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References from Nutraceuticals and phytoceuticals in the treatment of bipolar disorder: A systematic review and network meta-analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: a randomized, double-blind, placebo-controlled trial
10.1111/pcn.13441 · 2022 · External reference
The effect of adding curcumin to sodium valproate in treatment of patients with bipolar disorder in the acute phase of mania: a randomized double-blind clinical trial
10.3389/fpsyt.2023.1068277 · 2023 · External reference
Short-Term effects of folate supplementation in combination with vitamin B6 for treating acute manic episodes in bipolar I Disorder: a randomized controlled trial
10.1002/brb3.70432 · 2025 · External reference
Mitochondrial complex i activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder
10.1001/archgenpsychiatry.2010.22 · 2010 · External reference
A systematic review of nutraceuticals for the treatment of bipolar disorder
10.1177/0706743720961734 · 2021 · External reference
The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double-blind, randomized, placebo-controlled, clinical trial
10.1002/brb3.2394 · 2021 · External reference
Netmeta: an R package for network meta-analysis using frequentist methods
10.18637/jss.v106.i02 · 2023 · External reference
The Bech-Rafaelsen mania scale and the Hamilton depression Scale: evaluation of homogeneity and inter-observer reliability
10.1111/j.1600-0447.1979.tb04484.x · 1979 · External reference
Unresolved reference
1961 · External reference
Unresolved reference
1996 · External reference
Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial
10.1111/j.1600-0447.2009.01368.x · 2009 · External reference
Omega-3 fatty acids in bipolar patients with a low omega-3 index and reduced heart rate variability: the “BIPO-3” trial
10.1186/s40345-022-00253-9 · 2022 · External reference
N-Acetyl cysteine for depressive symptoms in bipolar Disorder-A Double-Blind randomized placebo-controlled trial
10.1016/j.biopsych.2008.04.022 · 2008 · External reference
DSM-IV: diagnostic and statistical manual of mental disorders
10.1001/jama.1994.03520100096046 · 1994 · External reference
Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial
10.1186/1741-7015-10-91 · 2012 · External reference
A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo
10.1186/s12916-019-1280-2 · 2019 · External reference
Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder
10.1017/neu.2020.25 · 2020 · External reference
A placebo-controlled trial of acetyl-l-carnitine and α-lipoic acid in the treatment of bipolar depression
10.1097/jcp.0b013e31829a83f5 · 2013 · External reference
Inositol as an add-on treatment for bipolar depression
10.1034/j.1399-5618.2000.020107.x · 2000 · External reference
Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder
10.4088/jcp.13m08413 · 2013 · External reference
Conceptual and technical challenges in network meta-analysis
10.7326/0003-4819-159-2-201307160-00008 · 2013 · External reference
Efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence
10.1001/jamapsychiatry.2017.0624 · 2017 · External reference
Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic pain
10.1007/s10787-024-01623-8 · 2025 · External reference
The efficacy of adjunctive Garcinia mangostanaLinn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial
10.1192/bjp.2025.108 · 2025 · External reference
Antiepileptic drugs for the acute and maintenance treatment of bipolar disorder
10.1080/10673220127901 · 2001 · External reference
The never-ending problem: sample size matters
10.1016/j.euroneuro.2023.10.002 · 2023 · External reference
Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: a randomized controlled trial
10.1111/bdi.12652 · 2018 · External reference
Palmitoylethanolamide: a multifunctional molecule for Neuroprotection, chronic Pain, and immune modulation
10.3390/biomedicines13061271 · 2025 · External reference
The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: a randomized placebo-controlled study
10.1016/j.jad.2018.10.083 · 2019 · External reference
Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands
10.2174/0929867321666140303143455 · 2014 · External reference
Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis “Nutra NMA SCZ
10.1038/s41380-024-02645-y · 2025 · External reference
The concept and management of acute episodes of treatment-resistant bipolar disorder: a systematic review and exploratory meta-analysis of randomized controlled trials
10.1016/j.jad.2020.07.109 · 2020 · External reference
Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis
10.1038/s41380-026-03759-1 · 2026 · External reference
Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study
10.1192/bjp.188.1.46 · 2006 · External reference
The effect of adjunctive nutraceuticals in bipolar disorder: a systematic review of randomized placebo-controlled trials
10.1016/j.jad.2019.04.039 · 2019 · External reference
Supplementation of Omega-3 increases serum levels of brain-derived neurotrophic factor and decreases depression status in patients with bipolar Disorder: a Randomized, Double-Blind, placebo-controlled clinical trial
10.1111/jhn.70076 · 2025 · External reference
A meta-epidemiological study of positive results in clinical nutrition research: the good, the bad and the ugly of statistically significant findings
10.3390/nu14235164 · 2022 · External reference
A rating scale for depression
10.1136/jnnp.23.1.56 · 1960 · External reference
Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies
10.1002/jrsm.1044 · 2012 · External reference
Unresolved reference
2022 · External reference
Quantifying heterogeneity in a meta-analysis
10.1002/sim.1186 · 2002 · External reference
The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations
10.7326/m14-2385 · 2015 · External reference
The challenge of reforming nutritional epidemiologic research
10.1001/jama.2018.11025 · 2018 · External reference
Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode
10.1007/s11033-019-04989-z · 2019 · External reference
Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
10.1016/j.biopsych.2006.03.056 · 2006 · External reference
Network meta-analyses should be the highest level of evidence in treatment guidelines
10.1007/s00406-016-0715-4 · 2016 · External reference
Advances in molecular psychiatry–March 2023: mitochondrial function, stress, neuroinflammation–bipolar disorder, psychosis, and Alzheimer’s disease
10.1038/s41380-023-01968-6 · 2023 · External reference
Quantifying publication bias in meta-analysis
10.1111/biom.12817 · 2018 · External reference
Stimulation of peroxisome proliferator-activated Receptor-α by N-palmitoylethanolamine engages Allopregnanolone biosynthesis to modulate emotional behavior
10.1016/j.biopsych.2019.02.006 · 2019 · External reference
Vitamin D supplementation in bipolar depression: a double blind placebo controlled trial
10.1016/j.jpsychires.2017.07.021 · 2017 · External reference
What is nutritional Psychiatry? Position statement from the international society for nutritional psychiatry research
2026 · External reference
Methodological and reporting recommendations for clinical trials in nutritional Psychiatry: guidelines from the International Society for nutritional psychiatry research
2024 · External reference
The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management
10.1002/wps.20997 · 2022 · External reference
A 52-week prophylactic randomised control trial of omega-3 polyunsaturated fatty acids in bipolar disorder
10.1111/bdi.13037 · 2021 · External reference
Multi-nutrients as adjunctive treatment for bipolar disorder: a randomized-controlled trial
2023 · External reference
Evaluating the effect of Coenzyme Q10 augmentation on treatment of bipolar depression: a double-blind controlled clinical trial
10.1097/jcp.0000000000000938 · 2018 · External reference
A novel insight into the antidepressant effect of cannabidiol: possible involvement of the 5-HT1A, CB1, GPR55, and PPAR\uc0\u947 receptors Cannabidiol and brain function: current knowledge and future perspectives
10.1093/ijnp/pyae064 · 2025 · External reference
A new depression scale designed to be sensitive to change
10.1192/bjp.134.4.382 · 1979 · External reference
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
10.1371/journal.pmed.1003082 · 2020 · External reference
Epigenetics and bipolar disorder: new opportunities and challenges
10.1002/ajmg.c.20015 · 2003 · External reference
Understanding the molecular mechanisms underlying mood stabilizer treatments in bipolar disorder: potential involvement of epigenetics
10.1016/j.neulet.2016.06.045 · 2018 · External reference
Omega-3 fatty acids for the treatment of bipolar disorder Symptoms: a narrative review of the current clinical evidence
10.3390/md23020084 · 2025 · External reference
The basal pharmacology of Palmitoylethanolamide
10.3390/ijms21217942 · 2020 · External reference
Unresolved reference
2023 · External reference
Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase
10.1007/s11011-021-00776-7 · 2021 · External reference
Interpretation of random effects meta-analyses
10.1136/bmj.d549 · 2011 · External reference
Ranking treatments in frequentist network meta-analysis works without resampling methods
10.1186/s12874-015-0060-8 · 2015 · External reference
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: the world federation of societies of biological psychiatry (WFSBP) and Canadian Network for mood and anxiety treatments (CANMAT) taskforce
10.1080/15622975.2021.2013041 · 2022 · External reference
The efficacy of probiotics for treatment of bipolar disorder-type 1: a randomized, double-blind, placebo controlled trial
2020 · External reference
Effects of omega-3 supplement in the treatment of patients with bipolar i disorder
2016 · External reference
Industry involvement and transparency in the most cited clinical trials, 2019-2022
10.1001/jamanetworkopen.2023.43425 · 2023 · External reference
RoB 2: a revised tool for assessing risk of bias in randomised crossover trials (beta)
2020 · External reference
A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression
10.1007/s00702-017-1817-5 · 2018 · External reference
Nutraceuticals in mood disorders: current knowledge and future directions
10.1097/yco.0000000000000826 · 2023 · External reference
Evaluation of inconsistency in networks of interventions
10.1093/ije/dys222 · 2013 · External reference
Clinical characteristics and cognitive function in bipolar disorder patients with different onset symptom
2023 · External reference
A rating scale for mania: reliability, validity and sensitivity
10.1192/bjp.133.5.429 · 1978 · External reference
Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: a double-blind, randomized, placebo-controlled, clinical trial
10.1016/j.jad.2023.10.121 · 2024 · External reference
Adjunctive herbal medicine with carbamazepine for bipolar disorders: a double-blind, randomized, placebo-controlled study
10.1016/j.jpsychires.2005.06.002 · 2007 · External reference