Research graph
References from Gut-liver axis and multi-omics analysis reveal the protective effect and mechanism of luteolin against dibutyl phthalate induced liver injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Sporoderm-broken spores of Ganoderma lucidum alleviates liver injury induced by DBP and BaP co-exposure in rat
10.1016/j.ecoenv.2022.113750 · 2022 · External reference
Dibutyl phthalate (DBP) promotes epithelial-mesenchymal transition (EMT) to aggravate liver fibrosis into cirrhosis and portal hypertension (PHT) via ROS/TGF-β1/Snail-1 signalling pathway in adult rats
10.1016/j.ecoenv.2024.116124 · 2024 · External reference
Long-term co-exposure DBP and BaP causes imbalance in liver macrophages polarization via activation of notch signaling regulated by miR-34a-5p in rats
10.1016/j.cbi.2022.109919 · 2022 · External reference
Dibutyl phthalate (DBP) induces cervical injury and promotes malignant transformation of cervical epithelial cells
10.1016/j.fct.2025.115885 · 2026 · External reference
Interference of dibutylphthalate on human prostate cell viability
10.1016/j.ecoenv.2017.09.030 · 2018 · External reference
Metabolic heterogeneity, networks, and biomarkers of drug-induced liver injury
2025 · External reference
Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin
10.1016/j.taap.2009.09.001 · 2009 · External reference
Protective effect of osmanthus water extract on liver dysfunction caused by DBP based on organoids and organ chips technologies
10.1016/j.foodres.2025.116976 · 2025 · External reference
Inflammation and gut microbiota in the alcoholic liver disease
10.26599/fmh.2024.9420020 · 2024 · External reference
Glabridin attenuates dibutyl phthalate-induced testicular toxicity via regulating oxidative stress, inflammation, apoptosis, and Wnt/β-catenin pathway
10.1016/j.tice.2025.103223 · 2026 · External reference
The effects of postnatal exposure to di-n-butyl phthalate (DBP) on the male reproductive system in animals: a systematic review and meta-analysis
10.1016/j.repbre.2025.03.005 · 2025 · External reference
Therapeutic potential of flavonoid-enriched Chinese medicinal herbs in atherosclerosis, hypertension, myocardial infarction, and heart failure
10.1016/j.prmcm.2025.100701 · 2025 · External reference
Adenovirus type 36 regulates adipose stem cell differentiation and glucolipid metabolism through the PI3K/Akt/FoxO1/PPARγ signaling pathway
10.1186/s12944-019-1004-9 · 2019 · External reference
10.1016/j.jep.2025.119377
10.1016/j.jep.2025.119377 · 2025 · External reference
Luteolin attenuates the pulmonary inflammatory response involves abilities of antioxidation and inhibition of MAPK and NFκB pathways in mice with endotoxin-induced acute lung injury
10.1016/j.fct.2011.07.012 · 2011 · External reference
Hepatotoxic effects of exposure to different concentrations of Dibutyl phthalate (DBP) in schizothorax prenanti: insights from a multi-omics analysis
10.1016/j.aquatox.2025.107390 · 2025 · External reference
Synergistic multi-target anti-inflammatory mechanisms of luteolin, chikusetsusaponin IVa and carabrone in houyanqing formula
10.1016/j.jep.2025.120096 · 2025 · External reference
Resveratrol alleviates lipopolysaccharide-induced acute lung injury through blocking the excessive autophagy/mitophagy via SIRT1/PGC-1α and TNF/NF-κB/JNK pathways
10.1016/j.ijbiomac.2025.146500 · 2025 · External reference
Sirtuin 3, a pivotal actor in liver diseases: research progress and implications
10.1016/j.ijbiomac.2025.146364 · 2025 · External reference
Novel insights into DBP-Induced zebrafish liver inflammatory damage: ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway
10.1016/j.envpol.2025.126395 · 2025 · External reference
Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice
10.3945/jn.114.193128 · 2014 · External reference
Luteolin alleviates non-alcoholic fatty liver disease in rats via restoration of intestinal mucosal barrier damage and microbiota imbalance involving in gut-liver axis
10.1016/j.abb.2021.109019 · 2021 · External reference
Ferulic acid from Angelica sinensis (Oliv.) diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways
