1038/s41573-021-00371-6 · 2022 · External reference
Protein degraders enter the clinic — a new approach to cancer therapy
10.1038/s41571-023-00736-3 · 2023 · External reference
Emerging albumin-binding anticancer drugs for tumor-targeted drug delivery: current understandings and clinical translation
10.3390/pharmaceutics14040728 · 2022 · External reference
Brexanolone to treat postpartum depression in adult women
10.64719/pb.4397 · 2025 · External reference
Beyond the rule of 5: lessons learned from AbbVie’s drugs and compound collection: miniperspective
10.1021/acs.jmedchem.7b00717 · 2018 · External reference
SPARC expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients
10.1593/tlo.09109 · 2009 · External reference
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Albumin-based nanoparticles with factorial design as a promising approach for remodeled repaglinide: evidence from In Silico, In Vitro, and In Vivo Evaluations
10.3390/pharmaceutics17030350 · 2025 · External reference
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Pharmacokinetics of paclitaxel-containing liposomes in rats
10.1208/ps050432 · 2003 · External reference
Liposomal formulations of poorly soluble camptothecin: drug retention and biodistribution
10.3109/08982104.2012.742537 · 2013 · External reference
PROTAC technology: opportunities and challenges
10.1021/acsmedchemlett.9b00597 · 2020 · External reference
The albumin-based nanoparticle formation in relation to protein aggregation
10.1016/j.saa.2021.119489 · 2021 · External reference
Dual centrifugation – a new technique for nanomilling of poorly soluble drugs and formulation screening by an DoE-approach
10.1016/j.ijpharm.2017.07.047 · 2017 · External reference
Stopping the beating heart of cancer: KRAS reviewed
10.1016/j.sbi.2021.06.013 · 2021 · External reference
Mechanism and kinetics of the loss of poorly soluble drugs from liposomal carriers studied by a novel flow field-flow fractionation-based drug release −/transfer-assay
10.1016/j.jconrel.2016.04.031 · 2016 · External reference
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
10.1073/pnas.1316793111 · 2014 · External reference
Cellular senescence: the good, the bad and the unknown
10.1038/s41581-022-00601-z · 2022 · External reference
A DoE-dual centrifugation-driven screening platform for liposomal incorporation of poorly soluble APIs: application to the PROTAC ACBI2
2026 · External reference
Albumin-encapsulated HSP90-PROTAC BP3 nanoparticles not only retain protein degradation ability but also enhance the antitumour activity of BP3 in vivo
10.1080/1061186x.2023.2185247 · 2023 · External reference
Tailoring the lamellarity of liposomes prepared by dual centrifugation
10.3390/pharmaceutics15020706 · 2023 · External reference
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
10.1038/s41467-022-33430-6 · 2022 · External reference
Development of liposome systems for enhancing the PK properties of bivalent PROTACs
10.3390/pharmaceutics15082098 · 2023 · External reference
SpheroidJ: an open-source set of tools for spheroid segmentation
10.1016/j.cmpb.2020.105837 · 2021 · External reference
Unresolved reference
2023 · External reference
Mitotane nanocarriers for the treatment of adrenocortical carcinoma: evaluation of albumin-stabilized nanoparticles and liposomes in a preclinical In vitro study with 3D spheroids
10.3390/pharmaceutics14091891 · 2022 · External reference
Optimizing imaging of three-dimensional multicellular tumor spheroids with fluorescent reporter proteins using confocal microscopy
10.2310/7290.2008.00023 · 2008 · External reference
Quantitative live-cell confocal imaging of 3D spheroids in a high-throughput format
10.1177/2472630318756058 · 2018 · External reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/s0169-409x(00)00129-0 · 2001 · External reference
An overview of PROTACs: a promising drug discovery paradigm
10.1186/s43556-022-00112-0 · 2022 · External reference
Cyclodextrins as functional excipients: methods to enhance complexation efficiency
10.1002/jps.23077 · 2012 · External reference
Technical notes: a simple technique for reducing edge effect in cell-based assays
10.1177/1087057103256465 · 2003 · External reference
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
1986 · External reference
Engineering the biophysical properties of lipid nanostructures for drug delivery
10.1038/s43246-026-01073-5 · 2026 · External reference
Self-assembled cyclodextrin aggregates and nanoparticles
10.1016/j.ijpharm.2009.11.035 · 2010 · External reference
Ternary systems of naproxen with hydroxypropyl-β-cyclodextrin and aminoacids
10.1016/s0378-5173(03)00265-5 · 2003 · External reference
Transfer of cholesterol between liposomal membranes
10.1016/0005-2736(79)90234-7 · 1979 · External reference
Gwyddion: an open-source software for SPM data analysis
10.2478/s11534-011-0096-2 · 2012 · External reference
Interfering with pH regulation in tumours as a therapeutic strategy
10.1038/nrd3554 · 2011 · External reference
Head-to-Head comparison of the penetration efficiency of lipid-based nanoparticles into tumor spheroids
10.1021/acsomega.0c02879 · 2020 · External reference
PEGylated versus non-PEGylated pH-sensitive liposomes: new insights from a comparative antitumor activity study
10.3390/pharmaceutics14020272 · 2022 · External reference
Remodeling the physicochemical and pharmacokinetic properties of PROTAC via lipid nanodisks for cancer therapy
10.1002/advs.202501384 · 2025 · External reference
A pitfall of the 3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethonyphenol)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay due to evaporation in wells on the edge of a 96 well plate
10.1007/s10529-005-5803-x · 2005 · External reference
Targeting cancer with small-molecule pan-KRAS degraders
10.1126/science.adm8684 · 2024 · External reference
The influence of size and composition on the cholesterol mobilizing properties of liposomes in vivo
10.1016/0005-2736(93)90270-a · 1993 · External reference
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential
10.1080/14787210.2023.2170350 · 2023 · External reference
Galactose-decorated liver tumor-specific nanoliposomes incorporating selective BRD4-targeted PROTAC for hepatocellular carcinoma therapy
10.1016/j.heliyon.2021.e08702 · 2022 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Study of β-cyclodextrin-ketoconazole-tartaric acid multicomponent non-covalent association by positive and negative ionspray mass spectrometry
10.1002/(sici)1096-9888(199808)33:8<729::aid-jms687>3.0.co;2-u · 1998 · External reference
The uniqueness of albumin as a carrier in nanodrug delivery
10.1021/acs.molpharmaceut.1c00046 · 2021 · External reference
Functionalized liposome and albumin-based systems as carriers for poorly water-soluble anticancer drugs: an updated review
10.3390/biomedicines10020486 · 2022 · External reference
Targeted polymeric nanoparticles enable epithelial translocation of PROTACs and preserve intracellular protein degradation activity
10.1016/j.ejps.2026.107587 · 2026 · External reference
Nanoparticle-based medicines in clinical cancer therapy
10.1016/j.nantod.2022.101512 · 2022 · External reference
CRISPR-mediated reversion of oncogenic KRAS mutation results in increased proliferation and reveals independent roles of Ras and mTORC2 in the migration of A549 lung cancer cells
10.1091/mbc.e23-05-0152 · 2023 · External reference
KRAS mutations in solid tumors: characteristics, current therapeutic strategy, and potential treatment exploration
10.3390/jcm12020709 · 2023 · External reference
