Research graph
References from Complement C3 in the silica nanoparticles protein corona promotes macrophage M1 polarization and subacute pulmonary fibrotic remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Single-Cell map of diverse immune phenotypes in the breast tumor microenvironment
10.1016/j.cell.2018.05.060 · 2018 · External reference
Endoplasmic reticulum stress-mediated glycophagy drives macrophage M1 polarization in silica nanoparticles-induced pulmonary fibrosis
2025 · External reference
Attenuated T cell activation and rearrangement of T cell receptor beta repertoire in silica nanoparticle-induced pulmonary fibrosis of mice
10.1016/j.envres.2022.113678 · 2022 · External reference
Influence of surface chemistry and morphology of nanoparticles on protein corona formation
10.1002/wnan.1788 · 2022 · External reference
Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism
10.1073/pnas.2200363119 · 2022 · External reference
Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
10.1073/pnas.0608582104 · 2007 · External reference
In vivo toxicologic study of larger silica nanoparticles in mice
10.2147/ijn.s126823 · 2017 · External reference
Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
10.1038/nnano.2016.269 · 2017 · External reference
LGALS3 regulates endothelial-to-mesenchymal transition via PI3K/AKT signaling pathway in silica-induced pulmonary fibrosis
10.1016/j.tox.2024.153962 · 2024 · External reference
Inhibition of iron ion accumulation alleviates polystyrene nanoplastics-induced pulmonary fibroblast proliferation and activation
10.1016/j.intimp.2025.115367 · 2025 · External reference
Application research progress of nanomaterial graphene and its derivative complexes in tumor diagnosis and therapy
10.2174/0109298673251648231106112354 · 2024 · External reference
Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis
10.1136/thoraxjnl-2013-204596 · 2015 · External reference
Aging of nanoplastics significantly affects protein Corona composition thus enhancing macrophage uptake
10.1021/acs.est.2c05772 · 2023 · External reference
Targeting the tissue-complosome for curbing inflammatory disease
10.1016/j.smim.2022.101644 · 2022 · External reference
The “ins and outs” of complement-driven immune responses
10.1111/imr.12472 · 2016 · External reference
Real-time in situ analysis of biocorona formation and evolution on silica nanoparticles in defined and complex biological environments
10.1039/c6nr06399c · 2017 · External reference
Chronic hypersensitivity pneumonitis, an interstitial lung disease with distinct molecular signatures
10.1164/rccm.202001-0134oc · 2020 · External reference
Macrophage polarization and its impact on idiopathic pulmonary fibrosis
10.3389/fimmu.2024.1444964 · 2024 · External reference
Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes
10.1038/s41467-022-30654-4 · 2022 · External reference
Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis
10.1096/fj.201500044 · 2016 · External reference
Adverse effects of amorphous silica nanoparticles: focus on human cardiovascular health
10.1016/j.jhazmat.2020.124626 · 2021 · External reference
The underlying function and structural Organization of the Intracellular protein Corona on graphdiyne oxide nanosheet for local immunomodulation
10.1021/acs.nanolett.1c01048 · 2021 · External reference
Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation
10.1172/jci152973 · 2021 · External reference
Inflammation and immunity in IPF pathogenesis and treatment
10.1016/j.rmed.2018.12.015 · 2019 · External reference
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure
10.1038/s41467-022-33152-9 · 2022 · External reference
IRF4 participates in pulmonary fibrosis induced by Silica particles through regulating macrophage polarization and fibroblast activation
10.1007/s10753-023-01890-7 · 2024 · External reference
Nanotechnology in cosmetics
10.1016/j.fct.2015.06.020 · 2015 · External reference
Global life cycle releases of engineered nanomaterials
10.1007/s11051-013-1692-4 · 2013 · External reference
Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3
10.1128/iai.73.7.4245-4252.2005 · 2005 · External reference
Protein corona: implications for nanoparticle interactions with pulmonary cells
10.1186/s12989-017-0223-3 · 2017 · External reference
Protein corona, understanding the nanoparticle-protein interactions and future perspectives: a critical review
10.1016/j.ijbiomac.2020.12.108 · 2021 · External reference
Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid
10.1016/j.nano.2015.12.369 · 2016 · External reference
Impact of silica nanoparticle surface chemistry on protein corona formation and consequential interactions with biological cells
10.1016/j.msec.2017.02.028 · 2017 · External reference
