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References from Development of Sex-Specific Physiologically Based Toxicokinetic (PBTK) Models for GenX in Mice and Their Application to Human Health Risk Assessment. Local targets link to admitted publications; unresolved targets remain external evidence.
Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture – A pilot investigation in a male volunteer
10.1016/j.envint.2024.109047 · 2024 · External reference
Comparative in vitro study of structure related uptake of ten perfluoroalkyl substances by human and rat renal transporters
10.1007/s00204-026-04508-7 · 2026 · External reference
Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)
10.1289/ehp6233 · 2020 · External reference
Evaluation of chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague-Dawley rats
10.1016/j.toxrep.2015.06.001 · 2015 · External reference
Sex, age, and species differences of perfluorooctanoic acid modeled by flow- versus permeability-limited physiologically-based pharmacokinetic models
10.1016/j.tox.2024.153806 · 2024 · External reference
Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification
10.1016/j.envint.2019.03.058 · 2019 · External reference
Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values
10.1289/ehp7671 · 2021 · External reference
10.1016/j.envint.2020.105581
10.1016/j.envint.2020.105581 · 2020 · External reference
Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat
10.1016/j.envint.2020.106204 · 2021 · External reference
Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation
10.1016/j.emcon.2021.10.004 · 2021 · External reference
Development of a physiologically based pharmacokinetic model for ethylene glycol and its metabolite, glycolic Acid, in rats and humans
10.1093/toxsci/kfi119 · 2005 · External reference
Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption
10.1021/acs.est.3c06910 · 2023 · External reference
Nationwide distribution of perfluoroalkyl ether carboxylic acids in Chinese diets: An emerging concern
10.1016/j.envint.2024.108648 · 2024 · External reference
Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration
10.1080/00498254.2019.1683776 · 2020 · External reference
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Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling With mrgsolve: A Hands‐On Tutorial
2019 · External reference
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External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications
10.1016/j.envint.2021.106824 · 2021 · External reference
Sex Differences in Pharmacokinetics and Pharmacodynamics
10.1146/annurev.pharmtox.44.101802.121453 · 2004 · External reference
Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey
10.1016/j.tox.2015.12.006 · 2016 · External reference
Comparing the toxic potency in vivo of long-chain perfluoroalkyl acids and fluorinated alternatives
10.1016/j.envint.2018.01.011 · 2018 · External reference
Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice
2021 · External reference
Emerging Perfluorinated Chemical GenX: Environmental and Biological Fates and Risks
2024 · External reference
Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes—Conclusions from the 3rd International ESTP Expert Workshop
10.1177/0192623312448935 · 2012 · External reference
PFOA substitute GenX at a sub-cytotoxic level exhibits thyroid-disrupting effects by inhibiting the expression of thyroid transcription factor 1
10.1016/j.envpol.2024.125594 · 2025 · External reference
Hematological effects in F344 rats and B6C3F1 mice during the 13-week gavage toxicity study of methylene blue trihydrate
10.1093/toxsci/65.1.126 · 2002 · External reference
Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice
10.1021/acs.est.3c08033 · 2024 · External reference
Basic anatomical and physiological data for use in radiological protection: reference values. A report of age- and gender-related differences in the anatomical and physiological characteristics of reference individuals. ICRP Publication 89
2002 · External reference
Harnessing PET to track micro- and nanoplastics in vivo
10.1038/s41598-021-90929-6 · 2021 · External reference
Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model
10.1007/s00204-018-2365-y · 2019 · External reference
Sex-specific risk assessment of PFHxS using a physiologically based pharmacokinetic model
10.1007/s00204-017-2116-5 · 2018 · External reference
Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS)
10.1016/j.chemosphere.2024.141654 · 2024 · External reference
Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina
2020 · External reference
PBPK modeling of C7 HFPO-TA: Linking mouse pharmacokinetics to human exposure and risk through biomonitoring data
10.1016/j.jhazmat.2026.142490 · 2026 · External reference
Legacy per- and polyfluoroalkyl substances (PFASs) and alternatives (short-chain analogues, F-53B, GenX and FC-98) in residential soils of China: Present implications of replacing legacy PFASs
10.1016/j.envint.2019.105419 · 2020 · External reference
A physiologically based pharmacokinetic model for atrazine and its main metabolites in the adult male C57BL/6 mouse
10.1016/j.taap.2010.11.009 · 2011 · External reference
Novel insights into the mechanisms of bioaccumulation and tissue-specific distribution of hexafluoropropylene oxide homologues, novel PFOA alternatives, in zebrafish (Danio rerio)
10.1016/j.envint.2024.109053 · 2024 · External reference
