Research graph
References from Sex-specific intestinal transcriptional responses to oral polyvinyl chloride microplastic exposure in Wistar rats, with an in-vitro validation in a human gut model. Local targets link to admitted publications; unresolved targets remain external evidence.
Presence of airborne microplastics in human lung tissue
10.1016/j.jhazmat.2021.126124 · 2021 · External reference
Protective role of kelulut honey against toxicity effects of polystyrene microplastics on morphology, hormones, and sex steroid receptor expression in the uterus of rats
10.3390/toxics11040324 · 2023 · External reference
In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis
10.3892/or.16.6.1357 · 2006 · External reference
QuPath: open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Impact of intestinal concentration and colloidal structure on the permeation-enhancing efficiency of sodium caprate in the rat
10.1021/acs.molpharmaceut.1c00724 · 2022 · External reference
Microplastics in our diet: a growing concern for human health
10.1016/j.scitotenv.2025.178882 · 2025 · External reference
Microplastics, a global issue: human exposure through environmental and dietary sources
10.3390/foods12183396 · 2023 · External reference
Sex differences: transcriptional signatures of stress exposure in male and female brains
10.1111/gbb.12643 · 2020 · External reference
Orally ingested Micro- and Nano-Plastics: a hidden driver of inflammatory bowel disease and colorectal cancer
10.3390/cancers16173079 · 2024 · External reference
Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-kappaB signal in mice
10.1016/j.envpol.2023.121068 · 2023 · External reference
Effects of exposure to waterborne polystyrene microspheres on lipid metabolism in the hepatopancreas of juvenile redclaw crayfish, Cherax quadricarinatus
10.1016/j.aquatox.2020.105497 · 2020 · External reference
Polyvinyl chloride microplastics induced gut barrier dysfunction, microbiota dysbiosis and metabolism disorder in adult mice
10.1016/j.ecoenv.2022.113809 · 2022 · External reference
Polystyrene micro- and nanoparticles exposure induced anxiety-like behaviors, gut microbiota dysbiosis and metabolism disorder in adult mice
10.1016/j.ecoenv.2023.115000 · 2023 · External reference
Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver
10.1186/s12944-025-02613-7 · 2025 · External reference
The gut microbiome: an orchestrator of xenobiotic metabolism
10.1016/j.apsb.2019.12.001 · 2020 · External reference
PPARs and metabolic disorders associated with challenged adipose tissue plasticity
10.3390/ijms19072124 · 2018 · External reference
Consequences of nano and microplastic exposure in rodent models: the known and unknown
10.1186/s12989-022-00473-y · 2022 · External reference
Visualising androgen receptor activity in male and female mice
10.1371/journal.pone.0071694 · 2013 · External reference
ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction
10.1186/s13098-015-0027-2 · 2015 · External reference
Plastics contamination of store-bought rice
10.1016/j.jhazmat.2021.125778 · 2021 · External reference
Differential effects of calcium on PI3K-Akt and HIF-1alpha survival pathways
10.1007/s10565-016-9345-x · 2016 · External reference
Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver
10.1016/j.ecoenv.2023.115417 · 2023 · External reference
Recent progress in intestinal toxicity of microplastics and nanoplastics: systematic review of preclinical evidence
10.3390/microplastics3020013 · 2024 · External reference
Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia
10.1038/s41598-017-00889-z · 2017 · External reference
Presence of microplastics and nanoplastics in food, with particular focus on seafood
2016 · External reference
Low-dose oral ferrous fumarate aggravated intestinal inflammation in rats with DSS-induced colitis
10.1097/01.mib.0000174374.83601.86 · 2005 · External reference
Fleur de Sel—An interregional monitor for microplastics mass load and composition in European coastal waters?