10.1016/j.jep.2024.119118 · 2025 · External reference
Investigation of luteolin's antibacterial mechanism against staphylococcus aureus through network pharmacology and molecular docking approaches
2025 · External reference
Linarin alleviates high-fat diet-induced NAFLD via modulating the PI3K/Akt/mTOR pathway, autophagy, and gut microbiota
2025 · External reference
Plasticizers: distribution and impact in aquatic and terrestrial environments
10.1039/d4em00317a · 2024 · External reference
Research progress on rodent models and its mechanisms of liver injury
10.1016/j.lfs.2023.122343 · 2024 · External reference
Steady-state human pharmacokinetics of monobutyl phthalate predicted by physiologically based pharmacokinetic modeling using single-dose data from humanized-liver mice orally administered with dibutyl phthalate
10.1021/acs.chemrestox.8b00361 · 2019 · External reference
Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: a comprehensive review
10.1016/j.heliyon.2023.e18140 · 2023 · External reference
Luteolin: a promising modulator of apoptosis and survival signaling in liver cancer
10.1016/j.prp.2024.155430 · 2024 · External reference
Ecotoxicological evaluation of zebrafish liver (Danio rerio) induced by dibutyl phthalate
10.1016/j.jhazmat.2021.128027 · 2022 · External reference
Vascular endothelial effects of dibutyl phthalate: in vitro and in vivo evidence
10.1016/j.cbi.2024.111120 · 2024 · External reference
Carcinogenicity of butyl benzyl phthalate, dibutyl phthalate, and diisononyl phthalate
10.1016/s1470-2045(26)00334-7 · 2026 · External reference
Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse
10.1016/j.intimp.2015.05.009 · 2015 · External reference
Assessing the toxicological effects and mechanism of plasticizer exposure on inflammatory bowel disease based on network toxicology and molecular docking
10.1016/j.fct.2025.115543 · 2025 · External reference
Luteolin as an adjuvant effectively enhances CTL anti-tumor response in B16F10 mouse model
10.1016/j.intimp.2021.107441 · 2021 · External reference
Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring
10.1016/j.chemosphere.2017.01.011 · 2017 · External reference
Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice
10.1016/j.phymed.2021.153586 · 2021 · External reference
Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway
10.1016/j.freeradbiomed.2014.03.009 · 2014 · External reference
Chronic DBP exposure may cause reduced fertility in female mice by interfering with the HPO axis
10.1016/j.envpol.2025.127039 · 2025 · External reference
Luteolin as a potential hepatoprotective drug: molecular mechanisms and treatment strategies
10.1016/j.biopha.2023.115464 · 2023 · External reference
Epigenetic and epitranscriptomic landscape of phthalate toxicity: implications for human health and disease
10.1016/j.envpol.2025.127559 · 2026 · External reference
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c
10.1016/j.bbrc.2016.11.101 · 2017 · External reference
Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population
10.1016/j.envint.2021.106608 · 2021 · External reference
Toxicity of Dibutyl phthalate (DBP) toward isolated human blood lymphocytes: apoptosis initiated from intracellular calcium enhancement and mitochondrial/lysosomal cross talk
2024 · External reference
Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice
10.3892/ol.2017.6762 · 2017 · External reference
Intergenerational metabolism-disrupting effects of maternal exposure to plasticizer acetyl tributyl citrate (ATBC)
10.1016/j.envint.2024.108967 · 2024 · External reference
Subacute dibutyl phthalate exposure impairs hepatic T cells and facilitates hepatitis B progression in mouse liver
10.1016/j.ecoenv.2025.118398 · 2025 · External reference
Luteolin and glycyrrhetinic exert cooperative effect on liver cancer by selfassembling into carrier-free nanostructures
10.1016/j.cclet.2025.111325 · 2025 · External reference
The protective effect of luteolin on cadmium induced liver intestinal toxicity in chicken by Gut-liver axis regulation
10.1016/j.psj.2024.104242 · 2024 · External reference
