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References from Chronic exposure to aerosolized PM2.5 in rats alters plasma protein levels and ex vivo coronary artery response to sphingosine-1-phosphate. Local targets link to admitted publications; unresolved targets remain external evidence.
Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome
10.1097/ccm.0b013e3181feb46a · 2011 · External reference
Post-translational modifications of S1PR1 and endothelial barrier regulation
2020 · External reference
The impact of fine particulate matter 2.5 on the cardiovascular system: a review of the invisible killer
10.3390/nano12152656 · 2022 · External reference
Physicochemical metamorphosis of re-aerosolized urban PM2.5
10.1016/j.jaerosci.2024.106416 · 2024 · External reference
Sphingosine 1-phosphate: lipid signaling in pathology and therapy
10.1126/science.aar5551 · 2019 · External reference
Long-term exposure to PM and all-cause and cause-specific mortality: a systematic review and meta-analysis
10.1016/j.envint.2020.105974 · 2020 · External reference
Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions
10.1152/ajpregu.90899.2008 · 2009 · External reference
Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the global burden of diseases study 2015
10.1016/s0140-6736(17)30505-6 · 2017 · External reference
Endothelial Spns2 and ApoM regulation of vascular tone and hypertension via Sphingosine-1-Phosphate
10.1161/jaha.121.021261 · 2021 · External reference
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
10.1183/13993003.03957-2020 · 2021 · External reference
Comparative electrocardiographic, autonomic and systemic inflammatory responses to soy biodiesel and petroleum diesel emissions in rats
10.3109/08958378.2015.1057884 · 2015 · External reference
High blood pressure and cardiovascular disease
10.1161/hypertensionaha.119.14240 · 2020 · External reference
The association between air pollution and cognitive impairment: a systematic review and meta- analysis of global studies
10.1186/s12889-025-24560-9 · 2025 · External reference
LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ET(B)) receptors in cultured endothelium-intact rat coronary arteries
10.1016/j.vph.2010.09.006 · 2010 · External reference
Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia
10.1001/jamaneurol.2019.4914 · 2020 · External reference
The use of wire myography to investigate vascular tone and function
10.1007/978-1-0716-1924-7_23 · 2022 · External reference
Air pollution and hypertension: mechanistic and epidemiological insights
10.33963/v.phj.105320 · 2025 · External reference
Reference data of the main physiological parameters in control sprague-dawley rats from pre-clinical toxicity studies
2010 · External reference
PM2.5 air pollution and cause-specific cardiovascular disease mortality
10.1093/ije/dyz114 · 2020 · External reference
Unresolved reference
2025 · External reference
Endothelin-1: biosynthesis, signaling and vasoreactivity
10.1016/bs.apha.2016.05.002 · 2016 · External reference
Sphingosine-1-phosphate signaling in blood pressure regulation
10.1152/ajprenal.00572.2018 · 2019 · External reference
Endothelin-1 levels and cardiovascular events
10.1016/j.tcm.2019.01.007 · 2020 · External reference
Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology
10.1016/j.phrs.2020.104793 · 2020 · External reference
Plasma S1P (Sphingosine-1-Phosphate) links to hypertension and biomarkers of inflammation and cardiovascular disease: findings from a translational investigation
10.1161/hypertensionaha.120.17379 · 2021 · External reference
Animal research: reporting in vivo experiments: the ARRIVE guidelines
10.1111/j.1476-5381.2010.00872.x · 2010 · External reference
Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction
10.1016/j.prostaglandins.2013.10.001 · 2013 · External reference
Sources, metabolism, and regulation of circulating sphingosine-1-phosphate
10.1194/jlr.r059543 · 2015 · External reference
Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology
10.1152/ajpheart.00026.2020 · 2020 · External reference
Lipidomics insight into chronic exposure to ambient air pollution in mice
10.1016/j.envpol.2020.114668 · 2020 · External reference
The critical role of endothelial function in fine particulate matter-induced atherosclerosis
10.1186/s12989-020-00391-x · 2020 · External reference
Serum sphingosine 1-Phosphate (S1P): a novel diagnostic biomarker in early acute ischemic stroke
10.3389/fneur.2020.00985 · 2020 · External reference
Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle
10.1016/0014-2999(95)00494-7 · 1995 · External reference
Vasodilator effects of endothelin-converting enzyme inhibition and endothelin ETA receptor blockade in chronic heart failure patients treated with ACE inhibitors
10.1161/01.cir.94.9.2131 · 1996 · External reference
Sphingosine 1-phosphate and its receptors in ischemia
10.1016/j.cca.2021.06.020 · 2021 · External reference
Sphingosine-1-phosphate signaling and its role in disease
10.1016/j.tcb.2011.09.003 · 2012 · External reference
Oxidative stress and the cardiovascular effects of air pollution
10.1016/j.freeradbiomed.2020.01.004 · 2020 · External reference
Air pollution and cardiovascular disease: car sick
2020 · External reference
Impaired endothelial function in isolated human uremic resistance arteries
10.1046/j.1523-1755.2001.0600031077.x · 2001 · External reference
Metabolomic signatures of the short-term exposure to air pollution and temperature
10.1016/j.envres.2021.111553 · 2021 · External reference
Sphingosine 1-phosphate and inflammation
10.1093/intimm/dxz037 · 2019 · External reference
Concentration-dependent alterations in the human plasma proteome following controlled exposure to diesel exhaust
10.1016/j.envpol.2023.123087 · 2024 · External reference
Effect of injury on plasma proteins
1967 · External reference
Unresolved reference
External reference
Plasma exudation in the airways: mechanisms and function
10.1183/09031936.93.04101268 · 1991 · External reference
Health effects of fine particulate air pollution: lines that connect
10.1080/10473289.2006.10464485 · 2006 · External reference
Long-term PM2.5 exposure and respiratory, cancer, and cardiovascular mortality in older US adults
10.1093/aje/kwx166 · 2017 · External reference
Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells
2022 · External reference
Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease
10.1007/s00395-010-0112-5 · 2010 · External reference
Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction
10.1006/bbrc.1994.1494 · 1994 · External reference
Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
10.1097/01.sla.0000055547.93484.87 · 2003 · External reference
The role of G protein-coupled receptors in the right ventricle in pulmonary hypertension
10.3389/fcvm.2018.00179 · 2018 · External reference
Airway exposure to urban aerosolized PM2. 5 particles induces neuroinflammation and endothelin-mediated contraction of coronary arteries in adult rats
10.1016/j.envadv.2022.100184 · 2022 · External reference
Sphingosine-1-Phosphate signaling in cardiovascular diseases
10.3390/biom13050818 · 2023 · External reference
Effects of coal-fired PM(2.5) on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE(-/-) mice
10.1186/s40360-020-00411-8 · 2020 · External reference
Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats
10.1016/j.scitotenv.2017.03.064 · 2017 · External reference
Vasoconstrictor stimulus determines the functional contribution of myoendothelial feedback to mesenteric arterial tone
10.1113/jp274797 · 2018 · External reference
Guidelines for the measurement of vascular function and structure in isolated arteries and veins
10.1152/ajpheart.01021.2020 · 2021 · External reference
Unresolved reference
2024 · External reference
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes
10.1016/0006-291x(91)91601-8 · 1991 · External reference
Chemical constituents and sources of ambient particulate air pollution and biomarkers of endothelial function in a panel of healthy adults in Beijing, China
10.1016/j.scitotenv.2016.03.228 · 2016 · External reference
The role of MAPK pathways in airborne fine particulate matter-induced upregulation of endothelin receptors in rat basilar arteries
10.1093/toxsci/kfv229 · 2016 · External reference
IRE1alpha/XBP1s branch of UPR links HIF1alpha activation to mediate ANGII-dependent endothelial dysfunction under particulate matter (PM) 2.5 exposure
2017 · External reference
Ambient air pollution and atherosclerosis: a potential mediating role of sphingolipids
10.1161/atvbaha.122.317753 · 2022 · External reference
Global association between ambient air pollution and blood pressure: a systematic review and meta-analysis
10.1016/j.envpol.2018.01.001 · 2018 · External reference
PM(2.5)-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis
10.1016/j.envint.2019.105444 · 2020 · External reference
Dynamic recovery after acute single fine particulate matter exposure in male mice: effect on lipid deregulation and cardiovascular alterations
