Research graph
References from Fish Immunotoxicity Research (2015 – 2025): A Systematic Review of Methodological Approaches, Progress and Data Gaps. Local targets link to admitted publications; unresolved targets remain external evidence.
Identification of immunotoxic effects of chemicals and assessment of their relevance to man
10.1016/0278-6915(88)90006-3 · 1988 · External reference
New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project
10.3389/ftox.2024.1339104 · 2024 · External reference
Unresolved reference
External reference
Immunotoxic effects of environmental pollutants in marine mammals
10.1016/j.envint.2015.10.007 · 2016 · External reference
Organochlorine levels in common seals (Phoca vitulina) which were victims and survivors of the 1988 phocine distemper epizootic
10.1016/0048-9697(92)90039-u · 1992 · External reference
10.1016/0048-9697(94)90091-4
10.1016/0048-9697(94)90091-4 · External reference
Zebrafish embryos as an alternative to animal experiments--a commentary on the definition of the onset of protected life stages in animal welfare regulations
10.1016/j.reprotox.2011.06.121 · 2012 · External reference
Assessing Fish Immunotoxicity by Means of In Vitro Assays: Are We There Yet?
10.3389/fimmu.2022.835767 · 2022 · External reference
Ecological Risks Due to Immunotoxicological Effects on Aquatic Organisms
10.3390/ijms22158305 · 2021 · External reference
Immunotoxicological effects of insecticides in exposed fishes
10.1016/j.cbpc.2021.109064 · 2021 · External reference
Endocrine disrupters affect the immune system of fish: The example of the European seabass
10.1016/j.fsi.2025.110303 · 2025 · External reference
Modulation of immune response by organophosphorus pesticides: fishes as a potential model in immunotoxicology
10.1155/2015/213836 · 2015 · External reference
Thyroid function and immune status in perch (Perca fluviatilis) from lakes contaminated with PFASs or PCBs
10.1016/j.ecoenv.2021.112495 · 2021 · External reference
Microplastics accumulation in gastrointestinal tracts of Mullus barbatus and Merluccius merluccius is associated with increased cytokine production and signaling
2022 · External reference
Dioxin and PCB levels in sea trout with ulcerative disease syndrome
10.1016/j.aquatox.2025.107336 · 2025 · External reference
Involvement of fish immunomarkers in environmental biomonitoring approach: Urban and agri-viticultural context
10.1016/j.ecoenv.2015.05.021 · 2015 · External reference
mRNA Expression and Biomarker Responses in Perch at a Biomonitoring Site in the Baltic Sea – Possible Influence of Natural Brominated Chemicals
10.3389/fmars.2019.00316 · 2019 · External reference
Advancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)
10.1016/j.jenvman.2024.120784 · 2024 · External reference
Host-pathogen interactions under pressure: A review and meta-analysis of stress-mediated effects on disease dynamics
10.1111/ele.14319 · 2023 · External reference
20 Years of fish immunotoxicology - what we know and where we are
10.1080/10408444.2017.1288024 · 2017 · External reference
10.2903/j.efsa.2018.5311
10.2903/j.efsa.2018.5311 · External reference
Adverse outcome pathways: a concise introduction for toxicologists
10.1007/s00204-017-2020-z · 2017 · External reference
Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations
10.1016/j.envres.2022.114650 · 2023 · External reference
Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?
