Research graph
References from Single-nucleus transcriptomics reveals chronic GenX exposure-induced neurotoxicity and predicted alterations in microglia-neuron communication networks in mouse brain. Local targets link to admitted publications; unresolved targets remain external evidence.
Per- and polyfluoroalkyl substances in the environment
10.1126/science.abg9065 · 2022 · External reference
An overview of potential alternatives for the multiple uses of per- and polyfluoroalkyl substances
10.1021/acs.est.4c09088 · 2025 · External reference
Health Impacts of Per- and Polyfluoroalkyl substances (pfass): a comprehensive review
2025 · External reference
Epidemiology evidence for health effects of 150 per- and polyfluoroalkyl substances: a systematic evidence map
10.1289/ehp11185 · 2022 · External reference
Emerging perfluorinated chemical GenX: environmental and biological fates and risks
10.1021/envhealth.4c00164 · 2025 · External reference
Exposure to a GenX homologue results in sexually dimorphic bile acid metabolism disorders mediated by hepatic PPARα in mice
10.1021/acs.est.5c08503 · 2025 · External reference
Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS)
10.1016/j.chemosphere.2024.141654 · 2024 · External reference
Exposure to GenX and its novel analogs disrupts hepatic bile acid metabolism in male mice
10.1021/acs.est.1c02471 · 2022 · External reference
Effect of per- and polyfluoroalkyl substances (PFAS) levels on helminth infections in small mammals
10.1016/j.ecoenv.2026.119807 · 2026 · External reference
Exploring maternal and developmental toxicity of perfluoroalkyl ether acids PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics
10.1016/j.scitotenv.2024.175978 · 2024 · External reference
Developmental and neurobehavioural toxicity of per- and polyfluoroalkyl substances in aquatic organisms: mechanistic insights from molecular disruption to behavioural dysfunction
10.1016/j.aquatox.2026.107719 · 2026 · External reference
Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice
10.1016/j.envpol.2021.118202 · 2021 · External reference
The effects of prenatal GenX (HFPO-DA) exposure on gut microbiota and metabolic function in pregnant rats and their offspring
10.1016/j.envpol.2025.127363 · 2026 · External reference
The blood-brain barrier in health and disease: Important unanswered questions
10.1084/jem.20190062 · 2020 · External reference
Impact of peripheral inflammation on blood-brain barrier dysfunction and its role in neurodegenerative diseases
10.3390/ijms26062440 · 2025 · External reference
Intestinal barrier and behavior
10.1016/bs.irn.2016.08.006 · 2016 · External reference
Damage of polyethylene microplastics on the intestine multilayer barrier, blood cell immune function and the repair effect of Leuconostoc mesenteroides DH in the large-scale loach (Paramisgurnus dabryanus)
10.1016/j.fsi.2024.109460 · 2024 · External reference
Neurotoxicities induced by micro/nanoplastics: a review focusing on the risks of neurological diseases
10.1016/j.jhazmat.2024.134054 · 2024 · External reference
Absorption, distribution, and toxicity of per- and polyfluoroalkyl substances (PFAS) in the brain: a review
10.1039/d1em00228g · 2021 · External reference
Neurotoxicity and potential mechanisms of exposure to per- and polyfluoroalkyl substances (PFASs)
10.1007/s12035-025-05573-2 · 2025 · External reference
Per- and polyfluoroalkyl substances (PFAS) exposure in plasma and their blood-brain barrier transmission efficiency-a pilot study
10.1016/j.envint.2024.108719 · 2024 · External reference
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
10.1038/nrneurol.2017.188 · 2018 · External reference
Recent research trends in neuroinflammatory and neurodegenerative disorders
10.3390/cells13060511 · 2024 · External reference
Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis
10.1186/s12974-025-03493-5 · 2025 · External reference
Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice
10.1016/j.envint.2025.109501 · 2025 · External reference
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
10.1186/s40035-020-00221-2 · 2020 · External reference
Microglia in neurodegeneration
10.1038/s41593-018-0242-x · 2018 · External reference
Predifferentiation neurotoxicity of GenX exposure on hiPSC-derived cortical neurons
10.1021/acs.est.5c13193 · 2026 · External reference
Effects of PFOA and emerging alternatives at environmental concentrations on murine- and human-derived microglia: a comparative study
10.1016/j.envres.2026.123876 · 2026 · External reference
Hexafluoropropylene oxide dimer acid (GenX) induces apoptosis in primary cortical neurons via stimulating ROS production and NF-κB activation
2025 · External reference
GenX induces neuroinflammatory responses in BV2 microglial cells through mTOR signaling-mediated inhibition of autophagy
10.1016/j.ecoenv.2025.119107 · 2025 · External reference
Key concepts in transcriptomics data analysis in the era of next-gen sequencing
10.1007/978-3-032-18966-0_11 · 2026 · External reference
Research progress of single cell RNA sequencing in nervous system
10.1007/s11033-025-11155-1 · 2025 · External reference
Integrating scRNA-seq to explore offspring neurodevelopmental toxicity induced by Cyfluthrin exposure during pregnancy: a fate decision for NSCs
10.1016/j.jhazmat.2025.138205 · 2025 · External reference
Single-cell dissection of dimethomorph-induced neurotoxicity in the gestational brain: metabolic disruption and blood-brain barrier dysfunction
10.1021/acs.est.5c11595 · 2026 · External reference
Single-nucleus transcriptomics reveals prenatal and postnatal Pb exposure-induced cell-specific neurotoxicity and dysregulated microglia-neuron communication in mice brain
10.1021/acs.est.5c00613 · 2025 · External reference