10.1016/j.jhazmat.2021.125504 · 2021 · External reference
Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells
10.1016/j.envpol.2018.11.108 · 2019 · External reference
Barrier maintenance by S1P during inflammation and sepsis
10.1080/21688370.2021.1940069 · 2021 · External reference
Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia
10.1001/jamaneurol.2019.4914 · ExternalCitation · doi-reference
Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction
10.1006/bbrc.1994.1494 · ExternalCitation · doi-reference
The use of wire myography to investigate vascular tone and function
10.1007/978-1-0716-1924-7_23 · ExternalCitation · doi-reference
Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease
10.1007/s00395-010-0112-5 · ExternalCitation · doi-reference
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes
10.1016/0006-291x(91)91601-8 · ExternalCitation · doi-reference
Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle
10.1016/0014-2999(95)00494-7 · ExternalCitation · doi-reference
Endothelin-1: biosynthesis, signaling and vasoreactivity
10.1016/bs.apha.2016.05.002 · ExternalCitation · doi-reference
Sphingosine 1-phosphate and its receptors in ischemia
10.1016/j.cca.2021.06.020 · ExternalCitation · doi-reference
Airway exposure to urban aerosolized PM2. 5 particles induces neuroinflammation and endothelin-mediated contraction of coronary arteries in adult rats
10.1016/j.envadv.2022.100184 · ExternalCitation · doi-reference
PM(2.5)-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis
10.1016/j.envint.2019.105444 · ExternalCitation · doi-reference
Long-term exposure to PM and all-cause and cause-specific mortality: a systematic review and meta-analysis
10.1016/j.envint.2020.105974 · ExternalCitation · doi-reference
Global association between ambient air pollution and blood pressure: a systematic review and meta-analysis
10.1016/j.envpol.2018.01.001 · ExternalCitation · doi-reference
Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells
10.1016/j.envpol.2018.11.108 · ExternalCitation · doi-reference
Lipidomics insight into chronic exposure to ambient air pollution in mice
10.1016/j.envpol.2020.114668 · ExternalCitation · doi-reference
Concentration-dependent alterations in the human plasma proteome following controlled exposure to diesel exhaust
10.1016/j.envpol.2023.123087 · ExternalCitation · doi-reference
Metabolomic signatures of the short-term exposure to air pollution and temperature
10.1016/j.envres.2021.111553 · ExternalCitation · doi-reference
Oxidative stress and the cardiovascular effects of air pollution
10.1016/j.freeradbiomed.2020.01.004 · ExternalCitation · doi-reference
Physicochemical metamorphosis of re-aerosolized urban PM2.5
10.1016/j.jaerosci.2024.106416 · ExternalCitation · doi-reference
Dynamic recovery after acute single fine particulate matter exposure in male mice: effect on lipid deregulation and cardiovascular alterations
10.1016/j.jhazmat.2021.125504 · ExternalCitation · doi-reference
Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology
10.1016/j.phrs.2020.104793 · ExternalCitation · doi-reference
Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction
10.1016/j.prostaglandins.2013.10.001 · ExternalCitation · doi-reference
Chemical constituents and sources of ambient particulate air pollution and biomarkers of endothelial function in a panel of healthy adults in Beijing, China
10.1016/j.scitotenv.2016.03.228 · ExternalCitation · doi-reference
Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats
10.1016/j.scitotenv.2017.03.064 · ExternalCitation · doi-reference
Sphingosine-1-phosphate signaling and its role in disease
10.1016/j.tcb.2011.09.003 · ExternalCitation · doi-reference
Endothelin-1 levels and cardiovascular events
10.1016/j.tcm.2019.01.007 · ExternalCitation · doi-reference
LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ET(B)) receptors in cultured endothelium-intact rat coronary arteries
10.1016/j.vph.2010.09.006 · ExternalCitation · doi-reference
Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the global burden of diseases study 2015
10.1016/s0140-6736(17)30505-6 · ExternalCitation · doi-reference
Impaired endothelial function in isolated human uremic resistance arteries
10.1046/j.1523-1755.2001.0600031077.x · ExternalCitation · doi-reference
Health effects of fine particulate air pollution: lines that connect
10.1080/10473289.2006.10464485 · ExternalCitation · doi-reference
Barrier maintenance by S1P during inflammation and sepsis