Risk assessment and source identification of perfluoroalkyl acids in surface and ground water: Spatial distribution around a mega-fluorochemical industrial park, China
10.1016/j.envint.2016.02.020 · 2016 · External reference
Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model
10.1016/j.reprotox.2011.04.006 · 2012 · External reference
Prenatal Exposure of PFAS in Cohorts of Pregnant Women: Identifying the Critical Windows of Vulnerability and Health Implications
10.1021/acs.est.4c00453 · 2024 · External reference
Sources, occurrence and toxic effects of emerging per- and polyfluoroalkyl substances (PFAS)
10.1016/j.ntt.2023.107174 · 2023 · External reference
Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
10.1016/j.envint.2024.108577 · 2024 · External reference
10.1021/envhealth.6c00088
10.1021/envhealth.6c00088 · External reference
Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II)
10.1016/j.envint.2021.106907 · 2022 · External reference
Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
10.1016/j.envint.2021.106843 · 2021 · External reference
Evaluation of the Immunomodulatory Effects of 2,3,3,3-Tetrafluoro-2-(Heptafluoropropoxy)-Propanoate in C57BL/6 Mice
2017 · External reference
A Web-Based System for Bayesian Benchmark Dose Estimation
10.1289/ehp1289 · 2018 · External reference
Comparison of bioconcentration and kinetics of GenX in tilapia Oreochromis mossambicus in fresh and brackish water
10.1016/j.chemosphere.2021.132289 · 2022 · External reference
Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME
10.18637/jss.v033.i03 · 2010 · External reference
Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME
10.18637/jss.v033.i03 · 2010 · External reference
Emissions, Transport, and Fate of Emerging Per- and Polyfluoroalkyl Substances from One of the Major Fluoropolymer Manufacturing Facilities in China
10.1021/acs.est.7b06657 · 2018 · External reference
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Development of an oral reference dose for the perfluorinated compound GenX
10.1002/jat.3812 · 2019 · External reference
Evaluation of chronic toxicity and carcinogenicity of HFPO-DA in mice
10.1016/j.yrtph.2025.106014 · 2026 · External reference
Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA
10.1093/toxsci/kfag045 · 2026 · External reference
Estrogen-induced changes in protein binding of bupivacaine during in vitro fertilization
10.1097/00000542-199710000-00023 · 1997 · External reference
GenX caused liver injury and potential hepatocellular carcinoma of mice via drinking water even at environmental concentration
10.1016/j.envpol.2024.123574 · 2024 · External reference
A review of sources, multimedia distribution and health risks of novel fluorinated alternatives
10.1016/j.ecoenv.2019.109402 · 2019 · External reference
Differential Developmental Neurotoxicity and Tissue Uptake of the Per- and Polyfluoroalkyl Substance Alternatives, GenX and PFBS
10.1021/acs.est.3c05023 · 2023 · External reference
Uptake, distribution, and depuration of emerging per- and polyfluoroalkyl substances in mice: Role of gut microbiota
10.1016/j.scitotenv.2022.158372 · 2022 · External reference
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Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat
10.1016/j.taap.2015.10.017 · 2015 · External reference
Physiologically based pharmacokinetic modeling of human exposure to perfluorooctanoic acid suggests historical non drinking-water exposures are important for predicting current serum concentrations
10.1016/j.taap.2017.07.001 · 2017 · External reference
Perfluorooctanoic acid and its alternatives disrupt the osteogenesis and osteoclastogenesis balance: Evidence from the effects on cell differentiation process
10.1016/j.scitotenv.2024.178331 · 2025 · External reference
Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A
10.1016/j.taap.2015.10.016 · 2015 · External reference
Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs): Occurrence and Association with Serum Biochemical Parameters in Residents Living Near a Fluorochemical Plant in China
10.1021/acs.est.0c02888 · 2020 · External reference
Environmental Exposure to Emerging Alternatives of Per- and Polyfluoroalkyl Substances and Polycystic Ovarian Syndrome in Women Diagnosed with Infertility: A Mixture Analysis
10.1289/ehp11814 · 2023 · External reference
Accumulation and glucocorticoid signaling suppression by four emerging perfluoroethercarboxylic acids based on animal exposure and cell testing
10.1016/j.envint.2023.108092 · 2023 · External reference
Development and Human Extrapolation of Physiologically Based Toxicokinetic Models for Chlorinated Polyfluoroalkyl Ether Sulfonates from Rats
10.1021/acs.est.5c18780 · 2026 · External reference
Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans
10.1021/acs.est.4c05405 · 2024 · External reference
Per- and polyfluoroalkyl substances in Chinese surface waters: A review
10.1016/j.ecoenv.2023.115178 · 2023 · External reference
A novel high-throughput quantitative method for the determination of per- and poly-fluoroalkyl substances in human plasma based on UHPLC-Q/Orbitrap HRMS coupled with isotope internal standard
2024 · External reference
Sex- and Age-Related Metabolic Characteristics of Serum Free Fatty Acids in Healthy Chinese Adults
10.1021/acs.jproteome.9b00502 · 2020 · External reference
Estimation of species- and sex-specific PFAS pharmacokinetics in mice, rats, and non-human primates using a Bayesian hierarchical methodology
10.1016/j.taap.2025.117336 · 2025 · External reference