10.1016/j.jaap.2019.104711 · 2019 · External reference
Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry
10.1093/toxsci/kfae021 · 2024 · External reference
Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies
10.1210/jc.2003-030214 · 2003 · External reference
Exposure to polyethylene microplastics exacerbate inflammatory bowel disease tightly associated with intestinal gut microflora
10.1039/d4ra04544k · 2024 · External reference
A comprehensive review and update on the pathogenesis of inflammatory bowel disease
10.1155/2019/7247238 · 2019 · External reference
Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
10.1038/s41598-021-90981-2 · 2021 · External reference
An overview of chemical additives present in plastics: migration, release, fate and environmental impact during their use, disposal and recycling
10.1016/j.jhazmat.2017.10.014 · 2018 · External reference
The significance of PITX2 overexpression in human colorectal cancer
10.1245/s10434-011-1653-z · 2011 · External reference
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
10.1038/nprot.2008.211 · 2009 · External reference
Nano- and micro-polystyrene plastics interfered the gut barrier function mediated by exosomal miRNAs in rats
10.1016/j.envpol.2023.122275 · 2023 · External reference
Polyethylene microplastics impede the innate immune response by disrupting the extracellular matrix and signaling transduction
10.1016/j.isci.2023.107390 · 2023 · External reference
Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
10.1083/jcb.143.2.547 · 1998 · External reference
Effect of polystyrene nanoplastics and their degraded forms on stem cell fate
10.1016/j.jhazmat.2022.128411 · 2022 · External reference
Detection of microplastics in human lung tissue using muFTIR spectroscopy
10.1016/j.scitotenv.2022.154907 · 2022 · External reference
Micro- and nanoplastic toxicity on aquatic life: determining factors
10.1016/j.scitotenv.2019.136050 · 2020 · External reference
Discovery and quantification of plastic particle pollution in human blood
10.1016/j.envint.2022.107199 · 2022 · External reference
Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice
10.1016/j.chemosphere.2019.125492 · 2020 · External reference
Toxicological effects of microplastics and sulfadiazine on the microalgae Chlamydomonas reinhardtii
2022 · External reference
Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-kappaB pathway and trigger autophagy and apoptosis
10.1016/j.etap.2023.104136 · 2023 · External reference
Microplastics in the human body: a comprehensive review of exposure, distribution, migration mechanisms, and toxicity
10.1016/j.scitotenv.2024.174215 · 2024 · External reference
Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis
10.1186/s12989-021-00414-1 · 2021 · External reference
A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: differential lipid metabolism and inflammation reaction
10.1016/j.ecoenv.2022.114031 · 2022 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Association of ADIPOQ polymorphisms with obesity risk: a meta-analysis
10.1016/j.humimm.2014.09.004 · 2014 · External reference
Microplastics in human food chains: food becoming a threat to health safety
2023 · External reference
Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-kappaB and RIP1/RIP3/MLKL pathway in chicken kidney
10.1016/j.tox.2022.153296 · 2022 · External reference
Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice
10.1152/ajpendo.00163.2009 · 2009 · External reference
Considering sex as a biological variable in preclinical research
10.1096/fj.201600781r · 2017 · External reference
Sex-dependent metabolism of xenobiotics
10.3109/03602539808996322 · 1998 · External reference
Normal intestinal anatomy and physiology
2023 · External reference
Unresolved reference
2025 · External reference
Immune response to polystyrene microplastics: regulation of inflammatory response via the ROS-driven NF-kappaB pathway in zebrafish (Danio rerio)
10.1016/j.aquatox.2025.107308 · 2025 · External reference
Assessing the safety and efficacy of Lactobacillus plantarum MTCC 5690 and Lactobacillus fermentum MTCC 5689 in colitis mouse model
10.1007/s12602-018-9489-5 · 2019 · External reference
Microplastics in human feces: a pilot study exploring links with dietary habits
10.1186/s43591-025-00129-6 · 2025 · External reference
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
10.1038/nmicrobiol.2016.93 · 2016 · External reference
Detection of various microplastics in human stool: a prospective case series
10.7326/m19-0618 · 2019 · External reference
Ingested nano- and microsized polystyrene particles surpass the intestinal barrier and accumulate in the body
10.1016/j.impact.2021.100374 · 2022 · External reference
Polystyrene microplastics-induced ROS overproduction disrupts the skeletal muscle regeneration by converting myoblasts into adipocytes
10.1016/j.jhazmat.2021.125962 · 2021 · External reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
10.1093/nar/gkac194 · 2022 · External reference
Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice
10.1016/j.ecoenv.2024.116925 · 2024 · External reference
Improve your success with fish cell lines-small things that matter
10.1007/s11626-025-01042-1 · 2026 · External reference
TEER measurement techniques for in vitro barrier model systems
10.1177/2211068214561025 · 2015 · External reference
A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies
10.1371/journal.pone.0197101 · 2018 · External reference
Unresolved reference
2024 · External reference
Characterizing microplastic hazards: which concentration metrics and particle characteristics are most informative for understanding toxicity in aquatic organisms?