10.1080/21688370.2021.1940069 · ExternalCitation · doi-reference
Long-term PM2.5 exposure and respiratory, cancer, and cardiovascular mortality in older US adults
10.1093/aje/kwx166 · ExternalCitation · doi-reference
PM2.5 air pollution and cause-specific cardiovascular disease mortality
10.1093/ije/dyz114 · ExternalCitation · doi-reference
Sphingosine 1-phosphate and inflammation
10.1093/intimm/dxz037 · ExternalCitation · doi-reference
The role of MAPK pathways in airborne fine particulate matter-induced upregulation of endothelin receptors in rat basilar arteries
10.1093/toxsci/kfv229 · ExternalCitation · doi-reference
Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
10.1097/01.sla.0000055547.93484.87 · ExternalCitation · doi-reference
Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome
10.1097/ccm.0b013e3181feb46a · ExternalCitation · doi-reference
Animal research: reporting in vivo experiments: the ARRIVE guidelines
10.1111/j.1476-5381.2010.00872.x · ExternalCitation · doi-reference
Vasoconstrictor stimulus determines the functional contribution of myoendothelial feedback to mesenteric arterial tone
10.1113/jp274797 · ExternalCitation · doi-reference
Sphingosine 1-phosphate: lipid signaling in pathology and therapy
10.1126/science.aar5551 · ExternalCitation · doi-reference
Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology
10.1152/ajpheart.00026.2020 · ExternalCitation · doi-reference
Guidelines for the measurement of vascular function and structure in isolated arteries and veins
10.1152/ajpheart.01021.2020 · ExternalCitation · doi-reference
Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions
10.1152/ajpregu.90899.2008 · ExternalCitation · doi-reference
Sphingosine-1-phosphate signaling in blood pressure regulation
10.1152/ajprenal.00572.2018 · ExternalCitation · doi-reference
Vasodilator effects of endothelin-converting enzyme inhibition and endothelin ETA receptor blockade in chronic heart failure patients treated with ACE inhibitors
10.1161/01.cir.94.9.2131 · ExternalCitation · doi-reference
Ambient air pollution and atherosclerosis: a potential mediating role of sphingolipids
10.1161/atvbaha.122.317753 · ExternalCitation · doi-reference
High blood pressure and cardiovascular disease
10.1161/hypertensionaha.119.14240 · ExternalCitation · doi-reference
Plasma S1P (Sphingosine-1-Phosphate) links to hypertension and biomarkers of inflammation and cardiovascular disease: findings from a translational investigation
10.1161/hypertensionaha.120.17379 · ExternalCitation · doi-reference
Endothelial Spns2 and ApoM regulation of vascular tone and hypertension via Sphingosine-1-Phosphate
10.1161/jaha.121.021261 · ExternalCitation · doi-reference
Plasma exudation in the airways: mechanisms and function
10.1183/09031936.93.04101268 · ExternalCitation · doi-reference
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
10.1183/13993003.03957-2020 · ExternalCitation · doi-reference
The association between air pollution and cognitive impairment: a systematic review and meta- analysis of global studies
10.1186/s12889-025-24560-9 · ExternalCitation · doi-reference
The critical role of endothelial function in fine particulate matter-induced atherosclerosis
10.1186/s12989-020-00391-x · ExternalCitation · doi-reference
Effects of coal-fired PM(2.5) on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE(-/-) mice
10.1186/s40360-020-00411-8 · ExternalCitation · doi-reference
Sources, metabolism, and regulation of circulating sphingosine-1-phosphate
10.1194/jlr.r059543 · ExternalCitation · doi-reference
Comparative electrocardiographic, autonomic and systemic inflammatory responses to soy biodiesel and petroleum diesel emissions in rats
10.3109/08958378.2015.1057884 · ExternalCitation · doi-reference
The role of G protein-coupled receptors in the right ventricle in pulmonary hypertension
10.3389/fcvm.2018.00179 · ExternalCitation · doi-reference
Serum sphingosine 1-Phosphate (S1P): a novel diagnostic biomarker in early acute ischemic stroke
10.3389/fneur.2020.00985 · ExternalCitation · doi-reference
Sphingosine-1-Phosphate signaling in cardiovascular diseases
10.3390/biom13050818 · ExternalCitation · doi-reference
The impact of fine particulate matter 2.5 on the cardiovascular system: a review of the invisible killer
10.3390/nano12152656 · ExternalCitation · doi-reference
Air pollution and hypertension: mechanistic and epidemiological insights
10.33963/v.phj.105320 · ExternalCitation · doi-reference
