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References from Prognostic relevance of secondary actionable fusions in MLH1-deficient dMMR/MSI-H gastrointestinal tumors treated with pembrolizumab. Local targets link to admitted publications; unresolved targets remain external evidence.
Phase II open-label study of pembrolizumab in treatment-refractory, microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: KEYNOTE-164
10.1200/jco.19.02107 · 2020 · External reference
Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair-deficient cancer: results from the phase II KEYNOTE-158 study
10.1200/jco.19.02105 · 2020 · External reference
Pembrolizumab in microsatellite-instability–high advanced colorectal cancer
10.1056/nejmoa2017699 · 2020 · External reference
Association of primary resistance to immune checkpoint inhibitors in metastatic colorectal cancer with misdiagnosis of microsatellite instability or mismatch repair deficiency status
10.1001/jamaoncol.2018.4942 · 2019 · External reference
Classification and characterization of microsatellite instability across 18 cancer types
10.1038/nm.4191 · 2016 · External reference
Hyperprogressive disease is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1
10.1158/1078-0432.ccr-16-1741 · 2017 · External reference
Relationship between MLH1 promoter methylation, RAS/BRAF mutations, and response to immune checkpoint inhibitors in patients with advanced colorectal cancer
2020 · External reference
Analysis of somatic microsatellite indels identifies driver events in human tumors
10.1038/nbt.3966 · 2017 · External reference
Landscape of microsatellite instability across 39 cancer types
2017 · External reference
Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer
10.1016/j.ejca.2025.115338 · 2025 · External reference
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials
10.1016/s1470-2045(19)30691-6 · 2020 · External reference
Precision targeted therapy with BLU-667 for RET-driven cancers
10.1158/2159-8290.cd-18-0338 · 2018 · External reference
Prognostic impact of clinical factors in MSI-H/dMMR gastrointestinal tumors treated with immune checkpoint inhibitors: results from a multicenter real-world study
2026 · External reference
Unraveling resistance to immunotherapy in MSI-high colorectal cancer
10.3390/cancers15205090 · 2023 · External reference
Genetic mechanisms of mmune evasion in colorectal cancer
10.1158/2159-8290.cd-17-1327 · 2018 · External reference
Microsatellite instability and metastatic colorectal cancer: a clinical perspective
10.3389/fonc.2022.888181 · 2022 · External reference
Mechanisms and strategies to overcome drug resistance in colorectal cancer
10.3390/ijms26051988 · 2025 · External reference