10.3390/ijms22179460 · 2021 · External reference
Immunotoxicity of thyroid hormone system disrupting compounds in fish
10.1016/j.aquatox.2025.107309 · 2025 · External reference
A fresh perspective-advancing fish immunotoxicology in a complex world
2026 · External reference
Adverse outcome pathway networks I: Development and applications
10.1002/etc.4125 · 2018 · External reference
Adverse outcome pathway networks II: Network analytics
10.1002/etc.4124 · 2018 · External reference
Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations
10.1016/j.ecoenv.2016.11.024 · 2017 · External reference
Long-term exposure to low 17α-ethinylestradiol (EE2) concentrations disrupts both the reproductive and the immune system of juvenile rainbow trout, Oncorhynchus mykiss
10.1016/j.envint.2020.105836 · 2020 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
2021 · External reference
Unresolved reference
External reference
rrvgo: a Bioconductor package for interpreting lists of Gene Ontology terms
2023 · External reference
Unresolved reference
External reference
Immunotoxic effects of single and combined pharmaceuticals exposure on a harbor seal (Phoca vitulina) B lymphoma cell line
10.1016/j.marpolbul.2017.02.041 · 2017 · External reference
Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina
10.3389/ftox.2022.1010185 · 2022 · External reference
The Inclusion of a Supercritical Fluid Extract, Obtained From Honey Bee Pollen, in the Diet of Gilthead Sea Bream (Sparus aurata), Improves Fish Immune Response by Enhancing Anti-oxidant, and Anti-bacterial Activities
10.3389/fvets.2020.00095 · 2020 · External reference
Evaluation of in vitro and in vivo potential of Bacillus subtilis MBTDCMFRI Ba37 as a candidate probiont in fish health management
10.1016/j.micpath.2020.104610 · 2021 · External reference
Antioxidative and immunoprotective potential of Chlorella vulgaris dietary supplementation against chlorpyrifos-induced toxicity in Nile tilapia
10.1007/s10695-020-00814-8 · 2020 · External reference
ALDH7A1 is a protein that protects Atlantic salmon against Aeromonas salmonicida at the early stages of infection
10.1016/j.fsi.2017.08.043 · 2017 · External reference
Molecular cloning, characterization, and expression level analysis of a marine teleost homolog of catalase from big belly seahorse (Hippocampus abdominalis)
10.1016/j.fsi.2019.03.064 · 2019 · External reference
From Africa to the world—The journey of Nile tilapia
10.1111/raq.12738 · 2023 · External reference
Application of Multi-Omics Techniques in Aquatic Ecotoxicology: A Review
10.3390/toxics13080653 · 2025 · External reference
Comparative biomarker responses in Japanese medaka (Oryzias latipes) exposed to benzoapyrene and challenged with betanodavirus at three different life stages
10.1016/j.scitotenv.2018.10.256 · 2019 · External reference
The early ontogenetic development of immune cells and organs in teleosts
10.1016/j.fsi.2024.109371 · 2024 · External reference
Carp (Cyprinus carpio L.) innate immune factors are present before hatching
10.1016/j.fsi.2005.07.008 · 2006 · External reference
Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases
10.3390/ijms252212008 · 2024 · External reference
Early hematopoiesis and developing lymphoid organs in the zebrafish
10.1002/(sici)1097-0177(199904)214:4<323::aid-aja5>3.0.co;2-3 · 1999 · External reference
The effect of environmental stressors on growth in fish and its endocrine control
10.3389/fendo.2023.1109461 · 2023 · External reference
The intersection of stress, sex and immunity in fishes
10.1007/s00251-020-01194-2 · 2021 · External reference
Modification of the plasma complement protein profile by exogenous estrogens is indicative of a compromised immune competence in marine medaka (Oryzias melastigma)
10.1016/j.fsi.2017.09.020 · 2017 · External reference
Sex-specific immunomodulatory action of the environmentalestrogen 17α-ethynylestradiol alongside with reproductive impairment in fish
10.1016/j.aquatox.2018.07.019 · 2018 · External reference
Sex-dependent effects of subacute mercuric chloride exposure on histology, antioxidant status and immune-related gene expression in the liver of adult zebrafish (Danio rerio)
10.1016/j.chemosphere.2017.08.148 · 2017 · External reference
Main Components of Fish Immunity: An Overview of the Fish Immune System
10.3390/fishes8020093 · 2023 · External reference
Anatomy of teleost fish immune structures and organs
10.1007/s00251-020-01196-0 · 2021 · External reference
vivo verification of fish keratocyte explant culture for use as innate immunotoxicity screening assay: 2,4-Dicholorphenoxyacetic acid effects in fathead minnow (Pimephales promelas) keratocyte cell sheet migration
10.1016/j.chemosphere.2025.144276 · 2025 · External reference
Hepatopancreas toxicity and immunotoxicity of a fungicide, pyraclostrobin, on common carp
