Research graph
References from Assessment of acute functional effects of perfluorooctanoic acid (PFOA), heptafluorobutyric acid (HFBA), and hexafluoropropylene oxide dimer acid (HFPO-DA) in human iPSC-derived cardiomyocytes using multielectrode arrays. Local targets link to admitted publications; unresolved targets remain external evidence.
International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment
10.1016/j.celrep.2018.08.079 · 2018 · External reference
Short-chain perfluoroalkyl acids: environmental concerns and a regulatory strategy under REACH
10.1186/s12302-018-0134-4 · 2018 · External reference
Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins
10.1002/ieam.258 · 2011 · External reference
High-throughput multi-parameter profiling of electrophysiological drug effects in human embryonic stem cell derived cardiomyocytes using multi-electrode arrays
10.1093/toxsci/kfu084 · 2014 · External reference
Developmental effects of PFOS, PFOA and GenX in a 3D human induced pluripotent stem cell differentiation model
10.1016/j.chemosphere.2021.130624 · 2021 · External reference
PFAS exposure pathways for humans and wildlife: a synthesis of current knowledge and key gaps in understanding
10.1002/etc.4935 · 2021 · External reference
Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals
10.1016/j.envint.2021.106982 · 2022 · External reference
Membrane-water partition coefficients to aid risk assessment of perfluoroalkyl anions and alkyl sulfates
10.1021/acs.est.8b05052 · 2019 · External reference
A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm
10.1177/1087057115594589 · 2016 · External reference
Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters
10.1152/ajpcell.00143.2013 · 2013 · External reference
Partitioning and accumulation of perfluoroalkyl substances in model lipid bilayers and bacteria
10.1021/acs.est.8b02912 · 2018 · External reference
Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy
10.1186/s40246-024-00665-x · 2024 · External reference
Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China
10.1038/srep38039 · 2016 · External reference
An evaluation of hERG current assay performance: translating preclinical safety studies to clinical QT prolongation
10.1016/j.pharmthera.2010.08.008 · 2011 · External reference
An overview of the uses of per- and polyfluoroalkyl substances (PFAS)
10.1039/d0em00291g · 2020 · External reference
Emerging perfluorinated chemical GenX: environmental and biological fates and risks
10.1021/envhealth.4c00164 · 2025 · External reference
Effects of PFOS and PFOA on L-type Ca2+ currents in guinea-pig ventricular myocytes
10.1016/j.bbrc.2005.01.163 · 2005 · External reference
Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes
10.1016/j.taap.2021.115696 · 2021 · External reference
Associations of serum PFAS with electrocardiographic abnormalities in older adults and electrophysiological characterization
10.1021/acs.est.5c16480 · 2026 · External reference
Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes
10.1002/tox.22162 · 2016 · External reference
Short-chain PFAS: a global challenge-environmental fate, health risks, and promising removal technologies
2025 · External reference
Investigation on arrhythmogenic potential of phenanthrene using human induced pluripotent stem cell-derived cardiomyocytes
10.1007/s13273-024-00485-z · 2025 · External reference
Perfluoroalkyl acids: a review of monitoring and toxicological findings
10.1093/toxsci/kfm128 · 2007 · External reference
Development and validation of dual-cardiotoxicity evaluation method based on analysis of field potential and contractile force of human iPSC-derived cardiomyocytes / multielectrode assay platform
10.1016/j.bbrc.2021.03.039 · 2021 · External reference
Evaluation of phthalates induced cardiotoxicity using human iPSCs-derived cardiomyocyte and dual-cardiotoxicity evaluation methods
10.1016/j.ecoenv.2025.118196 · 2025 · External reference
Perfluoroalkyl chain-length-dependent environmental fate and treatment outcomes of PFAS in water
10.1038/s41545-026-00568-5 · 2026 · External reference
Physicochemical properties and interactions of perfluoroalkyl substances (PFAS) - challenges and opportunities in sensing and remediation
10.1016/j.scitotenv.2023.166764 · 2023 · External reference
Polyfluorinated compounds: past, present, and future
10.1021/es2011622 · 2011 · External reference
Perfluorooctanoic acid (PFOA) induces cardiotoxicity by activating the Keap1/Nrf2 pathway in zebrafish (Danio rerio) embryos
10.1016/j.ecoenv.2024.117098 · 2024 · External reference
Possible mechanism of perfluorooctane sulfonate and perfluorooctanoate on the release of calcium ion from calcium stores in primary cultures of rat hippocampal neurons
10.1016/j.tiv.2011.04.016 · 2011 · External reference
Unraveling the exposure spectrum of PFAS in fluorochemical occupational workers: structural diversity, temporal trends, and risk prioritization
10.1021/acs.est.4c13281 · 2025 · External reference
Predictive value of the hERG assay for anticipating the arrhythmogenic potential of new drugs
10.1016/j.drudis.2026.104615 · 2026 · External reference
Cross-site reliability of human induced pluripotent stem cell-derived cardiomyocyte based safety assays using microelectrode arrays: results from a blinded CiPA pilot study
10.1093/toxsci/kfy110 · 2018 · External reference
Bioaccumulation of perfluorinated alkyl acids: observations and models
10.1021/es404008g · 2014 · External reference
Early warnings by liver organoids on short- and long-chain PFAS toxicity
10.3390/toxics10020091 · 2022 · External reference
Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells
10.1002/tox.23680 · 2023 · External reference
Acute toxicity and risk assessment of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) in tropical cladocerans Moina micrura
10.1016/j.chemosphere.2022.137377 · 2023 · External reference
Maternal exposure causes mitochondrial dysfunction in brain, liver, and heart of mouse fetus: an explanation for perfluorooctanoic acid induced abortion and developmental toxicity
10.1002/tox.22760 · 2019 · External reference
Perfluorooctanoic acid and cardiovascular disease in US adults
10.1001/archinternmed.2012.3393 · 2012 · External reference
Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
10.1289/ehp.0901827 · 2010 · External reference
Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos
10.1016/j.chemosphere.2022.136999 · 2023 · External reference
Fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their potential precursors
10.1016/j.envint.2013.08.021 · 2013 · External reference
Lower toxicity of HFPO-DA compared to its predecessor PFOA to the earthworm Eisenia fetida: Evidence from oxidative stress and transcriptomic analysis
10.1016/j.jhazmat.2024.137003 · 2025 · External reference
Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: roles of peroxisome proliferator activated receptor alpha
10.1016/j.envpol.2021.118112 · 2021 · External reference
Toxicity of perfluorooctanoic acid on zebrafish early embryonic development determined by single-cell RNA sequencing
10.1016/j.jhazmat.2021.127888 · 2022 · External reference
Perfluorooctanoic acid (PFOA) disrupts cardiac performance of thick-shell mussel by inserting into the binding pocket of proliferator-activated receptor gamma and thereby causing lipid metabolism disorders
10.1016/j.envpol.2025.126369 · 2025 · External reference
Prevalent per- and polyfluoroalkyl substances (PFASs) pollution in freshwater basins in China: a short review
2025 · External reference
Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: a tool for cardiac safety assessment
10.1016/j.vascn.2016.06.004 · 2016 · External reference
Elevated levels of ultrashort- and short-chain perfluoroalkyl acids in US homes and people
10.1021/acs.est.2c06715 · 2023 · External reference