Molecular mechanisms of epithelial-mesenchymal transition
10.1038/nrm3758 · 2014 · External reference
Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy
10.1038/aps.2014.134 · 2015 · External reference
Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity
2024 · External reference
Influence of serum concentration and surface functionalization on the protein adsorption to mesoporous silica nanoparticles
10.1039/c9ra05585a · 2019 · External reference
Complement C3 produced by macrophages promotes renal fibrosis via IL-17A secretion
10.3389/fimmu.2018.02385 · 2018 · External reference
Role of the inflammasome in insulin resistance and type 2 diabetes mellitus
2023 · External reference
Tailoring the component of protein corona via simple chemistry
10.1038/s41467-019-12470-5 · 2019 · External reference
The protein corona from nanomedicine to environmental science
2023 · External reference
Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response
10.1021/nn101557e · 2010 · External reference
Macrophage activation and polarization
10.2741/2692 · 2008 · External reference
Biomolecular coronas provide the biological identity of nanosized materials
10.1038/nnano.2012.207 · 2012 · External reference
Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials
10.1021/nn405830g · 2014 · External reference
The nanosilica hazard: another variable entity
10.1186/1743-8977-7-39 · 2010 · External reference
Identifying cell receptors for the nanoparticle protein corona using genome screens
10.1038/s41589-022-01093-5 · 2022 · External reference
Effect and mechanism of paclitaxel loaded on magnetic Fe3O4@mSiO2-NH2-FA nanocomposites to MCF-7 cells
10.1080/10717544.2022.2154411 · 2023 · External reference
Temperature, concentration, and surface modification influence the cellular uptake and the protein corona of polystyrene nanoparticles
10.1016/j.actbio.2022.06.028 · 2022 · External reference
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment
10.1186/s12989-024-00568-8 · 2024 · External reference
The distribution of complement proteins in soft and hard Coronas impacts macrophage uptake of nanoparticles
10.1002/adhm.202503534 · 2026 · External reference
Proteomic and lipidomic analysis of nanoparticle Corona upon contact with lung surfactant reveals differences in protein, but not lipid composition
10.1021/acsnano.5b04215 · 2015 · External reference
Chemical and biophysical signatures of the protein Corona in nanomedicine
10.1021/jacs.2c02277 · 2022 · External reference
Idiopathic pulmonary fibrosis
10.1016/s0140-6736(17)30866-8 · 2017 · External reference
Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance
10.1021/nn400409h · 2013 · External reference
H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting macrophage M1 polarization
10.1016/j.jhazmat.2025.139286 · 2025 · External reference
Macrophage plasticity and polarization: in vivo veritas
10.1172/jci59643 · 2012 · External reference
Versatile protein coronation approach with multiple depleted serum for creating biocompatible, precision nanomedicine
2022 · External reference
Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction
10.1186/s12989-020-00353-3 · 2020 · External reference
Specifically formed Corona on Silica Nanoparticles enhances transforming growth factor beta1 activity in triggering lung fibrosis
10.1021/acsnano.6b07461 · 2017 · External reference
Nanoparticle porosity modulates protein Corona Formation and macrophage uptake in synovial fluid
10.1021/acsami.5c17246 · 2026 · External reference
Integrating mechanisms of pulmonary fibrosis
10.1084/jem.20110551 · 2011 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
Unexpected inhibitory role of Silica nanoparticles on lung cancer development by promoting M1 polarization of macrophages
10.2147/ijn.s472796 · 2024 · External reference
Evolution of the protein corona affects macrophage polarization
10.1016/j.ijbiomac.2021.09.081 · 2021 · External reference
Macrophages promote heat stress nephropathy in mice via the C3a-C3aR-TNF pathway
10.1016/j.imbio.2023.152337 · 2023 · External reference
C3a/C3aR synergies with TGF-beta to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome
10.1186/s12967-023-04764-6 · 2023 · External reference
Dynamic process, mechanisms, influencing factors and study methods of protein corona formation
10.1016/j.ijbiomac.2022.03.105 · 2022 · External reference
Exosomal miRNA reprogramming in pyroptotic macrophage drives silica-induced fibroblast-to-myofibroblast transition and pulmonary fibrosis
10.1016/j.jhazmat.2024.136629 · 2025 · External reference
The role of heat shock proteins in the regulation of fibrotic diseases
2020 · External reference
The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review
10.1186/s12964-024-01557-2 · 2024 · External reference