10.1016/j.cbpc.2022.109445 · 2022 · External reference
Bioaccumulation of manganese and its effects on oxidative stress and immune response in juvenile groupers (Epinephelus moara ♀ × E. lanceolatus ♂)
10.1016/j.chemosphere.2022.134235 · 2022 · External reference
Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish
10.1038/s41598-021-82711-5 · 2021 · External reference
Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish
10.1016/j.envint.2025.109688 · 2025 · External reference
Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB
10.1021/acs.est.1c07343 · 2022 · External reference
Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative
10.1073/pnas.1321614111 · 2014 · External reference
Stereoselective induction of developmental toxicity and immunotoxicity by acetochlor in the early life stage of zebrafish
10.1016/j.chemosphere.2016.09.004 · 2016 · External reference
Avermectin inhibits neutrophil extracellular traps release by activating PTEN demethylation to negatively regulate the PI3K-ERK pathway and reducing respiratory burst in carp
10.1016/j.jhazmat.2019.121885 · 2020 · External reference
Identification and functional characterization of a c-type lysozyme from Fenneropenaeus penicillatus
10.1016/j.fsi.2019.02.043 · 2019 · External reference
Expression Profiles of Zebrafish (Danio rerio) Lysozymes and Preparation of c-Type Lysozyme with High Bacteriolytic Activity against Vibrio vulnificus
2022 · External reference
The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
10.1111/j.1600-065x.2008.00701.x · 2008 · External reference
Diel rhythm of the inflammatory cytokine il1b in the Japanese medaka (Oryzias latipes) regulated by core components of the circadian clock
10.1016/j.fsi.2022.06.020 · 2022 · External reference
Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site
10.1006/cyto.1998.0470 · 1999 · External reference
Acute Phase Proteins and their Potential Role as an Indicator for Fish Health and in Diagnosis of Fish Diseases
10.2174/0929866524666161121142221 · 2017 · External reference
Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo
10.1042/bj3600039 · 2001 · External reference
Oxidative Stress in Fish: A Review
10.3329/jsr.v12i1.41716 · 2020 · External reference
Immune functions of phagocytic blood cells in teleost
10.1111/raq.12616 · 2022 · External reference
Advancing the fathead minnow (Pimephales promelas) as a model for immunotoxicity testing: Characterization of the renal transcriptome following Yersinia ruckeri infection
10.1016/j.fsi.2020.05.008 · 2020 · External reference
Polystyrene nanoplastics alter virus replication in orange-spotted grouper (Epinephelus coioides) spleen and brain tissues and spleen cells
10.1016/j.jhazmat.2021.125918 · 2021 · External reference
Ferroptosis is partially responsible for dexamethasone-induced T cell ablation, but not osteoporosis in larval zebrafish
10.1016/j.ecoenv.2022.113872 · 2022 · External reference
Commensal Microbiota Regulate Vertebrate Innate Immunity-Insights From the Zebrafish
10.3389/fimmu.2019.02100 · 2019 · External reference
Unresolved reference
2012 · External reference
17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection
10.1016/j.fsi.2011.04.007 · 2011 · External reference
PFAS-exposed zebrafish embryos show impaired innate immune response after infection with mycobacteria
10.1016/j.taap.2025.117484 · 2025 · External reference
The immune responses of the Chinese rare minnow (Gobiocypris rarus) exposed to environmentally relevant concentrations of cypermethrin and subsequently infected by the bacteria Pseudomonas fluorescens
10.1016/j.envpol.2019.03.126 · 2019 · External reference
Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis
10.1016/j.envpol.2018.08.070 · 2018 · External reference
Transcriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
10.1016/j.ecoenv.2022.113346 · 2022 · External reference
Publishing negative results is good for science
10.1099/acmi.0.000792 · 2024 · External reference
Standardization of experimental infection with Flavobacterium psychrophilum, the agent of rainbow trout Oncorhynchus mykiss fry syndrome
10.3354/dao042191 · 2000 · External reference
Assessment of the cytotoxic impact of cyanotoxin beta-N-methylamino-L-alanine on a fish immune cell line
10.1016/j.aquatox.2019.05.012 · 2019 · External reference
Cytotoxic and immunological responses of fish leukocytes to nodularin exposure in vitro
10.1002/jat.4154 · 2021 · External reference
Suppressive immunoregulatory effects of three antidepressants via inhibition of the nuclear factor-κB activation assessed using primary macrophages of carp (Cyprinus carpio)
10.1016/j.taap.2017.03.002 · 2017 · External reference
Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages
10.1021/acs.est.7b04226 · 2018 · External reference