Chlorogenic Acid alleviates early-life GenX exposure-induced neurotoxicity via decreasing lipopolysaccharide-induced pyroptosis by the systemic translocation and suppressing the PI3K/AKT/NF-κB pathway
10.1021/acs.chemrestox.5c00172 · 2025 · External reference
Assessment of the mode of action underlying the effects of GenX in mouse liver and implications for assessing human health risks
10.1177/0192623320905803 · 2020 · External reference
Blautia coccoides-derived metabolite trimethylamine-N-oxide exacerbates Alzheimer's disease progression via targeting HIF1α signaling
10.1080/19490976.2025.2605768 · 2026 · External reference
Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis
10.1186/s12967-025-06803-w · 2025 · External reference
Biomass fuel induces neuroinflammation and neurodegeneration via the astrocyte-microglia IL-17A/IL-17RA pathway
10.1016/j.jhazmat.2025.138569 · 2025 · External reference
Development and validation of an LC-MS/MS method for the quantitation of 30 legacy and emerging per- and polyfluoroalkyl substances (PFASs) in human plasma, including HFPO-DA, DONA, and cC6O4
10.1007/s00216-021-03762-1 · 2022 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
Serum PFAS concentrations and neuromorphometry in adolescents: the HOME study
10.1016/j.envres.2026.124338 · 2026 · External reference
Presence of legacy and emerging PFAS in human liver specimens banked in the United States from 2000 to 2024
10.1021/acs.est.5c14780 · 2026 · External reference
From maternal exposure to fetal risk: unraveling the PFAS exposure pathway and its placental toxicity mechanism
10.1021/acs.est.5c18201 · 2026 · External reference
Insight into perfluorooctanoic acid-induced impairment of mouse embryo implantation via single-cell RNA-seq
10.1016/j.jhazmat.2025.137375 · 2025 · External reference
Kynurenic acid plays a protective role in hepatotoxicity induced by HFPO-DA in male mice
10.1021/acs.est.3c08033 · 2024 · External reference
Association study of internal exposure levels of perfluoroalkyl substances and blood lipid levels in the elderly population and adverse Outcome pathway analysis
10.1016/j.envpol.2026.127644 · 2026 · External reference
Historical blood serum samples from wilmington, North Carolina: the importance of ultrashort-chain per- and polyfluoroalkyl substances
10.1021/acs.est.5c08146 · 2025 · External reference
External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: differences and implications
10.1016/j.envint.2021.106824 · 2021 · External reference
Exposure to PFOS, PFBS, PFOA and PFBA impairs cell cycle progression in bovine brain (Bos taurus) endothelial cells
10.1016/j.rvsc.2025.105585 · 2025 · External reference
Identification of potential mechanisms of cognitive dysfunction induced by environmentally relevant PFAS mixture in male rats
10.1016/j.envint.2026.110093 · 2026 · External reference
Comparative gut toxicity of HFPO-TA and PFOA in hook snout carp reveals risks of emerging PFAS alternatives
10.1016/j.ecoenv.2026.120025 · 2026 · External reference
Long-term exposure to environmentally relevant concentrations of hexafluoropropylene oxide dimer acid (GenX) induces trans-generational motor deficits through H3K27 demethylase jmjd-1.2 /PHF8 in Caenorhabditis elegans
10.1016/j.envpol.2025.126981 · 2025 · External reference
Integrated network toxicology and In Vitro/In Vivo experiments reveal molecular mechanisms of perfluorooctanoic acid exposure affecting intracerebral hemorrhage prognosis
10.1016/j.ecoenv.2025.119664 · 2026 · External reference
Perfluoroalkyl substance pollutants disrupt microglia function and trigger transcriptional and epigenomic changes
10.1016/j.tox.2025.154198 · 2025 · External reference
Evaluation of neural regulation and microglial responses to brain injury in larval zebrafish exposed to perfluorooctane sulfonate
10.1289/ehp12861 · 2023 · External reference
P2Y12 receptor function governs microglial surveillance and cell-cell interactions in the cerebral cortex
10.1002/glia.70109 · 2026 · External reference
Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs
10.1016/j.celrep.2025.116222 · 2025 · External reference
Mechanistic role of APOE lipidation in Alzheimer's disease pathogenesis
10.7150/thno.131926 · 2026 · External reference
Invivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification
10.1016/j.neuron.2022.07.027 · 2022 · External reference
Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis
10.1038/s41467-024-50818-8 · 2024 · External reference
Cell-cell communication dysregulation in tuberous sclerosis complex cortical tubers and focal cortical dysplasia
10.1186/s40478-025-02113-w · 2025 · External reference
IL-15 receptor alpha deficiency triggers depressive-like behaviors via enhanced microglial synapse pruning
10.1038/s41380-026-03593-5 · 2026 · External reference
Advances in understanding neuron-microglia interactions during sciatic nerve injury and regeneration
2026 · External reference
Microglia-specific interleukin-4 delivery by engineered extracellular vesicles restores inner blood-retinal barrier in diabetic retinopathy via GAS6-MERTK pathway
10.1186/s12951-025-03976-w · 2025 · External reference
Modulation of microglial phagocytosis via the GAS6-MERTK pathway regulates pathological angiogenesis in the mouse oxygen-induced retinopathy model
10.1038/s41419-025-07744-4 · 2025 · External reference
Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites
10.1016/j.celrep.2020.108642 · 2021 · External reference
Oligodendroglial energy metabolism and (re)myelination
2021 · External reference
Neuron-oligodendroglial interactions in health and malignant disease
10.1038/s41583-023-00744-3 · 2023 · External reference
Comparative proteomics highlights that GenX exposure leads to metabolic defects and inflammation in astrocytes
10.1021/acs.est.4c05472 · 2024 · External reference
