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References from Trichloroethylene and perchloroethylene metabolites have fetal sex-specific RNA expression impacts in a full term placental villous explant model. Local targets link to admitted publications; unresolved targets remain external evidence.
Aberrant expression of solute carrier family transporters in placentas associated with pregnancy complications
10.1016/j.placenta.2024.11.011 · 2025 · External reference
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Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water
10.1039/c9em00590k · 2020 · External reference
Controlling the false discovery rate - a practical and powerful approach to multiple testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
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Oxygen and tissue culture affect placental gene expression
10.1016/j.placenta.2017.04.024 · 2017 · External reference
Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences
10.1038/s42003-023-04623-6 · 2023 · External reference
Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment
10.1016/j.toxlet.2021.01.021 · 2021 · External reference
Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study
10.1186/1476-069x-13-72 · 2014 · External reference
Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy
10.3389/fimmu.2014.00253 · 2014 · External reference
Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps
10.1124/jpet.116.232629 · 2016 · External reference
Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis
10.1002/j.2040-4603.2012.tb00424.x · 2012 · External reference
Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease
10.1039/c9em00578a · 2020 · External reference
Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies
10.1093/humupd/dmae006 · 2024 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine revealed activation of the eIF2alpha/ATF4 integrated stress response in two in vitro placental models
10.1007/s00204-021-03011-5 · 2021 · External reference
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts
10.1016/j.tox.2019.152283 · 2019 · External reference
Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line
10.1016/j.taap.2017.11.006 · 2018 · External reference
Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models
10.1016/j.reprotox.2022.03.003 · 2022 · External reference
10.15620/cdc:111053
10.15620/cdc:111053 · External reference
The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction
10.1096/fj.07-8688com · 2007 · External reference
Adverse birth outcomes and maternal exposure to trichloroethylene and tetrachloroethylene through soil vapor intrusion in New York State
10.1289/ehp.1103884 · 2012 · External reference
Prenatal and early childhood exposure to tetrachloroethylene (PCE) and non-medical use of prescription drugs: A retrospective cohort study in Cape Cod, MA
10.1016/j.envres.2020.110384 · 2021 · External reference
Trichloroacetic acid accumulates in murine amniotic fluid after tri- and tetrachloroethylene inhalation
10.1111/j.1600-0773.1986.tb00078.x · 1986 · External reference
Systematic literature review of uses and levels of occupational exposure to tetrachloroethylene
10.1080/15459620802510866 · 2008 · External reference
Maternal infection and adverse fetal and neonatal outcomes
10.1016/j.clp.2005.04.006 · 2005 · External reference
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model
10.1016/j.tiv.2022.105429 · 2022 · External reference
QoRTs: a comprehensive toolset for quality control and data processing of RNA-Seq experiments
10.1186/s12859-015-0670-5 · 2015 · External reference
Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
10.1016/j.ajog.2016.03.001 · 2016 · External reference
Gestational dynamics of hofbauer cells in the human placenta: distribution, morphology, and immunophenotype
10.3390/jdb14020026 · 2026 · External reference
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters
10.1074/jbc.m009462200 · 2001 · External reference
Cardiovascular morbidities in adults born preterm: getting to the heart of the matter!
10.3390/children9121843 · 2022 · External reference
Placental villous explant culture 2.0: flow culture allows studies closer to the in vivo situation
10.3390/ijms22147464 · 2021 · External reference
Studies on placental transfer. Trichlorethylene
1970 · External reference
Trichloroethylene: an update on an environmental contaminant with multiple health effects
10.1146/annurev-pharmtox-022724-120525 · 2025 · External reference
Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity
10.1016/j.mrrev.2014.04.003 · 2014 · External reference
Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene
10.1080/009841099158204 · 1999 · External reference
Comprehensive genome-wide proteomic analysis of human placental tissue for the Chromosome-Centric Human Proteome Project
10.1021/pr301040g · 2013 · External reference
Physiological and anatomical determinants of placental drug transfer
10.1113/jp289604 · 2026 · External reference
The sequence alignment/map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
A pilot study characterizing tetrachloroethylene exposure with exhaled breath in an impacted community
10.1016/j.envpol.2021.118756 · 2022 · External reference
Impact of gestational hypertension and preeclampsia on low birthweight and small-for-gestational-age infants in China: a large prospective cohort study
10.1111/jch.14176 · 2021 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
Human placenta: a human organ for developmental toxicology research and biomonitoring
10.1016/j.placenta.2004.09.006 · 2005 · External reference
Determining cell type abundance and expression from bulk tissues with digital cytometry
10.1038/s41587-019-0114-2 · 2019 · External reference
Preterm birth, low birth weight, and their co-occurrence among women with preexisting chronic diseases prior to conception: a cross-sectional analysis of postpartum women in a low-resource setting in Ghana
10.1186/s40748-024-00188-2 · 2024 · External reference
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Preterm birth and asthma and COPD in adulthood: a nationwide register study from two Nordic countries
10.1183/13993003.01763-2022 · 2023 · External reference
Mechanisms of Fetal T Cell Tolerance and Immune Regulation
10.3389/fimmu.2020.00588 · 2020 · External reference
Neurologic Consequences of Preterm Birth
10.1007/s11910-018-0862-2 · 2018 · External reference
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10
10.1084/jem.184.2.539 · 1996 · External reference
Evaluation of contaminated drinking water and preterm birth, small for gestational age, and birth weight at Marine Corps Base Camp Lejeune, North Carolina: a cross-sectional study
10.1186/1476-069x-13-99 · 2014 · External reference
TM4: a free, open-source system for microarray data management and analysis
10.2144/03342mt01 · 2003 · External reference
The functional regeneration of syncytiotrophoblast in cultured explants of term placenta
10.1152/ajpregu.2001.280.4.r1116 · 2001 · External reference
N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate toxicity of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine in human placental villous trophoblast BeWo cells
10.1016/j.tox.2023.153611 · 2023 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Maternal mechanisms in air pollution exposure-related adverse pregnancy outcomes: A systematic review
10.1016/j.scitotenv.2025.178999 · 2025 · External reference
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Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L
1998 · External reference
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Exposure assessment of trichloroethylene
10.1289/ehp.00108s2359 · 2000 · External reference
Analytical methods impact estimates of trichloroethylene's glutathione conjugation and risk assessment
10.1016/j.toxlet.2018.07.006 · 2018 · External reference
The elusive role of placental macrophages: the hofbauer cell
10.1159/000497416 · 2019 · External reference