10.1186/s43591-022-00040-4 · 2022 · External reference
Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats
10.1016/j.toxlet.2022.09.002 · 2022 · External reference
A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals
2022 · External reference
The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in Obese mice
10.1038/s41387-022-00230-2 · 2023 · External reference
Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis
10.1016/j.scitotenv.2023.165461 · 2023 · External reference
Polystyrene microplastics induced ovarian toxicity in juvenile rats associated with oxidative stress and activation of the PERK-eIF2alpha-ATF4-CHOP signaling pathway
10.3390/toxics11030225 · 2023 · External reference
Low-dose polystyrene microplastics exposure increases susceptibility to obesity-induced MASLD via disrupting intestinal barrier integrity and gut microbiota homeostasis
10.1016/j.ecoenv.2025.118310 · 2025 · External reference
Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging
10.1016/j.jes.2025.05.036 · 2026 · External reference
ggplot2: elegant graphics for data analysis
10.1007/978-0-387-98141-3 · 2009 · External reference
Small intestinal permeability and gut-transit time determined with low and high molecular weight fluorescein isothiocyanate-dextrans in C3H mice
10.3390/nu10060685 · 2018 · External reference
Polystyrene-microplastics and Emamectin Benzoate co-exposure induced lipid remodeling by suppressing PPARalpha signals to drive ACSL4-dependent ferroptosis and carp splenic injury
10.1016/j.pestbp.2025.106396 · 2025 · External reference
Microplastics induced inflammation and apoptosis via ferroptosis and the NF-kappaB pathway in carp
10.1016/j.aquatox.2023.106659 · 2023 · External reference
Polystyrene nano-plastics impede skeletal muscle development and induce lipid accumulation via the PPARgamma/LXRbeta pathway in vivo and in vitro in mice
10.1007/s00204-024-03831-1 · 2024 · External reference
Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice
10.1186/s12951-024-02735-7 · 2024 · External reference
Analysis of microplastics in human feces reveals a correlation between fecal microplastics and inflammatory bowel disease status
10.1021/acs.est.1c03924 · 2022 · External reference
Impacts of microplastics on immunity
10.3389/ftox.2022.956885 · 2022 · External reference
Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: state of science, knowledge gaps and research needs
10.1016/j.impact.2023.100481 · 2023 · External reference
Toxicity of microplastics and nanoplastics in Mammalian systems
10.3390/ijerph17051509 · 2020 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Polystyrene microplastic-induced oxidative stress triggers intestinal barrier dysfunction via the NF-kappaB/NLRP3/IL-1beta/MCLK pathway
10.1016/j.envpol.2024.123473 · 2024 · External reference
You are what you eat: microplastics in the feces of young men living in Beijing
10.1016/j.scitotenv.2020.144345 · 2021 · External reference
Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis
10.1016/j.scitotenv.2020.143085 · 2021 · External reference
Integrated transcriptomics and proteomics analyses reveal the ameliorative effect of hepatic damage in tilapia caused by polystyrene microplastics with chlorella addition
10.1016/j.ecoenv.2024.117076 · 2024 · External reference
Chlorella alleviates the intestinal damage of tilapia caused by microplastics
10.1016/j.chemosphere.2024.141644 · 2024 · External reference
Polystyrene nanoplastics cause reproductive toxicity in zebrafish: PPAR mediated lipid metabolism disorder
10.1016/j.scitotenv.2024.172795 · 2024 · External reference
Unraveling the impact of micro- and nano-sized polymethyl methacrylate on gut microbiota and liver lipid metabolism: insights from oral exposure studies
10.1016/j.envpol.2025.126157 · 2025 · External reference
PPARgamma mediated lysosomal membrane permeabilization and lipophagy blockage were involved in microplastics and di (2-ethylhexyl) phthalate co-exposure induced immature testis injury
10.1016/j.freeradbiomed.2025.06.023 · 2025 · External reference
Combined exposure to polyvinyl chloride and polystyrene microplastics induces liver injury and perturbs gut microbial and serum metabolic homeostasis in mice
10.1016/j.ecoenv.2023.115637 · 2023 · External reference
